147 results about "CYSTEAMINE HYDROCHLORIDE" patented technology

The subject invention provides compositions and methods for treating diabetes in patients. In a preferred embodiment, the invention provides compositions methods for treating diabetes and/or preventing or alleviating complications associated with diabetes. Specifically exemplified herein is the concurrent administration of a cysteamine compound with at least one additional therapeutic agent to prevent and/or treat diabetes as well as prevent and/or treat complications associated with diabetes. In a preferred embodiment, oral administration of cysteamine hydrochloride with Metformin to a patient diagnosed with diabetes can substantially regulate the patient's glucose metabolism and insulin sensitivity.

The invention relates to a slow release pellet of high-stability type cysteamine hydrochloride and a preparation method thereof. The slow release pellet comprises the following components in portionsby weight: 30-70 portions of cysteamine hydrochloride, 20-40 portions of silicon dioxide and 5-25 portions of polymer material as coating wall material. The preparation method comprises the followingsteps: firstly, using silicon dioxide pellets to absorb liquid cysteamine hydrochloride in proportion to form cysteamine hydrochloride particles; then, using the coating wall material to encapsulate the cysteamine hydrochloride particles to form a membrane cavity control structure; and drying the structure to obtain slow release pellets of 50% cysteamine hydrochloride. The slow release pellet hasthe characteristics of stable product quality, high content, reasonable preparation method, easy batch production and simple using method and can be added into the premix.

The invention relates to the field of preparation methods of polyetheramine, and especially relates to a hyperbranched polythioether polyamine, and a preparation method and a use thereof. The preparation method is simple, raw materials are nontoxic and are easy to obtain, cysteamine hydrochloride can be prepared through hydrolyzing human and animal hair, alkynyl glycidyl ether can be directly purchased, and the method also has the advantages of low requirements of devices involved in the preparation process, no special or strict conditions, and mild reaction conditions. The molecular periphery of the hyperbranched polythioether polyamine has a plurality of primary amino groups, so the hyperbranched polythioether polyamine can be used as an epoxy resin flexible curing agent; and hyperbranched polythioether polyamine hydrochloride which is the precursor of the hyperbranched polythioether polyamine has a strong fluorescence effect, a good antibacterial performance and a good sterilizing performance.

The invention discloses digestion promoting mandarin fish feed with a disease resisting effect. The feed is prepared from fish meal, soybean meal, rapeseed meal, cottonseed meal, peanut meal, middling flour, prawn powder, blood worm powder, zeolite powder, alfalfa meal, bone meal, monopotassium phosphate, table salt, shrimp bran powder, cod-liver oil, palm oil, modified soybean phosphate, Vc-polyphosphoester, yeast powder, shrimp shell meal, an adhesive, choline chloride, mercaptamine, citric acid, taurine, flavomycin, saccharicterpenin, Chinese herbal medicine disease prevention additives, phagostimulant, a complex enzyme preparation and synbiotics. The mandarin fish feed can promote digestion of mandarin fish and improve the disease resistance of the mandarin fish.

The invention discloses quaternary ammonium salt type hyperbranched polythioether modified polymer microspheres and a preparation method thereof. The preparation method comprises the following steps of: under a photo-initiation condition, taking polyethylene glycol as a pore-foaming agent, taking alkyl dithiol, propargyl glycidyl ether and 1,7-octadiyne as raw materials, and preparing epoxy groupmicroporous polymer spheres by using a sulfydryl-alkyne addition suspension polymerization method; then, under the condition of 0 DEG C, taking methanol as a solvent, and initiating allyl glycidyl ether and a cysteamine compound by ultraviolet light to react to synthesize an [alpha]-epoxy-[omega]-ammonium-based intermediate; and, in a solvent and under the condition of 60 DEG C, synthesizing the hyperbranched ammonium polythioether modified polymer microspheres from the epoxy group microporous polymer spheres, the [alpha]-epoxy-[omega]-ammonium-based intermediate and sodium methoxide in one step. The obtained product has a good killing effect on escherichia coli, and the modified polymer microspheres can be recycled through simple filtration.

The invention discloses a method for preparing superoxide dismutase (SOD)-loaded gamma-poly glutamic acid hydrogel. The method comprises the following steps: adopting a 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride/N-hydroxysuccinimide (EDC/NHS) activation system, and forming an SOD-gamma-polyglutamic acid (PGA) immobilized product by using lysine residues and poly glutamic acid side chain carboxyl of SOD; crosslinking the SOD-gamma-PGA obtained by the reaction by using a diamine crosslinking agent cysteamine hydrochloride, so as to form an SOD-gamma-PGA gel system. The gel system can be applied to wound dressing or mask, and can play the antioxidant damage action, and the skin wound is quickly repaired.

The invention discloses feed for promoting growth of a river crab. The feed comprises the following raw materials: wheat, corn, dextrin, potato powder, wheat bran, fish meal, shrimp meal, bean pulp, peanut meal, rapeseed meal, cellulose, sodium carboxymethylcellulose, monocalcium phosphate, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin A, vitamin C, pantothenic acid, folic acid, inositol, choline, mineral pre-mixing powder, unshelling element, oil used for feed, garlic essential oil, cinnamon leaf oil and additive, wherein the additive comprises the following raw materials: vitamin E, vitamin B12, bacillus licheniformis, bacillus subtilis, mannan oligosaccharide and cysteamine hydrochloride. The feed has the beneficial effects of promoting the growth of the river crab, enhancing immunity of the river crab, being environmentally friendly due to no drug residue and providing comprehensive nutrients and sufficient energy.

A mild reducing composition and method for straightening human hair are described. The composition contains cysteamine hydrochloride in the range of 5-10% by weight at a pH range of 7.0-9.0. The composition is applied to hair and processed for 15-45 minutes. The hair is rinsed with water, dried with a blow-dryer and ironed with a straightening iron. The hair is allowed to air-oxidize for 24-72 hours. The resultant straightening lasts 2 to 4 months, and the hair gradually reverts to the pre-treatment state with no obvious re-growth. The treatment may be re-applied every 2 to 4 months without significant damage.

The invention belongs to the technical field of analysis and detection and discloses a cysteamine-modified copper nanocluster solution fluorescent probe as well as preparation and an application. Ascorbic acid is dissolved in ultrapure water, a copper ion solution and a cysteamine hydrochloride solution are sequentially added, the mixture is uniformly stirred and mixed, and the cysteamine-modifiedcopper nanocluster solution fluorescent probe is obtained. The cysteamine-modified copper nanocluster solution fluorescent probe is added to ultrapure water to be diluted, a to-be-detected picric acid solution is added, a fluorescence spectrometer is used for detection, and the concentration of picric acid in the to-be-detected solution is analyzed according to the relation between the fluorescence intensity and the concentration of picric acid. The cysteamine-modified copper nanocluster solution is used for detecting picric acid for the first time, and the fluorescence quenching probe is designed to perform fluorescence detection on picric acid, has the advantages of being simple to operate, high in detection speed, good in selectivity and high in sensitivity and has the linear range of0-80 mu mol/L and the detection limit of 0.139 mu mol/L.

The invention provides a magnetic material for efficiently detecting a circulating tumor cell and a preparation method of the magnetic material. The preparation method comprises the steps of: (1) allowing hyaluronic acid, 1-(3-dimethylamino propyl)-3-ethyl-carbodiimide hydrochloride, 1-hydroxybenzotriazole, cysteamine hydrochloride and dithiothreitol to react to prepare HA-SH, (2) grafting rhodamine onto HA-SH to prepare RhB-HA-SH, (3) allowing an Fe3O4 nanoparticle, RhB-HA-SH and H2O2 to react to prepare superparamagnetic fluorescent HA-SH, and (4) allowing superparamagnetic fluorescent HA-SH, 1-(3-dimethylamino propyl)-3-ethyl-carbodiimide hydrochloride, 1-hydroxybenzotriazole, PEG-FA and anti-EpCAM (epithelial cell adhesion molecule) to perform antibody reaction to prepare the magneticmaterial. The magnetic material is high in saturation magnetization, and good in magnetic response and biocompatibility, can achieve specific binding with the circulating tumor cell and has certain universality.

The invention provides a synthetic method for taurolidine and a medicinal preparation thereof. The method comprises the preparing steps: adopting cysteamine hydrochloride as raw material to carry out the reaction of chloridization, azide and hydrogenization, preparing the target product taurolidine by condensation reaction with formaldehyde. The synthetic route avoids the shortages of multistep process of the original synthetic route which consumes large amount of and complex chemical materials and is easy to cause side effect. By adopting the technique of the invention, the prepared taurolidine has higher purity, and the preparation made is more stable and has exacter healing effect.

The invention relates to a method for producing enteric cysteamine hydrochloride coated granules, which comprises the following process steps: 1, combining cysteamine hydrochloride and a capsule material to prepare mixed suspension; 2, adding the mixed suspension into 5-percent acetic acid solution, mixing at 50 DEG C to form coacervated capsules, adding water at 30 to 40 DEG C in a volume which is 1 to 3 times that of the coacervated capsules to form suck capsules, adding 37-percent formaldehyde solution and mixing at 10 DEG C to form solidified capsules; 3, washing the solidified capsules till no formaldehyde smell is given off to form microcapsules; and 4, dying under vacuum to obtain cysteamine hydrochloride coated granule preparation. In the method, the cysteamine hydrochloride coated with an imported coating material is prevented from being oxidized in any environment and the properties of the cysteamine hydrochloride coated granules are stable, the dissolution rate of the cysteamine hydrochloride coated granules in stomach is smaller than 2 percent, and the use of the cysteamine hydrochloride coated granules in a large dose does not cause canker; the cysteamine hydrochloride is released in intestinal tract accurately and can dissolve and be absorbed completely; and thus, the bioavailability is improved greatly. The product can be added into an auxiliary material as a raw material to form the low-content cysteamine hydrochloride coated granules.

The invention relates to stable mercaptamine enveloped by microcapsules. The stable mercaptamine is mainly prepared from the following materials in parts by weight: 20-55 parts of mercaptamine, 15-35 parts of corn starch, 0.1-10 parts of sodium carboxymethylcellulose, 1-10 parts of sodium alginate, 0.1-10 parts of ethyecellulose, 10-15 parts of beta-cyclodextrin and 10-50 parts of carnauba wax. The stable mercaptamine and the preparation process provided by the invention have the advantages that the problems of easy oxidation and easy moisture absorption are effectively solved, so that the purpose of protecting the mercaptamine is achieved; simultaneously, the release of the mercaptamine in the stomach is furthest limited, the occurrence of the gastric ulcer is avoided, and the full release in the intestinal tract is achieved, so that more effective utilization by animals is achieved, the growth of the animals is promoted and the application prospect is better.

The invention discloses a composite premix for the later stage of growing-fattening pigs. The composite premix comprises cynomorium songaricum extract and preferably comprises cysteamine hydrochloride, guanidinoacetic acid, licorice root extract, acanthopanax root extract, peppermint extract, dried tangerine peel extract, Chinese magnoliavine fruit extract, capsanthin extract and rosemary extract. The invention discloses composite premix feed for the late stage of growing-fattening pigs and the feed is prepared from the composite premix. The composite premix and the composite premix feed for the later stage of growing-fattening pigs can prevent intestinal and respiratory diseases in the later stage of growing-fattening pigs, improve human immunity, prevent diarrhea in the later stage of growing-fattening pigs, increase a yield and a survival rate in the later stage of growing-fattening pigs and improve pig carcass quality, feed conversion and a meat production cost.

The invention relates to a method using alkaline hydrolysis to prepare cysteamine hydrochloride, in particular to synthesizing cysteamine hydrochloride in alkali surroundings, which is characterized in that: ethanolamine solution and sulfate solution are used as raw material; 2- amino ethyl sulfate is firstly synthesized before made into ring in alkaline solution by 2-amino ethyl sulfate and carbon disulfide, thereby getting Alpha -mercaptothiazoline; alkaline hydrolysis is made upon Alpha -mercaptothiazoline to produce cysteamine hydrochloride. The preparation method for cysteamine hydrochloride by using alkaline hydrolysis has the advantages of simple method, short production period and low production cost. The recovery rate of synthesizing Alpha -mercaptothiazoline reaches more than 90%. The cysteamine hydrochloride can be widely applied in manufacturing anti-ulcer drugs such as ranitidine and cimetidine, manufacturing animal fodder additive, manufacturing cosmetic and hair wave-setting agent, manufacturing biochemical reagent and heavy metal ion complexion agent and manufacturing agent treating radiation syndrome and acute tetraethyl lead poisoning and in other areas.

The invention discloses a granulating coated slow release product of cysteamine hydrochloride and a preparation method thereof. The product is obtained by taking cysteamine hydrochloride, corn starch, vitamin C, powdered glucose, stearic acid and 85wt percent phosphoric acid solution as raw materials through the processes of heating for dissolving, millard reaction, stabilization treatment, atomized granulation, hardening waterproof coating, enteric coating, drying, sieving and the like, wherein the content of the cysteamine hydrochloride in the product is more than or equal to 30.50 percent and the water content ranges from 0 percent to 8.0 percent. The method thoroughly eradicates the odor of the cysteamine hydrochloride, the product has the fragrance of bulked corn, and the glucose added in the millard reaction can conduct physical coverage and cause the cysteamine hydrochloride to be slowly released, thus increasing the palatability of products. The addition of glucose in full-price materials not only does not affect feed intake, but also can increase the feed intake. In the process of technological treatment and storage of the products, the content of cysteamine hydrochloride is stable.

The invention belongs to the technical field of biotechnology and nanometer material and specifically relates to a ferroferric oxide magnetic nanometer material modified with cysteamine hydrochloride, and a preparation method and an application thereof in enrichment analysis for a glycosylation peptide fragment. According to the invention, the ferroferric oxide magnetic nanometer material modified with cysteamine hydrochloride and a glycosylation peptide fragment solution are mixed in a mixed solution of acetonitrile, water and trifluoroacetic acid; the mixture is hatched in an enzymolysis instrument; the nanometer material is separated and the supernate is removed under an action of an external magnetic field; the nanometer material is washed with the mixed solution of acetonitrile, water and trifluoroacetic acid; the glycosylation peptide fragment enriched on the material is eluted with the mixed solution of acetonitrile, water and formic acid; and the mass spectrometry is combined for identifying. According to the invention, the operation is simple and quick; the material can be reused; the cost is low; the sensitivity and the selectivity are higher; the ferroferric oxide magnetic nanometer material is suitable for the enrichment analysis for the glycosylation peptide fragment and has excellent application prospect.

The invention relates to a preparation method of a cysteamine hydrochloride controlled-release feed additive, which comprises the following steps: weighing 30-70 percent of cysteamine hydrochloride, 25-60 percent of glucose and 1-10 percent of water in percentage by weight, heating and dissolving the compositions into solution, adding alkaline contents in the solution to lead the pH value to be 3.5-6.0 at the temperature of 85-89 DEG C, stirring the solution at the speed of 50-100 turns per minute, and reacting for 60-80min, thereby obtaining a liquid finished product of the cysteamine hydrochloride controlled-release feed additive; adsorbing the liquid finished product with white carbon black for 5-20min to prepare a solid granule finished product; and coating the surface of the solid granule finished product with fatty acid mixture formed by stearic acid, palmitic acid and oleic acid, so as to prepare a coated solid finished product of the cysteamine hydrochloride controlled-release feed additive. The preparation method can more effectively improve the intensity and the reaction completion degree of Maillard reaction, shorten the time of the Maillard reaction, and more effectively remove the smelly egg and bitter taste of cysteamine hydrochloride, so that the mouthfeeling of animals to the product is better, and the stability of the product is excellent.

The invention relates to a growth agent for aquatic animals and a production method thereof, in particular to a stabilized cysteamine growth promoting agent used for aquatic feeds and a production method thereof, belonging to the technical field of feed additive production. The stabilized cysteamine growth promoting agent used for the aquatic feeds comprises raw materials of cysteamine hydrochloride and monohydrate zinc sulphate or heptahydrate zinc sulphate with the mass ratio of 1:1-1:3. The production method comprises the following steps of: mixing the cysteamine hydrochloride, the monohydrate zinc sulphate or the heptahydrate zinc sulphate, and water based on the mass ratio, and enabling the temperature of the mixed solution to be constantly at 40-50 DEG C; after the cysteamine hydrochloride and the zinc sulphate dissolve in the water, adding silicon dioxide and stirring for 20-90 minutes; and drying the mixed solution to be with 5-12 percent of moisture. The product of the invention has superfine product particle-size while ensuring the stability of the cysteamine, and overcomes the difficulty that traditional encapsulated type stabilized cysteamine agent is not suitable for aquatic feeds industry, wherein average particle size is smaller than 100 mesh standard sieve.

The invention provides a preparation method of 2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethylamine. The preparation method comprises mixing a dimethylamine hydrochloride solution, polyformaldehyde and a quaternary ammonium salt, heating the mixture to 50 to 70 DEG C, adding furfuryl alcohol into the reaction system, carrying out a first condensation reaction process to obtain an intermediate, mixing the intermediate, cysteamine hydrochloride, concentrated hydrochloric acid and perchloric acid, carrying out a second condensation reaction process at the system temperature of 15 to 25 DEG C to obtain a mixed solution of 2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethylamine hydrochloride, alkalifying the mixed solution, extracting the solution through dichloromethane and distilling the extract to obtain 2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethylamine. The preparation method has the advantages of high yield, high product purity, simple processes and industrialization easiness.

The invention discloses a synthetic method of dimethyl cysteamine hydrochloride. The method comprises the following steps of: synthesizing 5,5-dimethyl-2-isopropyl thiazoline by taking isobutylaldehyde, element sulfur, ammonia gas and triethylamine as raw materials; reducing the 5,5-dimethyl-2-isopropyl thiazoline into 5,5-dimethyl-2-isopropyl thiazolidine under the actions of sodium borohydride and acid; and reacting the 5,5-dimethyl-2-isopropyl thiazolidine and phenyl hydrazine under the air insulating situation to obtain dimethyl cysteamine hydrochloride. The method has the advantages of readily-available reaction raw materials, easiness for operating the reaction process, low requirement on the reaction equipment, relatively mild reaction conditions, feeding of the product of every step of reaction into a next step reaction after refining and purifying, high yield and high purity, and the purity of the finally-obtained dimethyl cysteamine hydrochloride is close to 100 percent.

The invention relates to an antibiotic-free premix feed for breeding sows. The antibiotic-free premix feed is prepared from the following components of table salt, lysine, bone meal, compound enzymes, choline chloride, chromium nicotinate, radix codonopsis, radix astragali, Chinese wolfberry fruits, radix scutellariae, methionine, threonine, vitamin A, vitamin D, vitamin E, vitamin B, folic acid, selenium yeast, cysteamine hydrochloride and soybean flavone, and besides, yucca, radix angelicae sinensis, radix rehmanniae preparata and pine needles are particularly added to be used as pig feed additives for replacing Western medicines and antibiotic drugs, so that the immunity of sows can also be enhanced, and the propagation performance of the sows can also be effectively improved. The antibiotic-free premix feed disclosed by the invention can supply adequate nutrients for the growth of the sows, complements various vitamins and minerals, and does not contain antibiotics, so that the antibiotics are avoided from being enriched in bodies of the breeding sows to influence the properties of piggies, and the antibiotic-free premix feed conforms to the health concept of modern people.

The invention discloses a feed formula capable of improving the immune performance of an animal. The feed formula is prepared from the following raw materials: corn, bean cakes, peanut meal, extruded soybeans, sweet potatoes, brown rice, cactus powder, wheat bran, hawthorn, calcium hydrophosphate, radix rehmanniae, astragalus membranaceus, radix sophorae flavescentis, honeysuckle, manyprickle acanthopanax roots, semen cuscutae, glossy privet fruits, angelica sinensis, andelion, perilla leaves, flos carthami, radix bupleuri, wolfberry fruits, polygonum multiflorum, liquorice, radix isatidis, mercaptamine and a salt. The invention further discloses a processing method of the feed formula capable of improving the immune performance of the animal. The prepared feed is abundant in nutrient, the immunocompetence of the animal can be effectively improved, and the feed does not contain hormone and antibiotic, does not generate a residue in the animal and meets the green and healthy requirements.