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A polyphenolic antioxidant for moisturizing lotions

An antioxidant and moisturizing lotion technology, which is used in skin care preparations, compounds of Group 4/14 elements of the periodic table, cosmetics, etc. , the effect of increasing solubility and improving insolubility

Active Publication Date: 2020-06-09
配方化妆品科技(广州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Resveratrol is a non-flavonoid polyphenolic compound containing a stilbene structure. It is not only a phytoalexin, but also a kind of anti-cancer, anti-oxidation, regulating blood lipids, affecting life expectancy and many other aspects that are beneficial to human health. It is a substance with important functions, but resveratrol is insoluble in water, and the emulsion made is prone to oil production and cannot be absorbed by the skin

Method used

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  • A polyphenolic antioxidant for moisturizing lotions
  • A polyphenolic antioxidant for moisturizing lotions
  • A polyphenolic antioxidant for moisturizing lotions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation method of polyphenolic antioxidant is:

[0035] (1) Synthesis of imine intermediates

[0036] Add magneton, 10mmol of p-hydroxyaniline, 15mmol of 3,5 dihydroxybenzyl alcohol, 0.5mmol of sodium ethoxide, 0.3mmol of ligand Xphos, 0.1mmol of catalyst ferrocene, and 5ml of acetonitrile in a 200mL reaction tube , oxygenate, close the valve and seal, put the reaction tube into a stirring oil bath, the temperature of the oil bath is 110°C, the reaction time is 10h, heat and stir to react, and the imine intermediate with the structure of formula 3 is obtained;

[0037] (2) Synthesis of polyphenol antioxidants

[0038] Cool down to 50°C, open the valve of the reaction tube, add 2mmol of niobium pentachloride, heat and activate at a temperature of 90°C for 80min, then add 13mmol of the enol ether substrate with the structure of formula 7 for 5h, and finally add 2.5ml 10% hydrogen peroxide solution was oxidized for 30 minutes, and the solvent was removed after th...

Embodiment 2

[0044] The weight of each raw material of the moisturizing lotion is: 40g of deionized water, 1.1g of sodium hyaluronate, 12g of hyaluronic acid, 11g of glycerin, 5g of white oil, 1g of cetearyl alcohol, 6g of sodium acryloyldimethyl taurate copolymer, Ethylparaben 4g, polyphenol antioxidant 5g, urea 2g, glyceryl caprylate 6.9g, iodopropynyl butylcarbamate 6g;

[0045] The preparation method of described moisturizing lotion is:

[0046] S1. Put white oil, cetearyl alcohol, stearic acid, sodium acryloyldimethyl taurate copolymer, ethylparaben, glyceryl caprylate, and iodopropynyl butyl carbamate Stir evenly in a constant temperature water bath, the temperature of the water bath is 80°C;

[0047] S2. Put deionized water, sodium hyaluronate, hyaluronic acid, glycerin and urea into a constant temperature water bath and stir evenly, and the temperature of the water bath is 80°C;

[0048] S3. Lower the temperature of the water bath to 46°C, and slowly add the oil phase mixture into ...

Embodiment 3

[0051] The weight of each raw material of the moisturizing lotion is: 31g of deionized water, 1.5g of sodium hyaluronate, 15g of hyaluronic acid, 15g of glycerin, 4g of white oil, 2g of cetearyl alcohol, 8g of sodium acryloyldimethyl taurate copolymer, Ethylparaben 5g, polyphenol antioxidant 7g, urea 1.5g, glyceryl caprylate 5g, iodopropynyl butylcarbamate 5g;

[0052] The preparation method of described moisturizing lotion is:

[0053] S1. Put white oil, cetearyl alcohol, stearic acid, sodium acryloyldimethyl taurate copolymer, ethylparaben, glyceryl caprylate, and iodopropynyl butyl carbamate Stir evenly in a constant temperature water bath, the temperature of the water bath is 75°C;

[0054] S2. Put deionized water, sodium hyaluronate, hyaluronic acid, glycerin and urea into a constant temperature water bath and stir evenly. The temperature of the water bath is 75°C;

[0055] S3. Lower the temperature of the water bath to 45°C, and slowly add the oil phase mixture into th...

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Abstract

The invention discloses a polyphenol antioxidant for moisturizing lotion. The polyphenol antioxidant is shown as a formula 5. A preparation method of the polyphenol antioxidant comprises the steps of(1) imine intermediate synthesis: para-hydroxyaniline of a formula I structure, 3, 5-dihydroxy benzyl alcohol of a formula 2 structure, a catalytic system and a solvent are added into a reaction tube;oxygenation is performed; a valve is closed for sealing; the reaction tube is put into a stirring oil bath pot; after heating and stirring reaction is performed for a certain time, an imine intermediate of a formula 3 structure is obtained; (2) polyphenol antioxidant synthesis: temperature reduction is performed; the reaction tube valve is opened; lewis acid is added; heating activation is performed; next, an enol ether type substrate of a formula 4 structure is added for performing ring-forming reaction; finally, an oxidant is added for oxidation; after the reaction is finished, the solventis removed; through separation and purification, the polyphenol antioxidant of a formula 5 structure is obtained.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a polyphenol antioxidant used in moisturizing emulsion. Background technique [0002] Due to the fast-paced life of modern people and the influence of various environments, the skin is often dry and dull. Moisturizing lotion has a good emollient and moisturizing effect, which can keep the skin moisturized. Now more and more attention is paid to skin maintenance, anti-wrinkle and anti-aging. The addition of antioxidants can help capture and neutralize free radicals, thereby eliminating free radicals. A class of substances that are harmful to the human body. [0003] Resveratrol is a non-flavonoid polyphenolic compound containing a stilbene structure. It is not only a phytoalexin, but also a kind of anti-cancer, anti-oxidation, regulating blood lipids, affecting life expectancy and many other aspects that are beneficial to human health. It is a substance with import...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F7/18A61K8/49A61Q19/00A61Q19/08
CPCA61K8/4926A61K2800/522A61Q19/00A61Q19/08C07F7/1892
Inventor 任磊
Owner 配方化妆品科技(广州)有限公司
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