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Pharmaceutical composition as well as preparation method and application thereof

A technology of composition and medicine, which is applied in the field of pharmaceutical composition and its preparation, can solve the problems of low extraction rate of medicinal active ingredients and poor product curative effect, achieve the effect of drying dampness and stopping dysentery, improve stability and controllable quality Sexuality, the effect of reducing the content

Inactive Publication Date: 2017-12-08
HARBIN ZHENBAO PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the treatment of traditional Chinese medicine for such diseases is mainly based on medicines for clearing away heat and detoxification, drying dampness and stopping dysentery.

Method used

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  • Pharmaceutical composition as well as preparation method and application thereof

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preparation example Construction

[0037] This embodiment also provides a preparation method of a pharmaceutical composition, which includes:

[0038] Step S1: Mix 360-390 parts by weight of celandine, 360-390 parts by weight of Pulsatilla chinensis and 360-390 parts by weight of bark peel, and reflux extract with 30-70% (vol%) ethanol solution for 1-2 times , 1-5 hours each time, combined the extracted filtrate and concentrated to obtain the first clear paste.

[0039] In this step, medium-concentration ethanol (30-70% ethanol solution) is used as an extraction solvent to extract the mixture of celandine, Pulsatilla pulsatillae, and Petrium chinensis. The content of the element, thereby improving the efficacy of the drug. At the same time, it can also reduce the content of water-soluble impurities, thereby improving the stability and quality controllability of the medicament.

[0040] Further, 40-60% (vol%) ethanol solution is used for reflux extraction for 1-2 times, each time for 2-3 hours.

[0041]Furthe...

Embodiment 1

[0047] The present embodiment provides a kind of pharmaceutical composition, it comprises:

[0048] Berberine hydrochloride 20g, chelerythrine 0.075g, Pulsatilla saponin B 4 7.5g, 0.8g of alopecia.

[0049] The preparation method of this pharmaceutical composition comprises:

[0050] a. Mix 390g of celandine, 360g of Pulsatilla chinensis and 360g of Pulsatilla chinensis, extract once with 70% (vol%) ethanol solution under reflux, each time for 2h, combine the extracted filtrates, and concentrate to obtain the first clear paste ;

[0051] b. 20g of berberine hydrochloride was mixed with the first ointment and dried to obtain the pharmaceutical composition.

Embodiment 2

[0053] The present embodiment provides a kind of pharmaceutical composition, it comprises:

[0054] Berberine hydrochloride 30g, chelerythrine 0.025g, Pulsatilla saponin B 4 12.5g, 2.2g of alopecia.

[0055] The preparation method of this pharmaceutical composition comprises:

[0056] a. 360g of celandine, 390g of Pulsatilla radix and 390g of Pulsatilla chinensis are mixed, refluxed and extracted twice with 30% (vol%) ethanol solution, each time for 1h, and the filtrates extracted are combined and concentrated to obtain the first clear paste ;

[0057] b. 30g of berberine hydrochloride was mixed with the first ointment and dried to obtain the pharmaceutical composition.

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Abstract

The invention provides a pharmaceutical composition as well as a preparation method and an application thereof, and belongs to the field of medicines. The pharmaceutical composition consists of the following components in parts by weight: 800-1200 parts of berberine hydrochloride, 1-3 parts of chelerythrine and 300-500 parts of pulsatilla saponin B4. An agent consists of the pharmaceutical composition and a pharmaceutically acceptable carrier or adjuvants. The preparation method of the pharmaceutical composition comprises the following steps: mixing herba chelidonii, Chinese pulsatilla root and cortex fraxini, and implementing reflux extraction by virtue of a 30-70% (vol%) ethanol solution for 1-2 times, wherein each time lasts for 1-5h, combining filtrates which are obtained from the extraction, and condensing the combined filtrate, so that a first clear paste is obtained; and mixing 20-30 parts by weight of berberine hydrochloride with the first clear paste. According to the preparation method, the contents of the chelerythrine, the pulsatilla saponin B4 and aesculin in the extract (the pharmaceutical composition) can be effectively improved, so that the efficacy of the pharmaceutical composition and the agent on treating such diseases as diarrhoea, dysentery and the like can be improved.

Description

technical field [0001] The present invention relates to the field of medicine, in particular to a pharmaceutical composition and its preparation method and use. Background technique [0002] According to traditional Chinese medicine, diarrhea refers to the increase in the frequency of defecation, loose stools, or even watery stools caused by feeling external evils, being injured by diet, or emotional disorders, or weak spleen and stomach, or deficiency of spleen and kidney yang. The main disease syndrome. Dysentery is characterized by increased stool frequency, abdominal pain, tenesmus, red and white sticky dysentery. [0003] At present, traditional Chinese medicine mainly treats such diseases with medicines for clearing heat and detoxification, drying dampness and stopping dysentery. However, due to certain defects in the preparation process, the extraction rate of the effective components in the medicinal materials is low, and the curative effect of the products is not g...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61K31/4741A61K31/704A61K31/7048A61P1/12
CPCA61K31/4375A61K31/4741A61K31/704A61K31/7048A61K2236/333A61K2236/39A61K2236/51A61K2300/00Y02A50/30
Inventor 方同华许照芹项彦华崔玉海
Owner HARBIN ZHENBAO PHARMA
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