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Novel method for quickly extracting and separating five types of alkaloids from macleaya cordata

An alkaloid technology, applied in organic chemistry and other directions, can solve the problems such as the separation of five alkaloid monomers and other problems that have not yet been seen, and achieve the effects of avoiding adverse effects, low cost and convenient operation.

Inactive Publication Date: 2012-08-01
NORTHWEST A & F UNIV
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  • Abstract
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AI Technical Summary

Problems solved by technology

At present, there is no report on the separation of the five alkaloid monomers in the large-scale preparation of Boluohui

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0040] (1) Take 1.0 kg Boluohui dry powder (whole grass or seeds or aboveground parts or roots), and add industrial ethanol according to the ratio of solid to liquid at 1:7~1:10 (kg / L). The extraction is assisted by intermittent ultrasound, the extraction temperature is 30-50°C, the number of extractions is 3 times, and the extraction time is 30-60 minutes each time. The time for a single continuous ultrasound is 5 seconds, and the time interval between two ultrasounds is 1 second. Ultrasonic power 1600W.

[0041] (2) Filter the extract by negative pressure or centrifugation, collect the filtrate, concentrate the filtrate to about 1.0 L under reduced pressure, and let stand overnight.

[0042] (3) Filter the above concentrate under reduced pressure to remove the precipitate. Concentrate the filtrate to 0.2 L, add 0.2 L of deionized water, shake well, and extract with ethyl acetate (3×0.2 L) and n-butanol (3×0.2 L) successively. The ethyl acetate extract and n-butanol extract...

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Abstract

The invention relates to the technical field of traditional Chinese medicines and in particular relates to a novel method for quickly extracting and separating five types of alkaloids from macleaya cordata. The method comprises the following steps of 1) performing solvent extraction on dry macleaya cordata powder, thus obtaining an extracted solution; 2) extracting the extracted solution sequentially by utilizing ethyl acetate and normal butanol, thus obtaining an ethyl acetate extract and a normal butanol extract respectively; 3) treating the ethyl acetate extract, thus obtaining high-purity sanguinarine and chelerythrine; and 4) treating the normal butanol extract, thus obtaining high-purity protopine, cryptopine and allocryptopine. The method provided by the invention has the advantages of simplicity in operation, high efficiency, low cost, high product purity and product recovery rate and suitability for industrial large-scale production.

Description

1. Technical field: [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a method for rapidly extracting components from Boluohui. [0002] A new method for isolating five alkaloids. 2. Technical background: [0003] Papaveraceae (Papaveraceae) Papaver (Papaveraceae) Macleaya ) plants, the genus has Bo Luohui ( M. cordata (Willd) R. Br.) and Xiao Guobo Luohui ( M . microcarpa (Maxim) Fedde) two species, widely distributed in our country, rich in resources, cold in nature, pungent, bitter, with heat-clearing and detoxifying, antibacterial and anti-inflammatory, insecticidal and antipruritic effects, etc., folks are used to treat scabies, cure poison and Killing insects and killing maggots, etc. [0004] Boluohui is rich in alkaloids, mainly containing sanguinarine, chelerythrine, protopine, cryptopine and allocryptopine, etc. . Boluohui alkaloids have extensive and important pharmacological activities, mainly as antit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D491/153C07D491/056
Inventor 周乐苗芳潘萌郑峰
Owner NORTHWEST A & F UNIV
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