Preparation method of effective part of radix bupleuri and application thereof
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A technology of effective parts and Bupleurum, applied in the field of preparation of effective parts of Bupleurum, can solve the problems of side effects and clinical efficacy need to be further investigated, and achieve the effects of low toxicity, obvious pharmacological effects and controllable quality.
Inactive Publication Date: 2010-01-20
JIANGXI HERBFINE HI TECH
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[0003] However, at present, Western medicine anti-hepatic fibrosis drugs are close to blank, and the side effects and clinical efficacy of γ-interferon and other drugs need to be further investigated
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Embodiment 1
[0048] As measured by an ultraviolet-visible spectrophotometer, the total saikosaponins in the effective parts of Bupleurum bupleuri of the present invention account for 3-85% of the mass fraction of the effective parts in terms of saikosaponin d.
Embodiment 2
[0050] As measured by the liquid chromatography ELSD detector, the mass fractions of saikosaponin a and d in the effective parts of Bupleurum bupleuri in the present invention are 1-30%, 1-30% respectively, and saikosaponin b1-4, f and other The total mass fraction of saponins in the active part is 1-25%. The total amount of saikosaponins a, d, b1-4 and f accounts for 3-85% of the mass fraction of the effective part.
Embodiment 3
[0051] Example 3 Anti-hepatic fibrosis efficacy and action mechanism of the effective fractions of Bupleurum chinensis of the present invention (Study on the effect of total saponins of Bupleurum chinensis on CCl4-induced liver fibrosis in rats)
[0052] 1 Experimental materials
[0053]1.1 Experimental animals and grouping: 130 clean-grade SD rats, male, 180-220g, were randomly divided into model group, blank group, high-dose group, middle-dose group, low-dose group, glycyrrhizin group, and Bupleurum saponin group. Hu traditional Chinese medicine compound group 7 groups, 18 rats in each group.
[0054] 1.2 Drugs Bupleurum total saponins, glycyrrhizin, Bupleurum traditional Chinese medicine compound
[0055] 1.3 Reagent CCL4, vegetable oil; alanine aminotransferase (ALT), aspartate aminotransferase (AST) kit, total bilirubin (T-BIL) kit, albumin (ALB) kit, glutamyl transpeptidase (GGT) ; Liver Hydroxyproline (HYP) Kit; Serum Hyaluronic Acid (HA), Type III Collagen (PCIII), T...
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Abstract
The invention relates to a preparation method for extracting an effective part from traditional Chinese medicine radix bupleuri and an application of the effective part obtained by utilizing the method and a preparation thereof in medicines for preventing and treating liver fibrosis, hepatocirrhosis, chronic hepatitis and the like. The preparation of the effective part of the radix bupleuri can be granules, soft capsules, capsules, dripping pills, tablets, dispersing tablets, effervescence tablets, injection and the like. The invention has simple operation method and utilizes a modern medicine effect sieving technology, an extracting and purifying technology, a preparation technology and a quality control technology to carry out deep development on the radix bupleuri preparation; the effective part of the radix bupleuri and the preparation thereof obtained by utilizing the technological method of the invention are rich in active components, have definite effective components, obvious pharmacological action, obviously enhanced medicine effect, stable performance, controllable quality, safety, reliability and small dose and are beneficial to the transportation and storage of the medicine and the taking of a patient.
Description
technical field [0001] The invention relates to a medicament with an effective part of a traditional Chinese medicine, in particular to a preparation method of the effective part of Bupleurum bupleuri; in addition, the medicament prepared from the effective part can be used in preventing and treating liver fibrosis, liver cirrhosis, chronic hepatitis and the like. Background technique [0002] Liver fibrosis is an inevitable stage in the development of various chronic liver diseases to cirrhosis. Almost any etiology that can cause chronic liver damage can lead to liver fibrosis, chronic hepatitis B, chronic hepatitis C, steatohepatitis (alcoholic or non-alcoholic), immune liver disease, schistosomiasis, drug-induced liver disease, etc. Can cause liver fibrosis. In my country, persistent infection of hepatitis virus, especially hepatitis B virus, is the main cause of liver fibrosis. About 35 million chronic hepatitis B patients in my country constitute a huge potential pati...
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