52 results about "Hydroxyanilines" patented technology

The invention relates to a method for preparing functionalized graphene oxide. The method is characterized in that the functionalized graphene oxide material having a soluble organic phase is prepared by reacting a graphene oxide water solution with an ortho-hydroxylaniline or ortho-phenylenediamine solution under the condition that polyphosphoric acid is used as a catalyst. The method for preparing functionalized graphene oxide has the following characteristics: (1) the group selectivity is high, and carboxyl functional groups on the graphene oxide lamella can be selectively utilized; (2) the product has good solubility and can be dissolved in common organic solvents; and (3) the advantages of simple operation method, low cost and the like are achieved. The technology well compensates for limitations of the traditional method for preparing the functionalized graphene oxide material, develops the functionalization path of the material, is expected to become the important step in chemical industry production of graphene-based materials, and has great potential applications in graphene-based composite materials, graphene-based photoelectric materials and organic photoelectric functional devices.

The invention discloses a benzoxazine resin containing Schiff base structure benzoxazine monomer and a preparation thereof, belonging to the filed of thermosetting liquid crystal resin. Diamine or bisphenol containing Schiff base structure is obtained by using aliphatic diamine and terephthalaldehyde or terephthalaldehyde and parahydroxyaniline as raw materials; and a benzoxazine monomer containing Schiff base structure is obtained by reacting the diamine or bisphenol containing Schiff base structure, paraformal-dehyde with straight chain fatty primary amines or monophenol and derivates thereof. The benzoxazine monomer containing Schiff base structure reacts with a curing reaction accelerating agent at the temperature of 150-165 DEG C so that the benzoxazine resin containing Schiff base structure is obtained. The benzoxazine resin containing Schiff base structure prepared in the invention is excellent is resistance to heat and heat conductivility, and is suitable for wide application in the fields of electronics industry and space flight and aviation.

Compositions for controlling harmful fungi, containing in a solid or liquid carriera) at least one p-hydroxyaniline derivative of the formula Ib) at least one amide compound of the formula IIwhere the substituents have the meanings indicated in the description;and methods of controlling harmful fungi using compositions of this type are described.

The present invention discloses compounds for the treatment of cancer and its application. These compounds comprises one of the following compound: Ammonium pyrrolidinedithiocarbamate Bay 11-7085 BIO Brefeldin A (+)-Butaclamol Calcimycin Calmidazoliur chloride Chelerythrine chloride CK2 Inhibitor 2 CGP-74514A hydrochloride CGS-12066A meleate Dequalinium dichloride Dihydroouabain Diphenyleneiodonium chloride Emetine dihydrochloride hydrate GR 127935 hydrochloride Nifedipine 6-Nitroso-1,2-benzopyrone Palmitoyl-DL-Carnitine chloride Parthenolide PD 169316 1,10-Phenanthroline monohydrate 4-Phenyl-3-furoxancarbonitrile Prazosin hydrochloride Protoporphyrin IX disodium Quinacrine dihydrochloride Quabain Retinoic acid p-hydroxyanilide Rottlerin Sanguinarine chloride Tetraethylthium disulfide and SU 9516. The invention also provides new uses of these compounds, compounds such as for the preparation of the treatment of cancer, inhibit cancer cell, cancer stem cell growth and provides a new pharmaceutical composition for treating cancers

The invention discloses synthesis of a novel triazine-derivative fire retardant (NPFR) based on triazine hexa-heterocycle and phosphaphenanthrene structure and application of the fire retardant in production of cotton textiles. The chemical structure of the fire retardant is as shown as tri-[4-(4-hydroxyaniline-phosphaphenanthrene)methylene-phenoxy]-1.3.5-triazine, called NPFR for short. A preparation method of the fire retardant includes: subjecting tricyanogen chloride (TCT) and parahydroxyben-zaldehyde to reaction to obtain 2,4,6-tri(4-formylphenoxyl)-1,3,5-triazine (ZJT); subjecting ZJT, p-aminophenol and 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) to obtain the NPFR. Since triazine hexa-heterocycle (namely the N-source ) with excellent thermal stability is taken as the core and DOPO group (namely the P-source) with excellent flame retardancy is introduced, the thermal stability of flame retardant molecules is improved, while flame retardancy is improved under N-P synergistic action. The novel triazine-derivative fire retardant (NPFR) has high maximum oxygen index and excellent carbonization rate when applied to the field of flame resistance of cotton textiles.

The invention belongs to the field of polymer preparation, and relates to self-healing hyperbranched polyurethane with high mechanical strength as well as a preparation method and application of the self-healing hyperbranched polyurethane. The method comprises the following steps: making polytetrahydrofuran, N-(4-hydroxy-3-methyl phenyl methylene)-p-hydroxyaniline (VA) and isophorone diisocyanate react to obtain an isocyanate-terminated polyurethane prepolymer, and then, making the isocyanate-terminated polyurethane prepolymer, hyperbranched polyester, triaminopyridine and tannic acid heated to 80 DEG C under the protection of nitrogen and react to obtain the self-healing crosslinked polyurethane based on the hydrogen bonds. The preparation method of the self-healing polyurethane is novel, the hyperbranched polyester reacts with the isocyanate group-terminated prepolymer to prepare the polyurethane with relatively strong self-healing capability and relatively high mechanical strength, and the self-healing polyurethane has a wide market prospect. Steps are simple, operation is convenient, and practicability is high.

The invention discloses triacetyl-3-hydroxyphenyladenosine represented by formula (I), the preparation, the pharmaceutical composition and the use thereof. Specially, the invention discloses a new compound of 2′,3′,5′-tri-O-acetyl-N6-(3-hydroxyphenyl)adenosine. Using hypoxanthine nucleoside as starting material, the compound is prepared by acetylating with acetic anhydride, chlorinating with thionyl chloride, and being substituted with 3-hydroxy aniline. The invention also discloses the pharmaceutical composition comprising triacetyl-3-hydroxyphenyladenosine. The dosage forms of the said pharmaceutical composition include tablet, capsule, pill, injection, sustained release preparation, controlled release preparation or particulate delivery system. The medicament for treatment or precaution of hyperlipemia prepared by the compound of the invention has the advantages of significant hypolipidemic activity, less toxicity and adverse effect as well as slow metabolism in vivo.

The invention discloses an optical-grade PET release film and a preparation method and application thereof, and belongs to the technical field of PET release liners.The preparation method comprises the steps that organic silicon resin, polyacrylate and functional silicone oil serve as raw materials, hexadecafluorophthalocyanine copper serves as a catalyst, sodium hydroxide provides hydroxyl anions, and hydroxyl-containing fluorinated hydroxyaniline is obtained; amino groups on the surface of fluorinated hydroxyaniline react with carboxyl groups of graphene oxide and are grafted on the surface of graphene oxide, then hydroxyl groups in the fluorinated hydroxyaniline and carboxyl groups of acrylic acid are subjected to esterification reaction under the action of a catalyst, so that acrylic acid is grafted on fluorinated modified graphene oxide, and the fluorinated modified graphene oxide is obtained. Therefore, hydroxyl and epoxy functional groups on the surface of the graphene oxide are consumed, hindering of electron transmission is reduced, the conductivity of the release film is improved, and the antistatic requirement of the release film is met.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a synthesis method of flame-retardant polyester ether polyol. The preparation method comprises the following steps: adding phthalic anhydride polyester polyol and a polyhydroxy aniline compound into a reaction kettle, stirring and heating for pre-reaction; and after the pressure in the kettle is negative pressure, pumping an amine catalyst, controlling the temperature and the pressure, adding alkylene oxide, carrying out polymerization reaction, and carrying out refining treatment to obtain the flame-retardant polyester ether polyol product. By means of the structural performance of polyester polyol, a polyhydroxy cyclic macromolecular structure and a nitrogen element are introduced into polyester ether molecules to improve the average functionality of a product and the content of flame-retardant elements, and the prepared polyester ether overcomes the defects of single polyester or polyether and has the advantages of low price, good flame retardance and high system compatibility.

The invention discloses a Schiff base epoxy oligomer chain extender as well as a preparation method and application thereof. The preparation method of the Schiff base epoxy oligomer chain extender comprises the following steps: adding p-hydroxybenzaldehyde and p-hydroxyaniline into ethanol, reacting at 30-70 DEG C for 2-5 hours, and performing suction filtration to obtain a 4-((4-hydroxybenzylidene) amino) phenol intermediate; and mixing the 4-((4-hydroxybenzylidene) amino) phenol intermediate, epoxy chloropropane and a catalyst, reacting at 80-100 DEG C for 3-7 hours, cooling to 50-70 DEG C, dropwise adding a strong alkali solution, reacting for 4-8 hours after dropwise adding, washing with deionized water, retaining an organic layer, and carrying out rotary evaporation on the organic layer to obtain the product. The rigidity, toughness and heat resistance of the modified nylon 6 prepared by applying the Schiff base epoxy oligomer chain extender are improved, and the modified nylon 6 still has processability similar to that of nylon 6.

The invention discloses a synthesis method of p-hydroxybenzonitrile, which comprises the following steps: carrying out diazotization reaction on p-hydroxyaniline to form a diazo compound, and reactingthe diazo compound with cuprous chloride and sodium cyanide to obtain the p-hydroxybenzonitrile. The p-hydroxyaniline is obtained by hydrogen reduction of p-nitrosophenol, and the p-nitrosophenol isobtained by nitrosation of phenol. The reaction temperature of each step is low, the reaction conditions are mild, and the reaction power consumption is greatly reduced. The reaction can be carried out by adopting a conventional reaction kettle, the equipment requirement is low, and the investment is small. According to the method, a dehydrating agent and filler are not used, only a small amount of catalyst is used, meanwhile, the catalyst can be recycled, the solid waste amount is small, only a small amount of solid catalyst is generated, and no difficult-to-treat wastewater is generated.

The invention discloses a corrosion-resistant photovoltaic module material and a preparation method thereof, and belongs to the technical field of photovoltaic modules, zinc oxide nanoneedles grow on the surface of modified mica powder in an oriented manner to obtain zinc oxide / mica powder, and the zinc oxide / mica powder is treated by 3-aminopropyltriethoxysilane to be grafted with 2-hydroxyaniline to obtain the corrosion-resistant photovoltaic module material. Zinc oxide can cooperate with aniline to be adsorbed on the metal surface to form a compact hydrophobic protection layer, and contact between a corrosion medium and metal is blocked through a physical shielding effect, so that an electrochemical corrosion reaction is inhibited; the growth of the zinc oxide nanoneedles can improve the specific surface area and the surface roughness of the modified mica, meanwhile, the zinc oxide nanoneedles are endowed with photocatalytic activity, active oxygen is generated under illumination, organic pollutants are decomposed, microorganism breeding is inhibited, and therefore biological corrosion is relieved; the aging of the anti-corrosion emulsion coating is reduced, and the adhesion of the coating to a photovoltaic cell can be increased through a mechanical interlocking effect by virtue of the nano needle-shaped structure.

The present invention discloses a lenvatinib impurity and a preparation method thereof. The lenvatinib impurity has a structure represented by a formula VI, the impurity uses 2-fluoro-4-hydroxyanilineas a starting material, a lenvatinib impurity intermediate represented by a formula V is prepared through a two-step alkylation reaction, and then the lenvatinib impurity represented by the formula VI is prepared through a condensation reaction. The purity and yield of the prepared impurity are stable, the impurity can be used for quality control of lenvatinib intermediates, bulk drugs and related preparation products, and the quality VI of the bulk drugs and the related preparation products is improved by qualitative and quantitative determination of specific impurities.

The present invention discloses a negative electrode porous carbon material and a preparation method thereof, belonging to the technical field of negative electrode materials for sodium ion batteries. The carboxyl groups of acrylic acid react with the carboxyl groups of 2-hydroxyaniline, and the remaining hydroxyl groups combine with silanol groups generated by hydrolysis of 3-mercaptopropyltrimethoxysilane. Sulfonic acid-modified acrylic acid / aniline is obtained under the action of hydrogen peroxide. After calcination, sulfur- and nitrogen-doped conductive hollow carbon spheres are formed. Sulfur doping can participate in the formation of the SEI film, generate a stable interface layer, reduce electrolyte decomposition and irreversible consumption of active lithium, and improve the initial coulombic efficiency. Nitrogen doping can construct an electron high-speed channel and improve conductivity. The conductive hollow carbon spheres are coated with MXene nanosheets and deposited on the surface of foamed carbon. Through the three-level synergy of layered, hollow, and foamed forms, a rigid-flexible effect can be achieved while alleviating volume expansion.

The invention discloses a negative electrode porous carbon material and a preparation method thereof, and belongs to the technical field of sodium ion battery negative electrode materials, carboxyl of acrylic acid reacts with carboxyl of 2-hydroxyaniline, residual hydroxyl groups are combined with silicon hydroxyl generated by hydrolysis of 3-mercaptopropyltrimethoxysilane, and the negative electrode porous carbon material is obtained. Sulfonic acid modified acrylic acid / aniline is obtained under the action of hydrogen peroxide, sulfur and nitrogen doped conductive hollow carbon spheres are formed after calcination, sulfur doping can participate in formation of an SEI film, a stable interface layer is generated, electrolyte decomposition and irreversible consumption of active lithium are reduced, the first coulombic efficiency is improved, and nitrogen doping can construct an electron high-speed channel and improve conductivity. The conductive hollow carbon spheres are coated with the MXene nanosheets and deposited on the surface of the foamy carbon, and the effect of combining rigidity and softness can be achieved while volume expansion is relieved through layered, hollow and foamy three-stage synergism.

The invention discloses a novel compound 4-(3 '-R substituted-5'-R substituted-4 '-hydroxyanilino) quinazoline derivative and a preparation method and application thereof. The structural formulas of the compound are shown as formulas I and II. The compound has good activity of preventing and treating chicken coccidiosis and can be used as a therapeutic agent for preventing and treating chicken coccidiosis in the field of preparation of medicines for preventing and treating chicken coccidiosis.

The invention discloses an electrochemical synthesis method of a 2-substituted benzoxazole derivative. The preparation method comprises the following specific preparation steps: sequentially adding an o-hydroxyaniline derivative, an electrolyte, an additive and an organic solvent by taking an unseparated electrolytic cell as a reactor, respectively inserting a positive electrode and a negative electrode of an electrode into a reaction solution, switching on a constant current, carrying out stirring reaction, and after the reaction is finished, carrying out column chromatography separation to obtain the 2-substituted benzoxazole derivative, wherein a dipeptide substance can be prepared in one step. According to the method, a metal catalyst and an oxidizing agent are not needed, only electro-catalytic oxidation is used, the byproduct is hydrogen, and the method has the advantages that raw materials are easy to obtain, operation is easy, reaction is mild and the like, and has high implementation value and social and economic benefits.

The invention provides a synthetic process of 2,4-dichloro-5-hydroxyl phenyl hydrazine. According to the method, 2,4-dichloro-5-hydroxyl aniline, ketazine and water are used as raw materials, and the 2,4-dichloro-5-hydroxyl phenyl hydrazine is synthesized through reaction at a certain temperature. Excessive ketazine and water are added in the reaction process to make the 2,4-dichloro-5-hydroxyl phenyl hydrazine completely react in a reaction system, reduced pressure distillation is adopted to remove the water and the ketazine after reaction is completed, and a solid substance is washed and dried to obtain the 2,4-dichloro-5-hydroxyl phenyl hydrazine. Compared with a traditional diazo-reaction process for synthesizing the 2,4-dichloro-5-hydroxyl phenyl hydrazine, the process includes few reaction steps and is simple, the device requirements are not high, reaction is easy to control, the yield is high, the production process is low, waste discharge is little, and the process is a green and environment-friendly production process.

The invention provides a synthesis method of lenvatinib. Firstly, the present invention uses 4-cyano-3-hydroxyaniline as the starting material, methylated by dimethyl carbonate, oximated by propionic acid at room temperature, and forms 6-cyano-7 by ring closure under PPA conditions. -Methoxy-4-quinolinone, which forms 6-cyano-7-methoxy-4-chlorolinone under the action of thionyl chloride, and synthesizes one of lenvatinib by hydrolysis of cyano group under acidic conditions Intermediate 6-formamido-7-methoxy-4-chloroquinoline. Then 4-hydroxy-2-chloroaniline and cyanogen bromide are formed at low temperature into 4-hydroxy-2-chlorocyanamide, and 4-hydroxy-2-chlorocyanamide is reacted with bromopropane to synthesize lenvati Another key intermediate 1-(2-chloro-4-hydroxyphenyl)-3-cyclopropyl urea of ​​Ni. Finally, the two intermediates 6-formamido-7-methoxy-4-chloroquinoline and 1-(2-chloro-4-hydroxyphenyl)-3-cyclopropylurea were carried out in alkaline environment Kylation reaction to prepare lenvatinib. The scheme has the advantages of mild reaction conditions, no highly toxic reagents, and environmental protection.

The invention provides a hydroxyaniline-modified covalent organic framework material and a preparation method and application thereof, the hydroxyaniline-modified covalent organic framework material provided by the invention selects a specific monomer for reaction, so that the obtained material is used as an adsorbent to be applied to pretreatment of a phenol-containing EDCs sample; according to the method, the trace phenol EDCs in the sample can be rapidly analyzed, the detection efficiency and sensitivity of the phenol EDCs in the sample are remarkably improved, a reliable scheme is provided for food safety monitoring, and the material can be repeatedly used, so that the cost is greatly saved.

The invention relates to the technical field of epoxy resin, and discloses double-end arylamine comb-type polyether toughened epoxy resin and a preparation method thereof.The preparation method comprises the steps that S, S '-di (alpha, alpha'-dimethyl-alpha ''-acetic acid) trithiocarbonate and oxycarbonyl-4-hydroxyaniline are reacted, a novel RAFT reagent is obtained, and the double-end arylamine comb-type polyether toughened epoxy resin is obtained; and finally, carrying out trifluoroacetic acid deprotection, so as to obtain the double-end arylamine comb-type polyether. According to the present invention, the epoxy resin is subjected to toughening modification, during the curing process, the active arylamine at the two ends can perform the ring-opening reaction with the epoxy resin so as to achieve the cross-linking curing of the polyether having the comb-type structure and the epoxy resin, and the flexible comb-type polyether chain segment can form the three-dimensional interpenetrating network cross-linking structure with the epoxy resin; the impact strength, the tensile property and the bending property of the epoxy resin are improved.

The invention relates to a transparent sports surface layer, a preparation method thereof and a sports paving material; wherein the transparent sports surface layer is prepared from the following rawmaterial components in parts by weight: 10-25 parts of diisocyanate, 50-100 parts of polyether polyol, 1-5 parts of 2-hydroxyaniline, 10-30 parts of a diluent, 1-5 parts of a drier and 2-10 parts of fumed silica. The whole sports surface layer is transparent, manufacturing of multifunctional (such as light emitting and energy storage) sports paving materials is facilitated, meanwhile, the sports performance is good, and the appearance is attractive.

The invention provides a gel polymer electrolyte membrane, a preparation method thereof and a semi-solid battery, and belongs to the technical field of secondary batteries. The gel polymer electrolyte membrane comprises a gel polymer matrix, an electrolyte and a first additive, and the first additive is poly (2, 5-dihydroxyaniline) and / or poly (3, 6-dihydroxyaniline); and the gel polymer electrolyte membrane is of a microporous structure. According to the gel polymer electrolyte membrane disclosed by the embodiment of the invention, poly (3, 6-dihydroxyaniline) and / or poly (2, 5-dihydroxyaniline) are / is introduced into the gel polymer electrolyte membrane, so that the ionic conductivity of a gel polymer matrix can be improved, and the cyclic reversibility of the gel polymer matrix is improved, and therefore, the gel polymer electrolyte membrane disclosed by the embodiment of the invention can enable a semi-solid battery to have excellent rate capability.

The invention provides a preparation method of a polyvinyl chloride plastic paste cross-linking agent, and relates to the technical field of cross-linking agents, and the cross-linking agent is prepared from the following raw materials: 30-40% of epoxy resin modified amino resin, 20-30% of polyethylene glycol modified polyvinyl chloride, and 20-35% of p-hydroxybenzoic acid modified polyvinyl chloride. The preparation method comprises the following steps: weighing 35-40% of amino resin, 35-40% of epoxy resin, 10-15% of isopropanol and 5-10% of p-hydroxyaniline, adding the amino resin, the epoxy resin, the isopropanol and the p-hydroxyaniline into a reaction kettle for reaction, starting a stirrer of the reaction kettle for stirring the amino resin, the epoxy resin, the isopropanol and the p-hydroxyaniline, controlling the rotating speed of the stirrer to be 100-150r / min and the reaction temperature to be 50-70 DEG C, and stirring for 30-60 minutes; the reaction time is 10-20 minutes, and carrying out vacuum drying treatment after the reaction is finished. According to the preparation method, the problems that a cross-linking agent prepared by a traditional preparation method is non-uniform in extinction effect and relatively high in production cost, and the preparation efficiency of a polyvinyl chloride plastic paste cross-linking agent is reduced are solved.

The invention discloses a polyphenol antioxidant for moisturizing lotion. The polyphenol antioxidant is shown as a formula 5. A preparation method of the polyphenol antioxidant comprises the steps of(1) imine intermediate synthesis: para-hydroxyaniline of a formula I structure, 3, 5-dihydroxy benzyl alcohol of a formula 2 structure, a catalytic system and a solvent are added into a reaction tube;oxygenation is performed; a valve is closed for sealing; the reaction tube is put into a stirring oil bath pot; after heating and stirring reaction is performed for a certain time, an imine intermediate of a formula 3 structure is obtained; (2) polyphenol antioxidant synthesis: temperature reduction is performed; the reaction tube valve is opened; lewis acid is added; heating activation is performed; next, an enol ether type substrate of a formula 4 structure is added for performing ring-forming reaction; finally, an oxidant is added for oxidation; after the reaction is finished, the solventis removed; through separation and purification, the polyphenol antioxidant of a formula 5 structure is obtained.

The invention discloses a new class of 4-(3'-R substituted-5'-R substituted-4'-hydroxyanilino) quinazoline derivatives, a preparation method and an application thereof. The structural formulas of the compounds are shown in formulas I and II. The compound of the invention has good activity of preventing and treating chicken coccidiosis, and can be used as a therapeutic agent for preventing and treating chicken coccidiosis in the field of preparation of medicines for preventing and treating chicken coccidiosis.

The invention discloses 1-((5-tert-butyl-2-hydroxyaniline) methylene)-2-naphthalenone and a preparation method and application thereof, and the compound is prepared by taking 2-hydroxy-1-naphthaldehyde and 2-amino-4-tert-butylphenol as raw materials and taking absolute ethyl alcohol or methyl alcohol as a solvent. The 1-((5-tert-butyl-2-hydroxyaniline) methylene)-2-naphthalenone prepared by the preparation method has a relatively strong inhibition effect on DPPH free radicals, and the inhibition effect is far higher than that of vitamin E on the DPPH free radicals. Therefore, the 1-((5-tert-butyl-2-hydroxyaniline) methylene)-2-naphthalenone has a good antioxidant effect, can be effectively used for preparing anti-aging drugs, and is an innovation in anti-aging drugs. The preparation methodhas the advantages of simple synthesis process, convenient operation, easily available raw materials, low production cost, easy industrial production, and very good social and economic benefits.

The invention discloses a preparation method and application of an N-substituted hydroxamic acid compound. The histone compound with a 4-benzamido-N-hydroxy-N-benzoylphenyl ammonia structure, i.e., the N-substituted hydroxamic acid compound, is represented by formula 1 as described in the specification. The preparation method comprises the following steps: with methyl p-aminobenzoate, benzoyl chloride and nitrobenzene as raw materials, allowing methyl p-aminobenzoate and benzoyl chloride to undergo aminoacylation and subjecting a reaction product to hydrolysis and acylation so as to prepare 4-benzamido-benzoyl chloride or 4-(4-chlorphenyl-formamido)benzoyl chloride or 4-phenylacetamido-benzoyl chloride; and reducing nitrobenzene into N-hydroxy aniline under the catalysis of Raney nickel and reacting N-hydroxy aniline with 4-benzamido-benzoyl chloride so as to obtain the target compound.

The invention discloses an infrared air pressure wave therapeutic apparatus and a preparation method and a use method of varicosity gel, and relates to the technical field of medical gel. The preparation method at least comprises the following steps: putting 940 type carbomer into deionized water, and standing for 12 hours; adding triethanolamine, and stirring to form gel; adding p-hydroxyaniline, and uniformly stirring; an oil phase 1 is obtained; the preparation method comprises the following steps: taking 11 ml of 95% alcohol, adding raw radix aconiti kusnezoffii essential oil, raw radix aconiti essential oil, asarum essential oil, azone, radix clematidis essential oil, safflower oil essential oil, lavender essential oil and borneol, and stirring until all the components are melted; an oil phase 2 is obtained; putting the oil phase 2 into the oil phase 1 while stirring, and uniformly stirring to obtain varicosity gel; and filling the varicosity gel into a ball bottle for later use. Through the design of the gel, the gel is matched with the infrared air pressure wave therapeutic apparatus, so that the use is more convenient, and meanwhile, different matched therapeutic methods can be adopted according to different degrees of varicosity, so that a better therapeutic effect is achieved.