102results about How to "Potent inhibition" patented technology

A flow management system for extracorporeal blood treatment application helps to ensure proper balance of incoming and outgoing fluids by precise balancing of relatively small balance chambers. The invention employs combinations of features that help to ensure accuracy including underfilling of the waste flow side of a fixed volume chamber and mechanical connections to synchronize valves and pumps.

A non-volatile semiconductor device has a memory cell array having electrically erasable programmable non-volatile memory cells, reprogramming an retrieval circuits that temporarily store data to be programmed in the memory cell array and sense data retrieved from the memory cell array, each reprogramming and retrieval circuit having a first latch and a second latch that are selectively connected to the memory cell array and transfer data each other, and a controller that controls the reprogramming and retrieval circuits on data-reprogramming operation to and data-retrieval operation from the memory cell array. Each reprogramming and retrieval circuit has a multilevel logical operation mode and a caching operation mode, in the multilevel logical operation mode, re-programming and retrieval of upper and lower bits of two-bit four-level data being performed using the first and the second lathes in storing the two-bit four-level data in one of the memory cells in a predetermined threshold level range, in the caching operation mode, data transfer between one of the memory cells selected in accordance with a first address and the first latch being performed while data transfer is being performed between the second latch and input output terminals in accordance with a second address with respect to one-bit two-level data to be stored in one of the memory cells.

The present invention provides a system and apparatus for efficient and reliable, control and distribution of data files or portions of files, applications, or other data objects in large-scale distributed networks. A unique content-management front-end provides efficient controls for triggering distribution of digitized data content to selected groups of a large number of remote computer servers. Network distribution messages are dispatched according to a sorted list of servers, based on factors such as nearness, server processor speed, reliability, and CPU Usage. For large numbers of servers, a store-and-forward approach becomes much more efficient. A first selected server receives the message from a content control manager (CCM). The first server requests instructions for the next server listed on an ordered list in the CCM and forwards a copy of that message to the next identified server. Each server reports its completion and requests further instructions from the CCM. This mechanism permits highly efficient and robust distribution of assignments and data content from the CCM to each required GL using a store-and-forward tree structure.

Vascular prostheses and methods of use are provided, wherein the vascular prosthesis includes a plurality of bistable unit cells configured to form a helical structure. A visualization catheter also is provided for use ensuring accurate measurement of a lesion and ensuring delivery and placement of the vascular prosthesis.

A method and system for determining the orientation of an optical device, the optical device having data carrier means for carrying data related to the optical device, the data carrier having data carrier means operable in at least one of an electrical mode and a magnetic mode; the data carrier means being associated with an optical device by at least at least one of the group of depositing on or printing on a posterior surface or anterior surface of the optical device, including the data carrier with the optical device material, wherein data carrier means emits a data signal periodically or in response to a external signal from an external means.

A method for tracking the wearable life of an ophthalmic product, the method comprising the steps of: providing the ophthalmic product with at least one data carrier for carrying data related to the ophthalmic product, the data carrier having a first device operable in a magnetic and/or electrical mode; providing an activation signal from an external means; activating the first device with the activation signal to cause the first device to emit the data in response to the activating signal; recording the time the first device is interrogated, processing the received data to determine the wearable life of the ophthalmic product based on the lapsed time.

A system for network accounting statistics collection including a statistics collector associated with each packet forwarding engine. Each statistics collector has one or more accounting elements, each of which includes some number of counters, such as packet and byte counters. Each statistics collector receives accounting instructions from the associated forwarding engine for packets processed by the forwarding engine, including packets that will be discarded without being forwarded. Each accounting instruction includes an identifier uniquely indicating one of the accounting elements, and information used to increment the counters within the accounting element. Upon receipt of an accounting instruction, the receiving statistics collector increments the counters in the accounting element. The accounting instruction is a relatively simple primitive operation in the disclosed system, enabling high-speed operation. Each statistics collector collects data over a fixed sampling interval that may range from a number of milliseconds to one or more minutes. Each sampling period begins with a reset of an accounting element store, and ends with at least one set of data being flushed to a management system for further processing and/or formatting.

The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I)

wherein Z is CH₂ or N—R⁴ and X, R¹, R², R⁴, R⁶, R⁷ and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.

A memory system including a memory controller and a memory and a related method are disclosed. The method includes communicating a command and error detection/correction (EDC) data associated with the command from the memory controller to the memory, decoding the command and executing an EDC operation related to the EDC data in parallel, and if the command is a write command, delaying execution of a write operation indicated by the write command until completion of the EDC operation, else immediately executing an operation indicated by the command without regard to completion of the EDC operation.

Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia or neuropathic pain, or preventing loss in neuronal function characteristic of neurodegenerative diseases involve administering to a subject in need of treatment a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or solvate thereof:

wherein

• [0001]
  • R¹ and R² are independently selected from hydrogen, halo, nitro, alkyl, acyl, alkylaryl, and XYR⁵;
  [0002]
  • or R¹ and R², taken together, form a 5, 6, 7 or 8-membered substituted or unsubstituted carbocyclic or heterocyclic group;
  [0003]
  • X and Y are independently selected from O, S, NH, and (CR⁶R⁷)_n;
  [0004]
  • R³ is hydrogen, alkyl or M⁺; M is aluminum, calcium, lithium, magnesium, potassium, sodium, zinc ion or a mixture thereof;
  [0005]
  • Z is N or CR⁴;
  [0006]
  • R⁴ is from selected from hydrogen, halo, nitro, alkyl, alkylaryl, and XYR⁵;
  [0007]
  • R⁵ is selected from aryl, substituted aryl, heteroaryl and substituted heteroaryl;
  [0008]
  • R⁶ and R⁷ are independently selected from hydrogen and alkyl; n is an integer from 1 to 6;
  [0009]
  • at least one of R¹, R² and R⁴ is other than hydrogen; and
  [0010]
  • at least one of X and Y is (CR⁶R⁷)_n. D-serine or cycloserine may be coadministered along with the compound of formula I.

A display device that can compensate for degradation of circuit elements while suppressing an increase in circuit size is implemented.

A data signal line (S(j)) is not only used as a signal line that transfers a signal for allowing an organic EL element (OLED) in each pixel circuit (11) to emit light at a desired luminance, but also used as a signal line for characteristic detection. In addition, a switch (334) is provided between the data signal line (S(j)) and an internal data line (Sin(j)). In such a configuration, during an AD conversion period during which analog data obtained for characteristic detection is converted into digital data, the switch (334) is brought into an off state and a potential of the data signal line (S(j)) obtained immediately before the AD conversion period is supplied from through a predetermined control line (CL) to the data signal line (S(j)).

Some embodiments provide an optimized multi-hit caching technique that minimizes the performance impact associated with caching of long-tail content while retaining much of the efficiency and minimal overhead associated with first hit caching in determining when to cache content. The optimized multi-hit caching utilizes a modified bloom filter implementation that performs flushing and state rolling to delete indices representing stale content from a bit array used to track hit counts without affecting identification of other content that may be represented with indices overlapping with those representing the stale content. Specifically, a copy of the bit array is stored prior to flushing the bit array so as to avoid losing track of previously requested and cached content when flushing the bit arrays and the flushing is performed to remove the bit indices representing stale content from the bit array and to minimize the possibility of a false positive.

It is an object to provide a USB upstream device, a USB connector, and a USB cable, capable of operating stably by preventing malfunction due to a signal line defined as a high impedance state depending on a data transmission mode in the USB upstream device, when inserting or removing the USB upstream device into or from the USB. In a USP upstream device 1, a switch circuit 11 is provided between a signal line D− and grounding voltage. When the USB upstream device 1 is connected to the USB, power is supplied through VBUS line in the USB cable and the signal line D− is cut off from the grounding voltage. When cut off from the USB, the power supply through the VBUS line is cut off, and the switch circuit 11 conducts. Then, a discharge route is established. Unnecessary charge such as leak current or the like is discharged to the grounding voltage through the switch circuit 11. As a result, in a state separated from the USB, a voltage level of the signal line D− is maintained at a low voltage level.

A sequence for applying pulses to control lines in a horizontal period is differentiated for every horizontal period or vertical period and a sequence for data driver circuitry to write signals in data lines in a horizontal period is differentiated for every horizontal period or vertical period so that potential fluctuations of data lines generated at the time of sampling are temporally made uniform so as to make recognition of streak-like irregularity difficult.

An improved device and method for performing automatic capture/threshold determination that is particularly useful in an implantable cardiac stimulation device. While conventional devices use a fixed shortening of the AV/PV delays during automatic capture/threshold determinations, any shortening can unnecessarily cause discomfort to patients with heart blocks and unnecessarily diminish the atrial kick for other patients. Accordingly, embodiments of the present invention periodically measure the AR/PR conduction times and tabulate and/or otherwise process this data. Preferably, these measured conduction times are also correlated with the current heart rate. Finally, when an automatic capture/threshold determination occurs, this measured conduction data, which corresponds to this patient, is used to adjust the AV/PV delays while minimizing patient discomfort and adverse hemodynamic effects. Alternatively, the AV/PV delays may be manually programmable by a medical practitioner.

The invention relates to 3-heterocyclyl indolyl compounds capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively, said compounds having the formula I,

wherein

• R¹, R², R³, R⁴, R^A, Y and Y are as defined in the specification. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and/or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.

In a semiconductor memory device operative to discharge residual charge in a read bit line in a read cycle, the bit line is in the reset state at all times except during read operation. The reset state of a bit line is canceled when selected and connected to a read circuit for read, and information stored in a selected memory cell is read via the selected bit line. Upon completion of the read of the memory cell, the selected bit line is disconnected from the read circuit and reset to thereby complete discharge of residual charge in the read bit line prior to read operation in the next cycle. This ensures that during read determination operation in the next read cycle, the potential of a selected bit line will not vary with the bit line residual discharge in the previous read cycle.