65 results about "Biologic response" patented technology

Methods and systems are provided for training a machine learning algorithm using at least one hardware processor to identify one or more predictive drug molecule features and / or predictive genetic biomarkers for cancer treatment. In some embodiments, the method uses at least one cancer drug discovery data set to train at least one learning algorithm in a predictive model, and uses a xenograft mouse model to validate the predictive model, and feeds back a biological response to the predictive model to further train the learning algorithm.

An example of a biological reactant includes a norbornenyl-functionalized or a trans-cyclooctene-functionalized oligonucleotide. The norbornenyl-functionalized oligonucleotide includes a norbornene group attached to a phosphate of a nucleotide attached to a 5' end of a plurality of linked nucleotides. The trans-cyclooctene-functionalized oligonucleotide includes a trans-cyclooctene group attached, via an alkyl chain, to a phosphate of a nucleotide attached to a 5' end of a plurality of linked nucleotides.

The invention provides a plasma dose calibration method and device, and the device comprises a biological reaction module which is used for carrying a biological sample and providing a stable processing environment, and guaranteeing that plasma energy is transmitted to the biological sample; the plasma generation module is connected with the biological reaction module and is used for generating plasmas to the biological reaction module, controlling a discharge mode and energy output according to the discharge parameters and monitoring physical characteristic data of the plasmas; the biological verification module is used for carrying out quantitative detection on biophysical reactions under different plasma release doses to obtain biological effect data; the control center is connected with the biological verification module and the plasma generation module and used for obtaining biological effect data and physical property data of the plasma so as to adjust discharge parameters of the plasma generation module and control the plasma dosage. A closed-loop control system of'parameter regulation and control-biological treatment-effect feedback 'is constructed.

1. The name of the design product: protein purification instrument. 2. The use of the design product: biological reaction instrument for protein chromatography separation. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

A remotely interfaced medical screening assembly for remotely screening and diagnosing a user includes a plurality of garments, a relay module, and a user interface device. Each garment substantially covers a respective body part of the user and is equipped with one or more sensors and stimulators, each of which can assess or elicit a biological parameter or biological response, respectively. Connectors are operationally engaged to the relay module and can be selectively mutually attached to operationally engage the sensors and the stimulators to the relay module. The user interface device is in wireless communication with the relay module and a healthcare provider's electronic device so that commands, biological parameters, and biological responses are communicable between the relay module and the healthcare provider's electronic device, allowing the healthcare provider to evaluate the user and to formulate a diagnosis.

Compositions and methods disclosed herein relate to improved in vitro cell-free systems for various biological reactions. In one aspect, a composition of the present disclosure includes: a cell-free extract derived from an organism; a nucleic acid; and an organelle that is heterologous to the organism.

The application discloses a kind of biological reaction devices of plant tissue, comprising, culture device, for the culture of plant tissue, the outer wall of the culture device is provided with detection device, for detecting the parameter and / or sampling of culture solution in the culture device;Heat transfer structure, for the temperature control of the culture device, the heat transfer structure has notch, the detection device is arranged on the outer wall of the culture device in the notch.The plant tissue is cultured by the culture device in the application, the temperature in the device is kept stable by heat transfer structure, prevent the influence caused by external temperature to the environment in the device.And detection device is arranged on the outer wall of the culture device in the notch of heat transfer structure, can avoid the damage or heat loss of heat transfer structure caused by detection device passing through heat transfer structure, ensure the integrity of heat transfer structure, make temperature keep stable, plant tissue better growth.

The application is suitable for the technical field of human body examination, and provides a medical endoscope fluorescence camera system, which comprises a fluorescent dye injection unit for guiding fluorescent dye to a target area, wherein the fluorescent dye generates specific fluorescent signals in the diseased tissue of the target area, the fluorescent dye is a chemical substance with target area lesion recognition capability, and the fluorescent dye generates fluorescent signals of specific wavelengths under specific excitation light irradiation under the metabolism or biological response of the target area, so as to detect canceration characteristics; the system further comprises an endoscope camera unit; the system effectively solves the segmentation problem of fluorescent images in different areas through adaptive partition threshold segmentation of a signal intensity analysis unit, image definition analysis and an Otsu method, and improves the recognition accuracy of the diseased area. A display device combines a graphical user interface to provide intuitive operation, helps doctors to analyze the lesion in real time, and achieves the purpose of improving the accuracy and efficiency of target area lesion diagnosis.

The utility model relates to the technical field of microalgae continuous culture, specifically discloses a continuous culture system and continuous culture method of isochrysis galbana, the culture system includes host computer and lower computer, the host computer is the remote monitoring and control platform based on mobile terminal, is connected with lower computer, is used for real -time monitoring, parameter setting and remote control, the lower computer includes pipeline type light biological reaction circulation unit, control unit, feed addition unit and liquid outlet collection unit, based on this culture system can realize the efficient, stable, low -cost continuous culture of isochrysis galbana.

Provided herein included methods and systems to identify exposure to environmental carcinogens, compounds, and other toxins are disclosed. Additionally provided, include methods and systems to identify risk associated with such environmental carcinogens, compounds, and other toxins. Various embodiments include machine learning models to identify cellular morphometric biomarkers (CMBs). Various methods and systems described herein are capable of using CMBs for diagnostic, prognostic, or forensic purposes. Some embodiments are directed to training a machine learning model for such using CMBs for diagnostic, prognostic, or forensic purposes, including (but not limited to) generating images of biological responses that can be used as a training data set. Additional embodiments are directed to computing devices and / or software that are capable of performing methods as described herein.

This invention provides an organizational attribute analysis system and apparatus that analyze organizational attributes through changes in the biological responses of users participating in online sessions conducted within an organization. [Solution] The tissue attribute analysis device 100 includes a bio-response analysis unit 12 that analyzes changes in the user's bio-response for each online session of multiple organizations in which the same user participates, based on video images obtained of the user during an online session conducted by multiple users, and a tissue attribute analysis unit 13 that analyzes the attributes of the organization based on the changes in bio-response analyzed by the bio-response analysis unit 12 for each online session of multiple organizations. The device analyzes the bio-response of participants in online sessions conducted within an organization and analyzes the attributes of the organization based on the analysis results.

This invention discloses an intelligent biological reaction monitoring system and method, belonging to the field of intelligent monitoring. The system includes: a reaction stage segmentation unit for segmenting and determining multiple reaction stages; a variable relationship mining unit for determining dominant and auxiliary variables, mining linear relationships between variables, coordinating insensitive loss functions, and supervising the training of a soft monitoring module; a continuous monitoring and acquisition unit for configuring monitoring equipment groups, performing continuous monitoring, and determining reaction monitoring data; a data analysis and screening unit for preprocessing data, performing linear analysis and abnormal reaction localization, and determining valid monitoring data; a game equilibrium decision-making unit for performing game equilibrium decisions on abnormal reaction identifiers and determining reaction regulation strategies; and a reaction monitoring management unit for responding to regulation strategies, performing feedback monitoring analysis and reaction monitoring management, improving the accuracy of biological reaction monitoring, achieving real-time online monitoring, and intelligently regulating abnormal situations.

This application discloses a method and apparatus for optimizing a bioreaction process using deep learning, relating to the field of cell bioengineering. The method includes acquiring the first bioreaction type, the first reaction stage, the first basic configuration parameters of the cell bioreactor, and the first monitoring parameters collected by multiple types of sensors in the current bioreaction process within a cell bioreactor; retrieving contextual data related to the first bioreaction type and the first reaction stage from a bioreaction knowledge vector base; constructing prompt words based on the contextual data, the first monitoring parameters, the first bioreaction type, the first reaction stage, the first basic configuration parameters, preset data analysis instructions, and historical question-and-answer data from monitoring and analysis; and inputting the prompt words into a trained large-scale cell bioreaction model, so that the large-scale cell bioreaction model outputs first control parameters for a programmable logic controller to predict the operating state of the cell bioreactor and correct for faults.

The utility model belongs to the technical field of laboratory equipment, and particularly relates to an automatic mixing biological reaction oscillation device which comprises a bottom plate, a shell is fixedly connected to the top surface of the bottom plate, and an oscillation structure is arranged on the inner side of the shell; the oscillation structure comprises a test tube rack, and a plurality of rows of test tube placing holes are formed in the test tube rack at equal intervals; through cooperative use of a rotating rod and a connecting block, a driving motor is started to drive the rotating rod to rotate, so that the rotating rod drives a connecting column to perform circular motion, and the connecting column drives a connecting block to move in the direction of a guide rail, so that a test tube rack is driven to perform reciprocating motion, and test tubes on the test tube rack are oscillated and uniformly mixed; therefore, a plurality of test tubes can be oscillated and uniformly mixed at the same time, the oscillation and uniform mixing efficiency of the test tubes is improved, the oscillation and uniform mixing of the test tubes do not need to be manually carried out, and the labor intensity of workers is reduced.

This invention relates to an organoid biomechanical response platform and a method for simulating the force exerted on human gait organs. The platform includes an organ-on-a-chip and a biomechanical response device. The biomechanical response device is divided into two types: simulating the force exerted on the organoid during prolonged standing and simulating the force exerted on the organoid during walking or running. The system simulating prolonged standing includes an interconnected pressure chamber base, a one-way valve, a stroke cylinder, a stroke reciprocating structure, and a motor. The system simulating walking or running includes an interconnected pressure chamber base, a stroke cylinder, a stroke reciprocating structure, and a motor. The organoid is placed within the pressure chamber base. The stroke reciprocating structure includes a connecting rod piston, a crankshaft connecting rod, and a crankshaft. The connecting rod portion of the connecting rod piston is connected to the crankshaft via the crankshaft connecting rod. The crankshaft is connected to the motor. The piston portion of the connecting rod piston extends into the stroke cylinder. Compared with existing technologies, this invention achieves stable, repeatable, and quantifiable mechanical stimulation, realistically reproducing human gait stress.

A product, composition, suspension and / or method to dissolve vaso-occlusive clots in vivo in a sickle diseased subject utilizing Target-specific Thrombolytic Urokinase Spheres (TTUS). The TTUS can target vaso-occlusive clots in vivo and then lyse the obstructive blood clots with high efficiency can be intravenously administered to a subject in need thereof. The TTUS are configured to dissolve vaso-occlusive clots by converting plasminogen in blood of the subject into plasmin molecules that dissolves the clot. The nanospheres can encapsulate an enzymatically active bioreactive agent, such as urokinase. Since the active enzyme is targeting and binding essentially only to obstructive clots, there is minimal risk of side-effects to the subject. The nanospheres are less than one micron in diameter, resulting in a size much smaller than red blood cells.

A microfabricated droplet dispensing structure is described, which may include a MEMS microfluidic fluidic valve, configured to open and close a microfluidic channel. The opening and closing of the valve may separate a target biological particle containing genomic material, and a bead from a sample stream, and direct these two particle into a single droplet formed at the edge of the substrate. The droplet may then be encased in a sheath flow of an immiscible fluid, and provided to a downstream workflow. A third microfluidic channel upstream of the valve may add a biologically reactive material to the sample stream.

The present disclosure is related to inorganic, biocompatible material compositions for bioactivatable devices, devices, and products comprising transition metal chalcogenides, such as molybdenum sulfides, that can be converted in vivo from a non-bioactive state to a bioactive state upon exposure to physiological conditions, wherein the bioactivated transition metal chalcogenide derivatives, such as molybdenum sulfide derivatives, exhibit copper-chelating activities. Various methods for the application of these compositions for enhancing biocompatibility and reducing or modulating copper-dependent biological reactions are provided.

Provided are a compound including a cleavable linker, a use thereof, and an intermediate compound for preparing the same, and more particularly, the compound including a cleavable linker of the present invention may include an active agent (for example, a drug, a toxin, a ligand, a probe for detection, etc.) having a specific function or activity, a —S(═O)(═N—)— functional group which is capable of selectively releasing the active agent, and a functional group which triggers a chemical reaction, a physicochemical reaction and / or a biological reaction by external stimulation, and may further include a ligand (for example, oligopeptide, polypeptide, antibody, etc.) having binding specificity for a desired target receptor.

This invention discloses a bioreactor device, components, and operating method. The device includes: a container forming a sealed containment space, with at least two fluid ports communicating with the containment space; at least one plate, which may be a planar plate or a microporous plate, arranged in parallel within the containment space; and a shaft connected to at least one end of the container, passing through each plate, the plates rotating with the shaft or the container, the shaft being hollow and having openings for conveying fluid within the shaft to each plate. This technical solution is particularly suitable for cell and cell spheroid culture, enabling batch production based on the number and size of cell aggregates, thereby producing highly reproducible, reliable, homogeneous, and uniformly sized products. This improves the controllability, scalability, safety, and compliance of bioreactors, enhances the level of automated production, and meets the needs of large-scale clinical production.

A parallel multi-step bio-reaction system(10) comprising: (a) a substrate arrangement(12) comprising a plurality of bio-reaction substrate holders(18) configured to hold a plurality of bio-reaction substrates(20); (b) a well arrangement(14) comprising a plurality of fluidic wells(22), the fluidic wells(22) corresponding to a plurality of steps of a multi-step bio-reaction; (c) an actuator(16) configured to: (i) move either the substrate arrangement(12) or the well arrangement(14) relative to the other of the substrate arrangement(12) or the well arrangement(14) to change the alignment of the bio-reaction substrates(20) as a group relative to the fluidic wells(22) as a group; and (ii) bring the bio-reaction substrates(20) into and out of contact with fluids in the fluidic wells(22).

Provided are a compound including a cleavable linker, a use thereof, and an intermediate compound for preparing the same, and more particularly, the compound including a cleavable linker of the present invention may include an active agent (for example, a drug, a toxin, a ligand, a probe for detection, etc.) having a specific function or activity, a SO2 functional group which is capable of selectively releasing the active agent, and a functional group which triggers a chemical reaction, a physicochemical reaction and / or a biological reaction by external stimulation, and may further include a ligand (for example, oligopeptide, polypeptide, antibody, etc.) having binding specificity for a desired target receptor.

The present invention provides a first aid tourniquet pressure monitoring and automatic alarm system, which relates to the technical field of pressure monitoring. The system includes a biological reaction monitoring module, a pressure adjustment analysis module, a real-time pressure adjustment module, a safety threshold detection module, and an emergency response activation module. In the present invention, through real-time monitoring of biological reactions, the changes in microblood flow, skin electrical impedance and tissue morphology of patients after using a tourniquet are captured, making the monitoring of individual reactions more comprehensive, and combining the patient's actual physiological state to evaluate the safety and effect of pressure, making the monitoring more dynamic and personalized, and the combination of real-time pressure adjustment and emergency response ensures that when the pressure exceeds the safe range, the pressure is quickly adjusted and a warning is issued through an alarm, avoiding secondary injuries caused by improper pressure, improving the safety and response speed of tourniquet use, and being able to more accurately prevent patient tissue damage, ensuring real-time effectiveness and safety during first aid.

To provide a system and method capable of proposing cosmetics verified to be suitable for a customer. [Solution] A cosmetics suggestion system, wherein the customer information receiving means is a means for receiving customer information, the screening result receiving means is a means for receiving screening results of candidate ingredients for cosmetics to be provided to the customer, the active ingredient determining means is a means for determining the active ingredients of the cosmetics that are suitable for the customer based at least on the screening results, and the output means is a means for outputting information on the cosmetics that are suitable for the customer, including information on the determined active ingredients, linked to the customer information received by the customer information receiving means, and the screening applies the candidate ingredients to three-dimensional skin tissue created from cells derived from the customer, and observes the biological response of the three-dimensional skin tissue as an evaluation index to select ingredients that can improve the customer's skin condition.

Systems, apparatus, articles of manufacture, and methods are disclosed to remotely measure biological response data. An example apparatus includes interface circuitry; machine readable instructions; and programmable circuitry to at least one of instantiate or execute the machine readable instructions to generate a study based on one or more target modalities; transmit the study to electronic devices corresponding to study participants; obtain response data corresponding to the study; and aggregate the response data across the participants and across the modalities.

The invention discloses a method and device for optimizing a biological reaction process by using deep learning, and relates to the field of cell bioengineering.The method comprises the steps that a first biological reaction type and a first reaction stage of the current biological reaction process in a cell bioreactor and first basic configuration parameters of the cell bioreactor are obtained, acquiring a first monitoring parameter through a multi-type sensor; retrieving context data related to the first biological reaction type and the first reaction stage in a biological reaction knowledge vector library; on the basis of the context data, the first monitoring parameter, the first biological reaction type, the first reaction stage, the first basic configuration parameter, a preset data analysis instruction and monitoring analysis historical question and answer data, constructing a cue word; and inputting the cue word into the trained large cell biological reaction model to enable the large cell biological reaction model to output a first control parameter, so that the programmable logic controller predicts the operation state of the cell bioreactor and corrects the fault.

The invention discloses an automatic in-vitro biological synthesis reaction system which comprises a reaction tank assembly, a mixing assembly, a feeding assembly, a reaction raw material quantity feedback part, a detection part and a control device in communication connection with all the components, and the reaction tank assembly is provided with a tank body used for containing reaction liquid for in-vitro biological reaction; the reaction mixing assembly is used for mixing reaction liquid; the feeding assembly is provided with a feeding pipe communicated with the tank body and a feeding pump communicated with the feeding pipe; the reaction raw material quantity feedback part is used for detecting the raw material quantity in the tank body to obtain raw material quantity parameters; the detection part is used for detecting the reaction liquid and / or the gas generated by the reaction to obtain detection parameters; the control device is provided with a feeding module, an operation module and a mixing module and is used for achieving automatic operation of the steps of automatic feeding, automatic stirring, automatic detection, automatic discharging, automatic cleaning and the like, and the workload and operation knowledge requirements of operators are reduced.

A low-gravity experiment device that can easily carry out a predetermined gravity experiment, and a low-gravity experiment system equipped with the low-gravity experiment device are provided. [Solution] The low-gravity experimental device 4 can perform low-gravity experiments, for example, related to biological reactions, while suppressing the effects on the semicircular canals of the living body. The low-gravity experimental device 4 can also perform low-gravity experiments, for example, with different accelerations. The low-gravity experimental device 4 of the present invention is a low-gravity experimental device 4 for performing low-gravity experiments while falling from a flying body 2, and includes a capsule device main body 10 that forms an internal space in which equipment for performing the low-gravity experiment is placed, a wire 12 extending from the capsule device main body 10, and a fall control mechanism 14 that is connected to the wire and controls the upward propulsive force.

Orthodontic systems and related methods are disclosed for designing and providing tooth moving systems. Methods and orthodontic systems include the generation of an overcorrection in the tooth-receiving cavities of an appliance worn in the dentition. The overcorrection may provide an improved and more accurately applied force or moment applied to a tooth. The overcorrected force or moment can move a tooth closer to a desired position than if not overcorrected as sufficient force can still be applied to the tooth as it gets closer to the desired position. The overcorrected force or moment may also better target the root of the tooth where the biological response to tooth movement occurs. The disclosed method comprises receiving input data comprising an initial tooth arrangement and a target tooth arrangement for a patient's teeth, determining a plurality of treatment stages for repositioning the patient's teeth from the initial tooth arrangement toward the target tooth arrangement, determining, for at least some of the treatment stages, an overcorrected movement corresponding to an overcorrected position for the tooth that is different from the target position specified by the treatment stage, and generating fabrication instructions for a plurality of dental appliances corresponding to the plurality of treatment stages.