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Application of medicine containing catechin to preparation of medicines for prevention and/or treatment of cancers

A technology of catechins and drugs, applied in the field of medicine, can solve problems such as narrow therapeutic range, poor therapeutic effect of anti-tumor drugs, and side effects of therapeutic drugs, and achieve the goal of prolonging survival rate, inhibiting tumor cell proliferation, and ensuring drug efficacy Effect

Inactive Publication Date: 2016-01-13
王孝仓
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to address the technical defects in the prior art, such as poor therapeutic effect of anti-tumor drugs, narrow therapeutic range, side effects of therapeutic drugs, etc., and provide effective technical solutions for different types of anti-tumor effects, specifically:

Method used

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  • Application of medicine containing catechin to preparation of medicines for prevention and/or treatment of cancers
  • Application of medicine containing catechin to preparation of medicines for prevention and/or treatment of cancers
  • Application of medicine containing catechin to preparation of medicines for prevention and/or treatment of cancers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1: Experiment of the therapeutic effect of catechin on cancer

[0040] 1 test material

[0041] 1.1 Experimental animals

[0042] Balb / c mice, DBA mice, 615 mice, and KM mice are all SPF grade experimental animals, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.

[0043] 1.2 Experimental tumor cells

[0044] The tumor cells used in the experiment include: EAC Ehrlich ascites carcinoma; U14 cervical carcinoma; CT26 colon carcinoma; Lewis lung adenocarcinoma; BGC823 gastric carcinoma;

[0045] 1.3 Test samples

[0046] The test sample is CDF (that is, pure catechin) sealed and stored at 4°C. When in use, it is prepared with distilled water at about 35-40°C to make a solution of the required concentration for oral administration to animals, and stored in a refrigerator at 4°C. Drug preparation The post-use period is 7 days.

[0047] 1.4 Drugs and reagents

[0048] Positive control drug: cyclophosphamide for injection, powder inje...

Embodiment 2

[0068] Example 2: In vitro inhibition experiment of catechins on tumor cells:

[0069] 1 Experimental materials

[0070] 1.1 Samples to be tested

[0071] Test sample CDF (i.e. pure catechin), dark brown powder, packed in airtight plastic box, stored in refrigerator at 4°C. When used, it is prepared with 1640 culture medium containing 10% calf serum and diluted in multiples for use in cell experiments, and it is freshly prepared when used. The period of use after the preparation of the medicine is 3 to 4 days.

[0072] 1.2 Tumor cell lines

[0073] EAC Ehrlich ascites carcinoma; U14 cervical carcinoma; CT26 colon carcinoma; Lewis lung adenocarcinoma; BGC823 gastric carcinoma; SMMC-7727 liver carcinoma. Second, the cells in the logarithmic growth phase were used for experiments.

[0074] 1.3 Instruments and reagents

[0075] Reagent:

[0076] ① Improved RPMI1640 culture medium: Hyclone Company; ② Mycoplasma-free neonatal bovine serum: Hangzhou Sijiqing Bioengineering Mat...

Embodiment 3

[0096] Embodiment 3: the preparation of catechin capsule

[0097] Prescription: catechin microcrystal 50g, starch 500g, dextrin 250g, magnesium stearate 6g; preparation method: take catechin 50g, add starch, dextrin, mix and sieve, granulate, pass through a 16-mesh sieve , dried at 50 degrees Celsius, whole grains, added 6g of magnesium stearate, mixed evenly, subpackaged into 1000 capsules, and obtained.

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Abstract

The invention provides application of a medicine containing catechin or catechin polymorphs to preparation of medicines for prevention and / or treatment of cancers. Through in-vivo experiment research, tumor cell proliferation can be inhibited remarkably after oral administration or injection of the catechin; through in-vitro experiment research, the catechin is capable of inhibiting tumor cell growth. The catechin is wide in anti-cancer range, has exact treatment effect on various cancers such as Ehrlich's ascites carcinoma, cervical cancer, colon cancer, lung adenocarcinoma, gastric cancer and liver cancer, and has no toxic or side effect, thereby being prominent in popularization prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of medicines including catechins in preparing medicines for preventing and / or treating cancer. Background technique [0002] Tumor is a new organism formed by the abnormal proliferation of cells in local tissues due to the loss of normal regulation of growth patterns at the gene level under the action of various tumorigenic factors. This neoplasm often forms a localized mass, hence the name. After normal cells transform into tumor cells, they have abnormal morphology, metabolism and function, and lose the ability to differentiate and mature to varying degrees. It grows vigorously and has relative autonomy. Even when the tumorigenic factors no longer exist, it can still grow continuously. It is not only incompatible with the body, but also harmful. [0003] When the tumor occurs, it will cause serious health hazards to the body, especially malignant tumors, which have...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61P35/00
Inventor 王孝仓
Owner 王孝仓
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