The invention provides a novel column-shaped three-dimensional cultivation method and device for medical dendrobium. The method is characterized by comprising the following steps of making a cultivation device serving as an auxiliary article in a hollow column-shaped body structure; filling a cultivation medium in the interior cavity of the hollow column-shaped body, wherein the hollow column-shaped body is at least 0.5 m in height and at least 8 cm in diameter, the external surface of the hollow column-shaped body is uniformly provided with seedling planting areas, and a cultivation medium composition mainly comprises the following raw materials in parts by volume: 5-15 parts of barks, 10-30 parts of saw dust and 3-10 parts of vermiculite; selecting healthily-growing seedlings to be hardened and then washing the hardened seedlings during cultivating and transplanting the dendrobium seedlings; and after sterilizing by using 800-1000 times of liquid carbendazim, transplanting the seedlings in different plant bunches according to the seedling planting areas, wherein row spaces of the transplanted plants are 4-6 cm*10-15 cm. Compared with the prior art, the cultivation method provided by the invention is very suitable for growth habits of the wild medical dendrobium; and the medical dendrobium cultivated by using the invention has the advantages of easiness for material obtaining, low cost, long service life, good water retention and fertilizer securing effects, high planting density, land utilization rate capable of being increased by 6-7 times, high and stable yield, good product quality and convenience for management.