41 results about "Pyrazoline" patented technology

A dry film resist, a photosensitive dry film, and a copper clad laminate. The dry film resist includes an alkali-soluble resin (A), a photopolymerization monomer (B), a photoinitiator (C), and a sensitizer (D); and the sensitizer (D) includes a compound containing a pyrazoline structure.

The present invention relates to an electrochemical process for the synthesis of pyrazolines and pyrazoles of formula (I). The method can be used in particular for the synthesis of the herbicide safener mefenpyr-diethyl. # imgabs0 #

The invention provides a method and a system for synthesizing 5-methyl-3, 5-dicyclopropyl pyrazoline through reaction-separation coupling of a micro-fluidic chip and a super-hydrophilic / underwater super-oleophobic film, belongs to the technical field of spaceflight liquid propellants, and aims to solve the technical problem that the 5-methyl-3, 5-dicyclopropyl pyrazoline cannot be continuously prepared. The preparation method disclosed by the invention comprises the following steps: respectively preheating 1, 3-dicyclopropyl-2-butene-1-one and hydrazine hydrate, introducing the preheated 1, 3-dicyclopropyl-2-butene-1-one and hydrazine hydrate into a micro-fluidic chip for reaction, and separating and dehydrating a cooled material which flows out after the reaction through a super-hydrophilic / underwater super-oleophobic membrane to obtain the 5-methyl-3, 5-dicyclopropyl pyrazoline. According to the present invention, the micro-chemical chip continuous flow synthesis technology and the super-hydrophilic / underwater super-oleophobic membrane separation technology are coupled in real time, such that the reaction-separation process integration continuity is achieved, the heterogeneous liquid-liquid mass transfer and mixing of the system are enhanced, and the efficient preparation of the 5-methyl-3, 5-dicyclopropyl pyrazoline and the real-time rapid oil-water separation are achieved.

The present invention belongs to the technical field of pharmaceutical synthesis, and specifically relates to a new intermediate compound I-1 of pyrazoline. The present invention uses 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine as a raw material to synthesize the new intermediate compound I-1. The present invention also provides a new method for synthesizing pyrazoline using the intermediate. Compared with the existing technology, the method can significantly shorten the reaction steps, has low production cost, and is simple to operate. The prepared zolpidem has high purity and yield, and is suitable for industrial production.

The present invention provides a vasodilator capable of dilating a blood vessel even in the presence of ROS. A vasodilator of the present invention includes:a compound represented by the following formula (1) or a salt thereof:where in the formula (1),an A ring and a B ring may be the same or different and are each a pyrazole ring having a substituent or a pyrazoline ring having a substituent, andL is a saturated or unsaturated hydrocarbon group.

The present invention relates to the design and synthesis of a class of novel chiral phosphine ligand, 1,2-bis(diphenylphosphinoalkylamido)-1,2-disubstituted ethane, and use in asymmetric catalytic reactions, such as asymmetric catalytic synthesis of pyrazoline-5-one with a chiral quaternary carbon center, i.e., highly enantioselective synthesis of 3-methyl-4-benzyl-4-(2-butyl-2,3-butadienyl)pyrazoline-5-one by using 3-methyl-4-benzylpyrazoline-5-one and benzyl (2-butyl-2,3-butadienyl) carbonate with tris(dibenzylideneacetone)dipalladium-chloroform adduct and this novel ligand as catalysts. The ligand designed by this present invention has the following advantages: the structure is novel, the synthesis and enlarge are simple, the enantioselective control effect in the practical reaction is excellent, which has a broad application prospect in chiral catalysis.

The invention provides a pyrazoline continuous production system and method, belongs to the technical field of chemical raw material preparation, and aims to solve the technical problem that pyrazoline cannot be continuously produced. The pyrazoline continuous production system comprises a storage tank, a ketone hydrazine condensation reaction kettle, a membrane separation dehydration device, a batching tank, a tubular reactor and a pyrazoline collection tank which are connected in sequence, the storage tank comprises a ketone storage tank and a hydrazine storage tank which are arranged in parallel; and the batching tank is also connected with a catalyst storage tank. The oil-water mixture is separated by adopting a membrane separation method, the method is simple and easy to implement, low in energy consumption, simple and clear in technical route, high in universality and capable of continuously separating the ketazine / water mixture and continuously producing the pyrazoline product, the pyrazoline yield is greatly improved, and the method is suitable for industrial production. A new thought different from intermittent reaction production is provided for continuous production of pyrazoline.

The invention discloses a crystal form of an N-formamido pyrazoline compound as well as a preparation method and application of the crystal form. The invention provides a crystal form of a compound as shown in a formula A. The crystal form is a crystal form I, a crystal form II, a crystal form III, a crystal form IV, a crystal form V, a crystal form VI or a crystal form VII, and discloses a preparation method, a composition and application of the crystal form in preparation of a P2X3 receptor antagonist. The invention also relates to application of the compound in preparation of drugs for treating respiratory system diseases, pains caused by various reasons, and skin diseases. The crystal form stability is good, the hygroscopicity is small, and the patent medicine prospect is good. # imgabs0 #

The present application provides methods of treating PI3Kδ related disorders using pyrazolopyrimidine derivatives.

The present invention relates to an electrochemical process for the synthesis of pyrazolines and pyrazoles of the formula (I). The process can be used in particular for the synthesis of the herbicide safener mefenpyr-diethyl.

The invention discloses a high-safety pyrazoline oxidation reaction device, and relates to the technical field of oxidation reaction devices, the high-safety pyrazoline oxidation reaction device comprises a shell and a heat conduction oil circulation temperature control assembly, and the side surface of the outer wall of the shell is connected with the heat conduction oil circulation temperature control assembly; the heat conduction oil circulation temperature control assembly comprises an oil outlet upper connector, an oil outlet lower connector, an oil outlet pipe, a circulation temperature control pump, an oil inlet pipe and an oil inlet connector. According to the present invention, by installing the heat conduction oil circulation temperature control assembly, the accurate control of the reaction temperature is achieved, the heat conduction oil temperature is adjusted in real time, the reaction temperature is stably controlled in the target interval, the abnormal reaction caused by the temperature fluctuation is avoided, and the temperature stability and the safety of the reaction system are maintained.

The present invention provides a synergistic herbicidal composition comprising of phenylpyrazoline class of herbicide such as Pinoxaden, Triazinone class of herbicide such as Metribuzin and at least one herbicidal compound is selected from Isoproturon or Metsulfuron-methyl.

To provide an ink having excellent storage stability and high light fastness.SOLUTION: Provided is an ink including a medium and carrier particles dyed with an anthraquinone compound as a cyan colorant, a monoazo compound as a magenta colorant, and a pyrazoline compound as a yellow colorant.SELECTED DRAWING: None

The present invention addresses the problem of providing a novel electroporation introduction agent.　The problem is solved by an introduction agent for introducing a nucleic acid and / or a protein into a cell by electroporation, the introduction agent containing (1) a basal medium for cell culture, (2) a C5 or C6 monosaccharide sugar alcohol, (3) an aqueous polysaccharide solution, (4) a nonionic surfactant, (5) a pyrazoline compound, and (6) N-acetyl-L-cysteine.

To provide a pyrazoline-based compound and a photocurable composition containing the same.SOLUTION: The pyrazoline compound has a structure represented by formula (I). The photocurable composition contains an alkali-soluble polymer (A), a monomer or oligomer (B) having a double bond, a photoinitiator (C), and a sensitizer (D) containing the pyrazoline-based compound. Since the pyrazoline-based compound has an absorption wavelength that can match the photoinitiator, the photosensitivity of the photocurable composition can be improved.SELECTED DRAWING: None

The invention relates to a double-pyrazoline structure sensitizer as well as a preparation method and application thereof. The double-pyrazoline structure sensitizer disclosed by the invention has a structure as shown in a formula (1). The bipyrazoline structure sensitizer has a wide UV absorption spectrum, and is strong in absorption, more excellent in photosensitive activity and good in solid form. Besides, the flexibility of the two pyrazoline groups is adjusted by introducing an ether bond and an additional alkoxy structure, so that on one hand, the designed molecular solid form is ensured to be good, and on the other hand, the compatibility in a photocuring system is ensured to be good. The photocuring composition containing the photocuring composition has excellent photosensitivity and developability, and the cured composition has good resolution and strong adhesive force.

The utility model provides an oxidation hydrolysis reaction system for replacing pyrazoline. The oxidation hydrolysis reaction system comprises an oxidation reactor, a first solid-liquid separator, a first distillation kettle, a hydrolysis reactor, an acidification reactor, a second solid-liquid separator, a first washing separation unit and a first drying machine, a solid phase outlet of the first solid-liquid separator and a liquid phase outlet of the second solid-liquid separator are both communicated with a feed port of the neutralization kettle, and a discharge port of the neutralization kettle is sequentially communicated with the evaporation unit, the crystallization kettle, the third solid-liquid separator, the dissolution kettle, the fourth solid-liquid separator and the second drying machine. According to the reaction system provided by the utility model, substituted pyrazole acid and potassium sulfate salt can be separated at the same time, the generation of three wastes is reduced, and the reaction system also has positive significance on environmental protection, greenness and sustainable development.

The application provides a sulfonic acid solid acid catalyst and a preparation method thereof and a method for catalyzing keto-nitrogen isomerization into 2-pyrazoline, and belongs to the technical field of novel aerospace fuels, so as to solve the technical problems of catalyst separation and recovery difficulty and large acid-containing wastewater discharge in the keto-nitrogen isomerization cyclization method catalyzed by a homogeneous acid. The solid acid catalyst mainly comprises methyl sulfonic acid and a carrier amorphous silica, and the main feature of the solid acid catalyst is a high B acid center. In addition, the application provides a method for synthesizing 2-pyrazoline by catalyzing keto-nitrogen isomerization with a sulfonic acid solid acid catalyst, compared with a traditional homogeneous acid method, the catalyst can be easily separated from the reaction system and can be recycled, so that the production cost is reduced; the generation of a large amount of acid-containing wastewater in the removal process of the acid catalyst is solved, so that the wastewater treatment cost is greatly reduced; the method has high catalytic efficiency, and the catalyst can be recycled for three times, so that the catalytic efficiency is maintained.

The invention discloses a medium-voltage fireproof cable and a preparation method thereof, and relates to the technical field of cables. When the medium-voltage fireproof cable is prepared, the mica-based fireproof layer is coated on the surface of the conductor, the copper protection layer is coated on the surface of the mica-based fireproof layer, and the protection sleeve is coated on the surface of the copper protection layer; the protective sleeve is prepared from modified polyethylene, modified silicon dioxide, a catalyst, a plasticizer and a lubricant; the modified polyethylene is prepared by the following steps: grafting maleic anhydride grafted polyethylene with 3-amino-1-phenyl-2-pyrazoline-5-ketone, reacting with diazonium salt, and reacting with allylboronic acid; the modified silicon dioxide is obtained by polymerizing p-hydroxystyrene on the surface of silicon dioxide modified by vinyltrimethoxysilane, then reacting with 3, 4-dinitrophenol, reducing, then reacting with 2-((2-nitrobenzyl) thio) ethylamine, and then deprotecting. The medium-voltage fireproof cable prepared by the invention has good fire resistance and aging resistance.

The application discloses a preparation method of pyrazoline, which comprises the following steps: (1) mixing a ketone hydrazine raw material with a Lewis acid catalyst, and heating to perform a reaction to obtain a reaction mixture; and (2) cooling and filtering the reaction mixture, and purifying to obtain a pyrazoline product. In the application, the Lewis acid catalyst acts as an electron pair acceptor, coordinates with a nitrogen atom or an oxygen atom in the ketone hydrazine, and activates the ketone hydrazine molecule; the activated ketone hydrazine molecule is more prone to intramolecular cyclization reaction, and forms a pyrazoline ring; the Lewis acid does not provide a proton, and thus the hydrolysis of the ketone hydrazine and side reactions caused by a protonic acid catalyst are avoided, and the selectivity and yield of the product are improved; in addition, the Lewis acid catalyst can be filtered and recycled for reuse, meets the principle of green chemistry, and reduces environmental pollution and resource waste; and the preparation method has low requirements on reaction conditions, is simple to operate, and is suitable for industrial production.

The present invention relates to a method of treating or preventing pain and inflammation associated to surgery in a mammal by administering the compound E-6087 to the mammal.

The invention discloses a pyrazolone compound as well as a preparation method and application thereof. The pyrazolone compound has a structure as shown in a formula (I), in the formula (I), R1 and R2 are substituent groups at any position on a benzene ring, and R1-R2 are the same or different and are independently selected from hydrogen or C1-C6 alkyl. Compared with 3-methyl-1-phenyl-2-pyrazoline-5-ketone (EDA), the pyrazolone compound disclosed by the invention can be used for more effectively inhibiting oxidative stress, inhibiting neuronal apoptosis and improving cerebral ischemia reperfusion injury. # imgabs0 #

The invention belongs to the technical field of medicines, and particularly discloses application of an aza-four-membered ring connected pyrazolopyridine compound in preparation of medicines for treating pulmonary arterial hypertension. Compared with the prior art, the pyrazolopyridine PDE10A inhibitor connected with the aza four-membered ring can inhibit the enzymatic activity of PDE10A so as to play a potential role in resisting pulmonary arterial hypertension, so that the invention further provides a new application of the compound, and the compound can be applied to preparation of drugs for treating pulmonary arterial hypertension. The invention also relates to application of the pyrazolopyridine PDE10A inhibitor connected with the aza four-membered ring in preparation of drugs for treating pulmonary arterial hypertension.

A dry film resist, a photosensitive dry film and a copper-clad laminate, the dry film resist comprising (A) an alkali-soluble resin, (B) a photopolymerizable monomer, (C) a photopolymerization initiator and (D) a sensitizer, the sensitizer comprising a compound containing a pyrazoline structure. The dry film resist has good overall performance due to the use of a specific type of sensitizer, and is particularly outstanding in photosensitivity, resolution, alignment recognition adaptability and electroplating resistance.

The invention relates to the technical field of organic synthesis, and particularly discloses a pyrazoline preparation method, which comprises: (1) mixing a ketazine raw material, a weak acid stabilizer and an acid catalyst, and heating to carry out a reaction to obtain a reaction mixture; and (2) cooling the reaction mixture, quenching, washing with water, distilling and purifying to obtain the pyrazoline product. According to the invention, the acid catalyst is used as an electron pair acceptor and is coordinated with nitrogen atoms in ketazine to activate ketazine molecules; the activated ketazine molecules are more easily subjected to intramolecular cyclization reaction to generate pyrazoline; due to the existence of the weak acid stabilizer, the active amino group of pyrazoline is protected, and the Michael addition reaction of pyrazoline and ketazine is inhibited; the preparation method has low requirements on reaction conditions, is simple and convenient to operate, is suitable for industrial production, effectively improves the selectivity and yield of pyrazoline products, and provides a new way for efficient preparation of pyrazoline.

The invention provides a reaction control phase transfer catalyst, a preparation method thereof and a method for catalytically synthesizing 2-pyrazoline, belongs to the technical field of aerospace industry, and aims to solve the technical problems that a solid catalyst is difficult to separate and recycle, poor in reutilization and easy to lose. The preparation method of the reaction control phase transfer catalyst comprises the following steps: mixing and dissolving a bidentate nitrogen heterocyclic compound, organic sulfonic acid and a solvent, then carrying out a reaction, after the reaction is finished, carrying out rotary evaporation and washing to separate out crystals, and drying to prepare the reaction control phase transfer catalyst. The reaction control phase transfer catalyst is an unconventional ionic liquid which is in a solid state at normal temperature. The novel reaction control phase transfer catalyst is applied to the catalytic synthesis reaction of 2-pyrazoline for the first time, in the reaction process, the novel reaction control phase transfer catalyst shows a peculiar liquid-solid self-separation phenomenon, reaction and separation coupling strengthening is achieved, and the efficient and green synthesis reaction process is guided out. More importantly, stable precipitation with high recovery rate of the reaction control phase transfer catalyst is realized, the purpose of repeated application of the catalyst is realized, and the problems of greenization, energy conservation, low comprehensive cost and the like in the process of the traditional inorganic / organic acid catalyst, solid catalyst and the like which are widely used in the industry at present can be solved.

This invention proposes a reaction-controlled phase transfer catalyst, its preparation method, and a method for catalytic synthesis of 2-pyrazoline, belonging to the technical field of the aerospace industry. It addresses the technical problems of difficult separation and recovery, poor reusability, and easy loss of solid catalysts. The preparation method of the reaction-controlled phase transfer catalyst of this invention includes the following steps: mixing and dissolving a bidentate nitrogen heterocyclic compound, an organic sulfonic acid, and a solvent; then reacting; after the reaction is complete, rotary evaporation and washing are performed to precipitate crystals, which are then dried to obtain the reaction-controlled phase transfer catalyst. The reaction-controlled phase transfer catalyst of this invention is a type of unconventional ionic liquid that is solid at room temperature. It is applied for the first time to the catalytic synthesis of 2-pyrazoline. In this reaction, the novel reaction-controlled phase transfer catalyst exhibits a unique liquid-solid self-separation phenomenon, achieving enhanced coupling between reaction and separation, and guiding a highly efficient and green synthesis reaction process. More importantly, it achieves stable precipitation with high recovery rate of the reaction-controlled phase transfer catalyst, realizing the invention's objective of catalyst reuse, and overcoming the problems of greening, energy saving, and low overall cost in processes using traditional inorganic / organic acid catalysts and solid catalysts widely used in industry.

The invention provides a pyrazoline sensitizer, a preparation method of the pyrazoline sensitizer, a photosensitive resin composition containing the pyrazoline sensitizer and application of the photosensitive resin composition. The pyrazoline sensitizer has a structure as shown in a formula I; the pyrazoline sensitizer has an excellent sensitizing effect, and is good in compatibility with resin and the like, so that the photosensitive resin composition containing the sensitizer is short in curing time, the ultraviolet curing efficiency is remarkably improved, and the pyrazoline sensitizer is particularly suitable for a UV-LED light curing system.

The invention discloses a method for synthesizing pyrazoline by catalyzing ketazine internal cyclization with a zinc-based catalyst, which comprises the following steps: sequentially adding a ketazine compound and the zinc-based catalyst into a device, and stirring for reaction to obtain a pyrazoline compound. The preparation method disclosed by the invention is simple in process condition and high in yield, and the Zn-based catalyst is easy to obtain, easy in product separation and convenient to recycle; few three wastes are generated in the synthesis process, the method is suitable for industrial amplification, and the obtained target product pyrazoline is diversified and unique in structure and meets the requirement of serving as a biological medicine intermediate in the aspect of biological medicine; in the optical aspect, the compound can be used for fluorescent materials or fluorescent probes, and the industrial application prospect is very wide.