78 results about "Thiazoline" patented technology

The present disclosure is directed to a preservative composition comprising a linear polyetheramine having a molecular weight greater than 118 Daltons (Da) and at least one isothiazolinone, whereby this preservative composition may further comprise a pyrithione salt and / or a metal salt. Also disclosed is an aqueous industrial material comprising the preservative composition as well as a method for enhancing in-contaniner preservative performance of an aqueous industrial material using the preservative composition.

The invention discloses an isothiazolinone non-curing coating and a preparation method thereof, and relates to the technical field of waterproof coatings. The coating comprises a base material, a compound isothiazolinone antibacterial agent, a mixed stabilizer, a compound plasticizer, a compound anti-aging agent, a filler, an adhesion promoter and a solvent, the compound type isothiazolinone antibacterial agent is prepared by mixing and compounding 2-methyl-4-isothiazolin-3-ketone and 5-chloro-2-methyl-4-isothiazolin-3-ketone according to a mass ratio of (1 to 3): 1, and the compound type isothiazolinone antibacterial agent is prepared by mixing and compounding 2-methyl-4-isothiazolin-3-ketone and 5-chloro-2-methyl-4-isothiazolin-3-ketone and 5-chloro-2-methyl-4-isothiazolin-3-ketone; the mixed stabilizer is formed by mixing organic bentonite, polyamide wax and fumed silica; the defects that an existing non-curing coating is poor in antibacterial performance, insufficient in aging resistance and poor in formula compatibility are overcome.

The invention relates to the technical field of oxygen free radical detection, in particular to a manufacturing process of a portable and reliable oxygen free radical detector. Comprising the following steps: mixing superoxide dismutase, potassium ferricyanide, an isothiazolinone preservative, hexammine ruthenium chloride, polyethylene glycol octylphenol ether, trehalose and bovine serum albumin, and uniformly stirring to prepare an enzyme preparation; mixing an enzyme preparation with the high polymer material solution to form reagent layer slurry with viscosity; uniformly coating the reagent layer slurry on a substrate material, and drying; printing an electrode material on the substrate material to form a working electrode and a counter electrode; the silver electrode is placed in an electrolyte containing chloride ions, potential is applied, the silver surface is subjected to a chlorination reaction, and a silver / silver chloride electrode is formed; covering the reagent layer above the electrode, tightly combining the reagent layer with the electrode in a sticking or hot pressing manner, and cutting to obtain the test paper; the prepared portable oxygen free radical detector can be used for conveniently and efficiently detecting oxygen free radicals of a human body at low cost.

The invention relates to a green, safe and environment-friendly granulation auxiliary agent for granular urea and a preparation method and application thereof.The granulation auxiliary agent is prepared from 10%-20% of crystalline fructose, 5%-15% of carboxymethyl cellulose, 5%-15% of polyaspartic acid, 0.1%-0.5% of isothiazolinone and 50%-79.9% of purified water. Adding carboxymethyl cellulose in a spreading manner at normal temperature, standing on the water surface, and starting to stir uniformly after absorbing water and swelling for 24 hours, so as to obtain a carboxymethyl cellulose aqueous solution; stirring and completely dissolving the residual purified water, crystalline fructose and polyaspartic acid in another reaction kettle, adding the solution into the carboxymethyl cellulose aqueous solution within 1.5-2.5 hours, and continuously stirring; and finally, adding isothiazolinone, and uniformly stirring to obtain the granulation auxiliary agent. When the granulation aid is used, 0.5-2.0 kg of the granulation aid is pumped into a urea production system by a pressure pump per ton of urea to ensure that the granulation aid is effectively, sufficiently and uniformly mixed with urea melt to play a role in granulation, so that the traditional urea granulation aid formaldehyde is replaced.

The application discloses a long-acting antibacterial adsorption filler and a preparation method thereof, and comprises the following steps: S1, preparation of composite activated alumina; S2, preparation of aminated composite alumina; S3, preparation of organically modified composite alumina; and S4, preparation of the long-acting antibacterial adsorption filler. The long-acting antibacterial adsorption filler is prepared by loading cerium and bismuth composite oxides on an activated alumina substrate, and then bridging with a silane coupling agent, and sequentially introducing maleic anhydride, 2,3-epoxypropyl trimethyl ammonium chloride and 2-mercaptothiazoline, so that the finally-prepared filler integrates multiple functions such as physical adsorption, chemical adsorption, contact sterilization and slow-release sterilization. The method effectively solves the technical problems of single function of a traditional adsorbent, inability to sterilize and easy secondary pollution, and achieves omnibearing and long-acting purification of indoor air pollutants.

The present invention relates to combinations of a compound of formula (A-1) with a compound selected from the group consisting of dimpropyridaz, emamectin and isocycloseram, bentioflumin, pioxaniliprole, isoflualanam, cybenzoxasulfyl, vinylfluthrin, cyclobunofen, flupymezotiaz, fentiazoluron, 1-(1,2-dimethylpropyl)-5-methyl-N-prop-2-ynyl-N-(3-pyridyl)pyrazole-4-carboxamide, 1 -[4- [5-ethylsulfonyl-1-methyl-4-[3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridin-2-yl]imidazol-2- yl]phenyl]cyclopropanecarbonitrile, [(Z)-[[3-ethylsulfonyl-5-[4-(trifluoromethoxy)phenyl]-2-pyridyl]-[[5- (trifluoromethyl)-2-pyridyl]amino]methylene]amino] acetate, 3-[3-ethylsulfonyl-5-[4- (trifluoromethoxy)phenyl]-2-pyridyl]-4-[5-(trifluoromethyl)-2-pyridyl]-1,2,4-oxadiazol-5-one, 1-(4- chlorophenyl)-2-fluoro-4-methyl-5-(2,2,2-trifluoroethylsulfanyl)benzene, and emamectin benzoate; and to methods of controlling or preventing damage to plants using such combinations; and to formulations, concentrates and seed treatments comprising such combinations.

The invention relates to a composite electrostatic eliminator and a preparation method thereof, and relates to the technical field of chemical assistants, the composite electrostatic eliminator comprises isopropanol, cetrimonium chloride, fatty alcohol-polyoxyethylene ether, polyvinyl alcohol, polyethylene glycol, triethanolamine, isothiazolinone, propylene glycol, disodium ethylene diamine tetraacetate, essence, modified carbon nanotubes, and a hydrophobic ionic liquid. The water-based polyurethane resin is prepared from water-based furan polyurethane, non-ionic water-based furan polyurethane, bismaleimide and the balance deionized water. Modified carbon nanotubes and hydrophobic ionic liquid are uniformly dispersed in a coating through electrostatic anchoring of cetrimonium chloride and emulsification of fatty alcohol-polyoxyethylene ether, an electron tunneling network in a low-humidity environment is formed, and it is ensured that the electrostatic dissipation capacity of the coating of the electrostatic elimination agent in the low-humidity environment is improved; a dynamic cross-linked network is formed through a Diels-Alder reaction generated by the nonionic waterborne furan polyurethane and the bismaleimide, a conductive path in a damaged area can be rebuilt under external thermal excitation, and the functional durability is improved.

The invention provides a preparation method of 2-mercaptothiazoline, and belongs to the field of organic synthesis.The preparation method comprises the steps that sodium ethyl xanthate is added into alkali liquor, and a mixed solution is obtained; then, slowly dropwise adding a 2-chloroethylamine hydrochloride aqueous solution into the mixed solution, stirring, putting into a microwave reactor, heating to 35-45 DEG C, carrying out heat preservation reaction for a certain time, ending the reaction after TLC monitors that the raw materials disappear, naturally cooling the reacted solution to 25-30 DEG C, stirring, filtering to obtain a 2-mercaptothiazoline crude product, recrystallizing with water, and filtering to obtain the 2-mercaptothiazoline. And carrying out vacuum drying to obtain the purified 2-mercaptothiazoline. The preparation method provided by the invention is simple in step, short in time, low in energy consumption and good in safety, the yield of the obtained 2-mercaptothiazoline product reaches 93.9%, and the purity reaches 99.7%.

This utility model discloses a waste treatment device for isothiazolinone production, relating to the field of isothiazolinone production technology. The waste tank is connected to a first filter, the first filter is connected to a settling tank, the settling tank is connected to a distillation tank, the distillation tank is connected to a degradation tank, the degradation tank is connected to a sedimentation tank, the sedimentation tank is connected to a second filter, the second filter is connected to a nanofiltration membrane device, and the nanofiltration membrane device is connected to a treatment water tank. This device can effectively remove harmful substances from the isothiazolinone production waste, achieving harmless treatment of the waste and also realizing resource recycling to a certain extent, thus possessing good environmental and economic benefits.

This utility model discloses a pretreatment device for raw materials in the production of high-purity Kathon, relating to the field of Kathon production technology. The inlet of an ultrasonic reactor is connected via pipelines to a methylchloroisothiazolinone raw material tank and a deionized water tank. The outlet of the ultrasonic reactor is connected via a screw pump to a ceramic membrane device. The liquid phase outlet of the ceramic membrane device is connected via pipelines to a distillation column. The top gas phase outlet of the distillation column is connected via pipelines to a light component tank, an organic solvent tank, and a purified methylchloroisothiazolinone tank. This device achieves effective separation and purification of different components, improving product purity, while simultaneously recovering organic solvents and reducing production costs.

The invention discloses a wearable sensor-minimally invasive diabetes monitoring patch and a preparation method thereof, and belongs to the technical field of biomedicine, the patch comprises a microneedle array module and a sensing unit; the microneedle array module is composed of a plurality of microneedles arranged in an array; the sensing unit is loaded in the microneedle, and the sensing unit comprises a multi-shell metal organic framework cascade enzyme system and a chromogenic substrate; the multi-shell metal organic framework cascade enzyme system is of a double-layer structure composed of an inner core and an outer shell, the inner core is a metal organic framework packaged with glucose oxidase and modified with carboxyl functional groups, and the outer shell is a metal organic framework packaged with horse radish peroxidase. And 2, 2-nitrogen-bis (3-ethylbenzothiazoline-6-sulfonic acid) is taken as a chromogenic substrate. According to the patch, the catalytic efficiency and the detection accuracy are improved, the stability is improved, the storage and transportation cost is reduced, the low detection limit can be achieved, the requirement for instant blood glucose detection is met, the size is small, and the cost is low.

The invention discloses a rubber composite material with marine antifouling property as well as a preparation method and application thereof, and relates to the technical field of marine fouling organism decay protection materials. The rubber composite material with the marine antifouling property comprises the following components which are blended and vulcanized: rubber, a filler, an antifouling agent, a plasticizer, an activating agent, a scorch retarder, an anti-aging agent, an accelerant and a vulcanizing agent, the antifouling agent comprises a copolymer modified by zwitter-ions and at least one of sodium benzoate, tannic acid, 6-gingerol, capsaicin, sulfobetaine, carboxylic acid betaine, phosphorylcholine, isothiazolinone and zinc pyrithione optionally selected from the group consisting of sodium benzoate, tannic acid, 6-gingerol, capsaicin, sulfobetaine, carboxylic acid betaine, phosphorylcholine, isothiazolinone and zinc pyrithione. The invention solves the three core problems of poor compatibility of an antifouling agent and a rubber matrix, short antifouling period caused by easy loss of the antifouling agent, and difficulty in balancing the antifouling property and mechanical property in the existing marine antifouling rubber material.

The invention discloses a preparation process of 3-hydroxy cephalosporin, which comprises the following steps: (1) under the action of alkali, carrying out sulfonylation reaction on thiazoline enol p-nitrobenzyl ester and p-toluenesulfonyl chloride to obtain a sulfonylation reaction intermediate; (2) carrying out morpholine protection reaction on the sulfonylation reaction intermediate obtained in the step (1) and morpholine under the action of alkali to obtain a morpholine protection intermediate; (3) preparing a feed liquid A from the morpholine protection intermediate and an acid-binding agent, preparing a feed liquid B from a brominating reagent, and simultaneously introducing the feed liquid A and the feed liquid B into a microchannel reactor for continuous reaction to obtain a brominated product; and (4) carrying out ring closing reaction on the brominated product in the step (3) under the action of acid to obtain the 3-hydroxy cephalosporin. The preparation process solves the problem of amplification effect of bromination reaction, and improves the yield and quality of the product.

The invention belongs to the field of polymer biological materials, and particularly relates to a thiazoline-pyrimidone structure-containing polymer which can be used as an effective component of sunscreen cream. The preparation method comprises the following steps: (1) in an anhydrous organic solvent, mixing a thiazoline-pyrimidone monomer and polyethylene glycol methacrylate for reaction to obtain a component A; and (2) in an inert atmosphere, mixing a free radical initiator with the component A, reacting to obtain a component B, and then separating a copolymer containing a thiazoline-pyrimidone structure from the component B to serve as the sun-screening agent for ultraviolet protection of mice, and the structure of the copolymer is as shown in a formula I. The invention further discloses a preparation method of the sun-screening agent for ultraviolet protection of mice. The polymer provided by the invention has a good effect on biological ultraviolet protection.

The present invention discloses a steroidal dihydropyrazole thiazoline derivative, 3β-hydroxy-pregnane-5-en-17β-yl-5'-(substituted phenyl)-1'-(4''-phenyl-[1'',3'']-thiazol-2''-yl)-4',5'-dihydropyrazole-3'-yl. The present invention also discloses the use of the steroidal dihydropyrazole thiazoline derivative. The steroidal dihydropyrazole thiazoline derivative of the present invention has a strong inhibitory effect on nitric oxide (NO) production in RAW 264.7 mouse peritoneal macrophages induced by lipopolysaccharide (LPS), especially compound 4 in the prepared steroidal dihydropyrazole thiazoline derivative has an IC of 0.05. 50 The value is better than that of the positive control methylprednisolone, and the toxicity to cells is low. The steroidal derivative containing a dihydropyrazole thiazoline heterocycle provided by the present invention is a new structural compound, which shows higher activity than existing first-line anti-inflammatory drugs.

This invention discloses a molecularly imprinted paper-based microfluidic colorimetric sensor for detecting histamine, its preparation, and its application. The colorimetric sensor (MIP@MIL) is polymerized from a metal-organic framework (MIL-101) using surface molecular imprinting and dual-monomer imprinting techniques. MIP@MIL exhibits a histamine detection limit of 0.77 μM and a detection time of 12.5 min, demonstrating good selectivity. The mechanism involves histamine blocking the imprinted pores of MIP@MIL and acting on MIL-101, thereby weakening the catalytic oxidation process of the chromogenic agent 2,2'-azido-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS). Furthermore, histamine increases the repulsive force of MIP@MIL against ABTS, thus enabling colorimetric detection of histamine. To further improve practical applicability, MIP@MIL was loaded onto qualitative filter paper and further modified onto microfluidic paper-based chips (μPADs). Using a smartphone, rapid and accurate visual detection of histamine in food was achieved, demonstrating its potential for food freshness detection.

The application discloses a preparation method and application of sodium thiazolinyl dithiopropane sulfonate, and comprises the following steps: adding 1,3-propane sulfolane solution and an oxidizing agent into a mixed solution containing 2-mercaptothiazoline, sodium hydrosulfide and a solvent at 5-25 DEG C, and then reacting at 20-35 DEG C, and then recrystallizing to obtain sodium thiazolinyl dithiopropane sulfonate; the one-pot method is used to synthesize sodium thiazolinyl dithiopropane sulfonate by using 2-mercaptothiazoline, sodium hydrosulfide and 1,3-propane sulfolane as raw materials, a series of problems such as low yield and low effective content caused by multi-step reaction and repeated purification are avoided, the yield (more than 80%) and the purity (more than 95%) of the product are greatly improved, and the product is beneficial to large-scale production.

The invention discloses a long-acting antibacterial adsorption filler and a preparation method thereof. The preparation method comprises the following steps: S1, preparing composite activated aluminum oxide; s2, preparation of aminated composite aluminum oxide; s3, preparation of organic composite aluminum oxide; and S4, preparing the long-acting antibacterial adsorption filler. According to the long-acting antibacterial adsorption filler, cerium and bismuth composite oxide is loaded on an activated aluminum oxide substrate, then maleic anhydride, 2, 3-epoxypropyltrimethylammonium chloride and 2-mercaptothiazoline are sequentially introduced through bridging of a silane coupling agent, and the finally prepared filler integrates multiple functions of physical adsorption, chemical adsorption, contact sterilization, slow-release sterilization and the like; according to the method, the technical problem that secondary pollution is easily caused due to the fact that a traditional adsorbent is single in function and cannot sterilize is effectively solved, and comprehensive and long-term purification of indoor air pollutants is achieved.

The application belongs to the technical field of sewage treatment and specifically relates to an oilfield water treatment corrosion inhibitor and a synthesis method thereof. The synthesis method comprises the following steps: in the presence of a reducing agent, 2-acetyl-2-thiazoline and N,N-dimethylaminopropylamine are subjected to a reductive amination reaction in a weak acid solvent; and then, in a weak alkaline environment, the reductive amination product is subjected to a tertiary amination reaction with chloroacetic acid. Based on 1 mol of 2-acetyl-2-thiazoline, the N,N-dimethylaminopropylamine and the chloroacetic acid are 0.9-1.1 mol and 0.9-1.3 mol, respectively. The application has the advantages of simple synthesis process, small dosage and good corrosion inhibition effect, and when the concentration is 10 mg / L, the corrosion inhibition rate reaches more than 97%.

This invention relates to an isothiazolinone solid bactericide and its preparation method. The bactericide comprises solid isothiazolinone hydrochloride particles, a water-soluble film-forming material coating layer on the particle surface, and a solid alkaline pH adjuster physically mixed with the coated particles. The molar ratio of the solid alkaline pH adjuster to the hydrochloride is 0.7–1.2:1, based on the amount of hydroxide provided. The process involves wetting and granulating the solid hydrochloride with a binder solution, drying and sieving to form particles, then coating them with a water-soluble film-forming material solution to obtain coated particles, and finally mixing them uniformly with the solid alkaline pH adjuster. This invention effectively isolates oxygen, moisture, and light through coating technology, significantly improving the product's storage stability, and utilizes the alkaline pH adjuster to ensure that the product is completely converted into a free state with bactericidal activity before use.

The invention discloses a PET release film applied to the field of polarizers and a preparation method of the PET release film in the technical field of optical functional film materials, the release film takes a two-way stretching PET film as a base material, and the surface of the release film is coated with a protective coating containing a specific modified compound. The modified compound comprises a hyperbranched polymer containing a phosphazene thiazoline structure and a graphene polyhedral oligomeric silsesquioxane hybrid material, and forms a stable cross-linked network with a sulfur-containing cross-linking agent under the action of an acid catalyst through accurate proportioning. The preparation process comprises the steps of corona treatment of the base membrane, preparation of a coating solution, micro gravure coating, stepped heating curing and the like. The problems that a traditional release film is poor in heat resistance, insufficient in flame retardance, weak in mechanical property and the like are effectively solved, the obtained product has excellent high-temperature resistance, flame retardance and mechanical strength, meanwhile, the good optical property is kept, and the release film is particularly suitable for the field of high-end polaroid manufacturing.

The invention discloses a polymer composite anti-aging bird-proof umbrella cover and a preparation method thereof in the field of polymer material modification, the umbrella cover takes polycarbonate and polybutylene terephthalate as a matrix, and a supramolecular ultraviolet absorbent containing a bithiazolinone-triazine structure and a polyether-polyurethane elastomer based on dynamic covalent bond crosslinking are added, so that the anti-aging bird-proof umbrella cover is prepared. The nano zinc oxide, the ethylene-butyl acrylate copolymer, the antioxidant and the ultraviolet light absorber are used as auxiliary materials for compounding. The ultraviolet absorbent and a hydrogen bond network are cooperated through intramolecular charge transfer to enhance light stability, and the dynamic covalent bond elastomer endows the material with self-repairing and impact resistance. The preparation method comprises the following steps: dispersing the nano zinc oxide, dissolving the ultraviolet absorbent and the elastomer, and carrying out melt blending granulation with the matrix resin; pre-mixing the granules with an auxiliary agent, and then carrying out secondary granulation; and after injection molding, carrying out electron beam irradiation treatment and coating an elastomer diluted solution for curing. The umbrella cover has excellent aging resistance, impact resistance and environmental adaptability, and the service life can be remarkably prolonged.

This invention relates to the preparation and application of a thiazolinone-oxanthracene peroxynitroso fluorescent probe. The probe has the following structural formula: This invention provides a method for synthesizing this fluorescent probe using thiazolinone-oxanthracene dye, pinacol ester of 4-bromomethylphenylboronic acid, etc., as raw materials; this fluorescent probe is a peroxynitroso fluorescent probe with near-infrared emission; firstly, this fluorescent probe is effective against ONOO... ‑ It exhibited good sensitivity, with a 7.5-fold increase in fluorescence intensity; secondly, this fluorescent probe showed good sensitivity to ONOO. ‑ It exhibits high selectivity, unaffected by other reactive oxygen species, biothiols, and amino acids; furthermore, this fluorescent probe is compatible with ONOO. ‑ It acts rapidly, with a response time of less than 5 minutes; in addition, the fluorescent probe is used to detect the content of peroxide nitrosamines in living cells.

The application provides an antiviral and antibacterial inorganic interior wall coating, which comprises, in terms of mass fraction, 20-40 parts of silica sol and 0.8-1.5 parts of an antiviral and antibacterial preservative. The antiviral and antibacterial preservative comprises triazole compounds, isothiazolinone compounds, pyridine oxide sulfide compounds and chlorohydroxy diphenyl ether compounds, which can play a synergistic role, so that the coating has excellent antiviral and antibacterial activity, durability and alkali resistance. The silica sol and the antiviral and antibacterial preservative are reasonably compounded, so that the antiviral and antibacterial preservative fully plays its performance advantages, and the coating has good uniformity and stability.

A method of making a formulation may include a step of forming a mixture comprising: a hydrotrope, a surfactant, a water-immiscible solvent, an isocyanate monomer, a salt, fosthiazate and water. Further, a step of adding an amine to the mixture to polymerizing the isocyanate monomer may be performed.

The present disclosure is generally directed to an aqueous industrial material including at least one primary aliphatic polyetheramine, an isothiazolin-3-one blend, and a solvent. The isothiazolin-3-one blend may include a first isothiazolin-3-one and a second isothiazolin-3-one. The primary aliphatic polyetheramine and the isothiazolin-3-one blend may be present in the aqueous industrial material at a weight ratio of from about 100:1 to 2:1.

This invention discloses a benzylpiperidine-containing thiazoline-2,4-dione derivative, its preparation method, and its application, belonging to the field of pesticide synthesis and application technology. This invention synthesizes a series of benzylpiperidine-containing thiazoline-2,4-dione derivatives by combining the highly active benzylpiperidine group with a thiazoline-2,4-dione structure via flexible bonds. Through tests on the inhibitory activity of the synthesized benzylpiperidine-containing thiazoline-2,4-dione derivatives against plant pathogenic fungi, it was found that the benzylpiperidine-containing thiazoline-2,4-dione derivatives synthesized in this invention can effectively inhibit plant pathogenic fungi, especially rice sheath blight pathogen.

The invention relates to a mining HBK special structure co-treatment material and a spraying system thereof. The material is prepared from the following components in parts by mass: 78-82 parts of plastic concrete, 4-6 parts of ceramic grinding powder, 20-22 parts of polypropylene fiber, 5-10 parts of polyisobutene, 12-15 parts of hollow glass beads, 5-10 parts of reflective powder, 7-9 parts of an antibacterial asexual nano material, 0.3-0.5 part of a mildew preventive, 1-1.5 parts of an antistatic agent, 5-15 parts of a radioactive absorbent, 0.6-1 part of a pH regulator, 1-2.5 parts of an accelerator and 4-5 parts of a flame retardant. 1-2.5 parts of a water reducing agent and 2-4 parts of a curing agent. The material disclosed by the invention contains the radioactive absorbent nano barium metaborate and the mildew preventive isothiazolinone in a certain proportion, so that the material can absorb and shield radioactive radon, is good in antibacterial and mildew-proof performance, reduces the mildew diffusion pollution of bacteria and fungi on the surface of a mining roadway, and ensures the body health of miners.

An embodiment provides a method, for measuring ozone in a sample, including: introducing at least one alkene to a sample, wherein the alkene in the presence of an amount of ozone produces a carbonyl solution; adding 3-methyl-2- benzothiazolinonehydrazone hydrochloride (MBTH) to the carbonyl solution, and thereafter adding an oxidant to produce at least one imine and oxidized MBTH; producing a conjugated indicator from a reaction of the at least one imine and the oxidized MBTH; and measuring, using a colorimetric technique, an amount of ozone. Other aspects are described and claimed.