222results about How to "Avoid weight gain" patented technology

Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming lactam bridges or the substitution of the terminal carboxylic acid with an amide group produces peptides exhibiting glucagon/GLP-1 receptor co-agonist activity. The solubility and stability of these high potency glucagon analogs can be further improved by modification of the polypeptides by pegylation, substitution of carboxy terminal amino acids, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 26 (GPSSGAPPPS), SEQ ID NO: 27 (K-RNRNNIA) and SEQ ID NO: 28 (KRNR).

The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes and associated metabolic disorders. In particular, the invention provides novel acylated glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.

The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.

This invention is directed to the use of SCD-1 inhibitors of the formula (I): where x, y, V, W, G, J, L, M, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein, in combination with other drug therapies to treat adverse weight gain.

A structure holds a display panel arranged inside a cabinet from the both sides by means of a holding member and a frame portion, which are supported by the circumferential surface section, so as to reduce thickness and frame width without using a bezel and to ensure rigidity. The cabinet is provided with a frame portion positioned on the display surface side of the display panel, a circumferential surface portion positioned at the periphery of the display panel, and a rear surface portion covering the other surface side of the display panel. A protruding section is arranged on the outer circumference side of the periphery of the display panel and the holding member to extend from the display surface side of the display panel toward the side opposite to the display surface, on an inner surface of the frame portion. A reinforcing section is arranged for connecting the inner circumference section of the protruding section with the inner surface section of a frame portion. The protruding section is provided with connecting sections, which are integrally formed with the inner surface of the frame portion, annularly arranged on the outer circumference of the display panel, and integrally formed at a plurality of positions on the protruding section in the circumference direction. The holding member has a section to be connected with the connecting section.

The present invention is directed to methods of treating a human for a variety of conditions by administering an agonist of the G protein coupled receptor TGR5. In addition, the invention includes methods for determining whether a test compound is likely to be effective in treating one of these conditions by assaying it for its ability to raise intracellular iodothyronine deiodinase levels or for its ability to bind to and activate TGR5.

The invention discloses a three-dimensional self-supported lithium-loving carrier-packaged metal lithium composite negative electrode and a preparation method thereof. The three-dimensional self-supported lithium-loving carrier-packaged metal lithium composite negative electrode comprises the following steps of 1) carbonizing melamine foam in an inertia atmosphere to obtain a nitrogen-rich lithium-loving three-dimensional self-supported carrier; and 2) packaging metal lithium in holes of the three-dimensional self-supported carrier to obtain the metal lithium composite negative electrode. Carbon sponge obtained by carbonization of melamine foam is used as a metal lithium carrier, and the metal lithium composite negative electrode has effects of guiding metal lithium to be uniformly deposited and preventing dendrite from being generated. Lithium-loving functional groups are uniformly arranged on the carrier, a lithium-loving coating layer is deposited on a hole surface of the carrier, the lithium-loving performance of the carrier is improved, the volume change of the metal lithium electrode during the circulation process is effectively buffered, moreover, the lithium-loving functional groups uniformly arranged on the three-dimensional carrier are used as active sites for metal lithium deposition, the nucleation over-potential is reduced, uniform nucleation of metal lithium can be effectively controlled, so that the dendrite generation is prevented.

The present invention provides methods for manufacturing heat treated products involving the use of probiotic bacteria, e.g. lactic acid bacteria and/or Bifidobacteria, cultures of such bacteria, supernatant from such cultures, and/or concentrates of such supernatant and/or fractions of such supernatant. The invention further provides heat treated products of such processes and their use for regulation of cellular uptake of fat and/or triglycerides and/or body weight management or weight reduction and/or redistribution of fat and/or reduction in visceral and/or abdominal fat deposition in a subject.

Methods for preventing or reducing weight gain due to factors such as drug use, cessation of smoking, and the like in a human subject, utilizing H₁-receptor agonists that have a pharmacological half-life that allows an efficient treatment regime thereof are disclosed.

A vehicle seat frame having high strength achieved without involving an increase in the weight of the seat frame. A back center frame (23) of a seatback frame (20) is hollow and has a rectangular pillar-like shape. A connection member (32) has a circular tube section (33) having a circular outer periphery, a ceiling section (34) projecting inward from axial one end of the circular tube section (33), and a flange section (35) projecting outward from the other axial end of the circular tube section (33). The ceiling section (34) of the connection member (32) is secured to the inner surface of one side plate section (23a) of the back center frame (23), that surface of the flange section (35) which is located on the circular tube section (33) side is secured to the outer surface of the other side plate section (23b) of the back center frame (23), and that surface of the flange section (35) which is located on the opposite side of the circular tube section (33) is connected to a bracket (14) with a recliner (30) in between.

The present disclosure provides Diels-Alder adducts of chalcone and prenylphenyl moieties capable of modulating the activity of cannabinoid receptors, and to oligomers of flavan-3-ol capable of modulating fat absorption and storage. Such Diels-Alder adducts of chalcone and prenylphenyl moieties or oligomers of flavan-3-ol can optionally be used in combination with other weight management agents, such as anorectic agents, a lipase inhibitors, other cannabinoid receptor modulators, psychotropic agents, insulin sensitizers, stimulants, or satiety agents, as well as to methods of use thereof such as treating or preventing weight gain or obesity, promoting weight loss, appetite suppression, modifying satiety, or the like.

The invention provides a porous sound-insulation structural body, comprising an outer side element and an inner side element arranged opposite to each other, wherein, the inner side element is provided with a plurality of through holes, and the thickness of the inner side element, the diameter Phi of the through holes and the numerical aperture are set to generate viscous-damping effect on the air in the through holes when the sound frequency is lower than 30 Hz. The invention is characterized in that the outer side element and the inner side element are arranged opposite to each other through an air layer; the inner side element can be in various shapes, more than two shapes or a combination of multiple shapes; the length of the inner side element part forming the through holes is preferably shorter than 1/2 of the sound wavelength of the sound insulation object and the thickness of the air layer is preferably shorter than 1/2 of the sound wavelength or in integral multiples of the half-wave of the sound insulation object. The porous sound-insulation structural body has the advantages of performing high sound insulation effect at relatively broad frequency band for low-frequency sound.

The invention provides methods for treating diabetes or obesity, as well as methods for inducing weight loss, preventing weight gain, or controlling weight in a patient in need thereof. The methods comprise administering to the patient at least one effective dose of a GLP-1 receptor agonist, or a regimen of GLP-1 receptor agonist comprising a plurality of substantially evenly spaced doses. The effective dose or regimen does not induce substantial nausea or appetite suppression in the patient.