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Method for producing enteric cysteamine hydrochloride coated granules

A cysteamine-coated and cysteamine hydrochloride technology is applied in the production field of enteric-coated cysteamine hydrochloride-coated particles, and can solve the problem that large-scale industrial production cannot be applied, large-scale industrial production is not easy, and disulfide is ineffective. and other problems to achieve the best absorption effect, improve bioavailability, and avoid adverse reactions.

Active Publication Date: 2011-06-01
WUXI ZHENGDA POULTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cysteamine is very easy to oxidize into disulfide in the air, and it will irritate the stomach wall in the stomach, resulting in severe gastric ulcer, so it cannot be used in large-scale industrial production.
Cysteamine hydrochloride also has disadvantages such as low melting point (70.2-70.7°C), easy deliquescence, active chemical properties (easy to oxidize, easy to complex, etc.), making it difficult to apply to large-scale industrial production

Method used

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  • Method for producing enteric cysteamine hydrochloride coated granules
  • Method for producing enteric cysteamine hydrochloride coated granules
  • Method for producing enteric cysteamine hydrochloride coated granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Mix and dissolve 1 part of cysteamine hydrochloride and 0.2 parts of capsule material (gelatin solution with mass concentration of 2.5% and gum arabic solution with mass concentration of 2.5%, weight ratio 1:1) to form a suspension. Add an appropriate amount of 5% acetic acid solution to the suspension, mix at 50°C, adjust the pH of the suspension to 4.0, and form coacervates. Then add 1 volume of water at 30°C to form a settling pocket. Then add 2.5 mL of formaldehyde solution with a mass concentration of 37%, mix at 10°C, and adjust the pH to 8.0 with an appropriate amount of 20% NaOH to form a solidified capsule. The obtained cured capsules are washed with water until there is no formaldehyde smell to form microcapsules. The obtained microcapsules are vacuum-dried to obtain the finished product.

Embodiment 2

[0031] Mix and dissolve 1 part of cysteamine hydrochloride and 0.3 parts of capsule material (gelatin solution with mass concentration of 4.0% and gum arabic solution with mass concentration of 4.0%, weight ratio 1:1) to form a suspension. Add an appropriate amount of 5% acetic acid solution to the suspension, mix at 50°C, adjust the pH of the suspension to 4.2, and form coacervates. Then add 2 times the volume of water at 35°C to form a settling pocket. Then add 2.5 mL of formaldehyde solution with a mass concentration of 37%, mix at 10°C, and adjust the pH to 8.5 with an appropriate amount of 20% NaOH to form a solidified capsule. The obtained cured capsules are washed with water until there is no formaldehyde smell to form microcapsules. The obtained microcapsules are vacuum-dried to obtain the finished product.

Embodiment 3

[0033] Mix and dissolve 1 part of cysteamine hydrochloride and 0.5 part of capsule material (gelatin solution with mass concentration of 5.0% and gum arabic solution with mass concentration of 5.0%, weight ratio 1:1) to form a suspension. Add an appropriate amount of 5% acetic acid solution to the suspension, mix at 50°C, adjust the pH of the suspension to 4.5, and form coacervates. Then add 3 times the volume of water at 40°C to form a sedimentation pocket. Then add 2.5 mL of formaldehyde solution with a mass concentration of 37%, mix at 10°C, and adjust the pH to 9.0 with an appropriate amount of 20% NaOH to form a solidified capsule. The obtained cured capsules are washed with water until there is no formaldehyde smell to form microcapsules. The obtained microcapsules are vacuum-dried to obtain the finished product.

[0034] Illustrate effect of the present invention below by contrast test:

[0035] Add the cysteamine hydrochloride products (test groups 1-3) and the exis...

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Abstract

The invention relates to a method for producing enteric cysteamine hydrochloride coated granules, which comprises the following process steps: 1, combining cysteamine hydrochloride and a capsule material to prepare mixed suspension; 2, adding the mixed suspension into 5-percent acetic acid solution, mixing at 50 DEG C to form coacervated capsules, adding water at 30 to 40 DEG C in a volume which is 1 to 3 times that of the coacervated capsules to form suck capsules, adding 37-percent formaldehyde solution and mixing at 10 DEG C to form solidified capsules; 3, washing the solidified capsules till no formaldehyde smell is given off to form microcapsules; and 4, dying under vacuum to obtain cysteamine hydrochloride coated granule preparation. In the method, the cysteamine hydrochloride coated with an imported coating material is prevented from being oxidized in any environment and the properties of the cysteamine hydrochloride coated granules are stable, the dissolution rate of the cysteamine hydrochloride coated granules in stomach is smaller than 2 percent, and the use of the cysteamine hydrochloride coated granules in a large dose does not cause canker; the cysteamine hydrochloride is released in intestinal tract accurately and can dissolve and be absorbed completely; and thus, the bioavailability is improved greatly. The product can be added into an auxiliary material as a raw material to form the low-content cysteamine hydrochloride coated granules.

Description

technical field [0001] The invention relates to the technical field of feed and feed additives, in particular to a production method of enteric-coated cysteamine hydrochloride coated particles. Background technique [0002] Cysteamine (Cys-teamine, CS), also known as β-mercaptoethylamine cysteamine, molecular formula C2H7NS, is an intermediate metabolite of cysteine. CS is a component of coenzyme A, which contains active sulfhydryl and hydrogen groups and has a variety of physiological functions. It has an inhibitory regulatory effect on animal growth hormone, thyroxine, insulin and other metabolites. A large number of studies have shown that: CS can reduce the content of somatostatin in the body, indirectly increase the concentration of growth hormone GH, promote the growth of livestock and poultry, and can increase feed remuneration and improve carcass quality. Cysteamine can also effectively promote the absorption and utilization of calcium and phosphorus in animals, red...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K1/16A23K20/10A23K40/10
Inventor 周玲
Owner WUXI ZHENGDA POULTRY
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