4 results about "Autologous plasma" patented technology

The present disclosure relates to a composition including non-autologous plasma or serum and a polymer; method of treating ophthalmic diseases (e.g., dry eye syndrome) or moisturizing and / or repairing non-keratinized surfaces including non-healing wounds with a composition including non-autologous plasma or serum and a polymer; and a therapeutic agent delivery device for delivery of the composition to the eye or a non-keratinized surface of a subject.

The application discloses a bone regeneration kit and implant system for immediate implantation, and belongs to the technical field of oral implant medical devices. The kit comprises a patient personalized component and a universal component; the patient personalized component comprises a segmented personalized abutment and a rigid barrier membrane, the abutment comprises, from top to bottom, a transgingival forming part, a titanium mesh fixing part and an implant connecting part, and the rigid barrier membrane is fixed to the titanium mesh fixing part through a mounting hole; the universal component comprises a plasma matrix preparation component and a bone crumb collector. The application further provides an implant system comprising the kit, an implant and a complete autologous plasma matrix bone block. The rigid barrier membrane is directly fixed to the abutment to form a three-level rigid support, and the titanium nail fixing is omitted; the transgingival forming part of the abutment is customized based on digital scanning to realize soft tissue simultaneous sealing and aesthetic shaping; the bone crumb collector scrapes autologous bone crumb from the bundle-shaped bone area of a tooth extraction socket, and the autologous bone crumb is mixed with autologous plasma matrix to form a bone block without adding exogenous materials. The application realizes the synergistic effect of rigid maintenance of bone space, complete autologous bone regeneration and soft tissue simultaneous forming.

This invention relates to the fields of biomedical engineering and regenerative medicine, and particularly to a plasma matrix composite membrane activated by autologous keratinized epithelial tissue fragments, its preparation method, and its applications. The composite membrane is obtained by mixing autologous keratinized epithelial tissue fragments with a liquid autologous plasma matrix in a specific ratio, utilizing tissue factors on the surface of the tissue fragments to trigger platelet activation, spontaneously forming a gel, and then pressing it into a membrane. This invention is the first to utilize the biointerface of autologous keratinized epithelial tissue fragments to activate platelets, eliminating the need for exogenous thrombin and achieving completely autologous in-situ gelation. The composite membrane formed after pressing possesses excellent mechanical properties and barrier function, and can be prepared in a single operation in the operating room without the need for in vitro cell culture. The composite membrane of this invention is used for oral soft tissue augmentation, such as widening of keratinized gingiva and alveolar ridge soft tissue augmentation, and has advantages such as no donor site damage, high biosafety, and ease of operation.

The present disclosure relates to a composition including non-autologous plasma or serum and a polymer; method of treating ophthalmic diseases (e.g., dry eye syndrome) or moisturizing and / or repairing non-keratinized surfaces including non-healing wounds with a composition including non-autologous plasma or serum and a polymer; and a therapeutic agent delivery device for delivery of the composition to the eye or a non-keratinized surface of a subject.