11 results about "CYSTEAMINE HYDROCHLORIDE" patented technology

The invention discloses a deodorant skin-friendly fabric and a preparation method thereof, and relates to the field of fiber fabrics. When the deodorant skin-friendly fabric is prepared, microcrystalline cellulose sequentially reacts with ethylene (chloromethyl) dimethoxysilane and 1-amino-4-butylguanidine dihydrochloride, and modified cellulose is prepared; the preparation method comprises the following steps: polymerizing dimethyl terephthalate, 2-vinyl propane-1, 3-diol and ethylene glycol, and reacting with mercaptopropyl methyl dimethoxy silane to prepare modified polyester; the preparation method comprises the following steps: reacting anhydrous citric acid with cysteamine hydrochloride to prepare an ultraviolet absorbent; the preparation method comprises the following steps: reacting 3-[(2, 3)-epoxypropoxy] propyl methyl dimethoxy silane with DOPO (9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide) to prepare modified siloxane; and mixing the modified polyester and the modified cellulose, spinning, and sequentially carrying out surface treatment by using an ultraviolet absorbent and a silane mixed solution to obtain the deodorant skin-friendly fabric. The deodorant skin-friendly fabric prepared by the invention has flame-retardant and durable capabilities.

The invention relates to the technical field of organic polymer adhesives, and particularly discloses a modified castor oil polyurethane adhesive containing catalytic groups as well as a preparation method and application of the modified castor oil polyurethane adhesive. The adhesive comprises two components, and the component A comprises the following components in parts by weight: 30.0-50.0 parts of modified castor oil and 0.0-30.0 parts of refined castor oil; the component B is prepared from the following components in parts by weight: 30.0 to 50.0 parts of polyisocyanate or a polyisocyanate modifier and 0.00 to 0.05 part of a dewatering agent; the modified castor oil is prepared by the route that refined castor oil and cysteamine hydrochloride are subjected to sulfydryl-alkene addition reaction and then neutralized by strong base. The modified castor oil contains hydroxyl, an amino reaction group and a quaternary ammonium salt catalytic group at the same time, the reaction speed with an isocyanate group is high, a mixture of the two components has certain thixotropy, and a cross-linked product has high strength.

This invention relates to the field of organic polymer adhesives, specifically disclosing a modified castor oil polyurethane adhesive containing catalytic groups, its preparation method, and its application. The adhesive is a two-component compound. By weight, component A comprises 30.0-50.0 parts modified castor oil and 0.0-30.0 parts refined castor oil; component B comprises 30.0-50.0 parts polyisocyanate or a modified polyisocyanate and 0.00-0.05 parts dehydrating agent. The modified castor oil is prepared by first reacting refined castor oil and cysteine ​​hydrochloride via a mercapto-olefin addition reaction, followed by neutralization with a strong base. The modified castor oil simultaneously contains hydroxyl, amino reactive groups, and quaternary ammonium salt catalytic groups, exhibiting rapid reaction with isocyanate groups. The mixture of the two components exhibits certain thixotropy, and the crosslinked product has high strength.

The invention belongs to the technical field of medicines, and in particular discloses an application of cystamine hydrochloride (CYS) in preparation of a medicine for treating diabetic nephropathy. The invention finds that cysteamine hydrochloride can reduce the glomerular volume increase and mesangial hyperplasia of a mouse with diabetic nephropathy, and meanwhile, cysteamine hydrochloride can improve proteinuria caused by kidney injury of diabetic nephropathy. Therefore, cysteamine hydrochloride can be used for treating and delaying diabetic nephropathy. According to the application, the application field of cysteamine hydrochloride medicine is expanded, and a new scheme is provided for treatment of diabetic nephropathy.

The invention discloses a high-elasticity antibacterial fiber and a preparation method thereof, and relates to the technical field of high polymer materials. When the high-elasticity antibacterial fiber is prepared, N, N-bis (2-ethoxyl) aminomethylene diethyl phosphonate, allyl glycidyl ether and a phosphazene alkali P4-t-Bu solution are subjected to a reaction in an argon atmosphere, and polyether polyol is prepared; the preparation method comprises the following steps: carrying out polycondensation on polyether polyol, isophthalic acid and 1, 3-propylene glycol in a nitrogen atmosphere to prepare a polyether ester elastomer; the preparation method comprises the following steps: modifying a polyether ester elastomer and cysteamine hydrochloride through ultraviolet irradiation, reacting with 1H-pyrazole-1-formamidine hydrochloride to prepare modified polyether ester, and carrying out solution spinning to obtain the modified polyether ester elastic fiber. And reacting the synthesized d-borneol with acryloyl chloride to obtain d-borneol acrylate, and then carrying out impregnation and ultraviolet radiation treatment on the fiber to obtain the high-elasticity antibacterial fiber. The high-elasticity antibacterial fiber prepared by the invention has excellent high elasticity, antibacterial property and flame retardant property.

The invention relates to a synthesis method of an aliphatic long-carbon-chain epoxy resin curing agent, so that other non-edible oil resources in the nature are used for modifying an amine curing agent, and the situation that most of amine modification raw materials are from edible oil such as soybean oil and palm oil is improved. Compared with a commercial curing agent, the toughness of a self-made epoxy resin system is greatly improved, the elongation at break is improved by 220%, the impact toughness is improved by 190%, the bending strength is reduced by 26.76%, and the bending modulus is reduced by 9.54%. The preparation method is characterized in that methyl oleate and ethylene glycol are used as raw materials to prepare long-carbon-chain diester through transesterification, and the long-carbon-chain diester and cysteamine hydrochloride are subjected to thiol-ene click reaction under the irradiation of an ultraviolet lamp by using 2, 2-dimethoxy-2-phenyl acetophenone as an initiator to synthesize the aliphatic long-carbon-chain epoxy resin curing agent. Therefore, the mechanical property of the epoxy resin is effectively improved.

The invention provides composite hydrogel for promoting tissue regeneration and repair as well as a preparation method and application of the composite hydrogel, and belongs to the field of hydrogel materials. The method comprises the following steps: carrying out anhydride aminolysis ring-opening reaction on a styrene-maleic anhydride alternating copolymer, amino polyethylene glycol methyl ether, 3-aminophenylboronic acid and cysteamine hydrochloride; the preparation method comprises the following steps: carrying out a first amidation reaction on GRGDS pentapeptide and an SPDP cross-linking agent, then carrying out a disulfide bond exchange reaction on the obtained product and GPLGIAGQ-PEG-SH, and finally carrying out a second amidation reaction on the obtained product and 3-maleimide propionic acid-NHS ester; the preparation method comprises the following steps: carrying out a modification reaction on a PEDOT: PSS aqueous dispersion and 3-aminopropyltriethoxysilane; the preparation method comprises the following steps: mixing a multifunctional polymer, a signal molecule, a conductive component, four-arm PEG-hydrazide and oxidized sodium alginate, and sequentially carrying out physical gelation and chemical crosslinking to obtain the composite hydrogel. Therefore, the intelligent responsiveness, the biological activity and the conductivity of the hydrogel are synergistically improved.

The application discloses a production process of 2,2'-(propane-2,2'-diylbis(sulfonamidyl))diethylamine and its hydrochloride. 2,2'-(propane-2,2'-diylbis(sulfonamidyl))diethylamine is a common active oxygen response small molecule. At present, the synthesis process of the molecule has the problems of complex synthesis steps, multi-step post-treatment, difficult reuse of solvent, low reaction rate and low reaction yield, and high-pollution gas purification. The application adopts a new production process. Cysteamine hydrochloride and acetone are reacted in a reaction system by one-step method to prepare 2,2'-(propane-2,2'-diylbis(sulfonamidyl))diethylamine dihydrochloride product. After alkaline washing, 2,2'-(propane-2,2'-diylbis(sulfonamidyl))diethylamine product is obtained. The production process does not need high-pollution hydrogen chloride gas catalysis, has high reaction efficiency and yield, the involved solvent can be recycled and reused, the reactants and products are easy to separate, the product has high purity, the reaction device is simple, the process is environment-friendly, and the reaction end point is easy to monitor.

This invention discloses a method for preparing electroresponsive silk fibroin microneedles, comprising the following steps: adding cysteine ​​hydrochloride solution dropwise to an activated silk fibroin solution to achieve a final cysteine ​​hydrochloride concentration of 20-80 mmol / L; adjusting the pH of the final solution to 5-6; stirring the reaction mixture, then allowing it to stand to obtain a thiolated silk fibroin solution; dialyzing the reacted silk fibroin solution in a dialysis bag; after dialysis, centrifuging to obtain the supernatant and then purifying the thiolated silk fibroin solution; pouring the purified thiolated silk fibroin solution into a microneedle mold and removing air bubbles by vacuuming in a vacuum drying oven; then drying the degassed mold system under a constant temperature and humidity environment; and finally, after drying and demolding, obtaining the electroresponsive silk fibroin microneedles. The electroresponsive silk fibroin microneedles of this invention can achieve changes in swelling degree under low voltage stimulation and exhibit high swelling characteristics under energized conditions, enabling controlled drug release.

The invention relates to the technical field of copper foil production, in particular to a production process of copper foil for chip packaging. The production process comprises the steps that an electrolyte is prepared, a functional additive and sodium chloride are added into the electrolyte, and the functional additive is synthesized through a two-step reaction of 3, 3 '-dithiodipropionic acid, thionyl chloride and cysteamine hydrochloride; carrying out electrolytic deposition under specific process conditions; and finally, washing, drying, slitting and rolling to obtain a copper foil finished product. The copper foil produced by the invention not only has excellent oxidation resistance and heat resistance, but also has the advantages of low roughness, high peel strength and the like, and the service life of the prepared copper foil product is prolonged to a certain extent while the quality of the prepared copper foil product is effectively ensured. In addition, according to the production process provided by the invention, a roughening treatment procedure and an anti-oxidation layer coating procedure which are heavy in pollution and high in energy consumption in a traditional process are thoroughly omitted, and the production process is more environment-friendly and more economical.

The invention discloses a synthesis method of cysteamine hydrochloride, and relates to the technical field of pharmaceutical manufacturing intermediates, the synthesis method comprises the following steps: S1, synthesis of 2-aminoethyl sulfate; s2, synthesizing alpha-mercaptothiazoline by taking the 2-aminoethyl sulfate as a raw material; s3, synthesizing S, S '-bis (2-aminoethyl ester) dithioformic acid by taking the alpha-mercaptothiazoline as a raw material; and S4, synthesizing cysteamine hydrochloride by taking the S, S '-bis (2-aminoethyl ester) dithioformic acid as a raw material. According to the invention, alpha-mercaptothiazoline and 2-aminoethyl sulfate react to generate an intermediate dithioformic acid S, S '-bis (2-aminoethyl ester), and then hydrolysis is carried out, so that the purposes of reducing serious hydrogen sulfide pollution, improving the atom utilization rate, improving the yield and being environmentally friendly are achieved.