101results about How to "Shorten hemostasis time" patented technology

The invention discloses a method for preparing a modified regenerated cellulose/alginate hemostatic composite material, and relates to a method for preparing a hemostatic material, belonging to the technical field of biomedical composite materials. The invention aims to solve the technical problem that an existing alginate material has an unsatisfactory hemostatic effect, poor structure integrity, and relatively low mechanical strength and stability. The method comprises a first step of modification of regenerated cellulose; a second step of preparation of an oxidized regenerated cellulose/sodium alginate water solution; a third step of molding of the hemostatic composite material; and a fourth step of cross-linking and solidification of the hemostatic composite material. According to the modified regenerated cellulose/alginate hemostatic composite material, due to the introduction of a sodium carboxylic acid structure at the C6 site of the regenerated cellulose molecule through the selective oxidization of a TEMPO-NaClO-NaBr oxidation system, the hemostatic property, structure integrity, mechanical strength and stability of the modified regenerated cellulose/alginate hemostatic composite material are improved, and the defects of poor wet strength, low mechanical integrity and easy deformation of ordinary alginate non-woven fabrics are overcome.

The invention relates to a medical flocking hemostasis material for stopping bleeding and protecting arteries, veins and wounds of tissues, application of the medical flocking hemostasis material and a method for preparing the medical flocking hemostasis material. The medical flocking hemostasis material comprises a flocking layer and a base layer, the flocking layer is used as a wound contacting layer and made of functional fibers, and the functional fibers are fixed on the upper surface of the base layer in a flocking method. The flocking method comprises a mechanical flocking method and an electrostatic flocking method. The medical flocking hemostasis material can be used for stopping bleeding and protecting the arteries, the veins and the wounds of the tissues, and further can be used as a medicine slow-release carrier. The invention further discloses method for controlling bleeding of the arteries, bleeding of the veins and bleeding of the wounds of the tissues by the aid of the medical flocking hemostasis material. Compared with a hemostasis material in the prior art, the medical flocking hemostasis material has the advantages that a hemostasis performance, comfortableness and the like are greatly improved.

The present invention relates to compositions comprising complexes of human cells and polymer fibers and methods of their use for therapeutic purposes. Methods of making such compositions are also provided. The presen t invention encompasses compositions comprising poly-.beta.-1.fwdarw.4-N-acetylglucosamine polymers and stored platelets and their use for promoting wound healing and achieving hemostasis.

The invention discloses a preparation method for efficient anti-bacterial composite hemostatic sponge. The preparation method comprises the following steps: S1, adding sodium chloride and phosphonium salt into a sodium alginate solution to obtain a solution A; S2, adding an emulsifier into dispersion liquid to obtain a solution B, and preparing a 4 to 6 percent calcium chloride solution to serve as a solution C; S3, adding the solution A into the solution B in a water-oil ratio of 1 to (3-7) by an emulsion-crosslinking method, stirring to form an emulsion, adding the solution C into the emulsion for reacting, curing, centrifuging, washing and drying to obtain porous alginate drug-carrying microspheres; S4, dissolving chitosan hydrochloride into water to obtain an aqueous solution, adding the porous alginate drug-carrying microspheres prepared in the step S2 and a hemostatic medicament, performing freeze drying repeatedly, washing and sterilizing to obtain the hemostatic sponge. The hemostatic sponge has high water absorptivity, can rapidly stop bleeding, plug wounds, inhibit wound infection and effectively promote healing of the wounds; the thrombus risk is avoided.

An apparatus for sealing a puncture in a blood vessel is disclosed having a tissue-confining device for compressing tissue in the vicinity of the puncture, which longitudinally extends between a proximal end and a distal end and is connected to an adjustable artery clamp for controllably applying pressure, such as by a fluid circuit, onto the blood vessel, so as to reduce the hemostatis time. The artery clamp comprises in a preferred embodiment a proximal plunger and a distal plunger positioned upstream and downstream, respectively, to the puncture. The apparatus is also suitable for treating a pseudoaneurysm.

The invention discloses an anti-bacterial high-viscosity medical glue, which is prepared from the following ingredients: 2-cyano-acrylate isopropyl, polyisoprene, polypropylene, povidone iodine, magnesium sulfate, naringenin, halloysitum rubrum nano-powder, vitamin A palmitate, plant essential oil, paraffins, alginate, disodium EDTA, methacrylamide, polyvinyl alcohol, dioctyl phthalate, 1.5g/ml luffa extract, 0.8g/ml rhizoma bletillae extract, glycerol and sterile water. The invention further discloses a preparation method of the anti-bacterial high-viscosity medical glue. The adhesive strength and 48-hour compressive strength of the medical glue are in a relatively high level, the medical glue is high in anti-bacterial ratio, short in hemostasis time, high in overall healing efficiency, free from irritation on wound tissues and excellent in overall performance, and conforms to the application requirements of clinics for the medical glue.

The invention discloses collagen-based composite hemostasis powder and a preparation method thereof. The method is characterized by comprising the following steps: modifying type I collagen by using dencichine, preparing the modified type I collagen into a solution with the concentration of 1-2 percent by using polylysine-modified chitosan; preparing medical gelatin into a 1-3% solution; preparing the modified chitosan into a 1-3% solution; blending the three solutions according to a mass ratio of 0.5-1:2-8:8-2; stirring at the temperature of 4-10 DEG C for 8-10 hours, and performing freeze drying to prepare composite sponge; sequentially impregnating the composite sponge in a modifier and a blood coagulation factor in an ultrasonic cleaner, fully washing, performing freeze drying, and grinding by a grinder to prepare the collagen-based composite hemostasis powder. The powder has the effects of rapidly and effectively stopping bleeding, resisting bacteria, diminishing inflammation, relieving pain, promoting wound healing and repairing, has high adhesion property, hydrophilicity, biological degradability and biocompatibility and is low in price and suitable for wound hemostasis or repair.

The invention provides a blood vessel closure structure which can be completely degraded. The structure especially aims at arterial puncture mouth closure. The structure comprises an anchor in a bloodvessel lumen, an anti-hemorrhagic compression object outside the lumen and a connecting suture; the portions, kept in the body, of the structure are all made from material which can be completely degraded; according to one particularly preferable embodiment, the anchor in the blood vessel lumen is closely attached to the blood vessel inner wall and anchors a puncture mouth; the anti-hemorrhagic compression object presses the blood vessel outer wall tightly and blocks the puncture mouth; the suture connects the anchor and the compression object, and through an auto-tightened knot, the sandwichstructure is fixed. By means of the blood vessel closure structure which can be completely degraded, the burden of longstanding manual pressing for hemostasis of a doctor is reduced, and time in bedof a patient is shortened; compared with a blood vessel suture closure structure, the blood vessel blocking closure structure has the advantages that the operative steps are simplified, and the learning cost and the hemostasis failure rate of a surgeon are reduced; the objects implanted in the body can be completely degraded, so that a suture removing process brought by use of non-degradable material is avoided.

The invention provides a chitosan fiber-based efficient hemostatic material and a preparation method thereof. The preparation method comprises the following steps of spinning chitosan to obtain a chitosan fiber base material, and grafting carboxyl and catechol structures on the chitosan fiber base material at the same time. The hemostatic material can quickly absorb moisture in blood to swell, so that the hemostatic rate is remarkably improved. The carboxyl is introduced, so that the hemostatic material has super-strong imbibition capacity, platelets in blood of a bleeding part are quickly adhered and aggregated to form thrombus, hydroxyl on the catechol group can be complexed with iron ions in red blood cells, the red blood cells are aggregated to play a role in stabilizing blood clots, and finally, the effect of quickly stopping bleeding is achieved. The efficient hemostatic material provided by the invention is especially suitable for the condition of massive bleeding.

The invention provides an administration method, which includes the following steps that: a fluid is introduced into a container for holding a medicament, so that the fluid flows along a pressure relief channel, and discharged at a pressure relief through hole of the container, after the flow velocity of the fluid is stabilized, during use, the pressure relief through hole is closed and the fluidenters into a pressurized channel, flows along the pressurized channel, is discharged from the outlet of the pressurized channel and the medicament is pushed into the outlet of the container. The method provided by the invention can deliver the medicament in the container in a more stable and consistently balanced manner and in a more gradual manner, effectively avoiding the medicament being spread on the mirrored field due to the counteraction of target tissue caused by the sudden release of pressure, making administration (such as hemostatic agent) more precise, improving the continuity of the laparoscopic operation, improving the hemostatic effect, and shortening the operation time.

The invention discloses a polysaccharide hemostatic dressing as well as a preparation method and an application thereof. The polysaccharide hemostatic dressing is membrane or sponge-like product prepared by carrying out a cross-linking reaction on aminopolysaccharides and oxidized polysaccharides, wherein the aminopolysaccharides refer to one or more of hyaluronic acid, chondroitin sulfate, heparin, chitosan, hydroxyethyl chitosan, hydroxypropyl chitosan, sulfonated chitosan, hydroxybutyl chitosan, carboxymethyl chitosan, succinyl chitosan or other chitosan derivatives; the oxidized polysaccharides refer to one or more of oxidized polysaccharides containing dialdehyde groups; and saccharide units containing the dialdehyde groups account for 1-70% of total saccharide units of the polysaccharide molecule. The polysaccharide hemostatic dressing disclosed by the invention has an obvious hemostasis effect, is capable of obviously shortening the hemostasis time of the wound surface, is non-toxic, and has excellent biocompatibility. The polysaccharide hemostatic dressing can be used for preparing medical apparatuses and instruments for traumatic hemostasis and surgical hemostasis, servesas hemostatic dressing medical apparatuses and instruments to be developed, and has wide market prospects.

The invention discloses a nanogold/lysine/oxidized regenerated cellulose composite hemostatic material and a preparation method thereof, relates to a hemostatic material and a preparation method thereof, and aims at solving the problems of obstruction to the biological absorption of a hemostatic material and slight improvement of the hemostatic performance due to a fact that the skin of a mammal is irritant to other body cells at a contact position and a large whitish granulation lump is formed at a use position in the use process of an existing oxidized regenerated cellulose modified material serving as the hemostatic material. The nanogold/lysine/oxidized regenerated cellulose composite hemostatic material is prepared from the nanogold and the oxidized regenerated cellulose on the surface of which the lysine is grafted; the preparation method of the hemostatic material comprises the steps of firstly, chemically grafting the lysine to the oxidized regenerated cellulose, secondly, preparing the aqueous dispersion of the nanogold, and 3, carrying out self-assembling of the nanogold, thereby obtaining the nanogold/lysine/oxidized regenerated cellulose composite hemostatic material. The invention successfully provides the nanogold/lysine/oxidized regenerated cellulose composite hemostatic material and the preparation method thereof.

The invention provides a nanogel hemostatic material modified with modified glucan as well as preparation and an application of the nanogel hemostatic material. The nanogel hemostatic material is formed by polymerizing modified glucose and monomers containing vinyl, wherein the modified glucose is glucose modified with glycidyl methacrylate. The nanogel hemostatic material has excellent water absorption and good biocompatibility, the size is increased after the nanogel hemostatic material absorbs water to expand, a polymer hydrogel layer is formed and can block a wound to stop bleeding, modified glucan nonogel has an excellent hemostatic effect on traumatic hemorrhage such as venous hemorrhage, arterial hemorrhage, body surface hemorrhage as well as internal organ hemorrhage such as liver hemorrhage, is a good and novel hemostatic and has good application prospects in clinical trauma. The invention further provides a preparation method of the modified polysaccharide modified nanogel hemostatic material. The raw materials are cheap and easy to obtain, the reaction condition is mild, the reaction operation is simple, and post-treatment is convenient.

The invention belongs to the technical field of biomedicine materials, and specifically relates to a modified chitosan-alginate-dragon's blood composite nano hemostatic material having a porous microsphere structure. Modified chitosan and alginate are compounded through an electrostatic effect to prepare a wall material of the microsphere; and dragon's blood is taken as the core material. The corematerial is embedded in the wall material. The mass ratio of the wall material to the core material is 1-3:1-5. The modified chitosan is amphiphilic modified chitosan. The alginate is one of sodium alginate and magnesium alginate. The invention also provides a preparation method of the composite nano hemostatic material. The provided modified chitosan-alginate-dragon's blood composite nano hemostatic material can rapidly stop bleeding of wounds, is also capable of continuously releasing drugs, inhibiting wound infection, and promoting wound healing, has good biological compatibility, and doesnot have any side or toxic effect. The problem that dragon's blood is difficult to dissolve during the preparation process is solved. The encapsulation rate of dragon's blood is increased, and the action time of drugs is prolonged.

The invention provides a water-soluble hemostatic material and a preparation method thereof and relates to a hemostatic material and a preparation method thereof, wherein the water-soluble hemostatic material and the preparation method thereof can be used for overcoming the problems that the existing oxidized regenerated cellulose materials are not water-soluble, have poor biological absorbability and slow hemostatic speed. The water-soluble hemostatic material is prepared from oxidized regenerated cellulose carboxylic sodium fabrics and hydrochloric acid. The preparation method comprises the following steps: winding the oxidized regenerated cellulose carboxylic sodium fabrics on a glass porous core of an acidification rotary reactor; adding the hydrochloric acid for close acidification; decompressing, filtering and washing with absolute ethanol; and freezing and drying to obtain the water-soluble hemostatic material. The water-soluble hemostatic material can be used as a hemostatic material.

The invention aims to provide fiber suitable for clinical application, in particular to the application of hemostasis, scalding, chronic wound treatment and others. The invention is a hemostatic material, wherein the hemostatic material includes fiber, and the material is possessed of biodegradability; the hemostatic material is characterized in that the fiber includes a polymer expressed by the following structural formula: FORMULA, wherein R is at least one of groups consisting of -NH2, -CH2CH20H, -OCH2CH2CH2OH, -OH, -ONa, -OK, -OCa; m, n and p respectively represent the quantity percent of corresponding repeat unit in the polymer molecule and can meet the following relationship formula: m+n+p=1, p/(m+n+p)=0.05-0.30; the degree of substitution D is defined as m/(m+n+p), the total degree of substitution of fiber is defined as Ds, and the degree of substitution of polymer at the center of the fiber cross section is defined as D0; when the degree of substitution of the edge of the fiber cross section is defined as D, the following relationship formula can be satisfied: Ds=0.09-0.8, Do/D=0-0.7.

The invention belongs to the technical field of medical materials, and particularly relates to alkyl chitosan-graphene oxide composite sponge and a preparation method and application thereof. The composite sponge comprises alkyl chitosan and graphene oxide adsorbed on alkyl chitosan, and adsorption capacity of graphene oxide is 3-28%. The composite sponge obtained by taking alkyl chitosan as a matrix and compositing graphene oxide and alkyl chitosan has excellent hemostatic performance and blood absorbing capacity. Embodiment results show that when the composite sponge is used for hemostasis,in-vitro whole blood coagulation time is less than 58s, hemostasis time of a rabbit femoral artery bleeding model is less than 155s, bleeding amount is less than 5.4g, and hemostasis effect is betterthan pure alkyl chitosan sponge or graphene oxide powder.

The present invention provides an absorbable semi-flowing cross-linked polypeptide biological surgical bleeding-stopping substance, which comprises a gelatin and a cross-linking agent, wherein a cross-linking agent is added to a gelatin solution to make high-reactivity amino acid side chains react with each other so as to form a cross-linking structure, and iron-calcium ions are added to increase the cross-linking degree so as to finally form the three-dimensional network cross-linked macromolecular polypeptide. According to the present invention, the absorbable semi-flowing cross-linked polypeptide biological surgical bleeding-stopping substance can be safely absorbed by human tissues, has characteristics of semi-fluidity, viscosity and adhesion, can promote the coagulation process of human body through physical and chemical principles, can rapidly stop bleeding, can treat surgical bleeding in the case of no damage on tissues so as to improve the convenience and the flexibility of surgical hemostasis and improve the safety and the effectiveness of surgical hemostasis, and can achieve the satisfactory bleeding-stopping effect in the cases of multi-point bleeding, large-area errhysis, bleeding in the narrow lacuna, hidden bleeding point or difficultly distinguished bleeding point, and bleeding difficultly operated and controlled by the existing bleeding-stopping methods.

The invention discloses a preparation method of an RGD-M13 phage/polylysine/oxidized regenerated cellulose composite haemostatic material, and relates to a preparation method of a haemostatic material. The invention aims at solving the problems of an existing oxidized regenerated cellulose modified haemostatic material that a haemostatic time is lightly improved, and the mechanical strength and bio-absorbing property of the oxidized regenerated cellulose are decreased. The method comprises the following steps: I. self-assembly of polylysine; II. self-assembly of an RGD-M13 phage; and III. cleaning and drying, so that the RGD-M13 phage/polylysine/oxidized regenerated cellulose composite haemostatic material is obtained. The RGD-M13 phage/polylysine/oxidized regenerated cellulose composite haemostatic material prepared by the invention, when applied to haemostasis, can shorten the haemostatic time by 25.17%-41.95%. The invention provides the RGD-M13 phage/polylysine/oxidized regenerated cellulose composite haemostatic material.