Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of chelerythrine to treatment of poultry drug-resisting colibacillosis

A technology of chelerythrine and colibacillosis, applied to medical preparations containing active ingredients, antibacterial drugs, pharmaceutical formulas, etc., to achieve good curative effect

Inactive Publication Date: 2016-11-23
SHENYANG VICA ANIMAL HUSBANDRY TECH
View PDF3 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chelidonine has been used clinically in human medicine, but in the field of veterinary and poultry medicine, there have been no relevant reports

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of chelerythrine to treatment of poultry drug-resisting colibacillosis
  • Application of chelerythrine to treatment of poultry drug-resisting colibacillosis

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0016] The extraction method of specific embodiment 1 chelerythrine

[0017] Extraction method of chelerythrine in blood water grass. Extraction: Weigh an appropriate amount of sample, add hydrochloric acid aqueous solution with a pH value of 1, put it in a water bath, and extract for 30 minutes at 100°C to extract sanguinarine and chelerythrine. Separation: Utilize macroporous adsorption resin to adsorb and separate sanguinarine and chelerythrine in blood water grass, and use 100% ethanol to elute and separate. The method has the advantages of less pollution, economy, good repeatability, high product yield and high purity, and is applicable to industrial production.

[0018] The extraction method of celandine in celandine: take 2 g of celandine powder, add 70% ethanol solution with a solid-liquid ratio of 1:20, extract for 30 minutes under the condition of 700w ultrasonic power, and use macroporous adsorption resin to absorb and separate . The extraction rate of chelerythr...

specific Embodiment 2

[0019] Specific Example 2 The assay method of chelerythrine

[0020] Determined by high performance liquid chromatography.

[0021] Chromatographic conditions and system adaptability test: using octadecylsilane bonded silica gel as filler; acetonitrile-0.1% phosphoric acid solution (25:75) as mobile phase; detection wavelength is 282nm; flow rate 1.0ml / min; theoretical column The number of plates shall not be less than 3000 based on the chelerythrine peak.

[0022] Preparation of reference substance solution: Take 10 mg of chelerythrine reference substance, accurately weigh it, put it in a 100ml measuring bottle, add methanol to dissolve and dilute to the mark, accurately measure 5ml, put it in a 10ml measuring bottle, add methanol to the mark, Shake well, filter, and take the continued filtrate, that is.

[0023] Preparation of the test solution: Take 10 mg of this product, accurately weigh it, put it in a 100ml measuring bottle, add methanol to dissolve and dilute to the m...

specific Embodiment 3

[0026] Specific embodiment 3 preparation preparation method

[0027] 1. Preparation of granules:

[0028] Take 1 part of the extracted culerythrine, 3 parts of powdered sugar, and 1 part of dextrin, pass through a 80-mesh sieve, mix evenly, use 80% alcohol to make a suitable soft material, and pass the soft material through a 14-mesh sieve to granulate , dried at 60°C, and the dried granules were sieved with a 12-mesh sieve and packaged.

[0029] 2. Preparation of injections:

[0030] Injection: Take 20 grams of air-dried or sun-dried whole grass powder, add PH4 sulfuric acid aqueous solution, decoct twice, 30 minutes each time. Filter through gauze, combine the filtrates, and concentrate to a thick syrup. Slowly add sodium hydroxide solution to PH9-10, let it stand, filter out the brown-black precipitate precipitated in the solution, add ethanol to dissolve it, filter with No. 3 vertical melting funnel, add ethanol to the filtrate, and then add PH4-5 phosphoric acid aqueou...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to application of chelerythrine to the treatment of poultry drug-resisting colibacillosis and in particular relates to a medicine which is prepared from the chelerythrine and other ministerial drugs and adjuvant drugs and is used for treating the poultry drug-resisting colibacillosis. The medicine provided by the invention can be prepared into suitable traditional Chinese medicine dosage forms including tablets, capsules, granules, pills, powder, ointment, sublimed preparations, powdered preparations, solutions, injections and the like according to market requirements and production conditions. The medicine provided by the invention has the characteristics of low medicine cost, simple production process, controllable quality and the like. The effective rate on the poultry drug-resisting colibacillosis reaches 93.5 percent, the death and culling rate can be reduced, the uniformity of chicken flocks is improved and the feed reward is increased; meanwhile, the medicine is environmentally friendly and has no pollution.

Description

technical field [0001] The invention relates to the application of chelerythrine in treating poultry drug-resistant colibacillosis, in particular to a medicine for treating poultry drug-resistant colibacillosis. Background technique [0002] Avian colibacillosis is an infectious disease of local or systemic infection caused by Escherichia coli, characterized by pericarditis, air sacitis, perihepatitis, peritonitis, synovitis, granuloma, enteritis, encephalitis, Inflammation, subcutaneous edema, sepsis and other clinical disease types, and often concurrent with viruses and other bacterial diseases, resulting in high mortality in chicken flocks and serious economic losses to the poultry industry. Due to the complex antigen structure of Escherichia coli, multiple serotypes, and multiple transmission routes, coupled with the generally poor breeding environment in my country and serious pathogen pollution, the incidence of the disease has become higher and higher in recent years,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4741A61K36/9066A61P31/04C07D491/056C07D491/153
Inventor 赵蕾蕾王洪礼赵宝凯
Owner SHENYANG VICA ANIMAL HUSBANDRY TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com