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Preparing method of oxiracetam injection and products thereof

A technology of oxiracetam and injection, which is applied in the field of preparation of oxiracetam injection preparations, can solve problems such as increasing the workload of medical staff, hand injuries of medical staff, and wasting medicine, so as to save effective medicine and avoid Effects of medical malpractice and workload reduction

Inactive Publication Date: 2003-06-18
诸葛华明 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its shortcomings are: on the one hand, there will be a certain amount of liquid in the ampoule and the syringe, wasting more expensive drugs; on the other hand, it is easy to cause cross-contamination during use; It may cause hand injuries to medical staff, and sometimes, once the compatibility is wrong, it will also cause medical accidents

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: Taking the preparation of 100 bottles of oxiracetam glucose injection as an example, the specific preparation method is to first weigh 500g glucose for injection, add 3000g water for injection and stir to dissolve, then add 0.02% (W / V ) about 2.0g of activated carbon for needles, heated to 50°C, kept warm for 15 minutes, filtered and decarbonized to obtain the filtrate; then added 100g of oxiracetam to the filtrate, stirred until dissolved, and then added water for injection to the solution to 10000g, Adjust the pH value to 4.5, then fine filter with a 0.45 μm filter membrane, pack into 100 bottles, press the cap and sterilize at 110°C for 30 minutes, and finally pack after inspection. The specification of the injection preparation is 100ml, containing 1g of oxiracetam and 5g of glucose.

Embodiment 2

[0021] Example 2: Taking the preparation of 100 bottles of oxiracetam sodium chloride injection preparation as an example, the specific preparation method is to first weigh 90g of sodium chloride for injection, add 3000g of water for injection and stir to dissolve, then add 0.02% (W / V) About 2.0g of activated carbon for needles, heated to 60°C, kept warm for 20 minutes, filtered and decarbonized, and obtained the filtrate; then added 100g of oxiracetam to the filtrate, stirred until dissolved, and then added to the solution for injection Water to 10,000g, adjust the value to 8.0, and then filter through a 0.45μm filter membrane and pack into 100 bottles, press the cap and sterilize at 120°C for 30 minutes, and finally pack after inspection. The specification of the injection preparation is 100ml, containing 1g of oxiracetam and 0.9g of sodium chloride.

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PUM

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Abstract

An oxiracetam injection is prepared from oxiracetam, gluclose (or sodium chloride) for injection and water for injection through proportioning, dissolving the glucose or sodium chloride for injection in the water for injection, adding activated carbon, heating, holding the temp. filtering, adding oxiracetam to the filtrate, stirring for dissolving, adding the water for injection, regulating pH value, fine filtering, bottling and sterilizing at 105-126.5 deg.C.

Description

technical field [0001] The present invention relates to medicament, relate to a kind of preparation method and product of oxiracetam injection preparation more specifically Background technique [0002] Oxiracetam (CAS62613-82-5) is an anti-hypoxic nootropic drug, a derivative of cyclic GABOB, which can promote the synthesis of phosphorylcholine and phosphorylethanolamine, promote brain metabolism, and penetrate the blood-brain barrier. It has a stimulating effect on the specific central nervous system, improves intelligence and memory, has very low toxicity, and has no mutagenic, carcinogenic or reproductive toxicity. Oxiracetam was developed by the Italian company ISFS.P.A. The conventional preparation method of oxiracetam injection: taking the production of 1000 as an example, the prescription consists of 1000g oxiracetam and 5000g water for injection. The specific preparation method is to first weigh 1000g of oxiracetam in the prescribed amount, add an appropriate amoun...

Claims

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Application Information

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IPC IPC(8): A61K31/4015A61P43/00
Inventor 诸葛华明诸葛国民
Owner 诸葛华明
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