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Chlorogenic acid injection, its preparing method and use

A technology of chlorogenic acid and powder injection, which is applied in the field of chlorogenic acid powder injection for injection and its preparation, can solve the problems of large loss of chlorogenic acid, low bioavailability, and slow onset of action, and achieve good bioavailability, Less toxic and side effects, the effect of clear ingredients

Inactive Publication Date: 2006-08-09
广东仁泰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chlorogenic acid is used in a variety of pharmaceutical preparations, and the single prescription is only administered orally, which has problems such as slow onset of action and low bioavailability, and also has the disadvantage of excessive loss of chlorogenic acid in the preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: the preparation of chlorogenic acid

[0016] Take 6kg of honeysuckle and grind it into coarse powder, soak and extract twice in 48L of deionized water at 80°C for 2 hours each time, combine the two extracts, filter and concentrate to 3g of crude drug / ml (2000ml), add 1000ml of milk of lime, grind thoroughly, Let stand for 24 hours. Filtrate the honeysuckle lime emulsion, rinse the obtained solid with a small amount of water, add 5000ml of 85% ethanol, add sulfuric acid to adjust the pH value to 2-4 (measured value 2.2), fully stir, and filter after standing overnight in the cold storage. Continue the filtrate to recover ethanol under reduced pressure Then continue to concentrate to 4g crude drug / ml (1500ml), add 9000ml deionized water and stir well, and refrigerate overnight in the refrigerator. The refrigerated liquid is centrifuged to remove insoluble matter, the pretreated macroporous adsorption resin on the supernatant (SA-4 macroporous adsorption res...

Embodiment 2

[0017] Embodiment 2: the preparation of chlorogenic acid

[0018] Take 6kg of honeysuckle and grind it into coarse powder, soak and extract twice in 54L deionized water at 80°C for 2 hours each time, combine the two extracts, filter and concentrate to 3g crude drug / ml (2000ml), add 1500ml milk of lime, grind thoroughly, Let stand for 24 hours. Filtrate the honeysuckle lime emulsion, rinse the gained solid with a small amount of water, add 5000ml of 85% ethanol, add sulfuric acid to adjust the pH value to 2-4 (measured value 2.8), fully stir, and filter after standing overnight in the cold storage. Then continue to concentrate to 4g crude drug / ml (1500ml), add 9000ml deionized water and stir well, and refrigerate overnight in the refrigerator. The refrigerated liquid is centrifuged to remove insolubles, and the pretreated macroporous adsorption resin (ADS-7 macroporous adsorbent resin, Tianjin Nankai Synthetic Company, bed volume BV=5000ml) on the clear liquid is washed with 2...

Embodiment 3

[0019] Embodiment 3: the preparation of chlorogenic acid

[0020] Take 6kg of honeysuckle and grind it into a coarse powder, soak and extract twice in 60L of deionized water at 80°C for 2 hours each time, combine the two extracts, filter and concentrate to 3g of crude drug / ml (2000ml), add 1500ml of lime milk, fully grind, Let stand for 24 hours. Filtrate the honeysuckle lime emulsion, rinse the obtained solid with a small amount of water, add 5000ml of 85% ethanol, add sulfuric acid to adjust the pH value to 2-4 (measured value 3.8), stir fully, put it in the cold storage to stand overnight, then filter, and then recover the filtrate under reduced pressure Continue to concentrate to 4g crude drug / ml (1500ml) after ethanol, add 9000ml deionized water and stir thoroughly, and refrigerate overnight in the refrigerator. The refrigerated liquid is centrifuged to remove insoluble matter, and the pretreated macroporous adsorption resin (ADS-17 macroporous adsorption resin, Tianjin ...

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Abstract

The present invention relates to a chlorogenic acid power injection. It is characterized by that it is made up by using purified effective component chlorogenic acid extracted from lonicera flower and medicinal auxiliary material for injection through a certain preparation process. Said chlorogenic acid powder injection mainly is used for curing angiocardiopathy and cerebrovascular disease. Besides, said invention also provides its preparation method and concretes steps.

Description

Technical field: [0001] The invention relates to the field of injection preparations, in particular to a chlorogenic acid powder for injection and a preparation method thereof. Background technique: [0002] Chlorogenic acid is the main component of the commonly used traditional Chinese medicine honeysuckle, and honeysuckle is mainly used in antibacterial, anti-inflammatory, antiviral and other fields clinically. Chlorogenic acid is used in a variety of pharmaceutical preparations, but the single prescription is only administered orally, which has the problems of slow onset of action and low bioavailability, and the disadvantage of excessive loss of chlorogenic acid in the preparation. Contents of the invention [0003] One of the objects of the present invention is to provide a chlorogenic acid powder injection, and another object of the present invention is to provide its preparation method and use. [0004] We provide a chlorogenic acid powder for injection, which is c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/215A61K36/35A61K9/14A61P9/00
Inventor 王伟刘二伟
Owner 广东仁泰药业有限公司
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