The present invention relates to one kind of efficient composite iodine disinfectant with powerful permeability and its compounding process. The disinfectant consists of mixture of PVP aqua and potassium iodide solution of iodine in certain proportion, synergist, stabilizer and deionized water for diluting to certain concentration. Owing to iodine carrier as main component, the synergist and the stabilizer to regulate the property of the system, the disinfectant has the advantages similar to that of PVP-I and the features of high permeability, high stability, less iodine color residue, high bactericidal effect and wide use range. The present invention may be disintegrated naturally and is environment friendly. The present invention may be used in effective disinfection of air in ward, operation room, hotel, waiting room in station, household and other places, the disinfection of medical equipment, and the pre-operation disinfection of skin, mucous membrane, etc.