6 results about "Phenyl hydrazine" patented technology

The invention relates to a synthesis process of an omarigliflozin intermediate, and belongs to the technical field of drug synthesis, one-step efficient conversion is adopted in the process of synthesizing the omarigliflozin intermediate, p-bromophenylhydrazine hydrochloride is used as a starting raw material, and a target product is obtained through indole cyclization, alkali precipitation and acidification crystallization. Toluene plays a role in cyclization and dehydration in a high-temperature reflux process, in a purification process of alkali precipitation and acidification crystallization, a sodium hydroxide aqueous solution is utilized to hydrolyze and convert a product into water-soluble sodium salt, the water-soluble sodium salt enters a water phase, a toluene layer containing a large amount of organic impurities and the water phase are layered in a standing and layering process, and the organic impurities in the toluene layer are removed; the preparation method comprises the following steps of: preparing a sodium salt, acidifying in a water phase by using hydrochloric acid, changing the sodium salt form of the product into an acid form, and crystallizing from the water phase, which is equivalent to recrystallization purification, so that the prepared product has higher purity, the purity is stabilized at 98% or above, and the purity of the product can meet the quality standard of medical intermediates.

The invention provides a suspending agent containing bifenazate and etoxazole, which is characterized by comprising the following active ingredients in percentage by weight: 10 to 40 percent of bifenazate, 1 to 20 percent of etoxazole, 0.1 to 2 percent of N, N-bis (3-aminopropyl) dodecyl amine, 0.1 to 0.3 percent of polyether modified polysiloxane, 0.5 to 3 percent of lauryl sodium sulfate, 1 to 10 percent of dispersing agent, 0.1 to 2 percent of thickening agent, 1 to 5 percent of antifreezing agent, 0.1 to 0.5 percent of defoaming agent and the balance of deionized water. The suspending agent containing bifenazate and etoxazole provided by the invention has an excellent control effect on red spiders, is good in fast-acting property and long in lasting period, and can effectively solve the problem of resistance.

The invention discloses a green reduction method for preparing 1, 2-diphenylhydrazine based on nitrobenzene, methanol and metal sodium, particularly relates to the technical field of organic synthesis, and relates to a green reduction method for preparing 1, 2-diphenylhydrazine based on nitrobenzene, methanol and metal sodium. According to the method, nitrobenzene is taken as a raw material, methanol is taken as a solvent and a proton source, metal sodium is taken as a reducing agent, and the 1, 2-diphenylhydrazine is generated through directional reduction and hydrazine coupling reaction under low-temperature and anhydrous conditions; wherein the 1, 2-diphenyl hydrazine is prepared from the following raw material components in parts by mass: 10 parts of nitrobenzene, 79.1 parts of methanol and 3.45-6.2 parts of metal sodium; by adopting a mild reduction system formed by metal sodium and methanol and accurately controlling the ratio of a reducing agent and a low-temperature reaction environment, efficient directional coupling reduction among nitrobenzene molecules is successfully realized, and excessive reduction or side reaction is effectively inhibited, so that the selectivity and yield of 1, 2-diphenylhydrazine are remarkably improved, and the method is suitable for industrial production. The target product synthesis efficiency is improved; the pollution is reduced.

The application belongs to the technical field of pesticide mite-killing, and discloses a mite-killing composition and application thereof. The mite-killing composition comprises active ingredient A and active ingredient B. The active ingredient A is a compound shown in formula I. The active ingredient B is selected from the group consisting of a heterocyclic mite-killing agent, a quinone mite-killing agent, a benzoyl acetonitrile mite-killing agent, a propylene nitrile mite-killing agent, an oxazole mite-killing agent, a pyrazole amide mite-killing agent, a biphenyl hydrazine mite-killing agent, an antibiotic mite-killing agent, an organic tin mite-killing agent, a tetrazine mite-killing agent, a thiazolidinone mite-killing agent and the like. The mite-killing composition has obvious synergistic effect, can effectively improve the activity on crop mites with the same amount of drugs, and can be used for preventing and treating mites on fruit trees, cotton, tea trees, ornamental plants, vegetables, cereals and the like.

This invention discloses a method for synthesizing 4-fluoro-3,5-dimethylphenylhydrazine hydrochloride, belonging to the field of pharmaceutical intermediate synthesis technology. The synthesis method involves the following steps: copper halide, hydrazine additives acting as catalysts, a phase transfer catalyst, K3PO4, and 4-fluoro-3,5-dimethylbromobenzene are added to a solvent, and the temperature is raised to 80℃-100℃; hydrazine hydrate is added dropwise to the above mixture, and after the addition is complete, the temperature is maintained at 80℃-100℃ for 6-10 hours; after the reaction is complete, the temperature is lowered to room temperature, dichloromethane is added, the mixture is filtered, and the filtrate is separated, the aqueous layer is removed, and the organic layer is washed with saturated brine; the washed organic phase is acidified to pH 2-3 to obtain crude 4-fluoro-3,5-dimethylphenylhydrazine hydrochloride; the crude product is recrystallized to remove impurities, yielding a finished product with a purity of over 99%. This invention utilizes readily available raw materials, achieves high yield, produces a high-purity finished product, has a simple preparation method, a short processing cycle, and low manufacturing cost.

The application relates to the technical field of high polymer material synthesis, and discloses high-performance polyphenyl sulfone and a synthesis method thereof, wherein the synthesis method is as follows: 4,4'-diphenol, 4,4'-dichlorodiphenyl sulfone, modified 2,6-difluorobenzene hydrazine and a polar aprotic solvent are mixed and dissolved, a salting agent and a water-carrying agent are added, a salting reaction and a polymerization reaction are carried out under an inert gas atmosphere, after the reaction is completed, precipitation, washing and drying are carried out, and high-performance polyphenyl sulfone is obtained. The high-performance polyphenyl sulfone has good impact resistance and high-temperature stability.