Modified chitosan-alginate-dragon's blood composite nano hemostatic material and preparation method thereof

A technology of alginate and hemostatic material, applied in pharmaceutical formulations, surgical adhesives, applications, etc., can solve problems such as unsatisfactory hemostatic effect, slow hemostasis, wound irritation, etc., to prolong the action time of the drug and improve the encapsulation rate. Effect

Active Publication Date: 2018-12-04
AGRI PRODS PROCESSING RES INST CHINESE ACAD OF TROPICAL AGRI SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a natural rapid hemostatic material without toxic and side effects to solve the common problems of current hemostatic materials such as toxic and side effects, slow hemostatic speed and unsatisfactory hemostatic effect
[0007] Another object of the present invention is to provide the preparation method of the above-mentioned rapid hemostatic material, to solve the problem in the prior art that unmodified chitosan needs to be dissolved with an acid solution, thereby causing irritation and toxic side effects to the wound

Method used

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  • Modified chitosan-alginate-dragon's blood composite nano hemostatic material and preparation method thereof
  • Modified chitosan-alginate-dragon's blood composite nano hemostatic material and preparation method thereof
  • Modified chitosan-alginate-dragon's blood composite nano hemostatic material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1 Preparation of Composite Nano Hemostatic Material with Wall Material and Core Material Mass Ratio of 1:1

[0049] 1. Preparation of carboxylated polyethylene glycol monomethyl ether

[0050] Dissolve 3.895g of mPEG with a molecular weight of 2000Da in 75ml of deionized water, then add 0.9925g of NaBr and 0.094g of TEMPO into the mPEG aqueous solution, after complete dissolution, add 46.75ml of NaClO to react at room temperature for 30min, then adjust the pH with 5M NaOH After reacting for 20 minutes, add HCl to adjust the pH to 1, then extract with an equal volume of chloroform several times, put it into 250ml of ice ethanol after vacuum distillation, recrystallize at -20°C for 12 hours, filter and dry to obtain carboxylated polymer Ethylene glycol monomethyl ether.

[0051] 2. Preparation of amphiphilic modified chitosan

[0052] Dissolve 0.1g chitosan and 0.1g HOBT in 50ml deionized water, stir vigorously to form a clear CS-HOBT solution, then add 0.2g N-a...

Embodiment 2

[0059] Example 2 Preparation of composite nano-hemostatic material with wall material and core material mass ratio of 1:3

[0060] 1. Preparation of carboxylated polyethylene glycol monomethyl ether

[0061] Dissolve 7.79g of mPEG with a molecular weight of 1000Da in 150ml of deionized water, then add 1.82g of NaBr and 0.18g of TEMPO into the mPEG aqueous solution, and after it is completely dissolved, add 86.91ml of NaClO to react at room temperature for 30min, then adjust with 5M NaOH The pH is 10.8. After reacting for 20 minutes, add HCl to adjust the pH to 1, then extract with an equal volume of chloroform several times, put it into 250ml of ice ethanol after vacuum distillation, recrystallize at -20°C for 12 hours, filter and dry to obtain carboxylation Polyethylene glycol monomethyl ether.

[0062] 2. Preparation of amphiphilic modified chitosan

[0063] Dissolve 0.5g chitosan and 0.5g HOBT in 100ml deionized water, stir vigorously to form a clear CS-HOBT solution, the...

Embodiment 3

[0069] Example 3 Preparation of Composite Nano Hemostatic Material with Wall Material and Core Material Mass Ratio of 1:5

[0070] 1. Preparation of carboxylated polyethylene glycol monomethyl ether

[0071] Dissolve 5.84g of mPEG with a molecular weight of 4000Da in 150ml of deionized water, then add 1.48g of NaBr and 0.141g of TEMPO into the mPEG aqueous solution, and after it is completely dissolved, add 70.12ml of NaClO to react at room temperature for 30min, then adjust with 5M NaOH The pH is 10.8. After reacting for 20 minutes, add HCl to adjust the pH to 1, then extract with an equal volume of chloroform several times, put it into 250ml of ice ethanol after vacuum distillation, recrystallize at -20°C for 12 hours, filter and dry to obtain carboxylation Polyethylene glycol monomethyl ether.

[0072] 2. Preparation of amphiphilic modified chitosan

[0073] Dissolve 0.3g chitosan and 0.3g HOBT in 100ml deionized water, stir vigorously to form a clear CS-HOBT solution, th...

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Abstract

The invention belongs to the technical field of biomedicine materials, and specifically relates to a modified chitosan-alginate-dragon's blood composite nano hemostatic material having a porous microsphere structure. Modified chitosan and alginate are compounded through an electrostatic effect to prepare a wall material of the microsphere; and dragon's blood is taken as the core material. The corematerial is embedded in the wall material. The mass ratio of the wall material to the core material is 1-3:1-5. The modified chitosan is amphiphilic modified chitosan. The alginate is one of sodium alginate and magnesium alginate. The invention also provides a preparation method of the composite nano hemostatic material. The provided modified chitosan-alginate-dragon's blood composite nano hemostatic material can rapidly stop bleeding of wounds, is also capable of continuously releasing drugs, inhibiting wound infection, and promoting wound healing, has good biological compatibility, and doesnot have any side or toxic effect. The problem that dragon's blood is difficult to dissolve during the preparation process is solved. The encapsulation rate of dragon's blood is increased, and the action time of drugs is prolonged.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a modified chitosan-alginate-dragon's blood composite nano-hemostatic material and a preparation method thereof. Background technique [0002] Trauma often occurs in people who encounter serious accidents in daily life, violent conflicts and soldiers injured on the battlefield. The occurrence of trauma is often life-threatening, and the uncontrollable bleeding caused by trauma is an important cause of human death. Usually, when the blood loss of the wounded exceeds one-third of the total blood volume, it can cause a systemic reaction of the human body such as hypohemolytic shock. Therefore, fast and effective hemostasis to the wounded is an important way to avoid casualties. At present, there are many types of commercial hemostatic agents in the market, but each has its own disadvantages, such as high production costs and short shelf life. In addition,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00C08G81/00
CPCA61L24/0015A61L24/08A61L2300/236A61L2300/30A61L2300/622A61L2400/04C08G81/00C08L5/08C08L5/04
Inventor 杨子明李普旺李思东陈日志陶金龙吕明哲周闯王超何祖宇陈煜孔令学
Owner AGRI PRODS PROCESSING RES INST CHINESE ACAD OF TROPICAL AGRI SCI
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