Soft capsule of dahurian rhododendron leaf and preparation method

A Manshanhong and soft capsule technology, which is applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of restricting market development and drug users, high ethanol content, and uncomfortable taste, etc., to achieve the desired effect Fast, advanced dosage form, comprehensive curative effect

Inactive Publication Date: 2004-08-11
哈药集团中药二厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high ethanol content of Xiaokechuan syrup, the taste is uncomfortable, and the dosage is large, it is especially unsuitable for children, women, and alcohol-sensitive people, and it is also prone to problems such as precipitation, which limits the development of the market and the expansion of drug users.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] [Example 1] Preparation process 1

[0096] Take 2000g of Manshanhong, add 10 times the amount of deionized water, extract the volatile oil by steam distillation for 3 hours, collect the volatile oil, and set aside; filter the extract, and store it in another container; add 10 times the amount of 90% ethanol to the dregs, and reflux extraction After 2 hours, filter, recover the ethanol from the filtrate until the alcohol content is 5%-15%, let it cool, let it stand for 48 hours, filter, combine the filtrate with the water extract, and concentrate to a relative density of 1.10-1.15 (80°C) The thick paste, the paste was dried in vacuum at 80°C for 12 hours, added appropriate amount of polyethylene glycol 200 and volatile oil, ultrafinely pulverized (100 mesh), compressed into soft capsules, subpackaged, and packaged to obtain final product.

Embodiment 2

[0097] [Example 2] Preparation process 2

[0098] Take 2000g Manshanhong, add 13 times the amount of deionized water, extract the volatile oil by steam distillation for 5 hours, collect the volatile oil, and set aside; filter the extract, and store it in another container; add 10 times the amount of 92% ethanol to the dregs, and reflux extraction After 2 hours, filter, recover the ethanol from the filtrate until the alcohol content is 10%-25%, let it cool, let it stand for 18 hours, filter, combine the filtrate with the water extract, concentrate to a relative density of 1.15-1.20 (80°C) The thick paste is dried under vacuum at 70°C for 24 hours, added with appropriate amount of peanut oil and volatile oil, superfinely pulverized (100 mesh), compressed into soft capsules, subpackaged, and packaged to obtain final product.

Embodiment 3

[0099] [Example 3] Preparation process 3

[0100] Take 2000g Manshanhong, add 16 times the amount of deionized water, extract the volatile oil by steam distillation for 7 hours, collect the volatile oil, and set aside; filter the extract, and store it in another container; add 10 times the amount of 92% ethanol to the dregs, and reflux extraction After 2 hours, filter, recover the ethanol from the filtrate until the alcohol content is 15%-30%, let it cool, let it stand for 24 hours, filter, combine the filtrate with the water extract, concentrate to a relative density of 1.18-1.24 (73°C) The thick paste was dried under vacuum at 60°C for 36 hours, added with appropriate amount of polyethylene glycol 600 and volatile oil, ultrafinely pulverized (100 mesh), compressed into soft capsules, subpackaged, and packaged to obtain final product.

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PUM

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Abstract

A dahurian rhododendron softgel for treating cough and asthma and dispelling phlegm is prepared from dahurian rhododendron through distilling to extract volatile oil, extracting from dregs in alcohol, recovering alcohol, mixing, concentrating, adding auxiliaries, superfine pulverizing and die pressing.

Description

[technical field] [0001] The invention relates to a medicine Manshanhong soft capsule for warming the lungs and eliminating phlegm, relieving cough and relieving asthma and a preparation method thereof, belonging to the field of traditional Chinese medicines. [Background technique] [0002] Chronic cough and asthma syndrome caused by cold phlegm involving the lungs, mainly manifested as simple type and wheezing type acute and chronic bronchitis. Breathing and chest tightness, phlegm in the throat, accompanied by lack of thirst, clear and long urine, thin white or greasy tongue coating, stringy and tense pulse. [0003] Acute and chronic bronchitis is a common and frequently-occurring disease in clinical practice. Especially in recent years, air pollution has become more and more serious, and the incidence rate has also shown an increasing trend year by year. According to reports, the incidence rate of bronchitis in my country is 0.8-2%, and there are about 10-26 million pat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61P11/00A61P11/06A61P11/14
Inventor 彭可让贾继明付饶王立新杨瑶珺陈金霞李吉良许庆瑞吕春玲张宇谢黎雯杨爱淑
Owner 哈药集团中药二厂
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