2 results about "Chelerythrine" patented technology

The application discloses a cannabinoid 1 type receptor-mediated brain-targeting lipid nanocapsule drug loading system and a preparation and application thereof, and belongs to the technical field of targeted drugs. The brain-targeting lipid nanocapsule drug loading system comprises a drug-loaded lipid nanocapsule, the surface of the lipid nanocapsule is modified with a ligand compound of a CB1 receptor, and the ligand compound is one of quebrachamine, methoxylated myristicin, chelerythrine, ostruthol or cannabigerol. The application utilizes the lipid nanocapsule carrier to load a compound X with neuroprotective activity, prolongs the circulation time of the compound X in the body, adsorbs a ligand compound Y on the surface of the lipid nanocapsule, can specifically recognize the CB1 receptor highly expressed on the brain nerve epidermal cells, can transport across the blood-brain barrier, and improves the drug concentration in the brain tissue and cells. The preparation method provided by the application is simple in operation, easy to popularize, can be used for preparing drugs crossing the blood-brain barrier, and has a wide application prospect.

The invention discloses a macleaya cordata recovery prescription medicine for preventing and treating fish nocardia disease as well as a preparation method and application of the macleaya cordata recovery prescription medicine. The compound medicine consists of 10 to 30 percent of macleaya cordata alkaloid hydrochloride compound, 5 to 15 percent of chitosan quaternary ammonium salt, 10 to 20 percent of mannan oligosaccharide and a medicinal carrier. The preparation method comprises the following steps: carrying out freezing and heat shock pretreatment on a macleaya cordata raw material, and carrying out ultrasonic-flash synergistic extraction by adopting acidified ethanol; performing concentration, macroporous resin purification and high-speed counter-current chromatography separation on the extracting solution to obtain a high-purity macleaya cordata alkaloid hydrochloride compound; and finally, mixing the compound with chitosan quaternary ammonium salt and a carrier, granulating, and carrying out enteric coating. According to the method, active alkaloids such as sanguinarine and chelerythrine in macleaya cordata can be efficiently extracted and refined. According to the compound medicine, through scientific compatibility, for example, macleaya cordata alkaloid is antibacterial, chitosan quaternary ammonium salt and mannan oligosaccharide are used for enhancing immunity and targeting, the bioavailability is improved by utilizing a modern preparation technology, and the compound medicine has a good effect of preventing and treating fish nocardia disease.