174results about How to "Exact therapeutic effect" patented technology

The invention belongs to the field of medical biology, and particularly relates to a method for extracting a konjac polypeptide extract from konjac flying powder, the konjac polypeptide extract obtained by the method and an application of the konjac polypeptide extract. In order to increase the content of konjac polypeptide in the konjac polypeptide extract, the optimized extraction technology provided by the invention adopts a complex enzyme to perform enzymolysis on the protein extraction liquid of the konjac flying powder; in the finally obtained konjac polypeptide extract, the content of konjac polypeptide is as high as 85-97%, and the molecular weight of the konjac polypeptide is 350-3500Da. Moreover, the invention also provides an application of the konjac polypeptide extract in preparing a medicine for treating diabetes and diabetic complications as well as a hypoglycemic medicinal composition containing the konjac polypeptide extract. In a word, the konjac polypeptide extract and the medicinal composition thereof provided by the invention have good prospect in medicine.

Of the bioactive gel injection material for bone repairing, each dose consists of component A in 1 ml and component B in 45-55 mg. The component A contains sodium alginate 10-40 mg, bone morphogenetic protein 0.1-1 mg and mannitol 10-20 mg in each ml of bacteria-free physiological saline. Of the component B, each mg contains water insoluble calcium compound 0.05-0.15 mg, gluconolactone 0.05-0.3 mg and polyvinyl pyrrolidone 0.004-0.016 mg except mannitol. The injection material for bone repairing has excellent biocompatibility and simple and safe use, and may be injected to required bone treating position. Animal experiment shows that it has similar bone forming activity to operation implanted solid bone repairing material containing bone morphogenetic protein.

The invention belongs to the technical field of clinical medicinal treatment, in particular to a wound treating device which comprises a semi-transparent membrane, medical sponge and a porous negative pressure drainage tube positioned in the medical sponge, and also comprises a medical ozone water generator and an ozone water input pipe connected with the medical ozone water generator, wherein the medical ozone water generator is positioned in the medical sponge. The invention has simple structure, low cost, convenient and simple use and accurate treatment effect.

An injection-type composite bone repair material for treating bone fracture, nonunion, dysostosis and osteoporosis contains the fibrin in mammal's blood as carrier, genetically recombinant bone morphogenetic protein, fibroblast growth factor and beta-converting growth factor. Its advantages are sure curative effect, wide application range and high safety.

A compound medicine containing kurarinol, prostaglandic E1 and aspirin is prepared through including the kurarinol and prostaglandin E1 by 6-0-malto-beta-cyclodextrin, mixing, adding others, and preparing the freeze dried powder injection. It can be used for treating cancers, cardiovascular and cerebrovascular diseases and hepatitis. Its advantages are sure curative effect, and no toxic by-effect.

An extract of prunella spike for treating rheumatoid arthritis and improving immune suppression contains phenolic acid (60-70%) and rosemaric acid (14-21%). Its preparing process is also disclosed.

A photodynamic therapy apparatus as an estimating apparatus is an apparatus for irradiating a tissue having absorbed photo-sensitive pharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser the catheter, including a connector, a light source, and a light detection unit. The laser the catheter is capable of being attached / detached to / from the connector. The light source outputs the excitation light to the laser the catheter via the connector. The light detection unit detects intensity or a spectrum of the fluorescence, the fluorescence being entered from the laser the catheter via the connector, to estimate whether the tissue has changed because of reaction between the excitation light emitted from the tip portion of the laser the catheter and the photo-sensitive pharmaceutical absorbed in the tissue.

The invention relates to an external application of traditional Chinese medicines, and in particular relates to a traditional Chinese medicinal naval plaster with effect of promoting digestion and eliminating stagnation. The traditional Chinese medicinal naval plaster comprises the following components in parts by mass: 10-30 parts of paederia scandens, 6-12 parts of atractylodes macrocephala koidz, 5-12 parts of semen raphani, 3-10 parts of fructus aurantii immaturus, 6-15 parts of fructus forsythiae, 3-10 parts of artemisiae anomala, and 3-9 parts of rhizoma pinelliae preparata. The traditional Chinese herbal medicine has the effects of fortifying the spleen and harmonizing the stomach, promoting digestion and eliminating stagnation, and removing blood stasis and reducing phlegm in the value range, and has an exact treatment effect on food retention and other symptoms caused by food retention of children.

The invention relates to an application of pregabalin in preparing a drug for treating and preventing ischemic cerebrovascular diseases, and belongs to the medicine field. Pregabalin is a conventional drug. According to the invention, a great many of experiments demonstrate that pregabalin can reduce NO and NOS level of an ischemic patient when the pregabalin is applied in the treatment of ischemic cerebrovascular diseases particularly cerebral ischemia or cerebral infarction, can reduce MDA content in serum, and has an obvious protect effect for brain hippocampus neurons. The medical application of gabapentin can provide a novel drug selection of patients suffering from the ischemic cerebrovascular diseases, and has wide medical application prospects.

The invention discloses itching-relieving skin-care emulsifiable paste and a preparation method thereof. According to the preparation method, skin-moistening and itching-relieving components are extracted from a plurality of Chinese herbal medicines, various aromatherapy skin moistening substances are used, so that effective antioxidation is realized, the medicine is respectively subjected to micro-emulsion gel and liposome micro-capsule coating according to different purposes, the pH value is 5.8 to 6.5, the itching-relieving skin-care emulsifiable paste comprise 65-75wt% of micro-emulsion gel and 25-35wt% of liposome micro-capsules, the liposome micro-capsules contain an itching relieving traditional Chinese medicine liquid and have diameters of 250-350nm, the micro-emulsion gel comprises a micro-emulsion with the particle size of 30-90nm, the optimized emulsifiable paste improves the 24-hour transdermal absorption rate to 68% or above, the intradermal drug retention amount can reach4mg or above within 24h, skin moistening and itching relieving components can be effectively delivered into the skin, dryness and allergic pruritus are inhibited, the skin of the pruritus part is repaired from outside to inside, itching can be rapidly relieved, the drug effect lasting time is long, and pruritus recurrence is inhibited.

The invention discloses application of scutellarein in preparing angiogenesis treatment medicines, and belongs to the field of pharmacy. Experimental study proves that the scutellarein has higher angiogenesis inhibition function, and has exact prevention and treatment functions on angiogenesis-related diseases such as tumor, leukemia, lymphoma and hemangioma angiogenesis, benign angiogenesis, arthritis diseased tissue angiogenesis, eye diseased tissue angiogenesis and the like, and meanwhile, the scutellarein also has remarkable inhibition on stigmatization during wound healing. The scutellarein can directly act on endothelial cells of vessels, has small administration dosage and high clinical effect during clinical application, side effects are small, and drug resistance is not generated easily.

The invention pertains to the field of Chinese traditional medicine, in particular to a traditional Chinese medicine used for treating hepatopathy and a preparation method thereof. The traditional Chinese medicine is made of the following bulk drugs: capillary wormwood herb, giant knotweed, spreading hedyotis herb, red sage root, red peony root, nutagrass flatsedge rhizome, wolfberry fruit and ginseng. The traditional Chinese medicine has the advantages of simple formula, definite treatment effect, few toxic and side effects as will as high cure rate and quick effect. The cure rate of the traditional medicine is over 98% for common hepatitis A and over 80% for hepatitis B and other hepatic diseases.

The invention relates to an invermectin in-vivo gel injection and a preparation method thereof, aiming at providing a long-acting injection for preventing and treating livestock parasite infections, and a preparation method thereof. Raw materials required by every 100 mL of the invermectin in-vivo gel injection comprise 5 g-10 g of injection grade invermectin, 10 g-20 g of poly(lactic-co-glycolicacid) (PLGA), 1 g -2 g of carbomer-941, 0.1 g -0.2 g of tween-80 and 85 mL-90 mL of an organic solvent. The injection is an in-vivo gel prepared from invermectin, and is used for preventing and treating gastrointestinal parasites of cattle, pigs and sheep, lungworm and externally parasitic diseases such as lice, and mites and fly larvae. The injection has an obvious effect; and the preparation method of the injection is simple and easily operational, and is suitable for large-scale production.

The invention discloses a traditional Chinese medicinal composition for treating insomnia. The traditional Chinese medicinal composition for treating insomnia comprises the following components by weight: 45-55 parts of Radix Paeoniae Alba, 45-55 parts of semen zizyphi spinosae, 45-55 parts of lily, 45-55 parts of rose, 55-65 parts of tuber fleeceflower stem, 25-35 parts of evodia rutaecarpa, 5-15 parts of dried ginger, 5-15 parts of borneol and 5-15 parts of cinnamon. The invention also discloses a preparation method of the above traditional Chinese medicinal composition for treating insomnia. The traditional Chinese medicinal composition for the treating insomnia has the advantages of low cost, exact curative effect and fast effectiveness, and can achieve radical curative effect.

The invention discloses a medicament for treating hepatopathy. The medicament is characterized by comprising the following components in parts by weight: 10-20 parts of lysimachia christinae hance, 5-15 parts of lygodium japonicum, 5-15 parts of cortex phellodendri, 6-12 parts of selaginella moellendorfii hieron, 5-15 parts of oriental wormwood, 5-15 parts of solanum lyratum and the like. The components of the medicament supplement each other and draw on strength of each other and have the effects of improving efficacy and reducing toxic or side effects. The medicament can achieve the effects of clearing heat and removing toxicity, promoting blood circulation and removing stasis, soothing liver and strengthening spleen as well as protecting liver and lowering transaminase and has accurate treatment effects on hepatopathy, such as acute icteric hepatitis, acute hepatitis, chronic hepatitis, hepatocirrhosis, chronic hepatocirrhosis ascites and liver cancer.

A process for preparing the medicine to treating alopecia areata includes such steps as preparing the basic culture medium from human AB-type serum, low-sugar culture medium (DMEM), Hepes, sodium bicarbonate and L-glutamine proportionally, culturing the low-passage human hair papilla cells, taking the supernatant and freeze-drying to obtain powder.

The present invention belongs to pharmaceutical field, which relates to the application of the sodium tanshinone IIA sulfonate as a protective agent for the blood brain barrier in mental diseases. The present invention provides the new function of the sodium tanshinone IIA sulfonate as a protective agent for the blood brain barrier in mental disease prevention and treatment. The in vitro and in vivo studies display that the sodium tanshinone IIA sulfonate possesses definite protection function for the blood brain barrier. The present invention also possesses definite prevention and treatment function for metal disease related to the blood brain barrier injury, which comprises ischemic cerebral apoplexy. The present invention skillfully takes the blood brain barrier as the therapy target for mental diseases, which breaks through the restriction that the treatment medicine should reach the effective drug therapy concentration in accordance with the pharmacokinetic characteristics. Medicine provided in the present invention can protect the brain when the drug reaches effective intravascular concentration. Therefore better choice for treatment of the mental disease is provided.

The invention provides the novel use of a pharmaceutical composition in preparing drugs for the treatment or prevention of male infertility, which is capable of improving quality of life, decreasing WBC count in prostate liquid and recovering prostate gland functions.

The invention belongs to the field of genetic engineering techniques disclosing the recombinant and application of intelligent adenovirus vector and khp53 anti-oncogene. The invention specifically involves recombinant viral vector of human tumor-suppressing gene, especially involves human p53 tumor-suppressing gene recombination intellectual adenovirus vector conducted by Kozak sequence, and also involves drug combinations with the gene recombinant vector. Through the combination utilization of elements enhancing eukaryotic gene expression such as MCMV promoter, intron and Kozak regular sequence etc, the problem of relative shortage expression of the p53 gene is solved; and through adopting AdMAX HiIQ recombinant adenovirus vector system, the problem of effective packaging exogenous gene high expressing the recombined adenovirus effectively, and finally,through site-specific homologous recombination in eukaryotic cells, 5-recombinated adenovirus rAdMH-khp53 with E1, E3 deleted is packaged out. Utilizing recombinant adenovirus of the invention, clinical-used gene drugs can be prepared for prevention and treatment of a variety of cancer.

The invention belongs to the field of biological gene therapy and particularly relates to an inhibitor for inhibiting a targeting linc01023 gene of brain glioma and application of the inhibitor. The nucleotide sequence of the targeting inhibitor is 5'-CTCCTTCTGACGGCGGAAA-3' (SEQ ID No.1). In order to achieve the gene therapy purpose of inhibiting the proliferation, migration and invasion of brainglioma, based on an RNAi technology, the inhibitor can act on the linc01023 gene in a targeted way by artificially synthesizing linc01023-targeted shRNA to promote the degradation of the linc01023 gene, a result of reducing the expression of the linc01023 gene is obtained, and a new thought is provided for clinically treating brain glioma.

The invention discloses a pharmaceutical composition for treating osteoporosis, a liposome preparation of the pharmaceutical composition, and a preparation method thereof. The pharmaceutical composition comprises the following components in mass part: 1-5 parts of icaritin, 1-5 parts of chiratin, 1-5 parts of loganin and an optional pharmaceutically acceptable carrier. According to the technical scheme of the invention, icaritin, chiratin and loganin are adopted as active pharmaceutical ingredients to be combined for the first time. It has been proved that, the pharmaceutical composition has an outstanding curative effects in treating osteoporosis. Meanwhile, based on the characteristics of traditional Chinese medicine, the pharmaceutical composition has the obvious advantages of moderate effect and little side effects. The pharmaceutical composition is prepared in the form of a liposome preparation, thus being good in targeting and obvious in sustained-release effect. The liposome preparation well reduces the toxic effect of the pharmaceutical composition and improves the stability of the pharmaceutical composition.

The present invention relates to a Chinese medicine for curing apoplexy and its production method. Said invention adopts 7 Chinese medicinal materials of artificial musk, small gleditsia fruit, leech, American ginseng, tangerine peel and borneol as raw material and utilizes thep rocess of extracting their effective components, and makes them into the dosage form for oral preparation. As compared with nimodipine it superior to control group in curative rate, effectual rate and total effective rate, and its production is simple.

The invention relates to a traditional Chinese medicine composition as well as a preparation method and a use thereof, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following bulk pharmaceutical chemicals in parts by weight: 160-240 parts of red ginsengs, 350-450 parts of roots of red rooted salvia and 160-240 parts of radix scrophulariae. The traditional Chinese medicine composition is compounded under the guide of the theories of traditional Chinese medicine, has the functions of invigorating qi for relieving desertion, promoting blood circulation to remove blood stasis and clearing heat and promoting dieresis, are used for treating angina pectoris, palpitate, chest pain, shortness of breath and fatigue. Moreover, the traditional Chinese medicine composition has a good curative effect for preventing and treating the first-grade cardiac failure and the second-grade cardiac failure, and can be used for realizing cardiac function protection by strengthening autophagy activities of the myocardial cells and reducing apoptosis.

The present invention discloses a compound injection in absolut ethyl alcohol or compound powdered injection preparation of prostaglandin E1, prostaglandin E1 potassium salt, prostaglandin E1 sodium salt or prostaglandin A1 and prostaglandin B1. The compound preparation is used in preventing and treating AIDS and abstaining from drugs. It has unique recipe, complementary components, determined curative effect and less toxic side effect.

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine for treating sterility and the preparation method thereof. The traditional Chinese medicine comprises the following bulk drugs: angelica body, chuangxiong rhizome , prepared rehmannia root, wine steamed and peeled tuckahoe, tangerine peel, fried nutagrass flatsedge rhizome, fried evodia fruit, corydalis tuber and moutan cortex. The traditional Chinese medicine has simple formula, definite curative effect, low cost, and is readily accepted by patients.

The invention discloses a method for preparing traditional Chinese medicine capsules for treating pimples and mottles, belonging to the technological field of production of traditional Chinese medicine preparation.The invention is made from root of dahurian angelica, white peony root, white poria, root of red rooted slbia, honey,etc.; besides, the invention can not only treat skin diseases such as the pimples and the mottles etc., but also can moisturize and care the skin, diminish wrinkles as well as keep healthy and flush skin.The Chinese traditional medicine capsules have the advantages of internal and external use, rapid treating effect, convenient usage, no cross contamination and no adverse effects as well as easy production process and low price.

The invention relates to a medicament for treating long-term low-grade fever, which is prepared from Chinese herbs. The medicament is prepared from raw materials of radix codonopsitis, astragalus root, liquorice, rhizoma cimicifugae, Chinese angelica root, largehead atractylodes rhizome, szechwan lovage rhizome, cassia twig, Chinese magnolcavine fruit, roasted semen ziziphi spinosae, thinleaf milkwort root, and the like and can be prepared into capsules for use. The medicament warms yang, benefits qi, warms meridian, promotes blood circulation, has favorable curative effect on long-term low-grade fever, night sweat, and other symptoms and has no obvious side effects.

The invention relates to a pharmaceutical composition for nerve regeneration after cerebral arterial thrombosis as well as a preparation method and application thereof, and the pharmaceutical composition for nerve regeneration after cerebral arterial thrombosis is provided for solving the problem of strong hepatotoxicity of existing chemical treatment medicaments for ischemic cerebrovascular disease. The pharmaceutical composition is prepared from the following raw materials: 15 parts of akebiaquinata, 6 parts of codonopsis pilosula, 10 parts of pomegranate bark, 10 parts of shiny-leaved yellowhorn shell, 10 parts of thunberg fritillary bulb, 20 parts of sealwort, 20 parts of the root of red-rooted salvia, 10 parts of glabrous sarcandra herb, 5 parts of ligusticum wallichii, 8 parts of seed of feather cockscomb, 15 parts of the root of fangji, 7 parts of burdock, 10 parts of the root of kudzu vine, and 10 parts of liquorice. The pharmaceutical composition can be used for promoting nerve regeneration after cerebral arterial thrombosis, so as to cure or prevent cerebral ischemia or cerebral infarction.

The invention provides application of a medicine containing catechin or catechin polymorphs to preparation of medicines for prevention and / or treatment of cancers. Through in-vivo experiment research, tumor cell proliferation can be inhibited remarkably after oral administration or injection of the catechin; through in-vitro experiment research, the catechin is capable of inhibiting tumor cell growth. The catechin is wide in anti-cancer range, has exact treatment effect on various cancers such as Ehrlich's ascites carcinoma, cervical cancer, colon cancer, lung adenocarcinoma, gastric cancer and liver cancer, and has no toxic or side effect, thereby being prominent in popularization prospect.

The invention relates to a medicament, namely a medicament for treating cancer, also relates to a compound with the actions of inhibiting and killing cancer cells and also relates to a Mongolian medicine extract with the anticancer effect. The medicament is characterized in that the medicament is a monocyclic sesquiterpene compound, the monocyclic sesquiterpene compound is an isomer of C15H22O2, C15H22O, C15H24 or C15H22O2 and is an extract of leayjerleaf cloves, serving as a Mongolian medicine. The medicament has the beneficial effects that the medicament is exact in effect of treating the cancer as having obvious actions of inhibiting and killing various cancer cells and is small in side effect to a human body without pains in the medication process; particularly, the compound can be extracted from the leayjerleaf cloves, serving as a Mongolian medicine, is easy in raw material acquisition, simple and convenient in method and low in cost, is capable of hopefully and remarkably lowering the curative cost and has the important significance of reliving pains of a patient with the cancer, increasing the health level of people and improving the life quality of the people.