45 results about "Cerebrovascular Ischemia" patented technology

The invention provides a Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases which comprises the following raw material herbs (by weight portions): astragalus root 480-660, radix salvia miltiorrhiza 60-160, red peony root 60-160, rhizome of Sichuan lovage 60-160, Chinese angelica root 60-160, safflower 60-160, leech 40-90, ground beetle 40-90, peach kernel 60-160, artificial ox gallstone 10-40, antelope's horn 10-40, buthus martensi kirsch 50-140, polygala root 60-160, acorus gramineus soland 60-160 and medicinal adjuvant. The invention also provides the method for preparation and use of the composition.

A neuroprotective composition for protecting neuronal cells against oxidative stress and methods for using and preparing the same. More particularly, the neuroprotective composition of the invention comprises a therapeutically effective amount of ceruloplasmin or a functional derivative thereof. The neuroprotective composition is characterized in that it protects neuronal cells from reactive oxygen species such as .O2- and .OH. In a preferred embodiment, the neuroprotective composition further comprises an antioxidant consisting of catalase or of an amphiphilic physiological antioxidative solution comprising a mixture of pyruvate, antioxidant, and lipid(s) such as fatty acids. The neuroprotective composition could be used for the treatment of brain trauma, brain or cerebrovascular ischemia, neurodegenerative diseases, poisoning of neuronal cells, the diminution of drugs side effects and for preservation of neuronal grafts.

A pharmaceutical composition comprising butylphthalide and borneol is disclosed. The pharmaceutical composition has synergistic effects on treating cerebrovascular diseases especially ischemic cerebrovascular diseases, and is capable of obviously enhancing treating effects of the butylphthalide, reducing the effective dose of the butylphthalide, and reducing the using amount. Untoward effects of the pharmaceutical composition during long-term application can be reduced.

The invention discloses a medicine for treating heart cardiovascular and cerebrovascular diseases and a preparation method thereof. The medicine is prepared by ginseng, radix salviae miltiorrhizae and rhizoma ligustici wallichii according to a certain weight mixture ratio. The medicine can be prepared into any preparation which is pharmaceutically acceptable, preferably a dripping pill. The medicine has the functions of replenishing qi and invigorating blood circulation, is used for treating cardiovascular and cerebrovascular diseases, is particularly used for treating ischemic cerebrovascular diseases, such as cerebral thrombosis, cerebral ischemia, cerebral infarction, and the like, and is used for treating apoplexy, qi-deficiency, blood stasis syndromes, hemiplegia, orolingual deflection, aphasia and hypodynamia.

A neuroprotective composition for protecting neuronal cells against oxidative stress and methods for using and preparing the same. More particularly, the neuroprotective composition of the invention comprises a mixture of pyruvate, antioxidant, and lipid(s) such as fatty acids. The neuroprotective composition could be used for the treatment of brain trauma, brain or cerebrovascular ischemia, neurodegenerative diseases, poisoning of neuronal cells, the diminution of drugs side effects and for preservation of neuronal grafts.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a consciousness restoring medicine / composition, a caulis piperis kadsurae-caulis sargentodoxae-caulis sinomenii consciousness restoring medicinal preparation and application of the medicine or the preparation. A caulis piperis kadsurae-caulis sargentodoxae-caulis sinomenii brain arousing composition provided by the invention is characterized by being mainly prepared from caulis piperis kadsurae, caulis sargentodoxae and caulis sinomenii. The brain arousing medicine / composition and the caulis piperis kadsurae-caulis sargentodoxae-caulis sinomenii brain arousing medicinal preparation have the beneficial effects that the caulis piperis kadsurae, the caulis sargentodoxae and the caulis sinomenii, the functions of which are mainly wind dispelling, blood circulation promotion and collateral dredging, are combined together, are assisted by other medicines, and jointly have the effects of preventing and treating cerebrovascular ischemia and a nervous-system disease, resisting aging and preventing and treating diseases of diabetes, a fatigue syndrome, senile dementia and the like.

The invention discloses medicine hydrochloric acid fasudil composite dry suspension for treating ischemic cerebrovascular disease, and belongs to the technical field of medicine. The composite dry suspension is prepared from hydrochloric acid fasudil, mannitol, sodium alginate, locust bean gum, sodium stearyl alcohol sulfonate, steviosin and 95% ethyl alcohol. Hdrochloric acid fasudil is a new-crystal-form compound; an X-ray powder diffraction pattern obtained through measurement of Cu-K alpha rays is shown in figure 1, and hydrochloric acid fasudil is different from hydrochloric acid fasudil reported in the prior art; it is found through experiments that the new-crystal-form compound is high in purity, mobility and stability, low in impurity content, not prone to moisture absorption and safe and reliable in clinical application; the dry suspension prepared from the new-crystal-form compound is high in stability and bioavailability and quite suitable for clinical application.

The invention discloses a traditional Chinese medicine combination, which is formed by raw medicines according to the proportion by weight as follows: ginseng or ginseng cauline leaf is 1 to 15 parts, and erigeron is 5 to 30 parts. Adopting the conventional traditional Chinese medicine combination formula, the invention has obvious neuroprotective effect and neural function improving, etc., by combining with the characteristics and advantages of the Chinese herb compound that are multi-component, multi-target, multi-level and multiple ways for treating complex disease; the invention can effectively block most pathological mechanisms of a plurality of disease nerve injury such as ischemic cerebrovascular disease, etc.; more particularly, for the improved aspect to the neurological symptom,the traditional Chinese medicine injection is helpful to enhance the living quality of a patient, and achieves the purpose of improving prognosis, and has important clinical application significance.The invention further discloses a preparation method of the traditional Chinese medicine combination and the pharmaceutical application.

The invention discloses a medicament composition for treating ischemic cerebrovascular diseases and an application thereof. The medicament composition uses pinocembrin and alogliptin as medicament active components, wherein the weight ratio between the two medicaments is preferably 1:(0.1-10), and is further preferably 1:1.5. The medicament composition has significant treatment and prevention effects on cerebral ischemia and cerebral infarction, and can be used for slowing down the conversion of cerebral ischemia into cerebral infarction diseases suffered by patients, reducing the sudden death rate of the patients suffering cerebral ischemia, improving the survival quality of the patients, and prolonging the survival time of the patients.

The present invention provides the pharmaceutical use of lometaxel. For: the application of lometaxel in the preparation of the following 1)-4) products: 1) a drug for preventing and / or treating ischemic cerebrovascular disease; 2) a drug for preventing and / or treating stroke; 3) using Neuroprotective medicine for ischemic cerebrovascular disease; 4) nerve repairing medicine for ischemic cerebrovascular disease; the present invention shows through experiments that lometaxel causes nerve damage caused by stroke, especially ischemic stroke Has excellent therapeutic effect.

The invention relates to a recovery refreshing granular preparation and a preparation method and an application thereof. The recovery refreshing granular preparation is composed of the following raw medicinal materials: 200g of ginseng, 240g of leeches, 180g of prepared rhizoma arisaematis, 180g of rheum officinale and 300g of pseudo-ginseng. The preparation method comprises the following steps: performing reflux extraction on ginseng, prepared rhizoma arisaematis, rheum officinale and pseudo-ginseng with ethanol; after adding the leeches and rheum officinale into filter residues, decocting and extracting the filter residues with water; performing precipitation with ethanol; performing concentration to prepare a clear paste; and adding auxiliary materials into the concentrated clear paste to prepare the recovery refreshing granular preparation. An extraction process of the recovery refreshing formula clear paste is established and optimized, effective components in the recovery refreshing formula can be fully extracted to play roles of breaking blood and removing stasis, dispelling wind and removing stasis and consolidating constitution and tonifying qi, the curative effect on ischemic cerebrovascular disease is remarkable, and a formula meeting the requirement of the granular preparation is obtained.

The invention discloses a traditional Chinese medicine composition for promoting blood circulation and application thereof, belonging to the field of medicine. The object of the present invention is to provide an effective medicine for treating cerebral ischemia injury. The invention provides a traditional Chinese medicine composition for promoting blood circulation. The composition is composed of the following ingredients: buffalo horn, pangosaurus, leech, earthworm, notoginseng, rehmannia glutinosa, angelica, salvia miltiorrhiza, summerless, ashen and dried lacquer. Crushed and sieved, decocted to prepare extract, dried and other processes to obtain tablets. The composition for invigorating blood circulation provided by the present invention improves the abnormal neurological behavior of animals caused by cerebral ischemia, reduces the area of ​​cerebral infarction in rats with cerebral ischemia, improves the loss of neurons in the ischemic penumbra area of ​​the cerebral cortex, and improves the situation of cerebral edema. Reduce the penetration of EB in the blood-brain barrier, improve the shrinkage of neurons, the reduction of the number of synapses and the destruction of capillary basement membrane, etc., and protect the brain tissue from cerebral ischemia. It can be used as a specific drug for the treatment of ischemic cerebrovascular diseases. .

The invention provides a novel pharmaceutical application of lomitapide. The application is application of lomitapide in the preparation of the following 1) - 4) products: 1) a drug for preventing and / or treating ischemic cerebrovascular diseases; 2) a drug for preventing and / or treating cerebral apoplexy; 3) a neuroprotective drug for ischemic cerebrovascular diseases; and 4) a nerve repair treatment drug for ischemic cerebrovascular diseases. Experiments show that lomitapide has an excellent treatment effect on cerebral apoplexy, especially nerve injury caused by ischemic cerebral apoplexy.