Pharmaceutical composition for nerve regeneration after cerebral arterial thrombosis as well as preparation method and application thereof

A composition and drug technology, applied in the field of medicine, can solve the problems of high drug prices, lack of effective drugs for cerebral ischemia or cerebral infarction, etc., and achieve the effects of being suitable for popularization and use, conducive to nerve cell repair, and improving drug compliance

Inactive Publication Date: 2014-08-20
强红枫
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the lack of effective drugs for the treatment of cerebral ischemia or cerebral infarction in the current medical practice and the high price of the existing technology, the present invention provides a drug for nerve regeneration after ischemic stroke

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1 Chinese medicine mixture

[0021]Prescription: 15 grams of Akebia, 6 grams of Codonopsis, 10 grams of pomegranate peel, 10 grams of Xingguan husk, 10 grams of Fritillaria, 20 grams of Polygonatum, 20 grams of Salvia, 10 grams of sarcophagus, 5 grams of Chuanxiong, Qingzizi 8 grams, 15 grams of Fangji, 7 grams of arctium, 10 grams of kudzu root, and 10 grams of licorice.

[0022] Preparation method: Take the medicinal materials of the above weight components, add water 5 times the total weight of the medicinal materials, soak for 30 minutes, decoct twice for 2 hours each time, filter, combine the filtrates, and concentrate the filtrates under reduced pressure to a relative density of 1.1 The extract, the relative density is the test result at 60 degrees Celsius, add ethanol until the alcohol content is 75% (v / v), let it stand for 24 hours, take the supernatant, recover the ethanol to concentrate, add water to 1000ml, stir Mix evenly, sub...

Embodiment 2

[0023] The preparation of embodiment 2 Chinese medicine tablet

[0024] Prescription: 150 grams of Akebia, 60 grams of Codonopsis, 100 grams of pomegranate peel, 100 grams of radix sorbifolium, 100 grams of Fritillaria, 200 grams of Rhizoma Polygonatum, 200 grams of Salvia miltiorrhiza, 100 grams of sarcophagus, 50 grams of Chuanxiong, Qingzizi 80 grams, 150 grams of Fangji, 70 grams of burdock, 100 grams of kudzu root, and 100 grams of licorice.

[0025] Preparation method: Take each medicinal material of the above weight components, add water 10 times the total weight of the medicinal materials, soak for 60 minutes, decoct once, 1 hour each time, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to a relative density of 1.25 The extract, the relative density is the test result at 60 degrees Celsius, add ethanol until the alcohol content is 80% (v / v), let it stand for 24 hours, take the supernatant, recover the ethanol, concentrate, vacuum dr...

Embodiment 3

[0026] The preparation of embodiment 3 traditional Chinese medicine fine powder

[0027] Prescription: 1.5kg Akebia, 0.6kg Codonopsis, 1.0kg pomegranate peel, 1.0kg radix sorbifolium husk, 1.0kg Zhejiang fritillaria, 2.0kg Polygonatum, 2.0kg Salvia miltiorrhiza, 1.0kg sarcocarpus, 0.5kg Chuanxiong, Qingzizi 0.8kg, Fangji 1.5kg, Arctium 0.7kg, Pueraria 1.0kg, Licorice 1.0kg.

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Abstract

The invention relates to a pharmaceutical composition for nerve regeneration after cerebral arterial thrombosis as well as a preparation method and application thereof, and the pharmaceutical composition for nerve regeneration after cerebral arterial thrombosis is provided for solving the problem of strong hepatotoxicity of existing chemical treatment medicaments for ischemic cerebrovascular disease. The pharmaceutical composition is prepared from the following raw materials: 15 parts of akebiaquinata, 6 parts of codonopsis pilosula, 10 parts of pomegranate bark, 10 parts of shiny-leaved yellowhorn shell, 10 parts of thunberg fritillary bulb, 20 parts of sealwort, 20 parts of the root of red-rooted salvia, 10 parts of glabrous sarcandra herb, 5 parts of ligusticum wallichii, 8 parts of seed of feather cockscomb, 15 parts of the root of fangji, 7 parts of burdock, 10 parts of the root of kudzu vine, and 10 parts of liquorice. The pharmaceutical composition can be used for promoting nerve regeneration after cerebral arterial thrombosis, so as to cure or prevent cerebral ischemia or cerebral infarction.

Description

technical field [0001] The invention relates to a pharmaceutical composition for nerve regeneration after ischemic stroke, which belongs to the field of medicine. Background technique [0002] Ischemic cerebrovascular disease (ICVD) accounts for about 80% of all cerebrovascular diseases. It has the characteristics of high morbidity, disability and cure rate, and has become one of the diseases that seriously affect human health. Ischemic cerebrovascular disease is one of the most important diseases in cerebrovascular diseases. It is a sudden imbalance between the supply and demand of oxygen and other nutrients provided by the local blood circulation and the metabolic needs of neurons, which eventually leads to the central area of ​​ischemia. A class of diseases in which neurons are damaged. Transient ischemic attack referred to as TIA, also known as transient ischemic attack or small stroke, it is due to the short-term insufficient blood supply of the arteries responsible f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61P9/10A61P25/00
Inventor 强红枫
Owner 强红枫
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