98results about How to "Advanced dosage form" patented technology

This invention relates to novel colonic purgative compositions in a solid dosage form, comprising at least one purgative and at least one soluble, or soluble, nonfermentable binder, such as polyethylene glycol. Further, this invention relates to methods of using the colonic purgative compositions. The present compositions and methods are designed to improve patient tolerance and compliance, while at the same time improving the quality of bowel cleansing. The formulations and methods of this invention are particularly useful to cleanse the bowel prior to diagnostic and surgical procedures and can also be employed in lower dosages as a laxative to promote elimination and/or to relieve constipation.

The present inventions relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drugs lopinavir and ritonavir. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester, N-alkyldimethylbenzylammonium chloride, sodium deoxycholate, dioctyl sodium sulfosuccinate, polyethyleneglycol-12-hydroxystearate, polyvinyl alcohol (PVA), and a block copolymer of polyoxyethylene and polyoxypropylene, or a combination thereof. The hydrophilic polymer is suitably selected from polyvinyl alcohol (PVA), a polyvinyl alcohol-polyethylene glycol graft copolymer, a block copolymer of polyoxyethylene and polyoxypropylene, polyethylene glycol, hydroxypropyl methyl cellulose (HPMC), and polyvinylpyrrolidone, or a combination thereof. The present invention also relates to processes for preparing both the solid composition and the aqueous dispersion, as well as to their use in therapy for the treatment and/or prevention of retroviral infections such as human immunodeficiency virus (HIV).

The invention discloses a gingko snail killing microemulsion agent and a preparing method, which relates to the technical field of plant source agricultural drug production. The invention takes the seed shell extract of the gingko containing a ginkgoic acid as the source drug, and the invention is made by configuring auxiliary surface active agents, solution agent and antifreeze agent as well as water. The producing method comprises the following operating steps: the gingko external seed shell extract, the microemulsion agent and the solution agent are blended to be an even and transparent oil phase; the steamed water or the deionized water are added slowly to form an oil enclosed water type emulsion during the agitating process; through agitating and heating, the emulsion is rapidly converted into a water enclosed oil type; a steady O or W type emulsion after being cooled to reach the constant indoor temperature is obtained. The invention has fine environmental compatibility of the emulsion conformation, also completely realizes the advantages of the gingko snail killing agent with high efficiency to the snail and safety to people and animals. The microemulsion agent takes water as the main solvent with slight influence to environment. In addition, the invention has remarkable synergism; the LC 50 and LC 90 of the 24h respectively are 0.56mg per liter and 3.5mg per liter, which are obviously better than that of the 24h snail killing effect (LC50 is equal to 1.35mg per liter and the LC90 is equal to 3.85mg per liter) of the external seed shell extract of the original drug.

The invention discloses a chitosan composition for prevention and treatment of chemical liver injury and a preparation method thereof. Main materials of chitosan, the root of kudzu vine, Poria, Ganoderma lucidum, medlar and gardenia are subjected to the medicinal material dry paste powder preparation, of chitosan preparation, mixing granulation and capsule filling and packing, so as to obtain the composition. The chitosan in the formula of the invention can promote the secretion of liver oxidase, activate and regenerate liver cells; the root of kudzu vine, Poria, Ganoderma lucidum, medlar and gardenia are Chinese herbal medicines used as both medicine and food, and have the effects of invigorating liver and kidney, clearing heat, removing dampness, promoting blood circulation and removing blood stasis; and the composition for prevention and treatment of chemical liver injury prepared from the above materials can achieve the effects of addressing both the symptoms and root cause and enhancing curative effect for chemical liver injury. The preparation method is simple, low in industrialized production cost, and easy for implementation, and has optimistic market outlook.

A Chinese medicine in the form of effervescent tablet for treating cough and resolving sputum is prepared from 8 Chinese-medicinal materials including pummelo peel, bitter almond, liquorice root, etc and 3 medicinal additives: citric acid, dicarbonate and polyethanediol.

The compound ginseng-astragalus immunopotentiator for enhancing immunological function of animal is injection, each 1000 ml of which contains ginsenoside 0.75 g and astragalus polysaccharide 3.0 g except water for injection. The compound ginseng-astragalus immunopotentiator may be used alone to enhance the cellular immunity and humoral immunity or as immunological adjuvant to result in excellent immunopotentiating effect. Pharmacological test shows that the immunopotentiator can raise the expression of chicken's peripheral blood T lymphocyte IL-2mRNA and IFN-gamma-mRNA. Safety test shows that the immunopotentiator has no irritation and no toxicity.

The invention relates to an insecticidal composition which comprises two active components including cyhalodiamide and chlorfenapyr. The insecticidal composition has obvious synergism for controlling rice-stem borer, and not only is capable of improving the controlling effect, but also is capable of reducing the dosage, and delaying the drug resistance, wherein the lasting period is prolonged.

The invention discloses a medicament for treating colonitis, which is prepared from the following bulk drugs by weight: 200 portions of calcite (calcined), 40 portions of halitum (calcined), 400 portions of clematis aethusifolia (calcined), 400 portions of rhododendron micranthum (calcined), 5 portions of nutmeg, 5 portions of coriander fruit, 5 portions of rhizoma zingiberis, 5 portions of long pepper, 5 portions of dwarf lilyturf root, 1 portion of pepper, 5 portions of dried white turnip, 5 portions of sal ammoniac, 5 portions of purple sal ammoniac, 5 portions of elecampane, and 10 portions of potassium nitrate. The formulation is a pure Chinese medicament preparation, has small toxic side effect, is suitable for the characteristic of chronic colonitis recurrent attacks, can be taken for a long time, and has remarkable curative effect; besides the formulation adopts a dosage form of enteric-coated granules to avoid the first pass effect in stomach absorption and act on affected parts directly, and each medicinal material in the formulation adopts the principle of relieving diarrhea with astringents and treating both principal and secondary aspects of a disease to achieve the aim of treatment, thus the medicament for treating colonitis is surely a classic anaesthetic worthy of development in clinical application.

This invention relates to unit dosage forms of temozolomide. These unit dosage forms are particularly well-suited for decreasing the pill burden and increasing patient compliance. The invention also relates to methods of treating proliferative disorders in a patient with these unit dosage forms. The invention additionally relates to kits comprising these unit dosage forms.

The invention provides a spray preparation for relieving pain and swelling, which comprises active ingredients and a substrate, wherein the active ingredients are prepared from the following raw material medicaments in part by weight: 80 to 120 parts of oxytropis, 30 to 70 parts of sub-rhubarb, 50 to 100 parts of tiebangchui aconite tuber, 80 to 120 parts of core removal medicine terminalia fruit, 80 to 120 parts of terminalia bellerica, 80 to 120 parts of emblic leafflower fruit, 20 to 50 parts of benzoin, 130 to 170 parts of Chinese tinospora stem and 10 to 40 parts of musk; and the substrate comprises the following auxiliary materials in part by weight: 100 to 800 parts of excipient and 50 to 500 parts of emulsifier. The spray preparation has the characteristics of advanced formulations, simplicity and convenience for process, quick response and the like. On the basis of ensuring a curative effect, the quality of products is improved, beneficiaries are enlarged, and the quality of the products is safer, more stable and controllable.

The present invention relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drug lopinavir. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester, N-alkyldimethylbenzylammonium chloride, sodium deoxycholate, dioctyl sodium sulfosuccinate, polyethyleneglycol-12-hydroxystearate, polyvinyl alcohol (PVA), and a block copolymer of polyoxyethylene and polyoxypropylene, or a combination thereof. The hydrophilic polymer is suitably selected from polyvinyl alcohol (PVA), a polyvinyl alcohol-polyethylene glycol graft copolymer, a block copolymer of polyoxyethylene and polyoxypropylene, polyethylene glycol, hydroxypropyl methyl cellulose (HPMC), and polyvinylpyrrolidone, or a combination thereof. The present invention also relates to processes for preparing both the solid composition and the aqueous dispersion, as well as to their use in therapy for the treatment and/or prevention of retroviral infections such as human immunodeficiency virus (HIV).

A dahurian rhododendron softgel for treating cough and asthma and dispelling phlegm is prepared from dahurian rhododendron through distilling to extract volatile oil, extracting from dregs in alcohol, recovering alcohol, mixing, concentrating, adding auxiliaries, superfine pulverizing and die pressing.

The invention relates to the field of antibacterial agent, in particular to a garlic oil enteric pellet capsule and a preparation method thereof. Wherein the garlic oil pellet capsule is composed of a coated pellets and a coating layer, the coated pellets comprises pharmaceutically active ingredients of garlic oil and coated pellet minor ingredient; wherein the coated pellet minor ingredient comprises pellet core, bonding agent, absorbing agent, disintegrating agent, antioxygen agent and antiplastering aid while the coating layer comprises an enteric coating and an isolated layer; the coated pellet comprises the following components according to weight percentage: 5-40% of garlic oil, 10-60% of pellet core, 2-10% of binding agent, 20-50% of absorbing agent, 0.5-5% of antioxygen agent, 0.5-10% of disintegrating agent and 2-20% of antiplastering aid.Compared with the existing allicin dosage form, the garlic oil enteric pellet capsule of the invention enjoys more advanced dosage form, thus ensuring effectiveness and stability of the capsule and high bioavailability; in addition, with the enteric pellet capsule of the invention, harm done to gastric mucosa as the capsule is dissolved inside the stomach is avoided and the allicin is not damaged by gastric acid so that drug effect of the capsule is not affected.