10 results about "Pyrazoline" patented technology

The present invention provides a vasodilator capable of dilating a blood vessel even in the presence of ROS. A vasodilator of the present invention includes:a compound represented by the following formula (1) or a salt thereof:where in the formula (1),an A ring and a B ring may be the same or different and are each a pyrazole ring having a substituent or a pyrazoline ring having a substituent, andL is a saturated or unsaturated hydrocarbon group.

The present invention provides a synergistic herbicidal composition comprising of phenylpyrazoline class of herbicide such as Pinoxaden, Triazinone class of herbicide such as Metribuzin and at least one herbicidal compound is selected from Isoproturon or Metsulfuron-methyl.

The present invention addresses the problem of providing a novel electroporation introduction agent.　The problem is solved by an introduction agent for introducing a nucleic acid and / or a protein into a cell by electroporation, the introduction agent containing (1) a basal medium for cell culture, (2) a C5 or C6 monosaccharide sugar alcohol, (3) an aqueous polysaccharide solution, (4) a nonionic surfactant, (5) a pyrazoline compound, and (6) N-acetyl-L-cysteine.

The application provides a sulfonic acid solid acid catalyst and a preparation method thereof and a method for catalyzing keto-nitrogen isomerization into 2-pyrazoline, and belongs to the technical field of novel aerospace fuels, so as to solve the technical problems of catalyst separation and recovery difficulty and large acid-containing wastewater discharge in the keto-nitrogen isomerization cyclization method catalyzed by a homogeneous acid. The solid acid catalyst mainly comprises methyl sulfonic acid and a carrier amorphous silica, and the main feature of the solid acid catalyst is a high B acid center. In addition, the application provides a method for synthesizing 2-pyrazoline by catalyzing keto-nitrogen isomerization with a sulfonic acid solid acid catalyst, compared with a traditional homogeneous acid method, the catalyst can be easily separated from the reaction system and can be recycled, so that the production cost is reduced; the generation of a large amount of acid-containing wastewater in the removal process of the acid catalyst is solved, so that the wastewater treatment cost is greatly reduced; the method has high catalytic efficiency, and the catalyst can be recycled for three times, so that the catalytic efficiency is maintained.

The application discloses a preparation method of pyrazoline, which comprises the following steps: (1) mixing a ketone hydrazine raw material with a Lewis acid catalyst, and heating to perform a reaction to obtain a reaction mixture; and (2) cooling and filtering the reaction mixture, and purifying to obtain a pyrazoline product. In the application, the Lewis acid catalyst acts as an electron pair acceptor, coordinates with a nitrogen atom or an oxygen atom in the ketone hydrazine, and activates the ketone hydrazine molecule; the activated ketone hydrazine molecule is more prone to intramolecular cyclization reaction, and forms a pyrazoline ring; the Lewis acid does not provide a proton, and thus the hydrolysis of the ketone hydrazine and side reactions caused by a protonic acid catalyst are avoided, and the selectivity and yield of the product are improved; in addition, the Lewis acid catalyst can be filtered and recycled for reuse, meets the principle of green chemistry, and reduces environmental pollution and resource waste; and the preparation method has low requirements on reaction conditions, is simple to operate, and is suitable for industrial production.

This invention proposes a reaction-controlled phase transfer catalyst, its preparation method, and a method for catalytic synthesis of 2-pyrazoline, belonging to the technical field of the aerospace industry. It addresses the technical problems of difficult separation and recovery, poor reusability, and easy loss of solid catalysts. The preparation method of the reaction-controlled phase transfer catalyst of this invention includes the following steps: mixing and dissolving a bidentate nitrogen heterocyclic compound, an organic sulfonic acid, and a solvent; then reacting; after the reaction is complete, rotary evaporation and washing are performed to precipitate crystals, which are then dried to obtain the reaction-controlled phase transfer catalyst. The reaction-controlled phase transfer catalyst of this invention is a type of unconventional ionic liquid that is solid at room temperature. It is applied for the first time to the catalytic synthesis of 2-pyrazoline. In this reaction, the novel reaction-controlled phase transfer catalyst exhibits a unique liquid-solid self-separation phenomenon, achieving enhanced coupling between reaction and separation, and guiding a highly efficient and green synthesis reaction process. More importantly, it achieves stable precipitation with high recovery rate of the reaction-controlled phase transfer catalyst, realizing the invention's objective of catalyst reuse, and overcoming the problems of greening, energy saving, and low overall cost in processes using traditional inorganic / organic acid catalysts and solid catalysts widely used in industry.

This invention discloses a method for preparing pyrazoline compounds with insecticidal activity, belonging to the field of pesticide chemistry. The invention includes the following steps: (1) In a solution environment, compound 1 and ethyl diazonate react to generate compound 2 under the action of a photocatalyst and additives; (2) In a solution environment, compound 2 reacts to generate compound 3 under the action of a reducing agent; (3) In a solution environment, compound 3 reacts with trimethylcyanosilanes under the action of triphenylphosphine, diiodoethane, and an alkali to generate compound 4; (4) In a solution environment, compound 4 removes the tert-butyloxycarbonyl group under the action of an acid and reacts with trifluoromethoxyphenyl isocyanate to generate 1-(4-trifluoromethoxyphenylformamido)-3-(4-chlorophenyl)-4-(3-cyanopropyl)-2-pyrazoline. The process of this invention is simple to operate, the reaction conditions are mild, and the experimental raw materials are easy to obtain and prepare, which is conducive to industrialization and promotion.

An ethoxy / propoxy modified pyrazoline organic matter, an application thereof, a photocurable composition, and a photoresist. The introduction of —CH2—CH2—O(EO) and / or —CH(CH3)—CH2—O(PO) enables an EO / PO modified pyrazoline organic matter to have excellent compatibility with other components in a photocuring system, and the organic matter is solid, and is easy to add and use. In addition, the ethoxy / propoxy modified pyrazoline organic matter has an absorption band of 360-400 nm, and is thus particularly suitable for use as a sensitizer in the photocuring system (such as a system containing a bisimidazole photoinitiator), thereby greatly improving the sensitivity of the photocuring system. On this basis, the EO / PO modified pyrazoline organic matter has high sensitivity enhancement, features low usage, is solid, and is easy to add and use.

The application discloses a kind of medium voltage fireproof cable and preparation method thereof, it is related to cable technical field.The application is when preparing medium voltage fireproof cable, mica base fire resistance layer is coated on the surface of conductor, copper protective layer is coated on the surface of mica base fire resistance layer, protective sleeve is coated on the surface of copper protective layer;The protective sleeve is prepared by modified polyethylene, modified silicon dioxide, catalyst, plasticizer, lubricant;The modified polyethylene is obtained by grafting 3-amino-1-phenyl-2-pyrazoline-5-ketone after maleic anhydride grafting polyethylene, and diazonium salt reaction, and then reacting with allyl boronic acid;The modified silicon dioxide is obtained by reacting with 3,4-dinitrophenol after polymerization on the surface of silicon dioxide modified by p-hydroxystyrene and vinyltrimethoxysilane, and then reducing, and reacting with 2-((2-nitrobenzyl)thio)ethylamine, and then deprotecting.The medium voltage fireproof cable prepared by the application has good fire resistance and anti-aging performance.

This invention relates to a phenylpyrazoline compound, its preparation method, and its application. It can improve the herbicidal activity, safety, or economy of phenylpyrazoline compounds and further reduce production costs. This invention provides an economically feasible method that is beneficial for the regionally selective preparation of intermediates on an industrial scale.