Ion-pair compound of chelerythrine from Chinese medicine extracts, preparation and application thereof
A technology of chelerythrine and compounds, which is applied in the direction of drug combination, application, carboxylate preparation, etc., can solve the problems of increasing the difficulty of compounding chelerythrine drugs, increasing production costs, increasing the difficulty of reaction, and achieving Conducive to long-term storage and in vivo use, increase stability, and enhance the effect of drug efficacy
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Embodiment 1
[0046] Example 1: The preparation method of the ion-pair compound generated by chelerythrine hydrochloride and shikimic acid sodium salt
[0047] Dissolve 10.0 g of chelerythrine hydrochloride (provided by the Hunan Province Traditional Chinese Medicine Extraction Engineering Research Center) in 1000 mL of water, and heat to above 90°C until all chelerythrine hydrochloride is dissolved to make celandine Red alkali hydrochloride aqueous solution (A); Dissolve 1.0 g of shikimic acid sodium salt in 200 mL of water to prepare shikimic acid sodium salt aqueous solution (B);
[0048] Slowly add (B) to (A) at above 90°C, stir continuously at 90°C, react for 30 minutes, cool to room temperature, filter, wash the precipitate fully with pure water, and dry the precipitate in vacuum at 60°C to obtain light yellow crystals, conduct 1 H-NMR, 13 The compound obtained by C-NMR and MS analysis is the ion-pair compound of chelerythrine shikimate.
Embodiment 2
[0049] Example 2: The preparation method of the ion-pair compound generated by chelerythrine and carnosic acid
[0050] Dissolve 10.0 g of chelerythrine (provided by Hunan Province Traditional Chinese Medicine Extraction Engineering Research Center) in 2000 mL of acetone, and stir to dissolve. Then directly add 10.0 g of carnosic acid, stir at normal temperature for 45 min, concentrate, dry to obtain a solid, then refine with ethyl acetate to obtain a light yellow crystal, carry out 1 H-NMR, 13 The compound obtained by C-NMR and MS analysis is the ion-pair compound of chelerythrine carnosic acid.
Embodiment 3
[0051] Embodiment 3: The preparation method of the ion-pair compound generated by chelerythrine hydrochloride and sodium rosmarinate
[0052] Take 4.5 g of chelerythrine hydrochloride (provided by the Hunan Province Traditional Chinese Medicine Extraction Engineering Research Center) and dissolve it in 1 L of water, then add 4.0 g of sodium rosmarinate, stir at 80 ° C for 30 min, cool, filter, wash, After drying, it was further refined with methanol to obtain light yellow crystals. by carrying out 1 H-NMR, 13 The compound obtained by C-NMR and MS analysis is an ion pair compound of chelerythrine and rosmarinic acid.
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