The application discloses an adaptive
drug repositioning method based on feature-driven isomorphic graph learning, relates to the technical fields of
drug repositioning and
graph neural networks, and comprises the following steps: acquiring
drug-
disease association data and corresponding graph
network data information; initializing feature embedding of
disease nodes and drug nodes according to the drug-
disease association data and the corresponding graph
network data information, and constructing a heterogeneous graph and an isomorphic graph; performing a heterogeneous graph
convolution operation through disease-to-drug direction and drug-to-disease direction propagation, and calculating the
importance weight between the disease nodes and the drug nodes by using an attention mechanism to generate
heterogeneous information; adaptively weighting the edges in the isomorphic graph through a learnable parameter
mask, controlling the binarization degree of the weight through L1 regularization and entropy regularization, performing an isomorphic graph
convolution operation, and generating isomorphic information. The application effectively reduces the
noise interference in the pre-defined graph by adaptively weighting the edges in the isomorphic graph through the learnable parameter
mask.