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3 results about "Bazedoxifene" patented technology
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Bazedoxifene, used as bazedoxifene acetate, is a medication for bone problems and possibly (pending more study) for cancer. It is a third-generation selective estrogen receptor modulator (SERM). Since late 2013 it has had U.S. FDA approval for bazedoxifene as part of the combination drug Duavee in the prevention (not treatment) of postmenopausal osteoporosis. It is also being studied for possible treatment of breast cancer and pancreatic cancer.
A bazedoxifene derivative, its preparation method and use
The present application relates to the field of medicinal chemistry and pharmacotherapy, and in particular to a class of bazedoxifene and its preparation method and application. The bazedoxifene derivative is used for gp130 small molecule inhibitor, the compound is a compound shown in formula (I), or a pharmaceutically acceptable salt or ester thereof, and relates to the application of tumor-related activity and the like, in particular the application in preparing drugs for preventing and / or treating diseases related to tumors, especially colorectal cancer.
Owner:CHINA PHARM UNIV
Use of bazedoxifene in a medicament or agent for inhibiting fibroblast differentiation
The application of bazedoxifene as an active ingredient in the preparation of a drug for blocking the differentiation of fibroblasts of the IL-6 family / gp130 signal axis. It has been verified that in the microenvironment of skin tissue, the early or very early appearance of pro-fibrotic stimulating factors (such as IL-11 and / or IL-6) can significantly inhibit the initiation of the pro-fibrotic molecular program, avoid the abnormal activation of myofibroblasts, thereby inhibiting the differentiation of fibroblasts into myofibroblasts, and can effectively inhibit the fibroblast migration of skin fibroblasts induced by pro-fibrotic stimulating factors (especially IL-11), effectively prevent skin fibrosis, and thereby prevent the formation of keloid.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Application of bazedoxifene in preparation of medicine for promoting motor function recovery after spinal cord injury
The invention provides an application of bazedoxifene in preparation of a medicine for promoting motor function recovery after spinal cord injury. Specifically, the invention provides an application of an active component, the active component is selected from bazedoxifene, or pharmaceutically acceptable salts thereof, or active derivatives thereof, and the active component is used for preparing a medicine or a kit for preventing and / or treating motor function recovery disorder after spinal cord injury. Or the active ingredient is used for preparing a preparation or a composition, and the preparation or the composition is used for inhibiting synaptic loss caused by lipid accumulation in foam cells.
Owner:SHANGHAI FIRST PEOPLES HOSPITAL