28 results about "Pyrazoline" patented technology

A dry film resist, a photosensitive dry film, and a copper clad laminate. The dry film resist includes an alkali-soluble resin (A), a photopolymerization monomer (B), a photoinitiator (C), and a sensitizer (D); and the sensitizer (D) includes a compound containing a pyrazoline structure.

The invention provides a method and a system for synthesizing 5-methyl-3, 5-dicyclopropyl pyrazoline through reaction-separation coupling of a micro-fluidic chip and a super-hydrophilic / underwater super-oleophobic film, belongs to the technical field of spaceflight liquid propellants, and aims to solve the technical problem that the 5-methyl-3, 5-dicyclopropyl pyrazoline cannot be continuously prepared. The preparation method disclosed by the invention comprises the following steps: respectively preheating 1, 3-dicyclopropyl-2-butene-1-one and hydrazine hydrate, introducing the preheated 1, 3-dicyclopropyl-2-butene-1-one and hydrazine hydrate into a micro-fluidic chip for reaction, and separating and dehydrating a cooled material which flows out after the reaction through a super-hydrophilic / underwater super-oleophobic membrane to obtain the 5-methyl-3, 5-dicyclopropyl pyrazoline. According to the present invention, the micro-chemical chip continuous flow synthesis technology and the super-hydrophilic / underwater super-oleophobic membrane separation technology are coupled in real time, such that the reaction-separation process integration continuity is achieved, the heterogeneous liquid-liquid mass transfer and mixing of the system are enhanced, and the efficient preparation of the 5-methyl-3, 5-dicyclopropyl pyrazoline and the real-time rapid oil-water separation are achieved.

The present invention belongs to the technical field of pharmaceutical synthesis, and specifically relates to a new intermediate compound I-1 of pyrazoline. The present invention uses 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine as a raw material to synthesize the new intermediate compound I-1. The present invention also provides a new method for synthesizing pyrazoline using the intermediate. Compared with the existing technology, the method can significantly shorten the reaction steps, has low production cost, and is simple to operate. The prepared zolpidem has high purity and yield, and is suitable for industrial production.

The present invention provides a vasodilator capable of dilating a blood vessel even in the presence of ROS. A vasodilator of the present invention includes:a compound represented by the following formula (1) or a salt thereof:where in the formula (1),an A ring and a B ring may be the same or different and are each a pyrazole ring having a substituent or a pyrazoline ring having a substituent, andL is a saturated or unsaturated hydrocarbon group.

The present invention relates to an electrochemical process for the synthesis of pyrazolines and pyrazoles of the formula (I). The process can be used in particular for the synthesis of the herbicide safener mefenpyr-diethyl.

The invention discloses a high-safety pyrazoline oxidation reaction device, and relates to the technical field of oxidation reaction devices, the high-safety pyrazoline oxidation reaction device comprises a shell and a heat conduction oil circulation temperature control assembly, and the side surface of the outer wall of the shell is connected with the heat conduction oil circulation temperature control assembly; the heat conduction oil circulation temperature control assembly comprises an oil outlet upper connector, an oil outlet lower connector, an oil outlet pipe, a circulation temperature control pump, an oil inlet pipe and an oil inlet connector. According to the present invention, by installing the heat conduction oil circulation temperature control assembly, the accurate control of the reaction temperature is achieved, the heat conduction oil temperature is adjusted in real time, the reaction temperature is stably controlled in the target interval, the abnormal reaction caused by the temperature fluctuation is avoided, and the temperature stability and the safety of the reaction system are maintained.

The present invention provides a synergistic herbicidal composition comprising of phenylpyrazoline class of herbicide such as Pinoxaden, Triazinone class of herbicide such as Metribuzin and at least one herbicidal compound is selected from Isoproturon or Metsulfuron-methyl.

To provide an ink having excellent storage stability and high light fastness.SOLUTION: Provided is an ink including a medium and carrier particles dyed with an anthraquinone compound as a cyan colorant, a monoazo compound as a magenta colorant, and a pyrazoline compound as a yellow colorant.SELECTED DRAWING: None

The present invention addresses the problem of providing a novel electroporation introduction agent.　The problem is solved by an introduction agent for introducing a nucleic acid and / or a protein into a cell by electroporation, the introduction agent containing (1) a basal medium for cell culture, (2) a C5 or C6 monosaccharide sugar alcohol, (3) an aqueous polysaccharide solution, (4) a nonionic surfactant, (5) a pyrazoline compound, and (6) N-acetyl-L-cysteine.

To provide a pyrazoline-based compound and a photocurable composition containing the same.SOLUTION: The pyrazoline compound has a structure represented by formula (I). The photocurable composition contains an alkali-soluble polymer (A), a monomer or oligomer (B) having a double bond, a photoinitiator (C), and a sensitizer (D) containing the pyrazoline-based compound. Since the pyrazoline-based compound has an absorption wavelength that can match the photoinitiator, the photosensitivity of the photocurable composition can be improved.SELECTED DRAWING: None

The invention relates to a double-pyrazoline structure sensitizer as well as a preparation method and application thereof. The double-pyrazoline structure sensitizer disclosed by the invention has a structure as shown in a formula (1). The bipyrazoline structure sensitizer has a wide UV absorption spectrum, and is strong in absorption, more excellent in photosensitive activity and good in solid form. Besides, the flexibility of the two pyrazoline groups is adjusted by introducing an ether bond and an additional alkoxy structure, so that on one hand, the designed molecular solid form is ensured to be good, and on the other hand, the compatibility in a photocuring system is ensured to be good. The photocuring composition containing the photocuring composition has excellent photosensitivity and developability, and the cured composition has good resolution and strong adhesive force.

The application provides a sulfonic acid solid acid catalyst and a preparation method thereof and a method for catalyzing keto-nitrogen isomerization into 2-pyrazoline, and belongs to the technical field of novel aerospace fuels, so as to solve the technical problems of catalyst separation and recovery difficulty and large acid-containing wastewater discharge in the keto-nitrogen isomerization cyclization method catalyzed by a homogeneous acid. The solid acid catalyst mainly comprises methyl sulfonic acid and a carrier amorphous silica, and the main feature of the solid acid catalyst is a high B acid center. In addition, the application provides a method for synthesizing 2-pyrazoline by catalyzing keto-nitrogen isomerization with a sulfonic acid solid acid catalyst, compared with a traditional homogeneous acid method, the catalyst can be easily separated from the reaction system and can be recycled, so that the production cost is reduced; the generation of a large amount of acid-containing wastewater in the removal process of the acid catalyst is solved, so that the wastewater treatment cost is greatly reduced; the method has high catalytic efficiency, and the catalyst can be recycled for three times, so that the catalytic efficiency is maintained.

The invention discloses a medium-voltage fireproof cable and a preparation method thereof, and relates to the technical field of cables. When the medium-voltage fireproof cable is prepared, the mica-based fireproof layer is coated on the surface of the conductor, the copper protection layer is coated on the surface of the mica-based fireproof layer, and the protection sleeve is coated on the surface of the copper protection layer; the protective sleeve is prepared from modified polyethylene, modified silicon dioxide, a catalyst, a plasticizer and a lubricant; the modified polyethylene is prepared by the following steps: grafting maleic anhydride grafted polyethylene with 3-amino-1-phenyl-2-pyrazoline-5-ketone, reacting with diazonium salt, and reacting with allylboronic acid; the modified silicon dioxide is obtained by polymerizing p-hydroxystyrene on the surface of silicon dioxide modified by vinyltrimethoxysilane, then reacting with 3, 4-dinitrophenol, reducing, then reacting with 2-((2-nitrobenzyl) thio) ethylamine, and then deprotecting. The medium-voltage fireproof cable prepared by the invention has good fire resistance and aging resistance.

The application discloses a preparation method of pyrazoline, which comprises the following steps: (1) mixing a ketone hydrazine raw material with a Lewis acid catalyst, and heating to perform a reaction to obtain a reaction mixture; and (2) cooling and filtering the reaction mixture, and purifying to obtain a pyrazoline product. In the application, the Lewis acid catalyst acts as an electron pair acceptor, coordinates with a nitrogen atom or an oxygen atom in the ketone hydrazine, and activates the ketone hydrazine molecule; the activated ketone hydrazine molecule is more prone to intramolecular cyclization reaction, and forms a pyrazoline ring; the Lewis acid does not provide a proton, and thus the hydrolysis of the ketone hydrazine and side reactions caused by a protonic acid catalyst are avoided, and the selectivity and yield of the product are improved; in addition, the Lewis acid catalyst can be filtered and recycled for reuse, meets the principle of green chemistry, and reduces environmental pollution and resource waste; and the preparation method has low requirements on reaction conditions, is simple to operate, and is suitable for industrial production.

The invention relates to the technical field of organic synthesis, and particularly discloses a pyrazoline preparation method, which comprises: (1) mixing a ketazine raw material, a weak acid stabilizer and an acid catalyst, and heating to carry out a reaction to obtain a reaction mixture; and (2) cooling the reaction mixture, quenching, washing with water, distilling and purifying to obtain the pyrazoline product. According to the invention, the acid catalyst is used as an electron pair acceptor and is coordinated with nitrogen atoms in ketazine to activate ketazine molecules; the activated ketazine molecules are more easily subjected to intramolecular cyclization reaction to generate pyrazoline; due to the existence of the weak acid stabilizer, the active amino group of pyrazoline is protected, and the Michael addition reaction of pyrazoline and ketazine is inhibited; the preparation method has low requirements on reaction conditions, is simple and convenient to operate, is suitable for industrial production, effectively improves the selectivity and yield of pyrazoline products, and provides a new way for efficient preparation of pyrazoline.

This invention proposes a reaction-controlled phase transfer catalyst, its preparation method, and a method for catalytic synthesis of 2-pyrazoline, belonging to the technical field of the aerospace industry. It addresses the technical problems of difficult separation and recovery, poor reusability, and easy loss of solid catalysts. The preparation method of the reaction-controlled phase transfer catalyst of this invention includes the following steps: mixing and dissolving a bidentate nitrogen heterocyclic compound, an organic sulfonic acid, and a solvent; then reacting; after the reaction is complete, rotary evaporation and washing are performed to precipitate crystals, which are then dried to obtain the reaction-controlled phase transfer catalyst. The reaction-controlled phase transfer catalyst of this invention is a type of unconventional ionic liquid that is solid at room temperature. It is applied for the first time to the catalytic synthesis of 2-pyrazoline. In this reaction, the novel reaction-controlled phase transfer catalyst exhibits a unique liquid-solid self-separation phenomenon, achieving enhanced coupling between reaction and separation, and guiding a highly efficient and green synthesis reaction process. More importantly, it achieves stable precipitation with high recovery rate of the reaction-controlled phase transfer catalyst, realizing the invention's objective of catalyst reuse, and overcoming the problems of greening, energy saving, and low overall cost in processes using traditional inorganic / organic acid catalysts and solid catalysts widely used in industry.

The invention discloses a method for synthesizing pyrazoline by catalyzing ketazine internal cyclization with a zinc-based catalyst, which comprises the following steps: sequentially adding a ketazine compound and the zinc-based catalyst into a device, and stirring for reaction to obtain a pyrazoline compound. The preparation method disclosed by the invention is simple in process condition and high in yield, and the Zn-based catalyst is easy to obtain, easy in product separation and convenient to recycle; few three wastes are generated in the synthesis process, the method is suitable for industrial amplification, and the obtained target product pyrazoline is diversified and unique in structure and meets the requirement of serving as a biological medicine intermediate in the aspect of biological medicine; in the optical aspect, the compound can be used for fluorescent materials or fluorescent probes, and the industrial application prospect is very wide.

This invention discloses a method for preparing pyrazoline compounds with insecticidal activity, belonging to the field of pesticide chemistry. The invention includes the following steps: (1) In a solution environment, compound 1 and ethyl diazonate react to generate compound 2 under the action of a photocatalyst and additives; (2) In a solution environment, compound 2 reacts to generate compound 3 under the action of a reducing agent; (3) In a solution environment, compound 3 reacts with trimethylcyanosilanes under the action of triphenylphosphine, diiodoethane, and an alkali to generate compound 4; (4) In a solution environment, compound 4 removes the tert-butyloxycarbonyl group under the action of an acid and reacts with trifluoromethoxyphenyl isocyanate to generate 1-(4-trifluoromethoxyphenylformamido)-3-(4-chlorophenyl)-4-(3-cyanopropyl)-2-pyrazoline. The process of this invention is simple to operate, the reaction conditions are mild, and the experimental raw materials are easy to obtain and prepare, which is conducive to industrialization and promotion.

A method of analyzing phenylhydrazine content in a 3-methyl-1-phenyl-2-pyrazolin-5-one active pharmaceutical ingredient includes obtaining a first measured value by measuring a phenylhydrazine content of a standard solution including phenylhydrazine or a salt thereof, a first acidic water and a first water-soluble organic solvent and having a phenylhydrazine concentration of 0.01 μg / mL to 10 μg / mL, obtaining a second measured value by measuring a phenylhydrazine content in a sample solution including a 3-methyl-1-phenyl-2-pyrazolin-5-one active pharmaceutical ingredient, a second acidic water and a second water-soluble organic solvent, and detecting a phenylhydrazine content in a 3-methyl-1-phenyl-2-pyrazolin-5-one active pharmaceutical ingredient based on the first measured value and second measured value. The first acidic water includes hydrochloric acid, the first water-soluble organic solvent is acetonitrile and / or methanol, the second acidic water includes hydrochloric acid, and the second water-soluble organic solvent is acetonitrile and / or methanol.

An ethoxy / propoxy modified pyrazoline organic matter, an application thereof, a photocurable composition, and a photoresist. The introduction of —CH2—CH2—O(EO) and / or —CH(CH3)—CH2—O(PO) enables an EO / PO modified pyrazoline organic matter to have excellent compatibility with other components in a photocuring system, and the organic matter is solid, and is easy to add and use. In addition, the ethoxy / propoxy modified pyrazoline organic matter has an absorption band of 360-400 nm, and is thus particularly suitable for use as a sensitizer in the photocuring system (such as a system containing a bisimidazole photoinitiator), thereby greatly improving the sensitivity of the photocuring system. On this basis, the EO / PO modified pyrazoline organic matter has high sensitivity enhancement, features low usage, is solid, and is easy to add and use.

The application provides a preparation method of a trifluoromethyl-substituted pyrazoline compound, and the preparation method comprises the following steps: reacting an olefin compound with 2,2,2-trifluorodiazoethane in the presence of a Lewis base to obtain the trifluoromethyl-substituted pyrazoline compound, and the reaction region selectivity of the application is good, and the yield is high.

A phosphate compound of a substituted pyrazoline azo derivative or a pharmaceutically acceptable salt thereof. Specifically, provided are a compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound has good pharmacokinetic properties, and is beneficial to preparation of formulation forms having better patient compliance.

The present invention relates to an electrochemical method for the synthesis of pyrazolines and pyrazoles of formula (I). This method can be used in particular for the synthesis of mefenpyr-diethyl, a phytotoxicity reducer for herbicides.

The invention discloses a polyalkyl fluorene organic blue fluorescent material containing a pyrazoline ring and application of the polyalkyl fluorene organic blue fluorescent material in preparation of a photovoltaic adhesive film. The structural general formula of the polyalkyl fluorene organic blue fluorescent material containing the pyrazoline ring is as follows: # imgabs0 #, wherein R is selected from one of bromine, fluorine, chlorine, nitro, cyano, hydrogen or C1-12 alkyl. The organic blue fluorescent material of the pyrazoline ring-containing polyalkyl fluorene structure is added into a photovoltaic adhesive film as a light conversion agent to serve as a light conversion material, can absorb ultraviolet light to protect a solar cell, and releases visible light to be absorbed by the solar cell, so that the efficiency of the solar cell is improved. The series of light conversion materials are simple in synthesis process, stable in yield and suitable for industrial production.

The application discloses a kind of medium voltage fireproof cable and preparation method thereof, it is related to cable technical field.The application is when preparing medium voltage fireproof cable, mica base fire resistance layer is coated on the surface of conductor, copper protective layer is coated on the surface of mica base fire resistance layer, protective sleeve is coated on the surface of copper protective layer;The protective sleeve is prepared by modified polyethylene, modified silicon dioxide, catalyst, plasticizer, lubricant;The modified polyethylene is obtained by grafting 3-amino-1-phenyl-2-pyrazoline-5-ketone after maleic anhydride grafting polyethylene, and diazonium salt reaction, and then reacting with allyl boronic acid;The modified silicon dioxide is obtained by reacting with 3,4-dinitrophenol after polymerization on the surface of silicon dioxide modified by p-hydroxystyrene and vinyltrimethoxysilane, and then reducing, and reacting with 2-((2-nitrobenzyl)thio)ethylamine, and then deprotecting.The medium voltage fireproof cable prepared by the application has good fire resistance and anti-aging performance.

This invention relates to a phenylpyrazoline compound, its preparation method, and its application. It can improve the herbicidal activity, safety, or economy of phenylpyrazoline compounds and further reduce production costs. This invention provides an economically feasible method that is beneficial for the regionally selective preparation of intermediates on an industrial scale.

The invention discloses a pyrazoline compound and a photocuring composition containing the pyrazoline compound, and the pyrazoline compound is shown as a formula I: in the formula I, R1 is C1-14 straight chain alkylene, cycloalkyl substituted alkylene, aryl substituted alkylene, or a divalent organic group containing carbonyl or alkenylene.