Pharmaceutical composition and application thereof to preparation of medicament for treating cerebrovascular disease

Abstract

A pharmaceutical composition comprises 3-methyl-1-phenyl-2-pyrazoline-5-ketone and (+)-2-borneol. The pharmaceutical composition can be used in treating cerebrovascular disease and has lower toxic and side effects.

Description

technical field [0001] The invention relates to a pharmaceutical composition and its application in the preparation of medicines for treating cerebrovascular diseases. Background technique [0002] Cerebrovascular disease is a group of diseases that seriously endanger human health, and has become one of the important causes of human disability and death. [0003] Cerebrovascular disease (CVD for short) refers to brain lesions caused by abnormalities in cerebrovascular vessels. Stroke generally refers to acute cerebrovascular disease. [0004] Cerebrovascular diseases can be simply divided into two categories, one is ischemic cerebrovascular disease caused by the reduction or interruption of blood flow, and the other is hemorrhagic cerebrovascular disease caused by rupture of blood vessels. Ischemic cerebrovascular disease is mainly cerebral infarction (including cerebral thrombosis and cerebral embolism). In addition to cerebral infarction, there is another type of ischemi...

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Problems solved by technology

3-Methyl-1-phenyl-2-pyrazolin-5-one clinical dosage for adults is 60mg / d (mg / day), studies have found that it has certain side effects, such as acute renal failure of unknown degree, hepatic Adverse reactions such as dysfunction, thrombocytopenia and disseminated intravascular coagulation

According to the 2010 edition of the Chinese Pharmacopoeia, natural borneol contains no less than 96.0% borneol, synthetic borneol contains no less than 55.0%, and about 38% isoborneol. Its purity is not high and it is not the main component. Especially the presence of camphor may have some unwanted effects

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