The invention discloses a device for measuring a Seebeck coefficient and a method of the device. The device comprises a main heater, an assistant heater, a first insulated thermal conductor, a second insulated thermal conductor, a first main probe, a first assistant probe, a second main probe, a second assistant probe, a first main thermocouple, a first assistant thermocouple, a second main thermocouple and a second assistant thermocouple; the first insulated thermal conductor and the second insulated thermal conductor are both used for carrying a sample to be measured; the first main probe, the first assistant probe, the second main probe and the second assistant probe are used for measuring the electric potential of the sample to be measured; the first main thermocouple, the first assistant thermocouple, the second main thermocouple and the second assistant thermocouple are used for measuring the temperature of the sample to be measured. The morphology of the measured sample can be flexible and diverse, the device can measure the material Seebeck coefficients under the different temperature conditions and is simple in structure, and due to the fact that the measurement method that an average value is resolved through multiple sets of the Seebeck coefficients which are resolved on the basis of the four probes is adopted, the measured Seebeck coefficient is high in measurement accuracy.