The invention discloses a laser welding machine based on water cooling and facilitating accurate butt joint. A work body, a control panel, a guide wire, a handheld type laser welding gun, a center control component, a welding device body, a water pump, a gas pump, a control switch, a water spraying head, an air blowing head and a fixed bolt are included; a water passing pipe, a gas passing pipe and the guide wire are connected to the outer side of the work body, and fixing buckles are fixed to the water passing pipe, the gas passing pipe and the guide wire; the handheld type laser welding gunis connected to the front end of the guide wire; a control piece is fixed to the upper side of the handheld type laser welding gun; the welding device body is fixed to a partition plate which is distributed at the middle position in the work body; and the control switch is installed in the control piece. According to the laser welding machine based on water cooling and facilitating accurate butt joint, the water pump, the gas pump, the water passing pipe and the gas passing pipe on the device can be used for providing air cooling and water cooling functions for the device, the cooling efficiency of the device on stainless steel after being welded is effectively improved, and therefore the using value of the device is improved.