6 results about "CYSTEAMINE HYDROCHLORIDE" patented technology

The invention relates to the technical field of organic polymer adhesives, and particularly discloses a modified castor oil polyurethane adhesive containing catalytic groups as well as a preparation method and application of the modified castor oil polyurethane adhesive. The adhesive comprises two components, and the component A comprises the following components in parts by weight: 30.0-50.0 parts of modified castor oil and 0.0-30.0 parts of refined castor oil; the component B is prepared from the following components in parts by weight: 30.0 to 50.0 parts of polyisocyanate or a polyisocyanate modifier and 0.00 to 0.05 part of a dewatering agent; the modified castor oil is prepared by the route that refined castor oil and cysteamine hydrochloride are subjected to sulfydryl-alkene addition reaction and then neutralized by strong base. The modified castor oil contains hydroxyl, an amino reaction group and a quaternary ammonium salt catalytic group at the same time, the reaction speed with an isocyanate group is high, a mixture of the two components has certain thixotropy, and a cross-linked product has high strength.

This invention relates to the field of organic polymer adhesives, specifically disclosing a modified castor oil polyurethane adhesive containing catalytic groups, its preparation method, and its application. The adhesive is a two-component compound. By weight, component A comprises 30.0-50.0 parts modified castor oil and 0.0-30.0 parts refined castor oil; component B comprises 30.0-50.0 parts polyisocyanate or a modified polyisocyanate and 0.00-0.05 parts dehydrating agent. The modified castor oil is prepared by first reacting refined castor oil and cysteine ​​hydrochloride via a mercapto-olefin addition reaction, followed by neutralization with a strong base. The modified castor oil simultaneously contains hydroxyl, amino reactive groups, and quaternary ammonium salt catalytic groups, exhibiting rapid reaction with isocyanate groups. The mixture of the two components exhibits certain thixotropy, and the crosslinked product has high strength.

The invention belongs to the technical field of medicines, and in particular discloses an application of cystamine hydrochloride (CYS) in preparation of a medicine for treating diabetic nephropathy. The invention finds that cysteamine hydrochloride can reduce the glomerular volume increase and mesangial hyperplasia of a mouse with diabetic nephropathy, and meanwhile, cysteamine hydrochloride can improve proteinuria caused by kidney injury of diabetic nephropathy. Therefore, cysteamine hydrochloride can be used for treating and delaying diabetic nephropathy. According to the application, the application field of cysteamine hydrochloride medicine is expanded, and a new scheme is provided for treatment of diabetic nephropathy.

The invention relates to a synthesis method of an aliphatic long-carbon-chain epoxy resin curing agent, so that other non-edible oil resources in the nature are used for modifying an amine curing agent, and the situation that most of amine modification raw materials are from edible oil such as soybean oil and palm oil is improved. Compared with a commercial curing agent, the toughness of a self-made epoxy resin system is greatly improved, the elongation at break is improved by 220%, the impact toughness is improved by 190%, the bending strength is reduced by 26.76%, and the bending modulus is reduced by 9.54%. The preparation method is characterized in that methyl oleate and ethylene glycol are used as raw materials to prepare long-carbon-chain diester through transesterification, and the long-carbon-chain diester and cysteamine hydrochloride are subjected to thiol-ene click reaction under the irradiation of an ultraviolet lamp by using 2, 2-dimethoxy-2-phenyl acetophenone as an initiator to synthesize the aliphatic long-carbon-chain epoxy resin curing agent. Therefore, the mechanical property of the epoxy resin is effectively improved.

The invention provides composite hydrogel for promoting tissue regeneration and repair as well as a preparation method and application of the composite hydrogel, and belongs to the field of hydrogel materials. The method comprises the following steps: carrying out anhydride aminolysis ring-opening reaction on a styrene-maleic anhydride alternating copolymer, amino polyethylene glycol methyl ether, 3-aminophenylboronic acid and cysteamine hydrochloride; the preparation method comprises the following steps: carrying out a first amidation reaction on GRGDS pentapeptide and an SPDP cross-linking agent, then carrying out a disulfide bond exchange reaction on the obtained product and GPLGIAGQ-PEG-SH, and finally carrying out a second amidation reaction on the obtained product and 3-maleimide propionic acid-NHS ester; the preparation method comprises the following steps: carrying out a modification reaction on a PEDOT: PSS aqueous dispersion and 3-aminopropyltriethoxysilane; the preparation method comprises the following steps: mixing a multifunctional polymer, a signal molecule, a conductive component, four-arm PEG-hydrazide and oxidized sodium alginate, and sequentially carrying out physical gelation and chemical crosslinking to obtain the composite hydrogel. Therefore, the intelligent responsiveness, the biological activity and the conductivity of the hydrogel are synergistically improved.

The invention discloses a synthesis method of cysteamine hydrochloride, and relates to the technical field of pharmaceutical manufacturing intermediates, the synthesis method comprises the following steps: S1, synthesis of 2-aminoethyl sulfate; s2, synthesizing alpha-mercaptothiazoline by taking the 2-aminoethyl sulfate as a raw material; s3, synthesizing S, S '-bis (2-aminoethyl ester) dithioformic acid by taking the alpha-mercaptothiazoline as a raw material; and S4, synthesizing cysteamine hydrochloride by taking the S, S '-bis (2-aminoethyl ester) dithioformic acid as a raw material. According to the invention, alpha-mercaptothiazoline and 2-aminoethyl sulfate react to generate an intermediate dithioformic acid S, S '-bis (2-aminoethyl ester), and then hydrolysis is carried out, so that the purposes of reducing serious hydrogen sulfide pollution, improving the atom utilization rate, improving the yield and being environmentally friendly are achieved.