The invention relates to a medicine composition for treating rheumatoid bone disease. The medicine composition is prepared from ramulus mori, tougucao, safflower, Chinese angelica, angelica dahurica, ephedra, radix aconiti carmichaeli, frankincense, myrrh, radix gentianae macrophyllae, kadsura pepper stem, sabia japonica, radix achyranthis bidentatae, radix paeoniae alba, papaya, rhizoma ligustici wallichii, salvia miltiorrhiza, herba lycopi, rhizoma sparganii, zedoary, leech, ground beetle, scorpion, sappanwood, giant knotweed, dragon's blood, notoginseng, clematis root, berba aristolochiae mollissimae, notopterygium, windproof, radix aconiti, white mustard seed, rhizoma atractylodis, stephania tetrandra, radix angelicae pubescentis, peach kernel, rhizoma acori graminei, passepartout, and Chinese pyrola herb; the preparation method includes steps of taking multiple natural Chinese herbal medicines as raw material and properly matching by weight; every raw material component plays the synergistic effect to commonly play the functions of promoting blood circulation to remove blood stasis, dispelling wind and removing obstruction in the meridians, removing toxicity for detumescence, removing heat to cool blood, strengthening the bones and muscles and others; the composition is used for treating various rheumatic arthritis, rheumatoid arthritis, cervical spondylosis, spondylodynia, scapulohumeral periarthritis, and other rheumatoid bone diseases; the treatment scope is wide, the effect is quick and the treatment effect is good.