25 results about "CYSTEAMINE HYDROCHLORIDE" patented technology

The invention relates to the technical field of biological medicines, in particular to a mesenchymal stem cell preparation for treating diabetes and a preparation method thereof. The stem cell preparation is prepared from the following components: umbilical cord mesenchymal stem cells and naringin coated SiO2, and preparation raw materials of the naringin coated SiO2 are prepared from the following components in parts by weight: 10 to 15 parts of tetraethoxysilane (TEOS), 4 to 6 parts of 3-mercaptopropyl oxysilane (MPTMS), 2 to 3 parts of naringin, 0.8 to 1.2 parts of succinic anhydride and 2 to 3 parts of cysteamine hydrochloride. The prepared stem cell preparation has synergistic blood lineage of each component, and can repair pancreas islet injury and inhibit inflammatory response.

The invention discloses injectable hydrogel with a myocardial tissue repairing function as well as a preparation method and application of the injectable hydrogel, and relates to the technical field of medical materials. The preparation method of the injectable hydrogel comprises the following steps: carrying out a reaction on deferoxamine and DSPE-PEG-NHS, so as to obtain DSPE-PEG-DFO; the preparation method comprises the following steps: wrapping carvedilol with DSPE-PEG-DFO under the hydrophilic and hydrophobic action, so as to obtain a drug-loaded nano-micelle; the preparation method comprises the following steps: reacting a polymer containing amino or hydroxyl with methacrylic anhydride to obtain a methylacryloyl modified polymer; reacting the carboxyl-containing polymer with cysteamine hydrochloride to obtain a sulfydryl modified polymer; mixing the drug-loaded nano-micelle, the methylacryloyl modified polymer and the sulfydryl modified polymer, and reacting under ultraviolet radiation to obtain the injectable hydrogel. The hydrogel disclosed by the invention is good in biocompatibility, can release deferoxamine and carvedilol in a ladder manner, is matched with a myocardial repair process, and realizes a function of repairing damaged myocardial tissues.

The invention belongs to the technical field of probiotic protection, and discloses a preparation method and application of probiotic-loaded sulfydryl hyaluronic acid-based hydrogel, sulfydryl hyaluronic acid is prepared by taking cysteamine hydrochloride as a substrate, and connection of L-glutamine is further catalyzed through a cross-linking agent, so that the sulfydryl hyaluronic acid-based hydrogel is obtained. The cross-linking agent is a mixture of N-hydroxysuccinimide and 1-ethyl-(3-dimethylaminopropyl) carbodiimide or a mixture of N-hydroxysuccinimide and 1-hydroxybenzotriazole (HOBT), and the cross-linking agent is a mixture of N-hydroxysuccinimide and 1-ethyl-(3-dimethylaminopropyl) carbodiimide and 1-hydroxybenzotriazole (HOBT). The hydrogel prepared by the preparation method disclosed by the invention is used as a probiotic carrier, so that the influence of complex gastrointestinal tracts is effectively resisted, the hydrogel accurately reaches an intestinal injury part and is split, and the targeted intestinal controllable release of probiotics is realized; meanwhile, the L-glutamine is introduced and has a synergistic effect with the probiotics to relieve specific intestinal diseases, so that the L-glutamine can be used as a probiotic supplement for the specific intestinal diseases.

The invention discloses a preparation method and application of a fluorinated amino covalent organic framework adsorption material, and relates to the technical field of covalent organic framework materials. According to the preparation method, 2, 4, 6,-tri (4-aminophenyl)-1, 3, 5-triazine is adopted as a point monomer, 2, 3, 5, 6-tetrafluorop-dibenzaldehyde and 2, 5-divinyl-1, 4-phthalaldehyde are adopted as side monomers, and the fluorinated covalent organic framework adsorption material is obtained through reaction; and carrying out post-modification reaction on the fluorinated amino covalent organic framework by adopting cysteamine hydrochloride to obtain the fluorinated amino covalent organic framework adsorption material. The prepared fluorinated amino covalent organic framework adsorption material has high selective adsorption and high adsorption capacity on PFAS, and due to the characteristics, the material has excellent adsorption performance on PFAS in water.

The invention is suitable for the technical field of environment and food safety detection, and provides a copper-based compound / graphene oxide nano-enzyme and a preparation method and application thereof.The preparation method comprises the following steps that cysteamine hydrochloride and copper chloride dihydrate are dissolved in deionized water, stirring is conducted under nitrogen protection, the pH is adjusted, then the mixed solution is transferred into an oil bath to be continuously stirred, and the copper-based compound / graphene oxide nano-enzyme is obtained; the preparation method comprises the following steps: preparing a two-dimensional copper-based compound, centrifuging, collecting precipitate, washing and drying to obtain the two-dimensional copper-based compound, dispersing the two-dimensional copper-based compound and graphene oxide in ultrapure water to prepare dispersion liquid, mixing the two-dimensional copper-based compound dispersion liquid and graphene oxide dispersion liquid, stirring at room temperature, and centrifugally drying to obtain the composite nano-enzyme. According to the method, the contradiction that the nano-enzyme activity pH is not matched with the optimal reaction pH of the formaldehyde is solved, the detection sensitivity and the anti-interference capability are remarkably improved, and an efficient technical scheme is provided for rapid and quantitative detection of the formaldehyde in multiple scenes such as food and environment.

The present invention discloses a method for enhancing antibody immobilization in an avian reovirus detection sensor. The present invention provides a preparation method for an electrochemical immunosensor for detecting reovirus, comprising the following steps: (1) treating the electrode; (2) modifying the electrode with a nanocomposite; (3) pre-treating before antibody immobilization; (4) antibody immobilization; (5) working electrode and detection. The nanocomposite is a gold-platinum nanocomposite, and the pre-treatment is incubation with a cysteamine hydrochloride solution. It is experimentally proven that the detection linear range of the sensor of the present invention is from 0 to 10 5.82 EID 50 / mL, and the lowest detection limit is 10 0.46 EID 50 / mL. Compared with the method of directly immobilizing antibodies, the detection linear range is increased by 10 times, and it has high sensitivity and good specificity.

The invention discloses a deodorant skin-friendly fabric and a preparation method thereof, and relates to the field of fiber fabrics. When the deodorant skin-friendly fabric is prepared, microcrystalline cellulose sequentially reacts with ethylene (chloromethyl) dimethoxysilane and 1-amino-4-butylguanidine dihydrochloride, and modified cellulose is prepared; the preparation method comprises the following steps: polymerizing dimethyl terephthalate, 2-vinyl propane-1, 3-diol and ethylene glycol, and reacting with mercaptopropyl methyl dimethoxy silane to prepare modified polyester; the preparation method comprises the following steps: reacting anhydrous citric acid with cysteamine hydrochloride to prepare an ultraviolet absorbent; the preparation method comprises the following steps: reacting 3-[(2, 3)-epoxypropoxy] propyl methyl dimethoxy silane with DOPO (9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide) to prepare modified siloxane; and mixing the modified polyester and the modified cellulose, spinning, and sequentially carrying out surface treatment by using an ultraviolet absorbent and a silane mixed solution to obtain the deodorant skin-friendly fabric. The deodorant skin-friendly fabric prepared by the invention has flame-retardant and durable capabilities.

The invention relates to the technical field of organic polymer adhesives, and particularly discloses a modified castor oil polyurethane adhesive containing catalytic groups as well as a preparation method and application of the modified castor oil polyurethane adhesive. The adhesive comprises two components, and the component A comprises the following components in parts by weight: 30.0-50.0 parts of modified castor oil and 0.0-30.0 parts of refined castor oil; the component B is prepared from the following components in parts by weight: 30.0 to 50.0 parts of polyisocyanate or a polyisocyanate modifier and 0.00 to 0.05 part of a dewatering agent; the modified castor oil is prepared by the route that refined castor oil and cysteamine hydrochloride are subjected to sulfydryl-alkene addition reaction and then neutralized by strong base. The modified castor oil contains hydroxyl, an amino reaction group and a quaternary ammonium salt catalytic group at the same time, the reaction speed with an isocyanate group is high, a mixture of the two components has certain thixotropy, and a cross-linked product has high strength.

The present invention discloses a pH-responsive nanocomplex, a preparation method thereof and applications, belonging to the technical field of biomedicine. The preparation method of the pH-responsive nanocomplex disclosed by the present invention includes: S1. Using N-(2-hydroxyethyl) acrylamide, PPTS and allyl vinyl ether as raw materials to react to generate AEEAA; S2. Reacting PAMAM with AEEAA to generate PAMAM-acetal-ene; S3. Reacting benzoin diethyl ether, cysteamine hydrochloride with PAMAM-acetal-ene to synthesize PAMAM-acetal-NH2; S4. Mixing and reacting PAMAM-acetal-NH2 with VDQACs in water to synthesize a pH-responsive nanocomplex. The present invention also discloses the pH-responsive nanocomplex prepared by this method and its application in the preparation of drugs for preventing and / or treating dental caries. The nanocomplex of the present invention releases the antibacterial drug VDQACs in response to pH changes to kill pathogenic bacteria; at the same time, the nanocomplex also has an unexpected remineralization induction function.

This invention relates to the field of organic polymer adhesives, specifically disclosing a modified castor oil polyurethane adhesive containing catalytic groups, its preparation method, and its application. The adhesive is a two-component compound. By weight, component A comprises 30.0-50.0 parts modified castor oil and 0.0-30.0 parts refined castor oil; component B comprises 30.0-50.0 parts polyisocyanate or a modified polyisocyanate and 0.00-0.05 parts dehydrating agent. The modified castor oil is prepared by first reacting refined castor oil and cysteine ​​hydrochloride via a mercapto-olefin addition reaction, followed by neutralization with a strong base. The modified castor oil simultaneously contains hydroxyl, amino reactive groups, and quaternary ammonium salt catalytic groups, exhibiting rapid reaction with isocyanate groups. The mixture of the two components exhibits certain thixotropy, and the crosslinked product has high strength.

The present invention discloses a pleuromutilin derivative compound, its preparation method, and application. The method comprises adding pleuromutilin and p-toluenesulfonyl chloride to methyl tert-butyl ether, mixing the mixture, adding sodium hydroxide solution dropwise with stirring, and reacting under reflux to obtain intermediate 1. Intermediate 1 and cysteamine hydrochloride are added to tetrahydrofuran, benzyltributylammonium chloride and sodium hydroxide solution are added dropwise with stirring, and the mixture is reacted with stirring for 4-5 hours to obtain intermediate 2. Intermediate 2, indole acid, and catalyst 2 are added to dichloromethane, and an amidation reaction is carried out at room temperature with stirring for 12-24 hours to obtain the pleuromutilin derivative compound. The pleuromutilin derivative compound of the present invention has a simple preparation process and a high yield. The derivative compound has good in vitro antibacterial activity and is particularly suitable as a new antibacterial drug for preventing and treating infectious diseases caused by bacteria in humans or animals.

The invention belongs to the technical field of medicines, and in particular discloses an application of cystamine hydrochloride (CYS) in preparation of a medicine for treating diabetic nephropathy. The invention finds that cysteamine hydrochloride can reduce the glomerular volume increase and mesangial hyperplasia of a mouse with diabetic nephropathy, and meanwhile, cysteamine hydrochloride can improve proteinuria caused by kidney injury of diabetic nephropathy. Therefore, cysteamine hydrochloride can be used for treating and delaying diabetic nephropathy. According to the application, the application field of cysteamine hydrochloride medicine is expanded, and a new scheme is provided for treatment of diabetic nephropathy.

The invention discloses a high-elasticity antibacterial fiber and a preparation method thereof, and relates to the technical field of high polymer materials. When the high-elasticity antibacterial fiber is prepared, N, N-bis (2-ethoxyl) aminomethylene diethyl phosphonate, allyl glycidyl ether and a phosphazene alkali P4-t-Bu solution are subjected to a reaction in an argon atmosphere, and polyether polyol is prepared; the preparation method comprises the following steps: carrying out polycondensation on polyether polyol, isophthalic acid and 1, 3-propylene glycol in a nitrogen atmosphere to prepare a polyether ester elastomer; the preparation method comprises the following steps: modifying a polyether ester elastomer and cysteamine hydrochloride through ultraviolet irradiation, reacting with 1H-pyrazole-1-formamidine hydrochloride to prepare modified polyether ester, and carrying out solution spinning to obtain the modified polyether ester elastic fiber. And reacting the synthesized d-borneol with acryloyl chloride to obtain d-borneol acrylate, and then carrying out impregnation and ultraviolet radiation treatment on the fiber to obtain the high-elasticity antibacterial fiber. The high-elasticity antibacterial fiber prepared by the invention has excellent high elasticity, antibacterial property and flame retardant property.

The invention relates to a synthesis method of an aliphatic long-carbon-chain epoxy resin curing agent, so that other non-edible oil resources in the nature are used for modifying an amine curing agent, and the situation that most of amine modification raw materials are from edible oil such as soybean oil and palm oil is improved. Compared with a commercial curing agent, the toughness of a self-made epoxy resin system is greatly improved, the elongation at break is improved by 220%, the impact toughness is improved by 190%, the bending strength is reduced by 26.76%, and the bending modulus is reduced by 9.54%. The preparation method is characterized in that methyl oleate and ethylene glycol are used as raw materials to prepare long-carbon-chain diester through transesterification, and the long-carbon-chain diester and cysteamine hydrochloride are subjected to thiol-ene click reaction under the irradiation of an ultraviolet lamp by using 2, 2-dimethoxy-2-phenyl acetophenone as an initiator to synthesize the aliphatic long-carbon-chain epoxy resin curing agent. Therefore, the mechanical property of the epoxy resin is effectively improved.

The invention provides composite hydrogel for promoting tissue regeneration and repair as well as a preparation method and application of the composite hydrogel, and belongs to the field of hydrogel materials. The method comprises the following steps: carrying out anhydride aminolysis ring-opening reaction on a styrene-maleic anhydride alternating copolymer, amino polyethylene glycol methyl ether, 3-aminophenylboronic acid and cysteamine hydrochloride; the preparation method comprises the following steps: carrying out a first amidation reaction on GRGDS pentapeptide and an SPDP cross-linking agent, then carrying out a disulfide bond exchange reaction on the obtained product and GPLGIAGQ-PEG-SH, and finally carrying out a second amidation reaction on the obtained product and 3-maleimide propionic acid-NHS ester; the preparation method comprises the following steps: carrying out a modification reaction on a PEDOT: PSS aqueous dispersion and 3-aminopropyltriethoxysilane; the preparation method comprises the following steps: mixing a multifunctional polymer, a signal molecule, a conductive component, four-arm PEG-hydrazide and oxidized sodium alginate, and sequentially carrying out physical gelation and chemical crosslinking to obtain the composite hydrogel. Therefore, the intelligent responsiveness, the biological activity and the conductivity of the hydrogel are synergistically improved.

The invention relates to the technical field of concrete materials, and particularly discloses fair-faced concrete and a preparation method thereof. The bare concrete comprises the following components: 500 to 580 parts of cement, 800 to 900 parts of mixed sand, 200 to 260 parts of silica fume, 40 to 100 parts of fly ash, 70 to 95 parts of a fiber material, 50 to 70 parts of an additive, 5 to 9 parts of a retarder, 1 to 5 parts of a water reducing agent and 180 to 230 parts of water, the preparation method of the admixture comprises the following steps: calcining magnesium carbonate and calcium carbonate to obtain a fired product, uniformly mixing the fired product with an activating agent aqueous solution, stirring and reacting at room temperature, and then drying and ball-milling to obtain the admixture. The activating agent aqueous solution is prepared from the following components: 30 to 40g / L of 1, 4-butanediol and 4 to 10g / L of cysteamine hydrochloride. The concrete prepared by the invention has good early compressive strength and cracking resistance, and has good impermeability and durability.

The invention provides an anti-aging hot melt adhesive and a preparation method thereof, and belongs to the technical field of hot melt adhesive preparation. The preparation process comprises the following steps: preparing the ultraviolet absorbent; preparing an anti-migration antioxidant; and preparing the hot melt adhesive. The preparation method comprises the following steps: adding anhydrous citric acid and cysteamine hydrochloride to carry out dehydration condensation reaction to produce a product, reacting the product with epoxy chloropropane, and then carrying out ring-opening polymerization reaction on the product and tetrahydrofuran; the hot melt adhesive prepared from the prepared ultraviolet absorbent and coupling agent modified montmorillonite loaded intramolecular synergistic macromolecular antioxidant containing thioether and aromatic secondary amine has good aging resistance.

The invention provides a water electrolysis catalyst, a preparation method thereof and a membrane electrode assembly using the catalyst. An embodiment water electrolysis catalyst includes an iridium oxide containing a rutile phase and an iridium-nickel oxide containing a hexagonal phase. A method of making a water electrolysis catalyst includes preparing a mixture including an iridium precursor, a nickel precursor, and cysteamine hydrochloride, drying the mixture, grinding the dried mixture, and firing the ground product, where the water electrolysis catalyst includes a rutile phase-containing iridium oxide and a hexagonal phase-containing iridium-nickel oxide.

A method for preparing an electro-responsive silk fibroin material comprises: (1) activation of silk fibroin, (2) thiolation of silk fibroin, which involves: adding a cysteamine hydrochloride solution dropwise to the activated silk fibroin solution, adjusting the pH value of the final solution to 5-6, performing a reaction under stirring at 0° C.-4° C., taking out the resulting product, and then leaving the resulting product to stand for a reacting at 2° C.-8° C. to obtain a thiolated silk fibroin; (3) purification of the thiolated silk fibroin; and (4) preparation of an electro-responsive silk fibroin material, which involves: taking the purified thiolated silk fibroin solution, pouring same in a mold, drying same after defoaming, and demolding same to obtain the electro-responsive silk fibroin material.

An embodiment water electrolysis catalyst includes iridium oxide including a rutile phase and iridium-nickel oxide including a hexagonal phase. An embodiment method of preparing a water electrolysis catalyst includes preparing a mixture including an iridium precursor, a nickel precursor, and cysteamine hydrochloride, drying the mixture, grinding the dried mixture, and firing a ground product, wherein the water electrolysis catalyst includes iridium oxide including a rutile phase and iridium-nickel oxide including a hexagonal phase.

The application discloses a production process of 2,2'-(propane-2,2'-diylbis(sulfonamidyl))diethylamine and its hydrochloride. 2,2'-(propane-2,2'-diylbis(sulfonamidyl))diethylamine is a common active oxygen response small molecule. At present, the synthesis process of the molecule has the problems of complex synthesis steps, multi-step post-treatment, difficult reuse of solvent, low reaction rate and low reaction yield, and high-pollution gas purification. The application adopts a new production process. Cysteamine hydrochloride and acetone are reacted in a reaction system by one-step method to prepare 2,2'-(propane-2,2'-diylbis(sulfonamidyl))diethylamine dihydrochloride product. After alkaline washing, 2,2'-(propane-2,2'-diylbis(sulfonamidyl))diethylamine product is obtained. The production process does not need high-pollution hydrogen chloride gas catalysis, has high reaction efficiency and yield, the involved solvent can be recycled and reused, the reactants and products are easy to separate, the product has high purity, the reaction device is simple, the process is environment-friendly, and the reaction end point is easy to monitor.

This invention discloses a method for preparing electroresponsive silk fibroin microneedles, comprising the following steps: adding cysteine ​​hydrochloride solution dropwise to an activated silk fibroin solution to achieve a final cysteine ​​hydrochloride concentration of 20-80 mmol / L; adjusting the pH of the final solution to 5-6; stirring the reaction mixture, then allowing it to stand to obtain a thiolated silk fibroin solution; dialyzing the reacted silk fibroin solution in a dialysis bag; after dialysis, centrifuging to obtain the supernatant and then purifying the thiolated silk fibroin solution; pouring the purified thiolated silk fibroin solution into a microneedle mold and removing air bubbles by vacuuming in a vacuum drying oven; then drying the degassed mold system under a constant temperature and humidity environment; and finally, after drying and demolding, obtaining the electroresponsive silk fibroin microneedles. The electroresponsive silk fibroin microneedles of this invention can achieve changes in swelling degree under low voltage stimulation and exhibit high swelling characteristics under energized conditions, enabling controlled drug release.

The invention relates to the technical field of copper foil production, in particular to a production process of copper foil for chip packaging. The production process comprises the steps that an electrolyte is prepared, a functional additive and sodium chloride are added into the electrolyte, and the functional additive is synthesized through a two-step reaction of 3, 3 '-dithiodipropionic acid, thionyl chloride and cysteamine hydrochloride; carrying out electrolytic deposition under specific process conditions; and finally, washing, drying, slitting and rolling to obtain a copper foil finished product. The copper foil produced by the invention not only has excellent oxidation resistance and heat resistance, but also has the advantages of low roughness, high peel strength and the like, and the service life of the prepared copper foil product is prolonged to a certain extent while the quality of the prepared copper foil product is effectively ensured. In addition, according to the production process provided by the invention, a roughening treatment procedure and an anti-oxidation layer coating procedure which are heavy in pollution and high in energy consumption in a traditional process are thoroughly omitted, and the production process is more environment-friendly and more economical.

The invention discloses a synthesis method of cysteamine hydrochloride, and relates to the technical field of pharmaceutical manufacturing intermediates, the synthesis method comprises the following steps: S1, synthesis of 2-aminoethyl sulfate; s2, synthesizing alpha-mercaptothiazoline by taking the 2-aminoethyl sulfate as a raw material; s3, synthesizing S, S '-bis (2-aminoethyl ester) dithioformic acid by taking the alpha-mercaptothiazoline as a raw material; and S4, synthesizing cysteamine hydrochloride by taking the S, S '-bis (2-aminoethyl ester) dithioformic acid as a raw material. According to the invention, alpha-mercaptothiazoline and 2-aminoethyl sulfate react to generate an intermediate dithioformic acid S, S '-bis (2-aminoethyl ester), and then hydrolysis is carried out, so that the purposes of reducing serious hydrogen sulfide pollution, improving the atom utilization rate, improving the yield and being environmentally friendly are achieved.

The invention discloses a compound feed additive for improving the production performance of beef cattle and application, and belongs to the field of livestock feed. The compound feed additive provided by the invention comprises 35-45 parts of soybean meal extract, 20-30 parts of active dry yeast and 15-25 parts of cysteamine hydrochloride. The compound feed additive is added into cattle total mixed ration according to the mass ratio of 1: 1000 to feed beef cattle, and experimental results show that the compound feed additive disclosed by the invention can be used for promoting the intake of the beef cattle, improving the activity of rumen digestive enzyme, improving the digestion and absorption efficiency of nutrient substances and increasing the daily gain; in conclusion, the compound feed additive can significantly improve the production performance of beef cattle and improve the breeding benefits of the beef cattle. The invention provides a green, safe, efficient and low-cost compound feed additive for beef cattle feeding, and has important economic significance and wide application prospects.