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Stable mercaptamine enveloped by microcapsules and preparation method thereof

A cysteamine hydrochloride, capsule coating technology, applied in the application, animal feed, animal feed and other directions, can solve the problems of not being able to apply large-scale production, failing to achieve the effect of coating, affecting the effect of product use, etc. Effectively used by animals, avoid gastric ulcers, and promote animal growth

Active Publication Date: 2014-03-26
HANGZHOU KINGTECHINA FEED CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cysteamine hydrochloride is very easy to oxidize and absorb moisture, causing it to be oxidized quickly during processing and storage, thus affecting the use effect of the product
In addition, because cysteamine hydrochloride is easily oxidized into disulfide in the air, it will irritate the stomach wall and cause severe gastric ulcer in the stomach, so it cannot be used in large-scale production
[0004] At present, in response to these shortcomings of cysteamine hydrochloride, coated cysteamine hydrochloride has also appeared on the market. Some cysteamine hydrochloride is simply mixed and granulated, and does not achieve the effect of coating ;Although some cysteamine hydrochloride is coated, whether it is stable during storage, especially whether it is stable when mixed with reducing raw materials, and whether it can pass through the stomach in the intestinal tract of animals to achieve a sustained release effect, needs further study

Method used

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  • Stable mercaptamine enveloped by microcapsules and preparation method thereof
  • Stable mercaptamine enveloped by microcapsules and preparation method thereof
  • Stable mercaptamine enveloped by microcapsules and preparation method thereof

Examples

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Effect test

Embodiment 1

[0024] (1) Weigh each raw material: cysteamine hydrochloride 28kg, corn starch 33.5kg, carmellose sodium 1.5kg, sodium alginate 1kg, ethyl cellulose 1kg, β-cyclodextrin 10kg, carnauba Wax 25kg and 95% food grade ethanol 40kg.

[0025] (2) Preparation method: in the first step, put cysteamine hydrochloride in a reaction kettle and heat and melt at 80-85°C; in the second step, prepare sodium carboxymethyl cellulose to 5% (w / w ) aqueous solution of sodium carboxymethyl cellulose; in the third step, cornstarch, sodium alginate, ethyl cellulose and β-cyclodextrin are put into the aqueous solution of sodium carboxymethyl cellulose prepared in the second step, stirred and mixed , rotating speed 150r / min, time 20min; the fourth step, add the melted cysteamine hydrochloride to the mixture prepared in the third step, mix well, then granulate with 20 meshes, place in a swirl fluidized bed for drying, and The air temperature is 60-80°C, and the outlet air temperature is 35-55°C; the fift...

Embodiment 2

[0028] (1) Weigh each raw material: cysteamine hydrochloride 30kg, corn starch 23kg, sodium carboxymethylcellulose 3kg, sodium alginate 2kg, ethylcellulose 2kg, β-cyclodextrin 10kg, carnauba wax 30kg And 45kg of 95% food grade ethanol.

[0029] (2) Preparation method: in the first step, put cysteamine hydrochloride in a reaction kettle and heat and melt at 80-85°C; in the second step, prepare 10% carboxymethyl cellulose sodium with distilled water Sodium plain solution; in the third step, put cornstarch, sodium alginate, ethyl cellulose and β-cyclodextrin into the sodium carboxymethylcellulose aqueous solution prepared in the second step, stir and mix, and the speed is 120r / min , time 20min; the fourth step, add the melted cysteamine hydrochloride to the mixture prepared in the third step, mix well, carry out 20 mesh granulation, place in swirling fluidized bed for drying, the inlet air temperature is 60-80 ℃, the outlet air temperature is 35-55 ℃; the fifth step is to add fo...

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Abstract

The invention relates to stable mercaptamine enveloped by microcapsules. The stable mercaptamine is mainly prepared from the following materials in parts by weight: 20-55 parts of mercaptamine, 15-35 parts of corn starch, 0.1-10 parts of sodium carboxymethylcellulose, 1-10 parts of sodium alginate, 0.1-10 parts of ethyecellulose, 10-15 parts of beta-cyclodextrin and 10-50 parts of carnauba wax. The stable mercaptamine and the preparation process provided by the invention have the advantages that the problems of easy oxidation and easy moisture absorption are effectively solved, so that the purpose of protecting the mercaptamine is achieved; simultaneously, the release of the mercaptamine in the stomach is furthest limited, the occurrence of the gastric ulcer is avoided, and the full release in the intestinal tract is achieved, so that more effective utilization by animals is achieved, the growth of the animals is promoted and the application prospect is better.

Description

(1) Technical field [0001] The invention relates to a stable microcapsule coated cysteamine hydrochloride and a preparation method thereof. (2) Background technology [0002] Cysteamine hydrochloride (Cysteamine, CS), also known as β-mercaptoethylamine, is a component of acetyl coenzyme A. Because it contains active sulfhydryl and amino groups, it has a variety of biological functions and is a biologically active substance in animals. Many studies have shown that CS achieves the growth-promoting effect by reducing the concentration of SS in the body, weakening or eliminating the inhibitory effect of SS on the digestive system; more importantly, it releases the inhibition of SS on the endocrine system, especially on GH and IGF-1 The effect is to strengthen the secretion of GH, IGF-1, etc., promote animal growth, and increase the ratio of feed to meat. [0003] Cysteamine is a white crystal with an unpleasant smell, easily soluble in water and alcohol, and reacts into disulfi...

Claims

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Application Information

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IPC IPC(8): A23K1/16
Inventor 李浙烽余荣陈强徐二华徐小芳
Owner HANGZHOU KINGTECHINA FEED CO LTD
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