The invention discloses an anti-seismic bridge frame. The anti-seismic bridge frame comprises a shell, and an inner shell is arranged in an inner cavity of the shell; fixing blocks are fixedly connected to the two sides of the bottom of the inner cavity of the shell, and a first sliding rod is fixedly connected between two opposite sides of the two fixing blocks; two first springs and two first sliding sleeves are arranged on the surface of the first sliding rod in a sleeving mode, second springs are fixedly connected to the tops of the first sliding sleeves, and the tops of the second springsare fixedly connected with the bottom of the inner shell. According to the bridge frame, the shell, second sliding sleeves, a second sliding rod, the inner shell, fourth springs, third springs, the fixing blocks, a mounting hole, a mounting plate, the first springs, the first sliding sleeves, the first sliding rod, a third damping pad, the second springs, an opening, a first damping pad, a seconddamping pad, a cover plate and damping columns are arranged and are cooperatively used, so that the problem that an existing bridge frame is poor in the anti-seismic effect is solved; and the anti-seismic bridge frame has the advantage of good in anti-seismic effect, and the practicability of the existing bridge frame is improved.