173results about How to "Exact therapeutic effect" patented technology

The invention belongs to the field of medical biology, and particularly relates to a method for extracting a konjac polypeptide extract from konjac flying powder, the konjac polypeptide extract obtained by the method and an application of the konjac polypeptide extract. In order to increase the content of konjac polypeptide in the konjac polypeptide extract, the optimized extraction technology provided by the invention adopts a complex enzyme to perform enzymolysis on the protein extraction liquid of the konjac flying powder; in the finally obtained konjac polypeptide extract, the content of konjac polypeptide is as high as 85-97%, and the molecular weight of the konjac polypeptide is 350-3500Da. Moreover, the invention also provides an application of the konjac polypeptide extract in preparing a medicine for treating diabetes and diabetic complications as well as a hypoglycemic medicinal composition containing the konjac polypeptide extract. In a word, the konjac polypeptide extract and the medicinal composition thereof provided by the invention have good prospect in medicine.

An injection-type composite bone repair material for treating bone fracture, nonunion, dysostosis and osteoporosis contains the fibrin in mammal's blood as carrier, genetically recombinant bone morphogenetic protein, fibroblast growth factor and beta-converting growth factor. Its advantages are sure curative effect, wide application range and high safety.

A compound medicine containing kurarinol, prostaglandic E1 and aspirin is prepared through including the kurarinol and prostaglandin E1 by 6-0-malto-beta-cyclodextrin, mixing, adding others, and preparing the freeze dried powder injection. It can be used for treating cancers, cardiovascular and cerebrovascular diseases and hepatitis. Its advantages are sure curative effect, and no toxic by-effect.

The invention relates to an external application of traditional Chinese medicines, and in particular relates to a traditional Chinese medicinal naval plaster with effect of promoting digestion and eliminating stagnation. The traditional Chinese medicinal naval plaster comprises the following components in parts by mass: 10-30 parts of paederia scandens, 6-12 parts of atractylodes macrocephala koidz, 5-12 parts of semen raphani, 3-10 parts of fructus aurantii immaturus, 6-15 parts of fructus forsythiae, 3-10 parts of artemisiae anomala, and 3-9 parts of rhizoma pinelliae preparata. The traditional Chinese herbal medicine has the effects of fortifying the spleen and harmonizing the stomach, promoting digestion and eliminating stagnation, and removing blood stasis and reducing phlegm in the value range, and has an exact treatment effect on food retention and other symptoms caused by food retention of children.

The invention discloses itching-relieving skin-care emulsifiable paste and a preparation method thereof. According to the preparation method, skin-moistening and itching-relieving components are extracted from a plurality of Chinese herbal medicines, various aromatherapy skin moistening substances are used, so that effective antioxidation is realized, the medicine is respectively subjected to micro-emulsion gel and liposome micro-capsule coating according to different purposes, the pH value is 5.8 to 6.5, the itching-relieving skin-care emulsifiable paste comprise 65-75wt% of micro-emulsion gel and 25-35wt% of liposome micro-capsules, the liposome micro-capsules contain an itching relieving traditional Chinese medicine liquid and have diameters of 250-350nm, the micro-emulsion gel comprises a micro-emulsion with the particle size of 30-90nm, the optimized emulsifiable paste improves the 24-hour transdermal absorption rate to 68% or above, the intradermal drug retention amount can reach4mg or above within 24h, skin moistening and itching relieving components can be effectively delivered into the skin, dryness and allergic pruritus are inhibited, the skin of the pruritus part is repaired from outside to inside, itching can be rapidly relieved, the drug effect lasting time is long, and pruritus recurrence is inhibited.

The invention pertains to the field of Chinese traditional medicine, in particular to a traditional Chinese medicine used for treating hepatopathy and a preparation method thereof. The traditional Chinese medicine is made of the following bulk drugs: capillary wormwood herb, giant knotweed, spreading hedyotis herb, red sage root, red peony root, nutagrass flatsedge rhizome, wolfberry fruit and ginseng. The traditional Chinese medicine has the advantages of simple formula, definite treatment effect, few toxic and side effects as will as high cure rate and quick effect. The cure rate of the traditional medicine is over 98% for common hepatitis A and over 80% for hepatitis B and other hepatic diseases.

The invention relates to an invermectin in-vivo gel injection and a preparation method thereof, aiming at providing a long-acting injection for preventing and treating livestock parasite infections, and a preparation method thereof. Raw materials required by every 100 mL of the invermectin in-vivo gel injection comprise 5 g-10 g of injection grade invermectin, 10 g-20 g of poly(lactic-co-glycolicacid) (PLGA), 1 g -2 g of carbomer-941, 0.1 g -0.2 g of tween-80 and 85 mL-90 mL of an organic solvent. The injection is an in-vivo gel prepared from invermectin, and is used for preventing and treating gastrointestinal parasites of cattle, pigs and sheep, lungworm and externally parasitic diseases such as lice, and mites and fly larvae. The injection has an obvious effect; and the preparation method of the injection is simple and easily operational, and is suitable for large-scale production.

The invention discloses a traditional Chinese medicinal composition for treating insomnia. The traditional Chinese medicinal composition for treating insomnia comprises the following components by weight: 45-55 parts of Radix Paeoniae Alba, 45-55 parts of semen zizyphi spinosae, 45-55 parts of lily, 45-55 parts of rose, 55-65 parts of tuber fleeceflower stem, 25-35 parts of evodia rutaecarpa, 5-15 parts of dried ginger, 5-15 parts of borneol and 5-15 parts of cinnamon. The invention also discloses a preparation method of the above traditional Chinese medicinal composition for treating insomnia. The traditional Chinese medicinal composition for the treating insomnia has the advantages of low cost, exact curative effect and fast effectiveness, and can achieve radical curative effect.

A process for preparing the medicine to treating alopecia areata includes such steps as preparing the basic culture medium from human AB-type serum, low-sugar culture medium (DMEM), Hepes, sodium bicarbonate and L-glutamine proportionally, culturing the low-passage human hair papilla cells, taking the supernatant and freeze-drying to obtain powder.

The present invention belongs to pharmaceutical field, which relates to the application of the sodium tanshinone IIA sulfonate as a protective agent for the blood brain barrier in mental diseases. The present invention provides the new function of the sodium tanshinone IIA sulfonate as a protective agent for the blood brain barrier in mental disease prevention and treatment. The in vitro and in vivo studies display that the sodium tanshinone IIA sulfonate possesses definite protection function for the blood brain barrier. The present invention also possesses definite prevention and treatment function for metal disease related to the blood brain barrier injury, which comprises ischemic cerebral apoplexy. The present invention skillfully takes the blood brain barrier as the therapy target for mental diseases, which breaks through the restriction that the treatment medicine should reach the effective drug therapy concentration in accordance with the pharmacokinetic characteristics. Medicine provided in the present invention can protect the brain when the drug reaches effective intravascular concentration. Therefore better choice for treatment of the mental disease is provided.

The invention provides the novel use of a pharmaceutical composition in preparing drugs for the treatment or prevention of male infertility, which is capable of improving quality of life, decreasing WBC count in prostate liquid and recovering prostate gland functions.

The invention belongs to the field of genetic engineering techniques disclosing the recombinant and application of intelligent adenovirus vector and khp53 anti-oncogene. The invention specifically involves recombinant viral vector of human tumor-suppressing gene, especially involves human p53 tumor-suppressing gene recombination intellectual adenovirus vector conducted by Kozak sequence, and also involves drug combinations with the gene recombinant vector. Through the combination utilization of elements enhancing eukaryotic gene expression such as MCMV promoter, intron and Kozak regular sequence etc, the problem of relative shortage expression of the p53 gene is solved; and through adopting AdMAX HiIQ recombinant adenovirus vector system, the problem of effective packaging exogenous gene high expressing the recombined adenovirus effectively, and finally,through site-specific homologous recombination in eukaryotic cells, 5-recombinated adenovirus rAdMH-khp53 with E1, E3 deleted is packaged out. Utilizing recombinant adenovirus of the invention, clinical-used gene drugs can be prepared for prevention and treatment of a variety of cancer.

The invention belongs to the field of biological gene therapy and particularly relates to an inhibitor for inhibiting a targeting linc01023 gene of brain glioma and application of the inhibitor. The nucleotide sequence of the targeting inhibitor is 5'-CTCCTTCTGACGGCGGAAA-3' (SEQ ID No.1). In order to achieve the gene therapy purpose of inhibiting the proliferation, migration and invasion of brainglioma, based on an RNAi technology, the inhibitor can act on the linc01023 gene in a targeted way by artificially synthesizing linc01023-targeted shRNA to promote the degradation of the linc01023 gene, a result of reducing the expression of the linc01023 gene is obtained, and a new thought is provided for clinically treating brain glioma.

The present invention relates to a Chinese medicine for curing apoplexy and its production method. Said invention adopts 7 Chinese medicinal materials of artificial musk, small gleditsia fruit, leech, American ginseng, tangerine peel and borneol as raw material and utilizes thep rocess of extracting their effective components, and makes them into the dosage form for oral preparation. As compared with nimodipine it superior to control group in curative rate, effectual rate and total effective rate, and its production is simple.

The present invention discloses a compound injection in absolut ethyl alcohol or compound powdered injection preparation of prostaglandin E1, prostaglandin E1 potassium salt, prostaglandin E1 sodium salt or prostaglandin A1 and prostaglandin B1. The compound preparation is used in preventing and treating AIDS and abstaining from drugs. It has unique recipe, complementary components, determined curative effect and less toxic side effect.

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine for treating sterility and the preparation method thereof. The traditional Chinese medicine comprises the following bulk drugs: angelica body, chuangxiong rhizome , prepared rehmannia root, wine steamed and peeled tuckahoe, tangerine peel, fried nutagrass flatsedge rhizome, fried evodia fruit, corydalis tuber and moutan cortex. The traditional Chinese medicine has simple formula, definite curative effect, low cost, and is readily accepted by patients.

The invention discloses a method for preparing traditional Chinese medicine capsules for treating pimples and mottles, belonging to the technological field of production of traditional Chinese medicine preparation.The invention is made from root of dahurian angelica, white peony root, white poria, root of red rooted slbia, honey,etc.; besides, the invention can not only treat skin diseases such as the pimples and the mottles etc., but also can moisturize and care the skin, diminish wrinkles as well as keep healthy and flush skin.The Chinese traditional medicine capsules have the advantages of internal and external use, rapid treating effect, convenient usage, no cross contamination and no adverse effects as well as easy production process and low price.

The invention relates to a medicament for treating long-term low-grade fever, which is prepared from Chinese herbs. The medicament is prepared from raw materials of radix codonopsitis, astragalus root, liquorice, rhizoma cimicifugae, Chinese angelica root, largehead atractylodes rhizome, szechwan lovage rhizome, cassia twig, Chinese magnolcavine fruit, roasted semen ziziphi spinosae, thinleaf milkwort root, and the like and can be prepared into capsules for use. The medicament warms yang, benefits qi, warms meridian, promotes blood circulation, has favorable curative effect on long-term low-grade fever, night sweat, and other symptoms and has no obvious side effects.

The invention relates to a pharmaceutical composition for nerve regeneration after cerebral arterial thrombosis as well as a preparation method and application thereof, and the pharmaceutical composition for nerve regeneration after cerebral arterial thrombosis is provided for solving the problem of strong hepatotoxicity of existing chemical treatment medicaments for ischemic cerebrovascular disease. The pharmaceutical composition is prepared from the following raw materials: 15 parts of akebiaquinata, 6 parts of codonopsis pilosula, 10 parts of pomegranate bark, 10 parts of shiny-leaved yellowhorn shell, 10 parts of thunberg fritillary bulb, 20 parts of sealwort, 20 parts of the root of red-rooted salvia, 10 parts of glabrous sarcandra herb, 5 parts of ligusticum wallichii, 8 parts of seed of feather cockscomb, 15 parts of the root of fangji, 7 parts of burdock, 10 parts of the root of kudzu vine, and 10 parts of liquorice. The pharmaceutical composition can be used for promoting nerve regeneration after cerebral arterial thrombosis, so as to cure or prevent cerebral ischemia or cerebral infarction.

The invention provides application of a medicine containing catechin or catechin polymorphs to preparation of medicines for prevention and/or treatment of cancers. Through in-vivo experiment research, tumor cell proliferation can be inhibited remarkably after oral administration or injection of the catechin; through in-vitro experiment research, the catechin is capable of inhibiting tumor cell growth. The catechin is wide in anti-cancer range, has exact treatment effect on various cancers such as Ehrlich's ascites carcinoma, cervical cancer, colon cancer, lung adenocarcinoma, gastric cancer and liver cancer, and has no toxic or side effect, thereby being prominent in popularization prospect.

The invention belongs to the technical field of medicines and particularly relates to a targeting inhibitor for an MCM3AP-AS1 gene and an application of the targeting inhibitor. The targeting inhibitor has the gene sequence as follows: 5'-GCTGTACCTAGTATGGTATGC-3'(SEQ ID No.1). The inhibitor can be specifically bound with the MCM3AP-AS1 gene, so that the MCM3AP-AS1 gene is silenced, influences of MCM3AP-AS1 on vascular endothelial cell proliferation, migration and vessel formation capability of gliomas are inhibited, and the purpose of treating gliomas is achieved.