Heat clearing Chinese proprietary capsule(tablet) of 'Ganlu Xiaodu' for treating cold and its preparation process

A technology of manna disinfection, cold and heat-clearing technology, applied in the directions of capsule delivery, anti-infective drugs, medical preparations containing active ingredients, etc. Achieve good dissolution rate and bioavailability, shorten the onset time, and reduce the dosage

Inactive Publication Date: 2005-12-07
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, Ganlu Xiaoxiao Wan is an ancient classic prescription, and its dosage form is a water pill. (For details, see the Ministry of Health of the People's Republic of China, Volume 9, Page 54 of Drug Standards). Obvious toxic and side effects, but due to the limitations of the dosage form and dosage, the market share has been small, far from meeting the needs of the majority of cold and fever patients
[0003] At present, Ganlu Xiaodu pills mainly have the following problems (1). The long dissolution time generally takes 50 minutes, resulting in slow oral absorption and reduced bioavailability, which is not conducive to the efficacy of the drug; (2). The dosage is relatively large , taking about 86-129 pills each time (equivalent to 6-9 grams of crude drug), causing inconvenience to patients, especially the elderly; It is directly formed into pan pills, so the drug content is low, and there is no quality standard control at present, and it is difficult to meet the hygiene inspection standards, etc.
In short, the solubility, dissolution rate, bioavailability and active ingredient content control of Ganlu disinfection pills need to be further improved.

Method used

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  • Heat clearing Chinese proprietary capsule(tablet) of 'Ganlu Xiaodu' for treating cold and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: the preparation of sweet dew disinfection capsule, tablet

[0035] 1. Prescription: 20g of Scutellaria baicalensis, 30g of talcum powder, 12g of Shichangpu, 8g of Shegan, 22g of capillary, 8g of white cardamom, 8g of mint, 10g of Akebia chinensis, 8g of forsythia, 10g of Chuan Fritillaria, 8g of patchouli, 11 flavors Composed of traditional Chinese medicine, the total weight is 144 grams.

[0036] 2. Preparation method:

[0037] 1) Medicinal material treatment: Weigh 1000g of medicinal material according to the prescription, and extract twice with 85% ethanol and water respectively. When extracting with 85% ethanol, extract 8000ml each time for 1 hour, and when extracting with water, extract 10000ml each time for 0.5 hour. concentrate. The alcohol extract is concentrated to dryness under reduced pressure, added with water to form a suspension, the volatile oil is extracted, and after enrichment, the suspension is concentrated under reduced pressure to ob...

Embodiment 2

[0043] Embodiment 2: the preparation of sweet dew disinfection capsule, tablet

[0044] 1. Prescription: with embodiment 1.

[0045] 2. Preparation method:

[0046] 1) Medicinal material treatment: Weigh 1000g of medicinal material according to the prescription, and extract twice with 90% ethanol and water respectively. When extracting with 90% ethanol, extract 7000ml each time for 1 hour, and when extracting with water, extract 9000ml each time for 1 hour. concentrate. The alcohol extract is concentrated to dryness under reduced pressure, added with water to form a suspension, the volatile oil is extracted, and after enrichment, the suspension is concentrated under reduced pressure to obtain an extract. Concentrate the water extract under reduced pressure to a relative density of 1.10, add 95% ethanol to make the solution contain 75% alcohol, stir evenly, let stand, pour out the supernatant, concentrate under reduced pressure to extract, and mix with alcohol extract , The ...

Embodiment 3

[0052] Embodiment 3: the preparation of sweet dew disinfection capsule, tablet

[0053] 1. Prescription: with embodiment 1.

[0054] 2. Preparation method:

[0055] 1) Medicinal material treatment: Weigh 1000g of medicinal material according to the prescription, and extract twice with 95% ethanol and water respectively. When extracting with 95% ethanol, extract 6000ml each time for 1 hour, and when extracting with water, extract 8000ml each time for 2 hours. concentrate. The alcohol extract is concentrated to dryness under reduced pressure, added with water to form a suspension, the volatile oil is extracted, and after enrichment, the suspension is concentrated under reduced pressure to obtain an extract. Concentrate the water extract under reduced pressure to a relative density of 1.15, add 95% ethanol to make the solution contain 80% alcohol, stir evenly, let stand, pour out the supernatant, concentrate under reduced pressure to extract, and mix with alcohol extract , The...

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Abstract

The invention discloses a heat clearing Chinese proprietary capsule (tablet) of 'Ganlu Xiaodu' for treating cold and its preparation process, which comprises eleven kinds of Chinese medicinal herbs including baikal skullcap root, talcum powder, grassleaved sweetflag rhizome and belamcanda rhizome. The preparing process comprises making extract by prescription contents, mixing 100 parts of extract with 2-5 parts of silicon dioxide to prepare capsule, or mixing 100 parts of extract with 0.2-0.5 part of magnesium stearate to obtain tablets, and the content of the active ingredient of baicalin in the extract in no less than 9.0%.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to a Chinese patent medicine Ganlu Xiaoxiao Capsule (tablet) for treating colds and clearing away heat and a preparation process thereof. Background technique [0002] In ancient times, Chinese patent medicines for treating colds were mostly pills or powders, but they were inconvenient to take because they were prone to mildew and deterioration in summer, and the dosage was large. In modern times, some ancient prescriptions or classic prescriptions are changed into tablets, capsules or granules. For example, Ganlu Xiaoxiao Pill is an ancient classic prescription, and its dosage form is water pill, (see the Ministry of Health of the People's Republic of China Drug Standards, Volume 9, page 54) mainly used for treating colds and clearing away heat. It has been proved to have significant curative effect through years of clinical practice, and it is safe and safe. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 王顺仙董欣张林林郑国华
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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