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Macleaya cordata leaf extract as well as preparation method and product thereof

A technology of Boluohui extract and leaf extract, which is applied in the field of Boluohui leaf extract and its preparation and products, can solve the problems of affecting extraction efficiency, large loss, instability, etc., reduce mortality and promote recovery Healthy effect

Active Publication Date: 2018-11-20
MICOLTA BIORESOURCE INC LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main components of the Boluohui injection disclosed in Comparative Document 2 are Boluohui and Andrographis paniculata. Active ingredients, but the active ingredients of Boluohui alkaloids are unstable in ethanol, and the loss is very large, which greatly affects the extraction efficiency, and because it is an injection, its administration method is injection

Method used

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  • Macleaya cordata leaf extract as well as preparation method and product thereof
  • Macleaya cordata leaf extract as well as preparation method and product thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1: preparation embodiment

[0054] Take 5000g of Anhui-produced fallen leaves, and the HPLC method detects that the original opioid content is 0.65%, allocryptine 0.12%, sanguinarine 0.15%, and chelerythrine 0.08%. % sulfuric acid solution was percolated, and sodium hydroxide was added to the percolation liquid to adjust pH=10 to alkali precipitation, and the obtained precipitate was vacuum-dried under reduced pressure to obtain 1500 g of extract, and the HPLC method detected that the original opioid content was 1.2%, and allocryptine was 0.3%. Sanguinarine 0.18%, chelerythrine 0.12%. The Boluohui leaf extract obtained in this example is recorded as sample 1.1.

Embodiment 2

[0055] Embodiment 2: preparation embodiment

[0056] Get 5000g of leaves from Anhui Province, and the HPLC method detects that the original opioid content is 0.65%, allocryptine 0.12%, sanguinarine 0.15%, and chelerythrine 0.08%. Use 20L 5% sulfuric acid solution at 100 ℃ Heat and reflux for extraction, add KOH to the extract to adjust the pH=10 to alkali precipitation, and the resulting precipitate is air-dried to obtain 1750 g of the extract, which is detected by HPLC with a content of 1.18% of pro-opiate, 0.26% of allocryptine, and 0.16% of sanguinarine. Chelidonine 0.10%. The Boluohui leaf extract obtained in this example is recorded as sample 1.2.

Embodiment 3

[0057] Embodiment 3: preparation embodiment

[0058] Get 5000g of leaves from Anhui Province, and the HPLC method detects that the original opioid content is 0.65%, allocryptine 0.12%, sanguinarine 0.15%, and chelerythrine 0.08%. Use 20L 0.1% hydrochloric acid solution at normal temperature Soak for 48 hours, add Ca(OH) to the extract 2 Adjust the pH to 10 for alkali precipitation, and microwave-dry the obtained precipitate to obtain 2050 g of the extract. The HPLC method is used to detect that the content of protopine is 0.98%, allocryptine is 0.22%, sanguinarine is 0.15%, and chelerythrine is 0.09%.

[0059] The extract of the leaves of Boluohui obtained in this example is recorded as sample 1.3.

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Abstract

The invention provides a macleaya cordata leaf extract as well as a preparation method and a product thereof. In the macleaya cordata leaf extract, the content of fumarine is not lower than 0.1%, thecontent of allocryptopine is not lower than 0.1%, and the sum of content of sanguinarine and chelerythrine is not lower than 0.2%. The preparation method comprises the following steps: extracting macleaya cordata leaves with an acidic aqueous solution, adding alkali into the extracting solution to regulate the pH value to be alkaline, performing alkaline precipitation, and drying the precipitate,thereby obtaining the product. The invention further provides application of the macleaya cordata leaf extract in preparation of medicines for preventing and treating respiratory diseases of livestockand poultry. The extract prepared in the invention is prepared into an oral preparation, and can be used for preventing and treating the respiratory diseases of livestock and poultry, promoting rapidrehabilitation of the livestock and poultry and effectively reducing the death rate of sick livestock and poultry.

Description

technical field [0001] The present invention belongs to the technical field of extracting active ingredients of natural products and its application, and specifically relates to an extract of Boliae leaves and its preparation method and application, in particular to a method for extracting alkaloids from planted and wild Bocalea leaves It mainly includes the methods of protopine, allocryptine, sanguinarine and chelerythrine, and their application in veterinary drugs for preventing and treating respiratory diseases of livestock and poultry and reducing the mortality rate of sick livestock and poultry. Background technique [0002] In recent years, with the rapid development of the livestock and poultry breeding industry and the improvement of the level of intensification, the density of livestock and poultry breeding has increased, resulting in an increasing incidence of some diseases. Pathogenic microorganisms are very harmful to the livestock and poultry breeding industry. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66A61K31/395A61K31/4741A61P11/00A61K127/00
CPCA61K31/395A61K31/4741A61K36/66A61K2236/331A61K2236/53A61P11/00A61K2300/00Y02A40/70
Inventor 曾建国陈燕乐杨广民
Owner MICOLTA BIORESOURCE INC LTD
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