The invention discloses a hot-rolled automobile structural steel plate with the yield strength of 420MPa and excellent cold-forming performance and a manufacturing method. The hot-rolled automobile structural steel plate with the yield strength of 420MPa and the excellent cold-forming performance comprises, by weight, 0.03-0.06% of carbon, 0.7-0.9% of manganese, 0.020-0.030% of niobium, 0.020-0.030% of titanium, less than 0.10% of silicon, no more than 0.005% of sulfur, no more than 0.015% of phosphorus, no more than 40 ppm of nitrogen, 0.025-0.050% of acid soluble aluminum, and the balance iron and inevitable impurities. According to the hot-rolled automobile structural steel plate with the yield strength of 420MPa and the excellent cold-forming performance and the manufacturing method, the Nb-Ti microalloying technique is adopted for a short process, S and N (S<=0.005%, and N<=40 ppa) in steel are fixed through a trace of Ti, the grain refining effect of Nb is brought into full playto obtain a fine F+P structure, and thus the cold-forming performance of the steel is improved while high strength is obtained.