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Ischemic cerebrovascular disease treatment composition, medicament, preparation method and application

A technology of cerebrovascular disease and composition, applied in the field of pharmaceuticals, can solve the problems of high toxicity and side effects, weak curative effect, etc., and achieve the effects of controllable quality, inhibition of brain tissue damage, and clear mechanism

Inactive Publication Date: 2014-10-08
HUNAN UNIV OF CHINESE MEDICINE
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Problems solved by technology

[0005] The invention provides a composition, medicament, preparation method and application for treating ischemic cerebrovascular disease, so as to solve the problems of weak curative effect and relatively large toxic and side effects of the drugs currently used for treating ischemic cerebrovascular disease

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  • Ischemic cerebrovascular disease treatment composition, medicament, preparation method and application

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Embodiment Construction

[0042] The embodiment of the present invention provides a composition, medicament, preparation method and application for treating ischemic cerebrovascular disease, which solves the problem of weak curative effect and relatively large toxic and side effects of the drugs currently used for treating ischemic cerebrovascular disease The problem.

[0043] In order to enable those skilled in the art to better understand the technical solutions in the embodiments of the present invention, and to make the above-mentioned purposes, features and advantages of the embodiments of the present invention more obvious and understandable, the technical solutions in the embodiments of the present invention are described below in conjunction with the accompanying drawings The program is described in further detail.

[0044] The embodiment of the present invention provides a composition for treating ischemic cerebrovascular disease, the composition is composed of ginsenoside Rg1 and astragalosid...

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Abstract

The invention belongs to the pharmaceutical technical field, and discloses an ischemic cerebrovascular disease treatment composition, a medicament, a preparation method and application, the ischemic cerebrovascular disease treatment composition comprises ginsenoside Rg1 and astragaloside, and the weight ratio of ginsenoside Rg1 to astragaloside is 5:4. The animal pharmacodynamics experiments prove that the ischemic cerebrovascular disease treatment composition can inhibit the cerebral ischemia reperfusion injury of brain tissue, has the anti-cerebral ischemia-reperfusion injury enhancement effect by the astragaloside and ginsenoside Rg1 compatibility, also can improve energy metabolism disorders of the cerebral ischemia reperfusion injured brain tissue, anti-oxidative stress damage functions and the like, and ultimately achieves the purposes of enhancing the efficacy and reducing the toxic and side effects.

Description

technical field [0001] The invention relates to the technical field of pharmacy, and more specifically, relates to a composition, a medicament, a preparation method and application for treating ischemic cerebrovascular disease. Background technique [0002] The pathological changes after cerebral ischemia are very complicated. Cerebral ischemia interrupts blood flow to the brain, which in turn leads to a cascade of damage to brain cells. Brain cells produce damage cascade reactions, mainly manifested as energy metabolism disorders, toxicity of free radicals and excitatory amino acids, blood-brain barrier damage, inflammatory reactions, and cell apoptosis. The above-mentioned manifestations are all caused by cerebral ischemia and occur in different periods, and affect each other. [0003] Studies have shown that some traditional Chinese medicines and compound prescriptions have the effect of anti-cerebral ischemia, but the content of active ingredients is low, and the ingre...

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Application Information

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IPC IPC(8): A61K31/7048A61P9/10A61K31/704
Inventor 邓常清黄小平唐映红
Owner HUNAN UNIV OF CHINESE MEDICINE
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