49 results about "Cerebrovascular Ischemia" patented technology

A safflower lyochrome rich is carthamin A (80-100%) and its preparing process and application to preparation of medicines to prevent and cure cardiovascular and cerebrovascular ischemia, and its medicines and preparing process are also disclosed.

The invention provides a Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases which comprises the following raw material herbs (by weight portions): astragalus root 480-660, radix salvia miltiorrhiza 60-160, red peony root 60-160, rhizome of Sichuan lovage 60-160, Chinese angelica root 60-160, safflower 60-160, leech 40-90, ground beetle 40-90, peach kernel 60-160, artificial ox gallstone 10-40, antelope's horn 10-40, buthus martensi kirsch 50-140, polygala root 60-160, acorus gramineus soland 60-160 and medicinal adjuvant. The invention also provides the method for preparation and use of the composition.

A neuroprotective composition for protecting neuronal cells against oxidative stress and methods for using and preparing the same. More particularly, the neuroprotective composition of the invention comprises a therapeutically effective amount of ceruloplasmin or a functional derivative thereof. The neuroprotective composition is characterized in that it protects neuronal cells from reactive oxygen species such as .O2- and .OH. In a preferred embodiment, the neuroprotective composition further comprises an antioxidant consisting of catalase or of an amphiphilic physiological antioxidative solution comprising a mixture of pyruvate, antioxidant, and lipid(s) such as fatty acids. The neuroprotective composition could be used for the treatment of brain trauma, brain or cerebrovascular ischemia, neurodegenerative diseases, poisoning of neuronal cells, the diminution of drugs side effects and for preservation of neuronal grafts.

A pharmaceutical composition comprising butylphthalide and borneol is disclosed. The pharmaceutical composition has synergistic effects on treating cerebrovascular diseases especially ischemic cerebrovascular diseases, and is capable of obviously enhancing treating effects of the butylphthalide, reducing the effective dose of the butylphthalide, and reducing the using amount. Untoward effects of the pharmaceutical composition during long-term application can be reduced.

The invention discloses a medicine for treating heart cardiovascular and cerebrovascular diseases and a preparation method thereof. The medicine is prepared by ginseng, radix salviae miltiorrhizae and rhizoma ligustici wallichii according to a certain weight mixture ratio. The medicine can be prepared into any preparation which is pharmaceutically acceptable, preferably a dripping pill. The medicine has the functions of replenishing qi and invigorating blood circulation, is used for treating cardiovascular and cerebrovascular diseases, is particularly used for treating ischemic cerebrovascular diseases, such as cerebral thrombosis, cerebral ischemia, cerebral infarction, and the like, and is used for treating apoplexy, qi-deficiency, blood stasis syndromes, hemiplegia, orolingual deflection, aphasia and hypodynamia.

The invention discloses a traditional Chinese medicine combination, which is formed by raw medicines according to the proportion by weight as follows: ginseng or ginseng cauline leaf is 1 to 15 parts, and erigeron is 5 to 30 parts. Adopting the conventional traditional Chinese medicine combination formula, the invention has obvious neuroprotective effect and neural function improving, etc., by combining with the characteristics and advantages of the Chinese herb compound that are multi-component, multi-target, multi-level and multiple ways for treating complex disease; the invention can effectively block most pathological mechanisms of a plurality of disease nerve injury such as ischemic cerebrovascular disease, etc.; more particularly, for the improved aspect to the neurological symptom, the traditional Chinese medicine injection is helpful to enhance the living quality of a patient, and achieves the purpose of improving prognosis, and has important clinical application significance. The invention further discloses a preparation method of the traditional Chinese medicine combination and the pharmaceutical application.

A neuroprotective composition for protecting neuronal cells against oxidative stress and methods for using and preparing the same. More particularly, the neuroprotective composition of the invention comprises a mixture of pyruvate, antioxidant, and lipid(s) such as fatty acids. The neuroprotective composition could be used for the treatment of brain trauma, brain or cerebrovascular ischemia, neurodegenerative diseases, poisoning of neuronal cells, the diminution of drugs side effects and for preservation of neuronal grafts.

A neuroprotective composition for protecting neuronal cells against oxidative stress and methods for using and preparing the same. More particularly, the neuroprotective composition of the invention comprises a mixture of pyruvate, antioxidant, and lipid(s) such as fatty acids. The neuroprotective composition could be used for the treatment of brain trauma, brain or cerebrovascular ischemia, neurodegenerative diseases, poisoning of neuronal cells, the diminution of drugs side effects and for preservation of neuronal grafts.

The invention discloses a medicament for treating cardiovascular and cerebrovascular diseases and a preparation method of the medicament. The medicament is prepared from a ginseng extract, a red-rooted salvia root extract and a hemlock parsley extract according to a certain weight proportion, wherein the ginseng extract, the red-rooted salvia root and the hemlock parsley extract can be obtained by commercial way or extracted from medicinal materials. The medicament can be prepared to form any pharmaceutically acceptable dosage form, preferably drop pills. The medicament has effects of tonifying qi and activating blood circulation, can be used for treating cardiovascular and cerebrovascular diseases, in particular treating in acute and early recovery phase of cerebral thrombosis, cerebral ischemia, cerebral infarction and other ischemic cerebrovascular diseases.

The present invention provides a pharmaceutical composition for preventing or treating learning disorders, memory disorders, Parkinson's disease, or ischemic cerebrovascular disease, which comprises a ginger extract or shogaol; and a pharmaceutically acceptable carrier. And also, the present invention provides a food composition for improving learning disorders or memory disorders or alleviating the symptoms of learning disorders or memory disorders which comprises a ginger extract or shogaol as an active ingredient, or a food composition for improving learning or memory which comprises a ginger extract or shogaol as an active ingredient.

The invention discloses a conjugate of paeonol and ozagrel, a pharmaceutical composition and medical application of the conjugate. The conjugate of paeonol and ozagrel has a structural formula shown in the specification. The invention also discloses application of the conjugate of paeonol and ozagrel in preparation of a medicine for preventing or treating cardiovascular and cerebrovascular diseases caused by platelet aggregation, and also discloses the pharmaceutical composition of the conjugate of paeonol and ozagrel, and a carrier containing the conjugate of paeonol and ozagrel or a pharmaceutically acceptable vector. The compound has the effect of preventing or treating cardiovascular and cerebrovascular diseases caused by platelet aggregation, and especially treating the thrombotic cardiovascular and cerebrovascular ischemia or infarct and other diseases.

The invention discloses a traditional Chinese medicine composition for treating an ischemic cerebrovascular disease and application thereof in preparation of a medicament for preventing or treating the ischemic cerebrovascular disease, and belongs to the technical field of medicines. Aiming at the problem that a chemotherapeutic medicament for the ischemic cerebrovascular disease at present is large in hepatotoxicity, the traditional Chinese medicine composition for treating the ischemic cerebrovascular disease provided by the invention comprises the following components in parts by weight: 15 parts of scutellaria baicalensis, 6 parts of honeysuckle, 10 parts of pomegranate bark, 10 parts of shiny-leaved yellowhorn shell, 10 parts of mint, 20 parts of ramulus mori, 20 parts of root of red-rooted salvia, 10 parts of lotus leaves, 5 parts of ligusticum wallichii, 8 parts of large-leaved gentian, 15 parts of scorpio, 7 parts of burdock, 10 parts of root of kudzu vine and 10 parts of liquorice. The traditional Chinese medicine composition has a good treatment effect in the aspect of treatment of the ischemic cerebrovascular disease, and has significant clinical popularization value.

The invention belongs to the pharmaceutical technical field, and discloses an ischemic cerebrovascular disease treatment composition, a medicament, a preparation method and application, the ischemic cerebrovascular disease treatment composition comprises ginsenoside Rg1 and astragaloside, and the weight ratio of ginsenoside Rg1 to astragaloside is 5:4. The animal pharmacodynamics experiments prove that the ischemic cerebrovascular disease treatment composition can inhibit the cerebral ischemia reperfusion injury of brain tissue, has the anti-cerebral ischemia-reperfusion injury enhancement effect by the astragaloside and ginsenoside Rg1 compatibility, also can improve energy metabolism disorders of the cerebral ischemia reperfusion injured brain tissue, anti-oxidative stress damage functions and the like, and ultimately achieves the purposes of enhancing the efficacy and reducing the toxic and side effects.

The invention relates to a pharmaceutical composition for nerve regeneration after cerebral arterial thrombosis as well as a preparation method and application thereof, and the pharmaceutical composition for nerve regeneration after cerebral arterial thrombosis is provided for solving the problem of strong hepatotoxicity of existing chemical treatment medicaments for ischemic cerebrovascular disease. The pharmaceutical composition is prepared from the following raw materials: 15 parts of akebiaquinata, 6 parts of codonopsis pilosula, 10 parts of pomegranate bark, 10 parts of shiny-leaved yellowhorn shell, 10 parts of thunberg fritillary bulb, 20 parts of sealwort, 20 parts of the root of red-rooted salvia, 10 parts of glabrous sarcandra herb, 5 parts of ligusticum wallichii, 8 parts of seed of feather cockscomb, 15 parts of the root of fangji, 7 parts of burdock, 10 parts of the root of kudzu vine, and 10 parts of liquorice. The pharmaceutical composition can be used for promoting nerve regeneration after cerebral arterial thrombosis, so as to cure or prevent cerebral ischemia or cerebral infarction.

Disclosed is the use of Ginsenoside F1 in preparing medicament for the treatment of ischemic heart disease and ischemic cerebrovascular diseases.

The invention relates to a medicine for treating ischemic cerebrovascular diseases, which is prepared from eleven kinds of medicinal herbs including goldthread root, hooked uncaria, leeches and achyranthes and cyathula root. The invention also discloses the process for preparing the medicament.

The invention discloses a pharmaceutical composition for treating ischemic cerebrovascular diseases and a preparation method thereof. The pharmaceutical composition for treating ischemic cerebrovascular diseases has effects of tonifying qi, nourishing yin, nourishing blood, removing blood stasis and dredging collaterals and is prepared from milkvetch root, tall gastrodia tuber, root of pilose asiabell, peach kernel, hawthorn fruit, tortoiseshell, prepared rehmannia root, suberect spatholobus stem, wolfberry, sichuan lovage rhizome, baked ginger and Chinese angelica. The pharmaceutical composition for treating ischemic cerebrovascular diseases can be added with conventional auxiliary materials and the mixture can be processed into tablets, particles, pills, capsules, a sustained release agent and an oral liquid by conventional processes.

The invention relates to a composition containing vinpocetine or pharmaceutically acceptable salt thereof and dextroborneol, and an application of the composition in preparation of medicines for treating cerebrovascular diseases, especially ischemic cerebrovascular diseases.

Application of novel cnidiumlactone for preparing a drug for treating ischemic heart disease and ischemic cerebrovascular disease.

The invention belongs to the field of medicines, relates to a traditional Chinese medicine composition, and particularly relates to a traditional Chinese medicine composition for nerve regeneration after cerebral arterial thrombosis and application thereof in preparation of a medicament for preventing nerve regeneration after cerebral arterial thrombosis. Aiming at the problem of large hepatotoxicity of the traditional chemotherapeutic medicament for an ischemic cerebrovascular disease, the traditional Chinese medicine composition for nerve regeneration after cerebral arterial thrombosis provided by the invention comprises the following components in parts by weight: 15 parts of morinda officinalis, 6 parts of lindera aggregata, 10 parts of pericarpium granati, 10 parts of akebiaquinata, 10 parts of thunberg fritillary bulb, 20 parts of radix achyranthis bidentatae, 20 parts of salviae miltiorrhizae, 10 parts of sarcandra glabra, 5 parts of ligusticum wallichii, 8 parts of feather cockscomb seed, 15 parts of golden cypress, 7 parts of burdock, 10 parts of fructus cnidii and 10 parts of liquorice. The traditional Chinese medicine composition has a good treatment effect on the nerve regeneration after the cerebral arterial thrombosis, and has significant clinical popularization value.

The invention relates to the technical field of biological medicines and particularly relates to application of purmorphamine to preparation of a drug for preventing / treating ischemic cerebrovascular diseases. Found through researches, purmorphamine serving as a Sonic hedgehog agonist has a pharmacological effect on preventing or treating ischemic cerebrovascular diseases. Pharmacological tests of a focal ischemic model of a rat prove that purmorphamine can be used for remarkably reducing the area of cerebral injury caused by cerebral ischemia-reperfusion of the rat and remarkably improving the ischemic neural behaviors of the rat. Purmorphamine is small in molecular weight so as to easily pass through blood brain barriers and have a strong brain protecting effect. Therefore, purmorphamine provided by the invention has a favorable application prospect to preparation of a drug for preventing / treating ischemic cerebrovascular diseases.

The invention relates to a puerarin sodium phosphate injection and a preparation method thereof. The puerarin sodium phosphate injection comprises puerarin sodium phosphate, a preservative, an isoosmotic adjusting agent, a pH value adjusting agent, an antioxygen, a local analgetic and injection water, wherein due to the addition of the antioxygen, the stability of the puerarin sodium phosphate injection can be improved, and due to the addition of the local analgetic, the pain of a patient can be lightened and no influence is caused to a main drug. The preparation method of the puerarin sodium phosphate injection mainly comprises the steps: weighing, dissolving, adsorbing a heat source by active carbon, filtering, metering volume, end-filtering, sub-packaging, plugging and covering. The puerarin sodium phosphate injection is used for adjuvant therapy of the coronary heart disease, the stenocardia, the myocardial infarction, the retina artery and vein occlusion, sudden deafness, ischemic cerebrovascular disease and the like. The puerarin sodium phosphate injection is stable in quality, accurate in treatment effect, and beneficial to acceptation by a patient.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a consciousness restoring medicine / composition, a caulis piperis kadsurae-caulis sargentodoxae-caulis sinomenii consciousness restoring medicinal preparation and application of the medicine or the preparation. A caulis piperis kadsurae-caulis sargentodoxae-caulis sinomenii brain arousing composition provided by the invention is characterized by being mainly prepared from caulis piperis kadsurae, caulis sargentodoxae and caulis sinomenii. The brain arousing medicine / composition and the caulis piperis kadsurae-caulis sargentodoxae-caulis sinomenii brain arousing medicinal preparation have the beneficial effects that the caulis piperis kadsurae, the caulis sargentodoxae and the caulis sinomenii, the functions of which are mainly wind dispelling, blood circulation promotion and collateral dredging, are combined together, are assisted by other medicines, and jointly have the effects of preventing and treating cerebrovascular ischemia and a nervous-system disease, resisting aging and preventing and treating diseases of diabetes, a fatigue syndrome, senile dementia and the like.

The invention relates to the technical field of medicine, food, reagents and the like, in particular to application of oligopeptide GRGDS in preparation of a drug for preventing and treating ischemiccerebrovascular diseases. Pharmacological tests of a rat local cerebral ischemia model show that the oligopeptide can significantly reduce the cerebral infarction volume of a cerebral ischemia rat, significantly improve the nerve injury of the rat after ischemia and reduce the apoptosis of nerve cells. The oligopeptide has a strong brain protection effect, is easy to penetrate through a blood brain barrier due to small molecular weight, and has remarkable advantages. Therefore, the oligopeptide GRGDS has good application prospects in preparation of the drug for preventing and treating ischemiccerebrovascular diseases.

The invention discloses medicine hydrochloric acid fasudil composite dry suspension for treating ischemic cerebrovascular disease, and belongs to the technical field of medicine. The composite dry suspension is prepared from hydrochloric acid fasudil, mannitol, sodium alginate, locust bean gum, sodium stearyl alcohol sulfonate, steviosin and 95% ethyl alcohol. Hdrochloric acid fasudil is a new-crystal-form compound; an X-ray powder diffraction pattern obtained through measurement of Cu-K alpha rays is shown in figure 1, and hydrochloric acid fasudil is different from hydrochloric acid fasudil reported in the prior art; it is found through experiments that the new-crystal-form compound is high in purity, mobility and stability, low in impurity content, not prone to moisture absorption and safe and reliable in clinical application; the dry suspension prepared from the new-crystal-form compound is high in stability and bioavailability and quite suitable for clinical application.

The invention discloses a traditional Chinese medicine combination, which is formed by raw medicines according to the proportion by weight as follows: ginseng or ginseng cauline leaf is 1 to 15 parts, and erigeron is 5 to 30 parts. Adopting the conventional traditional Chinese medicine combination formula, the invention has obvious neuroprotective effect and neural function improving, etc., by combining with the characteristics and advantages of the Chinese herb compound that are multi-component, multi-target, multi-level and multiple ways for treating complex disease; the invention can effectively block most pathological mechanisms of a plurality of disease nerve injury such as ischemic cerebrovascular disease, etc.; more particularly, for the improved aspect to the neurological symptom,the traditional Chinese medicine injection is helpful to enhance the living quality of a patient, and achieves the purpose of improving prognosis, and has important clinical application significance.The invention further discloses a preparation method of the traditional Chinese medicine combination and the pharmaceutical application.

Application of cnidiumlactone for preparing a drug for treating ischemic heart disease and ischemic cerebrovascular disease.

The invention discloses a traditional Chinese medicine composition for treating ischemic cerebrovascular disease and a preparation method thereof. The traditional Chinese medicine composition is mainly prepared from the following raw materials: angelica sinensis, radix codonopsis, prepared rehmannia root, glossy privet fruit, fructus psoraleae, radix puerariae, uncaria, white peony root, radix curcumae, Chinese yam, roasted rhizoma atractylodis macrocephalae and prepared radix licorice. The traditional Chinese medicine composition is used for treating the paracmastic ischemic cerebrovascular disease. The traditional Chinese medicine composition to which conventional auxiliaries can be added can be prepared into clinically acceptable tablets, granules, pills, capsules, dropping pills, sustained-release preparations and oral liquid preparations according to conventional process.

The invention discloses a medicament composition for treating ischemic cerebrovascular diseases and an application thereof. The medicament composition uses pinocembrin and alogliptin as medicament active components, wherein the weight ratio between the two medicaments is preferably 1:(0.1-10), and is further preferably 1:1.5. The medicament composition has significant treatment and prevention effects on cerebral ischemia and cerebral infarction, and can be used for slowing down the conversion of cerebral ischemia into cerebral infarction diseases suffered by patients, reducing the sudden death rate of the patients suffering cerebral ischemia, improving the survival quality of the patients, and prolonging the survival time of the patients.

The invention relates to a composition applied to preparation of a medicine for treating cerebrovascular diseases, in particular to ischemic cerebrovascular diseases, and the composition contains 2-amino-6-trifluoromethoxy benzothiazole or pharmaceutically acceptable salts thereof and borneol.