37 results about "Hydroxyanilines" patented technology

The invention discloses triacetyl-3-hydroxyphenyladenosine represented by formula (I), the preparation, the pharmaceutical composition and the use thereof. Specially, the invention discloses a new compound of 2′,3′,5′-tri-O-acetyl-N6-(3-hydroxyphenyl)adenosine. Using hypoxanthine nucleoside as starting material, the compound is prepared by acetylating with acetic anhydride, chlorinating with thionyl chloride, and being substituted with 3-hydroxy aniline. The invention also discloses the pharmaceutical composition comprising triacetyl-3-hydroxyphenyladenosine. The dosage forms of the said pharmaceutical composition include tablet, capsule, pill, injection, sustained release preparation, controlled release preparation or particulate delivery system. The medicament for treatment or precaution of hyperlipemia prepared by the compound of the invention has the advantages of significant hypolipidemic activity, less toxicity and adverse effect as well as slow metabolism in vivo.

The invention provides a synthesis method of lenvatinib. Firstly, the present invention uses 4-cyano-3-hydroxyaniline as the starting material, methylated by dimethyl carbonate, oximated by propionic acid at room temperature, and forms 6-cyano-7 by ring closure under PPA conditions. -Methoxy-4-quinolinone, which forms 6-cyano-7-methoxy-4-chlorolinone under the action of thionyl chloride, and synthesizes one of lenvatinib by hydrolysis of cyano group under acidic conditions Intermediate 6-formamido-7-methoxy-4-chloroquinoline. Then 4-hydroxy-2-chloroaniline and cyanogen bromide are formed at low temperature into 4-hydroxy-2-chlorocyanamide, and 4-hydroxy-2-chlorocyanamide is reacted with bromopropane to synthesize lenvati Another key intermediate 1-(2-chloro-4-hydroxyphenyl)-3-cyclopropyl urea of ​​Ni. Finally, the two intermediates 6-formamido-7-methoxy-4-chloroquinoline and 1-(2-chloro-4-hydroxyphenyl)-3-cyclopropylurea were carried out in alkaline environment Kylation reaction to prepare lenvatinib. The scheme has the advantages of mild reaction conditions, no highly toxic reagents, and environmental protection.

The invention discloses a new class of 4-(3'-R substituted-5'-R substituted-4'-hydroxyanilino) quinazoline derivatives, a preparation method and an application thereof. The structural formulas of the compounds are shown in formulas I and II. The compound of the invention has good activity of preventing and treating chicken coccidiosis, and can be used as a therapeutic agent for preventing and treating chicken coccidiosis in the field of preparation of medicines for preventing and treating chicken coccidiosis.

Disclosed is a method of the synthesis of ramalin. It comprises reacting a glutamic acid derivative, which is prepared using alkylchloroformate, with a hydrazine salt compound, which is prepared from hydroxy aniline, whether protected or not. The synthesis method allows ramalin, excellent in antioxidant and anti-inflammatory activity, to be simply synthesized at stable yield even without use of a highly toxic solvent such as DMF. In addition, the method is cost competitive, and provides ramalin at high efficiency, thus enabling the mass production of ramalin.

The invention discloses a preparation method for a modified aniline terpolymer / water-based resin composite anti-corrosive coating. The method comprises the following steps: a microemulsion polymerization method is adopted, aniline, o-hydroxyaniline and p-phenylenediamine are used as monomers, APS (ammonium persulfate) is used as an oxidant, and therefore an aniline-o-hydroxyaniline-p-phenylenediamine terpolymer with good water dispersibility is prepared under the action of an acid dopant and a surfactant having a sulfonic acid group; and water-based alkyd resin is used as a substrate, a modified polyaniline aqueous dispersion liquid is used as an additive, a mixed manner of ultrasonic treatment and mechanical stirring is utilized, and therefore the water-based alkyd resin / polyaniline composite heavy anticorrosive coating is prepared. The preparation method disclosed by the invention has the advantages of being friendly to the environment and convenient to operate, and having no pollution and low costs; and the prepared modified aniline terpolymer can also be compounded with other water-based resin substrates such as water-based epoxy resin, water-based polyurethane resin and water-based polyacrylate resin to prepare the composite anticorrosive coating.

The invention discloses the synthesis of a novel triazine derivative flame retardant (NPFR) based on a triazine six-membered heterocyclic ring and phosphaphenanthrene structure and its application on cotton textiles. Its chemical structure name is tri-[4 -(p-Hydroxyaniline-phosphaphenanthrene)methylene-phenoxy]-1,3,5-triazine, abbreviated as NPFR. Its preparation method is: synthesize 2,4,6-three (4-formylphenoxy)-1,3,5-triazine (ZJT) by reaction of cyanuric chloride (TCT) and p-hydroxybenzaldehyde; NPFR was synthesized by the reaction of ZJT, p-aminophenol and 9,10-dihydro-9-oxa-10-phosphinephenanthrene-10-oxide (DOPO). The present invention selects a triazine six-membered heterocyclic ring (N source) with excellent thermal stability as the core, and introduces a DOPO group (P source) with good flame retardant performance, which improves the thermal stability of the flame retardant molecule and Increased flame retardancy through N‑P synergy. When the novel triazine derivative flame retardant NPFR of the present invention is applied to flame retardancy of cotton fabrics, it has higher limiting oxygen index and excellent char formation rate.