Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of purmorphamine to preparation of drug for preventing/treating ischemic cerebrovascular diseases

A cerebrovascular disease and ischemic technology, applied in cardiovascular system diseases, blood diseases, drug combinations, etc., can solve problems such as cerebrovascular diseases that have not been seen before, and achieve the reduction of infarct size, rapid onset of effects, and improvement of neurobehavioral effects

Active Publication Date: 2015-06-24
SHANGHAI BAJIAYI PHARMA TECH
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there has been no report on the use of pimovamin for cerebrovascular diseases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of purmorphamine to preparation of drug for preventing/treating ischemic cerebrovascular diseases
  • Application of purmorphamine to preparation of drug for preventing/treating ischemic cerebrovascular diseases
  • Application of purmorphamine to preparation of drug for preventing/treating ischemic cerebrovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Purmorphamine (purmorphamine, (P-cyclohexyl-N-[4-(morpholine) phenyl]-2-(1-naphthyl)-9H-puroline)), provided by Guangdong Bajiayi Pharmaceutical Co., Ltd. , the purity is greater than 99%.

[0012] The structural formula is as follows:

[0013]

Embodiment 2

[0014] Example 2 Animal experiment of pimovamin for the treatment of ischemic cerebrovascular disease

[0015] The pharmacological experiment of making focal cerebral ischemia model by mouse suture method is a commonly used animal experiment to verify that drugs have the effect of preventing and treating ischemic cerebrovascular disease (Yin XM, Luo Y, Cao G, Bai L, Pei W, Kuharsky DK ,Chen J.Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemia.JBiol Chem.2002Nov1;277(44):42074-81.), so use it to verify the protection of purmorphamine on cerebral ischemia in experimental animals effect.

[0016] 1. Animals

[0017] C57 / 6BL mice, male, weighing 20-24 g, were reared in groups of 10 mice / cage, divided into 8 groups in total. Purchased from Shanghai Slack Laboratory Animal Co., Ltd., laboratory animal quality license number: SCXK (Shanghai) 2007-0005, kept in a clean animal room, feeding conditions include standard feed, tap w...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the technical field of biological medicines and particularly relates to application of purmorphamine to preparation of a drug for preventing / treating ischemic cerebrovascular diseases. Found through researches, purmorphamine serving as a Sonic hedgehog agonist has a pharmacological effect on preventing or treating ischemic cerebrovascular diseases. Pharmacological tests of a focal ischemic model of a rat prove that purmorphamine can be used for remarkably reducing the area of cerebral injury caused by cerebral ischemia-reperfusion of the rat and remarkably improving the ischemic neural behaviors of the rat. Purmorphamine is small in molecular weight so as to easily pass through blood brain barriers and have a strong brain protecting effect. Therefore, purmorphamine provided by the invention has a favorable application prospect to preparation of a drug for preventing / treating ischemic cerebrovascular diseases.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of purmorphamine in the preparation of drugs for the prevention and treatment of ischemic cerebrovascular diseases. Background technique [0002] Ischemic cerebrovascular disease (ischemic stroke) is a series of abnormalities in biochemical metabolism, loss of physiological functions, and pathological changes in brain tissue caused by brain blood supply disorders that cause ischemia and hypoxia in the corresponding area of ​​the brain tissue. A disease in which brain tissue is damaged on multiple levels and in many ways. Including: transient ischemic attack, cerebral embolism, cerebral thrombosis, watershed cerebral infarction, lacunar infarction, etc. It is one of the most common clinical cerebrovascular diseases. With the aging trend of my country's social population, various problems caused by ischemic cerebrovascular disease are becoming more and more ser...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5377A61P9/10A61P7/02A61P3/10
Inventor 邓文斌张恩德黄景华王习著
Owner SHANGHAI BAJIAYI PHARMA TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com