36 results about "Hydroxyanilines" patented technology

The invention relates to a method for preparing functionalized graphene oxide. The method is characterized in that the functionalized graphene oxide material having a soluble organic phase is prepared by reacting a graphene oxide water solution with an ortho-hydroxylaniline or ortho-phenylenediamine solution under the condition that polyphosphoric acid is used as a catalyst. The method for preparing functionalized graphene oxide has the following characteristics: (1) the group selectivity is high, and carboxyl functional groups on the graphene oxide lamella can be selectively utilized; (2) the product has good solubility and can be dissolved in common organic solvents; and (3) the advantages of simple operation method, low cost and the like are achieved. The technology well compensates for limitations of the traditional method for preparing the functionalized graphene oxide material, develops the functionalization path of the material, is expected to become the important step in chemical industry production of graphene-based materials, and has great potential applications in graphene-based composite materials, graphene-based photoelectric materials and organic photoelectric functional devices.

The invention discloses a benzoxazine resin containing Schiff base structure benzoxazine monomer and a preparation thereof, belonging to the filed of thermosetting liquid crystal resin. Diamine or bisphenol containing Schiff base structure is obtained by using aliphatic diamine and terephthalaldehyde or terephthalaldehyde and parahydroxyaniline as raw materials; and a benzoxazine monomer containing Schiff base structure is obtained by reacting the diamine or bisphenol containing Schiff base structure, paraformal-dehyde with straight chain fatty primary amines or monophenol and derivates thereof. The benzoxazine monomer containing Schiff base structure reacts with a curing reaction accelerating agent at the temperature of 150-165 DEG C so that the benzoxazine resin containing Schiff base structure is obtained. The benzoxazine resin containing Schiff base structure prepared in the invention is excellent is resistance to heat and heat conductivility, and is suitable for wide application in the fields of electronics industry and space flight and aviation.

The present invention discloses compounds for the treatment of cancer and its application. These compounds comprises one of the following compound: Ammonium pyrrolidinedithiocarbamate Bay 11-7085 BIO Brefeldin A (+)-Butaclamol Calcimycin Calmidazoliur chloride Chelerythrine chloride CK2 Inhibitor 2 CGP-74514A hydrochloride CGS-12066A meleate Dequalinium dichloride Dihydroouabain Diphenyleneiodonium chloride Emetine dihydrochloride hydrate GR 127935 hydrochloride Nifedipine 6-Nitroso-1,2-benzopyrone Palmitoyl-DL-Carnitine chloride Parthenolide PD 169316 1,10-Phenanthroline monohydrate 4-Phenyl-3-furoxancarbonitrile Prazosin hydrochloride Protoporphyrin IX disodium Quinacrine dihydrochloride Quabain Retinoic acid p-hydroxyanilide Rottlerin Sanguinarine chloride Tetraethylthium disulfide and SU 9516. The invention also provides new uses of these compounds, compounds such as for the preparation of the treatment of cancer, inhibit cancer cell, cancer stem cell growth and provides a new pharmaceutical composition for treating cancers

The invention discloses synthesis of a novel triazine-derivative fire retardant (NPFR) based on triazine hexa-heterocycle and phosphaphenanthrene structure and application of the fire retardant in production of cotton textiles. The chemical structure of the fire retardant is as shown as tri-[4-(4-hydroxyaniline-phosphaphenanthrene)methylene-phenoxy]-1.3.5-triazine, called NPFR for short. A preparation method of the fire retardant includes: subjecting tricyanogen chloride (TCT) and parahydroxyben-zaldehyde to reaction to obtain 2,4,6-tri(4-formylphenoxyl)-1,3,5-triazine (ZJT); subjecting ZJT, p-aminophenol and 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) to obtain the NPFR. Since triazine hexa-heterocycle (namely the N-source ) with excellent thermal stability is taken as the core and DOPO group (namely the P-source) with excellent flame retardancy is introduced, the thermal stability of flame retardant molecules is improved, while flame retardancy is improved under N-P synergistic action. The novel triazine-derivative fire retardant (NPFR) has high maximum oxygen index and excellent carbonization rate when applied to the field of flame resistance of cotton textiles.

The invention belongs to the field of polymer preparation, and relates to self-healing hyperbranched polyurethane with high mechanical strength as well as a preparation method and application of the self-healing hyperbranched polyurethane. The method comprises the following steps: making polytetrahydrofuran, N-(4-hydroxy-3-methyl phenyl methylene)-p-hydroxyaniline (VA) and isophorone diisocyanate react to obtain an isocyanate-terminated polyurethane prepolymer, and then, making the isocyanate-terminated polyurethane prepolymer, hyperbranched polyester, triaminopyridine and tannic acid heated to 80 DEG C under the protection of nitrogen and react to obtain the self-healing crosslinked polyurethane based on the hydrogen bonds. The preparation method of the self-healing polyurethane is novel, the hyperbranched polyester reacts with the isocyanate group-terminated prepolymer to prepare the polyurethane with relatively strong self-healing capability and relatively high mechanical strength, and the self-healing polyurethane has a wide market prospect. Steps are simple, operation is convenient, and practicability is high.

The invention discloses triacetyl-3-hydroxyphenyladenosine represented by formula (I), the preparation, the pharmaceutical composition and the use thereof. Specially, the invention discloses a new compound of 2′,3′,5′-tri-O-acetyl-N⁶-(3-hydroxyphenyl)adenosine. Using hypoxanthine nucleoside as starting material, the compound is prepared by acetylating with acetic anhydride, chlorinating with thionyl chloride, and being substituted with 3-hydroxy aniline. The invention also discloses the pharmaceutical composition comprising triacetyl-3-hydroxyphenyladenosine. The dosage forms of the said pharmaceutical composition include tablet, capsule, pill, injection, sustained release preparation, controlled release preparation or particulate delivery system. The medicament for treatment or precaution of hyperlipemia prepared by the compound of the invention has the advantages of significant hypolipidemic activity, less toxicity and adverse effect as well as slow metabolism in vivo.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a synthesis method of flame-retardant polyester ether polyol. The preparation method comprises the following steps: adding phthalic anhydride polyester polyol and a polyhydroxy aniline compound into a reaction kettle, stirring and heating for pre-reaction; and after the pressure in the kettle is negative pressure, pumping an amine catalyst, controlling the temperature and the pressure, adding alkylene oxide, carrying out polymerization reaction, and carrying out refining treatment to obtain the flame-retardant polyester ether polyol product. By means of the structural performance of polyester polyol, a polyhydroxy cyclic macromolecular structure and a nitrogen element are introduced into polyester ether molecules to improve the average functionality of a product and the content of flame-retardant elements, and the prepared polyester ether overcomes the defects of single polyester or polyether and has the advantages of low price, good flame retardance and high system compatibility.

The present invention discloses a lenvatinib impurity and a preparation method thereof. The lenvatinib impurity has a structure represented by a formula VI, the impurity uses 2-fluoro-4-hydroxyanilineas a starting material, a lenvatinib impurity intermediate represented by a formula V is prepared through a two-step alkylation reaction, and then the lenvatinib impurity represented by the formula VI is prepared through a condensation reaction. The purity and yield of the prepared impurity are stable, the impurity can be used for quality control of lenvatinib intermediates, bulk drugs and related preparation products, and the quality VI of the bulk drugs and the related preparation products is improved by qualitative and quantitative determination of specific impurities.

The invention discloses an electrochemical synthesis method of a 2-substituted benzoxazole derivative. The preparation method comprises the following specific preparation steps: sequentially adding an o-hydroxyaniline derivative, an electrolyte, an additive and an organic solvent by taking an unseparated electrolytic cell as a reactor, respectively inserting a positive electrode and a negative electrode of an electrode into a reaction solution, switching on a constant current, carrying out stirring reaction, and after the reaction is finished, carrying out column chromatography separation to obtain the 2-substituted benzoxazole derivative, wherein a dipeptide substance can be prepared in one step. According to the method, a metal catalyst and an oxidizing agent are not needed, only electro-catalytic oxidation is used, the byproduct is hydrogen, and the method has the advantages that raw materials are easy to obtain, operation is easy, reaction is mild and the like, and has high implementation value and social and economic benefits.

The invention provides a preparation method of a polyvinyl chloride plastic paste cross-linking agent, and relates to the technical field of cross-linking agents, and the cross-linking agent is prepared from the following raw materials: 30-40% of epoxy resin modified amino resin, 20-30% of polyethylene glycol modified polyvinyl chloride, and 20-35% of p-hydroxybenzoic acid modified polyvinyl chloride. The preparation method comprises the following steps: weighing 35-40% of amino resin, 35-40% of epoxy resin, 10-15% of isopropanol and 5-10% of p-hydroxyaniline, adding the amino resin, the epoxy resin, the isopropanol and the p-hydroxyaniline into a reaction kettle for reaction, starting a stirrer of the reaction kettle for stirring the amino resin, the epoxy resin, the isopropanol and the p-hydroxyaniline, controlling the rotating speed of the stirrer to be 100-150r/min and the reaction temperature to be 50-70 DEG C, and stirring for 30-60 minutes; the reaction time is 10-20 minutes, and carrying out vacuum drying treatment after the reaction is finished. According to the preparation method, the problems that a cross-linking agent prepared by a traditional preparation method is non-uniform in extinction effect and relatively high in production cost, and the preparation efficiency of a polyvinyl chloride plastic paste cross-linking agent is reduced are solved.

The invention discloses a polyphenol antioxidant for moisturizing lotion. The polyphenol antioxidant is shown as a formula 5. A preparation method of the polyphenol antioxidant comprises the steps of(1) imine intermediate synthesis: para-hydroxyaniline of a formula I structure, 3, 5-dihydroxy benzyl alcohol of a formula 2 structure, a catalytic system and a solvent are added into a reaction tube;oxygenation is performed; a valve is closed for sealing; the reaction tube is put into a stirring oil bath pot; after heating and stirring reaction is performed for a certain time, an imine intermediate of a formula 3 structure is obtained; (2) polyphenol antioxidant synthesis: temperature reduction is performed; the reaction tube valve is opened; lewis acid is added; heating activation is performed; next, an enol ether type substrate of a formula 4 structure is added for performing ring-forming reaction; finally, an oxidant is added for oxidation; after the reaction is finished, the solventis removed; through separation and purification, the polyphenol antioxidant of a formula 5 structure is obtained.

The invention discloses an infrared air pressure wave therapeutic apparatus and a preparation method and a use method of varicosity gel, and relates to the technical field of medical gel. The preparation method at least comprises the following steps: putting 940 type carbomer into deionized water, and standing for 12 hours; adding triethanolamine, and stirring to form gel; adding p-hydroxyaniline, and uniformly stirring; an oil phase 1 is obtained; the preparation method comprises the following steps: taking 11 ml of 95% alcohol, adding raw radix aconiti kusnezoffii essential oil, raw radix aconiti essential oil, asarum essential oil, azone, radix clematidis essential oil, safflower oil essential oil, lavender essential oil and borneol, and stirring until all the components are melted; an oil phase 2 is obtained; putting the oil phase 2 into the oil phase 1 while stirring, and uniformly stirring to obtain varicosity gel; and filling the varicosity gel into a ball bottle for later use. Through the design of the gel, the gel is matched with the infrared air pressure wave therapeutic apparatus, so that the use is more convenient, and meanwhile, different matched therapeutic methods can be adopted according to different degrees of varicosity, so that a better therapeutic effect is achieved.

The invention discloses a preparation method and application of an N-substituted hydroxamic acid compound. The histone compound with a 4-benzamido-N-hydroxy-N-benzoylphenyl ammonia structure, i.e., the N-substituted hydroxamic acid compound, is represented by formula 1 as described in the specification. The preparation method comprises the following steps: with methyl p-aminobenzoate, benzoyl chloride and nitrobenzene as raw materials, allowing methyl p-aminobenzoate and benzoyl chloride to undergo aminoacylation and subjecting a reaction product to hydrolysis and acylation so as to prepare 4-benzamido-benzoyl chloride or 4-(4-chlorphenyl-formamido)benzoyl chloride or 4-phenylacetamido-benzoyl chloride; and reducing nitrobenzene into N-hydroxy aniline under the catalysis of Raney nickel and reacting N-hydroxy aniline with 4-benzamido-benzoyl chloride so as to obtain the target compound.

The invention discloses a preparation method of a quinoline feed additive with an immunity improving function, and belongs to the technical field of functional feed additive synthesis. According to the key point of the technical scheme, the quinoline feed additive molecule has a structure, wherein R is phenyl or other alkyl or heterocyclic ring and the like. Two target molecules with novel structures are synthesized by taking Boc-3, 4-dihydroxyaniline as an initial raw material through multiple steps of substitution, deprotection, cyclization, click reaction and the like, the IDO1 enzyme activity is well inhibited through computer prediction, and experimental verification is carried out, so that the IDO1 enzyme activity inhibitor has a certain inhibition effect on urease and can be used as a potential feed additive.

The invention provides a method for preparing 2-fluoro-4-hydroxyaniline, which comprises the following steps of: performing catalytic hydrogenation on o-fluoronitrobenzene serving as a raw material in a continuous flow reactor to synthesize o-fluorophenylhydroxylamine, and rearranging under an acidic condition to obtain the 2-fluoro-4-hydroxyaniline. By adopting a continuous flow reaction technology, the technical defects of poor reaction selectivity, long reaction time, low reaction yield, high unit raw material cost, high safety risk and the like in the existing synthesis process of 2-fluoro-4-hydroxyaniline are systematically solved, and conditions are created for industrial production of 2-fluoro-4-hydroxyaniline.

The invention discloses a preparation method of a key intermediate of icotinib, belonging to the technical field of drug synthesis. The main points of the technical scheme of the present invention are: the present invention uses triethylene diethylene glycol (p-toluenesulfonate) and N-Boc-3,4-dihydroxyaniline as raw materials respectively, and undergoes crown ether cyclization reaction and halogenation reaction respectively. , amination reaction (amidation reaction), through the quinoline ring closure reaction, and finally through the chlorination reaction to obtain the key intermediate 4-chloro-quinazolino[6.7-6]-12-crown-of Icotinib 4. The newly designed synthetic route avoids the need to use strong acid solution in the original route, avoids the danger of operation and produces a large amount of acidic waste liquid, and the new route is not only simple to operate but also has a high reaction yield.