48 results about "Pharmacotherapy" patented technology

Various methods and systems for efficiently providing pharmacogenetic guidelines is disclosed. A drug prescription and a patient genotype can be analyzed to provide a drug therapy recommendation. The analysis can include comparing the patient genotype and the drug name to a drug profile database, a molecular biomarker database, hospital drug reaction records and omics databases, and calculating the patient response to the drug.

Exemplary light control devices and methods provide a regional variation of visual information and sampling (“V-VIS”) of an ocular field of view that improves or stabilizes vision, ameliorates a visual symptom, reduces the rate of vision loss, or reduces the progression of an ophthalmic or neurologic condition, disease, injury or disorder. The V-VIS devices and methods generate a moving aperture effect anterior to a retina that samples and delivers to the retina environmental light from an ocular field of view at a sampling rate between 50 hertz and 50 kilohertz. Certain of these V-VIS devices and methods may be combined with augmented or virtual reality, vision measurement, vision monitoring, or other therapies including, but not limited to, pharmacological, gene, retinal replacement and stem cell therapies.

The present application relates to the field of medicinal chemistry and pharmacotherapy, and in particular to a class of bazedoxifene and its preparation method and application. The bazedoxifene derivative is used for gp130 small molecule inhibitor, the compound is a compound shown in formula (I), or a pharmaceutically acceptable salt or ester thereof, and relates to the application of tumor-related activity and the like, in particular the application in preparing drugs for preventing and / or treating diseases related to tumors, especially colorectal cancer.

FIELD: neurology; psychiatry.SUBSTANCE: used as a non-pharmacological therapy for autism spectrum disorders in children. The method includes a set of procedures: interval hypoxic-hyperoxic training (HHT), hyperbaric oxygenation and ozone therapy. HHT consists of alternating inhalations of a hypoxic mixture with an oxygen content of 9 to 16 vol.% and a hyperoxic mixture with an oxygen content of 32 to 40 vol.% for a total duration of 45-50 minutes under the control of cardiovascular system parameters. Hyperbaric oxygenation is performed in a pressure chamber under a pressure of 1.3 atmospheres of 100% oxygen mixture, flow of 10 liters per minute, for 45 minutes using a mask. Ozone therapy is performed by rectal insufflation with an ozone-oxygen mixture with an ozone concentration of 85 μg / ml in a volume of 20–30 ml or by intravenous administration of a physiological solution enriched with ozone with an ozone concentration of 85 μg / ml at a rate of 200 ml per 100 ml of physiological solution. The procedures are carried out daily for 12 days.EFFECT: method is effective and has a positive impact on the patient’s condition.1 cl, 1 dwg, 3 ex

The present application relates to a kind of pterostilbene piperidine amide derivatives, its preparation method and medical use, belong to the field of medicinal chemistry and pharmacotherapy.The present application uses pterostilbene as raw material, designs, synthesizes a series of pterostilbene piperidine amide compounds with new structure, and its structure is characterized.The method used in the present application to prepare these compounds has the characteristics of easy-to-get raw material, simple operation and high yield, and can quickly synthesize target compounds.Compared with pterostilbene, the pterostilbene piperidine amide derivatives provided in the present application have significant cell proliferation inhibitory effect on tumor cells.

The present application belongs to the field of medicinal chemistry and pharmacotherapy, and particularly relates to a chalcone mannich base compound, a pharmaceutical composition and a preparation method and application thereof. The present application takes paeonol as a raw material, and obtains corresponding 3-substituted and 5-amino-methyl-substituted paeonol mannich base through mannich reaction of paeonol, polyoxymethylene and different organic amines. After the 3-substituted and 5-substituted paeonol mannich base is separated through column chromatography, the chalcone mannich base compound is obtained through Claisen-Schmidt reaction of the 3-substituted and 5-substituted paeonol mannich base and benzaldehyde containing different substituents. Experiments prove that the chalcone mannich base compound improves the physical and chemical properties of the chalcone mannich base and improves the drug efficacy, can solve the problem of poor water solubility, and has good anti-tumor cell proliferation activity.

Methods and compounds to therapeutically treat a molecular target to counteract circuit adaptations of long-term opioid use that are associated with a functional disability and negative affect in both CBP−O (chronic back pain managed without opioids) and CBP+O (chronic back pain managed with opioids).

Disclosed are methods to treat patients with AFib by monitoring their heart rhythm to determine the presence and / or the number of episodes of long duration AFib, and optionally the extent of AFib burden. Patients who meet threshold requirements are qualified for the treatment of AFib with a dosage of budiodarone. Patient monitoring is continued in order confirm that the patient is and remains responsive to budiodarone therapy including dose adjusting the patient to achieve such therapy. Subsequently, monitoring is continued to confirm that the patient remains responsive. These methods allow for treatment of the AFib and, correspondingly, reduce or delay the risk of stroke and / or congestive heart failure in the treated patient.

The invention discloses pine-soot ink moxibustion as well as a preparation method and a use method thereof, and relates to the technical field of traditional Chinese medicine moxibustion therapy. Comprising the following raw materials: pine-soot ink, tourmaline powder, radix aconiti preparata, semen strychni preparata, sanguisorba officinalis, rhizoma corydalis, pseudo-ginseng, angelica sinensis, safflower carthamus, ligusticum wallichii, radix saposhnikoviae, gastrodia elata, frankincense, earthworm, herba epimedii, dogwood, lucid ganoderma, astragalus membranaceus, gynostemma pentaphyllum, artificial musk, wintergreen oil, borneol and beautifying wax. According to the pine-soot ink moxibustion and the preparation method and the use method thereof, the pine-soot ink is used as a substrate, the tourmaline powder is compounded, and a raw material system of multiple traditional Chinese medicines is selected, so that the product not only has the hot compress and pharmacodynamic permeation functions of the traditional Chinese medicines, but also has the adsorption characteristic of the pine-soot ink and the physical effects of negative ion release and far infrared effect generation of tourmaline; multiple synergy of a drug therapy and a physical therapy is realized, so that better health-care effects of relaxing tendons and activating collaterals, dispelling cold and removing dampness and relieving bone and joint pain are achieved.

A method for developing novel drug therapies utilizing properties of existing drug therapies, the method comprising the steps of: developing a novel therapeutic mathematical model of a target biological network and synthesizing a drug therapy based on the novel therapeutic mathematical model. The novel therapeutic mathematical model is capable of generating novel therapeutic time-course progressions, which include time-course progression features found in existing therapeutic time-course progressions of existing therapeutic mathematical models of the target biological network. The time-course progression features can be correlated with the outcomes of the target biological network. Each new therapeutic intervention constant can be used to synthesize a drug regimen, and these drug regimens collectively constitute the novel drug therapy.

A system for training medical providers in obesity management and obesity-related comorbidities includes a user device presenting a conversational interface to a medical provider, an application server managing user sessions, a database server storing user data including course completion records and clinical performance audits, and a learning management system server delivering educational modules based on established competencies. An artificial intelligence server processes queries from the medical provider and provides personalized medical advice using a large language model trained on obesity-related medical content including obesity physiology, pharmacotherapy, and patient management. The artificial intelligence server receives outcome information related to patient health metrics following the personalized medical advice and retrains the large language model based on the outcome information. A performance audit system monitors clinical documentation, prescribing patterns, and patient outcomes of the medical provider to ensure ongoing compliance and performance improvements.

A pharmaceutical composition for treating obsessive-compulsive disorder is provided. The present invention relates to (1) a pharmaceutical composition comprising a dopamine D1 receptor agonist as an effective ingredient for treating obsessive-compulsive disorder, and / or (2) a pharmaceutical composition comprising a dopamine D1 and D2 receptor stimulator, which is administered in combination with a dopamine D2 receptor inhibitor for the purpose of stimulating the dopamine D1 receptor in the striatum, and / or (3) a pharmaceutical composition comprising a dopamine D2 receptor inhibitor, which is administered in combination with a dopamine D1 and D2 receptor stimulator.

The present invention provides a selective TYK2 inhibitor compound, its preparation method, and its application, belonging to the technical fields of medicinal chemistry and pharmacotherapy. The present invention provides a novel structural aryl pyrimidine amine compound with good safety and excellent TYK2 and JAK inhibitory activity, providing a new option for the preparation of drugs for the prevention or treatment of autoimmune diseases.

The present invention relates to the use of the GLP-1 receptor agonist semeglutide in a pharmaceutical therapy for the treatment of ejection fraction retention heart failure (HFpEF).

Patients suffering from rhinitis and rhinosinusitis often experience symptoms such as nasal discharge, congestion, sniffles, and excess phlegm secretion. These symptoms can cause a feeling of impaired airflow, loss of patency, and uncomfortable breathing. In this context, a treatment method is proposed to alleviate these signs and symptoms. The drug target is the TRPM8 receptor on nerve fibers of the ostiomeatal complex. The active ingredient, a TRPM8 agonist, is delivered using an electronically controlled nebulizer that produces a vigorous air plume of defined particle sizes, which prevents entry into the lungs. The quantity of phlegm expelled from the nasal passage is used as an index of anti-inflammatory effectiveness. The optimized drug candidates for delivery and therapy are from a group of p-menthanecarboxamides. Preferred embodiments of these include the p-menthane amino acid esters: GlyOnPr, GlyOiPr, D-Ala-OnPr, and D-Ala-OiPr, delivered as a liquid suspension or solution at 0.1 to 1% (1 to 10 mg / mL), 0.5 to 0.8 mL per nostril over 3 to 5 seconds, using a nebulizer. This regimen, administered three times per day for three to five days, will help the patient manage and control their nasal congestion and phlegm secretion, and sleep better at night. The preferred embodiments delivered into the nasal cavity create a sense of cool breathing, refreshing coolness, and a feeling of negative heat flux, like an air conditioner in the nose. The secretion of phlegm is clearly decreased, as measured with a top-loading balance. This pharmacological treatment for patients with nasal inflammation has the potential to alter the course of rhino-disorders permanently.

The application belongs to the technical field of pharmacotherapy, and particularly relates to application of ganoderic acid A in preparation of a medicine for preventing acute kidney injury caused by kidney ischemia-reperfusion. The ganoderic acid A can inhibit apoptosis, pyroptosis and necrosis in acute kidney injury induced by kidney ischemia-reperfusion, and reduce the levels of creatinine and urea nitrogen, which are kidney function indexes. The application first discovers that the ganoderic acid A has a protective effect on kidney ischemia-reperfusion, and the mechanism is related to inhibition of pan-apoptosis (PANoptosis) of renal tubular epithelial cells, which indicates that the ganoderic acid A has a prospect of developing into a medicine for preventing acute kidney injury caused by kidney ischemia-reperfusion.

Pharmaceutical formulations comprising buromantan or analogs of buromantan are disclosed, as well as methods of using the formulations for pharmaceutical therapy to reduce withdrawal syndrome and prevent relapse in the treatment of stimulant use disorders, to quit patients from drugs having a predisposition to abuse or addiction, or to promote regression learning in the treatment of mental disorders.

The system according to this embodiment aims to integrate patient data and enable healthcare professionals to make quick and accurate diagnoses and develop treatment plans. [Solution] The system according to the embodiment comprises a data collection unit, an analysis unit, a data provision unit, and a prediction unit. The data collection unit collects patient data. The analysis unit analyzes the data collected by the data collection unit. The data provision unit provides the analysis results obtained by the analysis unit to healthcare professionals. The prediction unit predicts the effectiveness of treatment plans and drug therapy based on the analysis results provided by the data provision unit.

The present invention relates to a system and method for managing neurological and psychological disorders, with a specific focus on Obsessive-Compulsive Disorder (OCD). The invention integrates pharmacotherapy, Deep Transcranial Magnetic Stimulation (Deep TMS), and Exposure and Response Prevention (ERP) therapy into a unified framework that addresses the chemical, neurological, and behavioural dimensions of OCD. The system utilizes advanced data analysis and machine learning algorithms to dynamically customize interventions based on patient-specific profiles, ensuring optimal therapeutic efficacy and reduced side effects. The System includes real-time data-driven adjustments, high-intensity engagement protocols, remote monitoring for long-term management, and scalable group therapy capabilities. The system also incorporates advanced neuromodulation technologies and compressed ERP techniques to accelerate behavioural restructuring and neural circuit modulation. By leveraging the synergy between these modalities, the invention provides a holistic and versatile solution for improving patient outcomes, ensuring sustained symptom relief and enhanced quality of life.

The invention belongs to the technical field of model training, and provides a post-disaster psychological intervention model training method, which comprises the following steps: S1, acquiring sample medical record data, and extracting triple content from the sample medical record data; s2, determining a scene category according to the patient chief complaint content, and distributing a scene label and a scene knowledge base for the sample medical record data; s3, according to the scene category combination with the maximum word frequency, obtaining a diagnosis result and a disease severity degree score; s4, verifying the logic consistency of the diagnosis result obtained in the step S3 and the clinical diagnosis extracted in the step S1, and obtaining a logic deviation degree; if the logic deviation degree and the disease severity are smaller than or equal to the threshold value, executing S5; otherwise, returning to S3; and S5, based on the diagnosis result, generating an integrated treatment scheme of a drug therapy and a psychotherapy. The method effectively solves the problem that the number of professional psychologists is limited, and large-scale post-disaster psychological assistance requirements cannot be met, psychological intervention resources can break through the limitation of time, geography and human resources, and efficient distribution is achieved.

Compositions and methods are provided to determine occupancy level of opioid receptors in a subject. The disclosed methods may be performed non-invasively in the inner ear of the subject, and may be performed at a point-of-care location to provide guidance to a practitioner on tapering on pharmacotherapy or on a patient's risk of relapse for substance abuse.

The present invention relates to the technical field of pharmaceutical formulations, and provides a dual-targeted nanoparticle, a preparation method therefor, and a use thereof. The dual-targeted particle comprises a browning inducer, i.e., Chiglitazar sodium, a photothermal reagent, i.e., indocyanine green, an adipocyte homing peptide, a cell penetrating peptide, a DSPE-PEG polymer, and a lipid matrix. The browning inducer and the photothermal reagent are encapsulated into a nanoparticle having excellent biocompatibility, and the surface of said nanoparticle is coated with the functionalized adipose homing peptide and the cell penetrating peptide to construct the dual-targeted nanoparticle. The combination of the dual-targeted nanoparticle and photothermal-drug therapy can effectively promote "browning" of white adipose, reduce weight and enhance glycolipid metabolism, and lay a foundation for developing safe and effective drugs against obesity and related metabolic disorders.

The application discloses an indoline compound and a preparation method and application thereof, and belongs to the fields of medicinal chemistry and pharmacotherapy. The compound shown in the formula I, isomers or pharmaceutically acceptable salts thereof have good anti-HBV activity, can effectively inhibit the replication of HBV DNA, can be applied to the preparation of anti-HBV drugs, and have excellent potential application prospect.

Disclosed are pharmaceutical preparations comprising bromantane or an analogue of bromantane, and methods of using said preparations for pharmacotherapy to alleviate withdrawal syndrome and prevent relapse in the treatment of stimulant use disorder, to transition patients off medications that have abuse or addiction liabilities, or to facilitate extinction learning in the treatment of mental disorders.

Disclosed are methods to treat patients with AFib by monitoring their heart rhythm to determine the presence and / or the number of episodes of long duration AFib, and optionally the extent of AFib burden. Patients who meet threshold requirements are qualified for the treatment of AFib with a dosage of budiodarone. Patient monitoring is continued in order confirm that the patient is and remains responsive to budiodarone therapy including dose adjusting the patient to achieve such therapy. Subsequently, monitoring is continued to confirm that the patient remains responsive. These methods allow for treatment of the AFib and, correspondingly, reduce or delay the risk of stroke and / or congestive heart failure in the treated patient.

The invention relates to the technical field of medicinal chemistry and pharmacotherapeutics, and mainly relates to a carborane-containing isoflavone derivative as well as a preparation method and application thereof. The carborane-containing isoflavone derivative provided by the invention is a compound as shown in a formula (I) or pharmaceutically acceptable salt thereof, and also provides a preparation method thereof, the compound shows antitumor activity in related cancer cell lines, overcomes the defect that the active action site and mechanism of the isoflavone compound are not clear, and has a good application prospect. The BNCT nano-material has good targeting property, can realize double functions of BNCT precise positioning treatment and tumor growth and migration inhibition, and has very high clinical application value.

The invention relates to a profiled sheet material which has a resorbable porous collagen sponge in which resorbable nanoparticles or microparticles or combinations thereof are dispersed, wherein the nanoparticles or microparticles have at least two different release profiles for the controlled and / or delayed release of pharmaceutical active ingredients. The invention further relates to a method for producing the sheet material and to the use thereof in a method for treating wounds or in a method for local pharmacotherapy.

The invention relates generally to a method of treatment for a human genetic disease, such as diseases characterized by unbalanced nucleotide pools, e.g., mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency, using gene therapy. The gene therapy may involve administration of one or more constructs, such as a viral vector, containing a nucleic acid encoding a functional protein. The functional protein may correspond to a nuclear gene. For treatment of TK2 deficiency, the gene therapy may involve administration of one or more constructs, such as a viral vector, containing a nucleic acid encoding a functional TK2 enzyme. The treatment may also involve the administration of pharmacological therapy in conjunction with the gene therapy. The treatment protocols of the disclosure, such as those involving gene therapy alone or in combination with pharmacological therapy, can be used to treat, prevent, and / or cure various other disorders of unbalanced nucleoside pools, especially those found in mitochondrial DNA depletion syndrome.

To provide compounds for treating various conditions treated by activation of serotonin receptors, such as psychiatric diseases and other neurological diseases, disorders, and conditions, in the fields of psychiatry, neurobiology, and pharmacotherapy.SOLUTION: To provide a psilocin derivative of formula (I), a process for preparing the same, a composition containing the same, and use thereof in activating a serotonin receptor in a cell.SELECTED DRAWING: Figure 1

Disclosed are pharmaceutical preparations comprising bromantane or an analogue of bromantane, and methods of using said preparations for pharmacotherapy to alleviate withdrawal syndrome and prevent relapse in the treatment of stimulant use disorder, to transition patients off medications that have abuse or addiction liabilities, or to facilitate extinction learning in the treatment of mental disorders.