Traditional Chinese medicine extract capable of improving CIK cell proliferation rate as well as preparation method and application of same

A cell proliferation and extract technology, applied in the direction of drug combination, pharmaceutical formulation, medical preparation containing active ingredients, etc., can solve the problems of low cytotoxicity, difficult cell source, clinical application limitation, etc. The effect of clear ingredients, good social and economic benefits
CN102755512AInactive Publication Date: 2012-10-31CHINA JILIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHINA JILIANG UNIV
Publication Date
2012-10-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a traditional Chinese medicine extract capable of obviously improving CIK (Cytokine-Induced Killer) cell proliferation rate. The extract is prepared from the raw materials of red ginseng, radix ophiopogonis and milk vetch according to a certain weight ratio. A formula of the extract comprises the steps as follows: the red ginseng, the radix ophiopogonis and the milk vetchare added with water and decocted, and are subjected to ethanol precipitation and filtered; ethanol is recovered; the extract liquid is enriched with macroporous resin columns, eluted to be colorlesswith distilled water and eluted with ethanol; the eluant is collected; the extract liquid is filtered with a microporous filtration film; and the filter liquor is condensed, the pH value is adjusted,the filter liquor is filtered again with the microporous filtration film, sterilized, and subpackaged, and then the traditional Chinese medicine extract is obtained. Pharmacological experiments show that the traditional Chinese medicine extract can remarkably improve the proliferation rate of CIK cells.
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Description

technical field

[0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a formula of a traditional Chinese medicine extract capable of increasing the proliferation rate of CIK cells, a preparation method and application thereof. Background technique

[0002] Tumor biotherapy is a hot spot in the field of tumor research today. Tumor biotherapy includes cytokines, gene therapy, monoclonal antibodies, tumor vaccines and adoptive immunotherapy, among which tumor cell adoptive immunotherapy occupies an important role in tumor biotherapy. important position. Cell adoptive immunotherapy is a biological treatment method that has been studied more and has entered clinical trials. It is to infuse autologous or allogeneic immune effector cells activated in vitro into patients to kill tumor cells in patients; it is suitable for patients with low cellular immune function, such as high-dose chemotherapy, radiotherapy, bone marrow transplantat...

Claims

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