Nutrient system for individualized responsive dosing regimens

Abstract

Individualized responsive dosing dietary supplement systems, compositions, methods of dosing, and processes of producing the same, which allow a consumer to generate individualistic biological responses / effects. More specifically, a dietary supplement system for generating individualized biological conditions / responses which utilizes ultra-low dosage amounts of vitamins, minerals, amino acids, co-enzymes, and / or other nutrients in a bio-active delivery system which preferably avoids first pass metabolism, such that an individual may take multiple doses of the same or different dietary supplement based on varying desired biological response within each 24 period is also disclosed.

Description

RELATED APPLICATIONS [0001] This application is a non-provisional application claiming priority to U.S. provisional application Ser. No. 60 / 561,097, filed on Apr. 8, 2004, pending, and incorporated by reference herein in its entirety.FIELD OF THE INVENTION [0002] The present technology relates generally to individualized responsive dosing dietary supplement systems, compositions, methods of treatment, and processes of producing the same, which allow a consumer to target identifiable, individualistic biological conditions or responses. More specifically, the present technology relates to a dietary supplement system for targeting individualized biological conditions or responses which utilizes ultra-low dosage amounts of vitamins, minerals, amino acids, co-enzymes, stimulants, and / or similar ingredients in a highly bio-active delivery system, such that an individual may take multiple doses of the same or different dietary supplement mixture based on varying biological need or desired ...

AI Technical Summary

Benefits of technology

[0013] Embodiments of the presently described technology provide one or more of the following advantageous features and / or objects:

[0016] (3) Efficient rate of absorption into an animal or human body to improve bioavailability, biokinetics, and biodelivery;

[0019] (6) A biological response equivalent dosing unit that does not approach RDA or UL amounts, but is still effective in enhancing the overall well being of an individual and generating a biological response;

[0029] Additionally, there is presently described a method for individualized responsive dosing to generate a biological response, comprising the steps of providing a selection of two or more nutrient formulations in delivery systems which substantially avoid first pass metabolism and which provide two or more vitamins, minerals, amino acids, co-enzyme, or other nutrient in amounts preferably less than 10% or 1% of RDA or UL, more preferably less than 0.01% of RDA or UL, and most preferably less than 0.0001% of RDA or UL and a water source comprising at least one mineral, nitrate, nitrite, and / or other nutrients in amounts preferably less than 0.001% of RDA or UL. Preferably, however, the dosage levels are at least 1×10{circumflex over ( )}-7% of RDA or UL. The two or more nutrient compositions are preferably separately configured to generate one or more pre-determined biological responses, including, but not limited to: stress-relief, cellular metabolism, energy conservation, energy utilization, energy enhancement, enhanced memory, enhanced cognitive function, calmness, awareness, stimulation of the hypothalamic-pituitary-thyroid axis, fatigue relief, enhanced immune response, antioxidation, liver detoxification, and alcohol metabolism.

Problems solved by technology

The intricate ways in which nutrients act on the body, however, are still far from clear.

Although mega-dose regimens are a common practice for the prevention of disease, there is a great deal of debate in the literature regarding the efficacy of such regimens.

Moreover, consuming large doses of vitamins, minerals, or other nutrients, in the absence of some deficiency or without proper medical supervision, may cause harmful toxic effects and / or result in hypervitaminosis.

Additionally, a consumer usually has little choice in choosing the variety of ingredients, dosage levels, or dosing regimens of a conventional dietary supplement, such as a standard vitamin tablet.

Conventional dietary supplements may be effective for a general purpose, but usually provide an excess of vitamins, minerals, stimulants, or other compounds which a consumer does not desire, or those supplements may not adequately target an individual's specific dietary need or desired biological response.

Additionally, conventional dosage forms of dietary supplements only allow a consumer to take one or two doses per 24 hour period.

As a result, conventional dietary supplements fail to recognize that the physiological state and resultant nutrient requirements of any single individual can depend upon and fluctuate based upon a number of different biophysical variables during the course of each day or dosing regimen.

Thus, standard “one size fits all” mega-dose dosage forms / regimens are not amenable to empirical dosage adjustment to achieve an individualized biophysiological objective or response.

Another drawback with most conventional dietary supplements is that they suffer from poor degrees and / or rates at which the various nutrients are absorbed into the systemic circulation of the body and made available for biophysiological activity (e.g., “bioavailability”).

For example, it is believed that one significant drawback to “mega-dosing” of vitamins and minerals is that increased dosages may not be adequately absorbed into the body, or may actually decrease absorption.

Thus, available transport mechanisms may become saturated and unable to absorb excess dosage.

Additionally, a drawback to vitamin or mineral delivery via a conventional tablet or capsule is that differences in luminal pH along the gastrointestinal tract lining, surface area per luminal volume, blood perfusion, presence of bile and mucus, and the nature of epithelial membranes may prevent efficient absorption, activation, and the like of a nutrient, thereby decreasing its bioavailability.

However, aside from a delayed biophysiologic response as gastric emptying becomes rate-limiting, gastric irritability, and potential allergic reactions from the ingestion of such coating materials occurs, and these enterically coated delayed release dosage forms dissolve and are absorbed within a narrow time frame.

However, the compositions and methods of the Jang patent do not provide for ultra-low dosage amounts of vitamins or minerals, dosing flexibility, or systems, compositions, or methods for individualized responsive dosing based on a desired biological response.

However, these patents do not utilize vitamins or minerals, and more specifically, ultra-low dosage amounts of nutrients which would operate to provide flexibility for individualized dosing.

Moreover, these products or processes do not provide a system or selection for varying the type or level of dosage depending on a biological response desired.