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Application of sanguinarine or toddaline in prevention and cure of schistosomiasis

A technology for the prevention and treatment of schistosomiasis and chelerythrine, which is applied in the directions of application, medical preparations containing active ingredients, and resistance to vector-borne diseases, can solve problems such as harm, high price, restrictions, etc. The effect of preventing schistosomiasis

Active Publication Date: 2008-07-02
长沙世唯科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, niclosamide molluscicide is very effective in preventing and controlling schistosomiasis. It is a molluscicide recognized in the world, but it is expensive, and its use in large areas in developing countries is restricted. High concentrations will also cause harm to aquatic organisms such as fish. , and can also lead to increased resistance of target organisms
Sodium pentachlorophenate has been used in many countries. It has a good molluscicide effect, but it has broad-spectrum toxicity to non-target organisms, especially fish and shrimp farming, and causes serious environmental pollution. It has long been listed as a banned product by the international community
[0015] At present, there are no related reports and patent applications of sanguinarine or chelerythrine and their salts in killing oncomelania, snail eggs, cercariae of Schistosoma japonicum, schistosomiasis, inhibiting schistosomiasis larvae and preventing and controlling schistosomiasis

Method used

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  • Application of sanguinarine or toddaline in prevention and cure of schistosomiasis
  • Application of sanguinarine or toddaline in prevention and cure of schistosomiasis
  • Application of sanguinarine or toddaline in prevention and cure of schistosomiasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Take 98% sanguinarine, dissolve it in 90% ethanol, add sulfuric acid under stirring, let stand for crystallization, refine and dry to obtain not less than 98% sanguinarine sulfate; take the obtained 98% chelerythrine , dissolved in 90% ethanol, adding sulfuric acid under stirring, standing still for crystallization, refining and drying to obtain not less than 98% chelerythrine sulfate.

[0077] Sampling was carried out according to the method of the test example to kill snails, snail eggs, and schistosome cercariae.

[0078] 98% Sanguinarine Sulfate:

[0079] In the snail killing test, when the concentration is 3.13mg / L, the temperature is 25°C, and the snails are soaked for 48-72 hours, the mortality rate of the snails is 99-100%.

[0080] In the mollusc-egg test, when the concentration is 3.13 mg / L, soak for 72 hours, the hatching rate of snail eggs is 0-5%.

[0081] In the test for killing schistosomiasis cercariae, 100% of the cercariae died after being exposed to...

Embodiment 2

[0089] Take the obtained 98% sanguinarine, dissolve it in 90% ethanol, add boric acid under stirring, let stand to crystallize, refine and dry to obtain not less than 98% sanguinarine borate, and quantitatively adjust it with water-soluble starch to obtain 60% sanguinarine borate powder. Take the resulting 98% chelerythrine, dissolve it in 90% ethanol, add boric acid under stirring, let stand for crystallization, refine, and dry to obtain not less than 98% chelerythrine borate, water-soluble The starch was quantitatively adjusted to obtain 60% chelerythrine borate powder.

[0090] Take the above two powders and carry out the tests of killing snails, killing snail eggs, and killing schistosome cercariae according to the method of the test example.

[0091] 60% sanguinarine borate powder:

[0092] In the snail killing test, when the concentration is 3.13mg / L, the temperature is 25°C, and the snails are soaked for 72-96 hours, the mortality rate of the snails is 99-100%.

[00...

Embodiment 3

[0102] Take 98% sanguinarine, dissolve it in 90% ethanol, add salicylic acid under stirring, let it stand for crystallization, refine and dry to obtain no less than 98% sanguinarine salicylate, and adjust it quantitatively with water-soluble starch Promptly obtain 98% sanguinarine salicylate powder. Take 98% chelerythrine, dissolve it in 90% ethanol, add salicylic acid under stirring, let stand for crystallization, refine and dry to get not less than 98% chelerythrine salicylate, water Quantitative adjustment of soluble starch can obtain 98% chelerythrine salicylate powder.

[0103] Take the above two powders and carry out the tests of killing snails, killing snail eggs, and killing schistosome cercariae according to the method of the test example.

[0104] 98% sanguinarine salicylate powder:

[0105] In the snail killing test, when the concentration is 3.13mg / L, the temperature is 25°C, and the snails are soaked for 72-96 hours, the mortality rate of the snails is 95-100%. ...

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Abstract

The invention relates to application of a sanguinarine or a chelerythrine for preventing and curing of schistosomiasis. The invention applies the sanguinarine and the chelerythrine on killing an oncomelania, a snail egg, a Japanese blood fluke cercaria, a schistosome and the prevention and cure of schistosomiasis. The inventor discovers that the sanguinarine or the chelerythrine can kill the oncomelania and the snail egg safely and effectively and can kill the Japanese blood fluke cercaria as well as a schistosomulum and an imago of the schistosome under a lower concentration, which has the functions of preventing and curing the schistosomiasis and does not pollute the environment.

Description

technical field [0001] The invention relates to a new application of sanguinarine, chelerythrine and their salts in the prevention and treatment of schistosomiasis—for killing oncomelania, snail eggs, cercariae of Schistosoma japonicum, adults of Schistosoma japonicum and juveniles of Schistosoma japonicum. Background technique [0002] Schistosomiasis, commonly known as "big belly disease", is an infectious and parasitic disease caused by humans or cattle, sheep, pigs and other mammals infected with schistosomiasis. There are 5 kinds of schistosomes parasitic on the human body including Schistosoma haematobium, Schistosoma mansoni, Schistosoma japonicum, Schistosoma intercalatum and Schistosoma mekong in the world. Schistosomiasis is prevalent in temperate, subtropical, and tropical regions. In 2001, WHO estimated that the global population infected with schistosomiasis was about 200 million people, 600 million people were threatened, and 76 countries were affected, most o...

Claims

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Application Information

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IPC IPC(8): A01N43/90A01P9/00A61K31/4741A61P33/12
CPCY02A50/30
Inventor 曾建国
Owner 长沙世唯科技有限公司
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