166results about How to "Dosage stable" patented technology

A topical treatment for skin disorders and diseases comprising a combination of at least one antifungal agent and at least one hydroxy acid agent formulated into shampoos, creams, lotions, gels, sprays, foams, pads, films, patches, and solutions for treatment of skin disorders and diseases in both humans and animals.

A topical treatment for onychomycosis and Tinea pedis comprising a delivery system further comprising at least one hydroxy acid agent having a pH-pKa value of 0.5 or greater and at least one antifungal agent formulated into creams, lotions, gels, sprays, foams, pads, films, patches, and solutions.

The present invention relates to ramipril compositions with improved stability. More particularly, the present invention is directed to pharmaceutical compositions comprising ramipril that are stabilized against decomposition into degradation products, namely, ramipril-diketopiperazine and ramipril-diacid, during formulation and storage conditions. The present invention also relates to methods for making and methods of manufacturing stabilized ramipril compositions.

The invention provides a ready-to-use adjuvant of livestock vaccines, preparation and applications thereof, belonging to the field of the adjuvant of livestock vaccines. The ready-to-use adjuvant is prepared from the following substances: 5-30 percent of oil, 0.1-10 percent of hydrophilic surfactant, 0.1-10 percent of oleophilic surfactant, 0.1-10 percent of polymeric micelle substance and 40-90 percent of water. The invention also provides a preparation method of the ready-to-use adjuvant, and the method comprises the following steps: respectively weighing the substances, mixing and then emulsifying, and degerming to obtain the ready-to-use adjuvant of the livestock vaccines. The invention also provides an oil-in-water type vaccine with the ready-to-use adjuvant. The ready-to-use adjuvant is an oil-in-water type adjuvant and has the advantages of simple ingredients, stable dosage form, convenience in use and easiness in injection. The preparation method of the ready-to-use adjuvant has a simple process and is low in cost, and the obtained dosage form is stable. The oil-in-water type vaccine has the advantages of long stable period, easiness in storage, good immune effect, protection period prolonging, easiness in injection and small side reaction.

The invention discloses a compound biological preservative. The compound biological preservative comprises the components as follows: 0.1-5 g of component B is added in each 1L of component A, the component A is fermentation liquor of Bacillusamyloliquefacienssubsp.plantarum BGP20 strains, and the component B is natamycin. The compound biological preservative is used for preventing and controlling diseases of fruits and vegetables in a storage period and particularly can be used for simultaneously preventing and treating bacterial soft rot and various fungal diseases (for example, phytophthora capsici, rhizopus soft rot, pythium blight and the like) of fruits and vegetables in the storage period, avoiding or reducing residual chemical pesticides and agricultural antibiotics and maintaining the quality of the fruits and vegetables in the storage period, so that the compound biological preservative has good economic and social benefits.

The invention discloses an oil-in-water type nanometer emulsion adjuvant and MRSA nanometer emulsion adjuvant vaccine and a preparing method thereof. The nanometer emulsion adjuvant is prepared from, by mass, 1-30% of surface active agent, 0.1-15% of cosurfactant, 0.1-15% of oil phase and 40-98.8% of water; the adjuvant is clear and transparent liquid from appearance, the particle size ranges from 1 nm to 100 nm, viscosity is low, the adjuvant belongs to a highly thermodynamics stabilizing system, and therefore high-speed centrifugation is stable without layering; when being compatible with the vaccine, the adjuvant can wrap the vaccine or be directly mixed with the vaccine physically for use, and immunity can be achieved by means of administration routes such as intramuscular injection and nasal drip. The adjuvant has the advantages of being low in cost, convenient to administrate, small in toxicity, good in liquidity and small in irritation to organism, and avoiding cross infection, the immune effect and stability of the vaccine are effectively improved, and the adjuvant has a wide application prospect.

The invention provides a chip module with excellent heat dissipation performance and a fabrication method of the chip module. The chip module comprises a chip body, wherein the chip body is connectedto a substrate by a welding ball, a dam is arranged around the chip body, a gap is formed between the dam and the chip body, a cooling indium sheet and a cooling cover are arranged above the chip body, the cooling cover is packaged on the cooling indium sheet. By arranging a dam structure around the chip body, the dosage of an additive during the fabrication process of the chip module is more stable, fewer holes are generated after welding, the liquid indium is smaller in mobility under a high temperature, the welding effect is better, and the final cooling effect of the chip module is more excellent.

The invention belongs to the technical field of veterinary biological products, and particularly relates to a triple vaccine for feline calicivirus infection, feline infectious rhinotracheitis and feline panleukopenia as well as a preparation method and application thereof. The triple vaccine comprises antigen components and a freeze-drying protective agent, and the antigen components comprise a feline calicivirus BJ strain inactivated antigen, a feline infectious rhinotracheitis virus SH strain inactivated antigen and a feline panleukopenia virus SY strain inactivated antigen. The feline calicivirus antigen, the feline infectious rhinotracheitis virus antigen and the feline panleukopenia virus antigen are prepared by adopting a full-suspension technology, the triple inactivated freeze-dried vaccine for feline calicivirus, feline infectious rhinotracheitis and feline panleukopenia is prepared through the processes of inactivation, concentration, freeze-drying and the like, three diseases are avoided by one injection, the animal immunization frequency is reduced, the animal stress frequency is reduced, and the economic cost of feeders is greatly reduced.

The present invention uses the oleanolic acid extracted from ligustrum fruit and zymolyzed dried powder made up by using silkworm chrysalis as main raw material, and adds the auxiliary materials of excipient and vitamins and utilizes a certain preparation process to obtain the invented liver-protecting functional food.

The invention provides a method for carrying out composite predictive control on coagulant dosage of water treatment and relates to a method for controlling coagulant dosage of water treatment, and the method can be used for solving the problem of complex control over nonlinear uncertain objects during a coagulation process. The method comprises the following specific steps of: establishing a composite predictive control model; through detecting the turbidity of untreated water and the turbidity of effluent during the coagulation process of water treatment and combining an effluent quality set value, inputting the turbidity of untreated water, the turbidity of effluent and the effluent quality set value into the composite predictive control model so as to solve the real-time control quantity of coagulant dosage of water treatment, wherein in the establishment of the composite predictive control model, the coagulant dosage of water treatment in a water plant is controlled by utilizing composite predictive control method of simplified DMC (Dynamic Matrix Control) and untreated water quality disturbance feed-forward predictive control, and the turbidity of untreated water during feed-forward control can be predicted by utilizing a time sequence predication method based on AR (Auto Regression) predication. According to the invention, the control accuracy is improved by utilizing the combination of simplified DMC and feed-forward predictive control, and the problem that sampling usually has a certain time interval is solved by utilizing the time sequence predication method based on AR predication; and the method provided by the invention can be used for controlling the coagulant dosage of water treatment in the water plant.

A Chinese medicine in the form of effervescent tablet for treating cough and resolving sputum is prepared from 8 Chinese-medicinal materials including pummelo peel, bitter almond, liquorice root, etc and 3 medicinal additives: citric acid, dicarbonate and polyethanediol.

The invention provides an automatic cleaning device for a graphite boat and a cleaning method based on the device. Hydrofluoric acid is supplemented into equipment through a pipeline via a diaphragm circulating pump, a safety door is completed closed in the liquid adding process, hydrofluoric acid is isolated from the outside, liquid adding is automatically stopped when the safety door is opened, liquid splashing is avoided, and the safety of operators is guaranteed. The parameters such as the use amount of adopted hydrofluoric acid, bubble cleaning time and water bath disacidifying time can be set through a touch screen visually and conveniently, manual monitoring and operation are not needed, and labor cost is reduced. The automatic cleaning device is provided with a scramming device, when an accident happens, all working valves can be switched off in time, and enlargement of the accident is avoided. The stable use amount of hydrofluoric acid can be guaranteed through a flow meter, the liquid adding amount of hydrofluoric acid can be changed through the touch screen, and automatic acid adding is more stable than manual acid adding. In the cleaning and disacidifying process, the cleaning degree can be determined through a hydrofluoric acid concentration sensor arranged in a cleaning tank, and higher safety and reliability are achieved.

The invention relates to a wind-water combined recovery system for slag heat in a circulating fluidized bed boiler, and a control method thereof. The wind-water combined recovery system for slag heatcomprises a closed circulating sub-system, a cold air heating sub-system and an air preheater bypass sub-system, wherein the closed circulating sub-system enables a circulating medium to reciprocate between a slag cooler and an air heater of the cold air heating sub-system through a circulating device, so that slag continuously carries out heat exchange with cold air; the heated cold air is conveyed into an air preheater and continues to absorb smoke heat coming from a smoke discharge port of the boiler; and the redundant smoke heat is sequentially transferred and conveyed to a feed water heatexchanger and a condensed heat exchanger in the air preheater bypass sub-system, so that the smoke heat carries out heat exchange with feed water and condensed water. According to the wind-water combined recovery system for slag heat in the circulating fluidized bed boiler, and the control method thereof, high recovery and utilization rate for the slag heat is achieved, so that the efficiency ofthe circulating fluidized bed boiler is increased, and the power generation coal consumption of a unit is reduced.

The invention discloses a traditional Chinese medicinal composition, a compound preparation and an application thereof. The traditional Chinese medicinal composition comprises the following components in parts by weight: 10-300 parts of Morus alba leaf extract, 10-300 parts of bitter gourd extract, 10-300 parts of Astragalus membranaceus extract and 10-300 parts of Ophiopogon japonicus. The compound preparation product prepared from the traditional Chinese medicinal composition is prepared from natural plant extracts, has stable quality, no toxic and side effects, convenience in administration, smooth action, definite therapeutic effect, stable dosage form, and controllable quality, and can meet the requirements of patients at prediabetic stage and type II diabetics.

The invention relates to a compound suspending emulsion containing propiconazole and azoxystrobin. The compound suspending emulsion comprises the following components in percentage by weight: 1-50% of crude drug propiconazole, 1-50% of crude drug azoxystrobin, 1-6% of emulsifying agent, 1-6% of dispersing and wetting agent, 0.1-5.0% of suspending agent, 1-20% of synergistic agent, 0.01-1.0% of thickening agent, 0.01-5% of preservative agent, 0.01-8% of anti-freezing agent and the balance of carrier.

The invention provides doxycycline hydrochloride soluble powder. Based on the total mass of various components being 100%, the doxycycline hydrochloride soluble powder is prepared from the following components in percentage by mass: 10% of doxycycline hydrochloride, 28-34% of sustained-release agent, 1-3% of complexing agent, 4-9% of antioxidant, and the balance of anhydrous dextrose. The stability of the doxycycline hydrochloride soluble powder is relatively high, the effective content of the doxycycline hydrochloride is slowly lowered, and the drug failure time is effectively prolonged.

The invention relates to a butadiene acrylonitrile rubber sheath formula. The formula comprises the following components: 100 parts of butadiene acrylonitrile rubber, 3 parts of polystyrene, 5 parts of ultralow density polyethylene, 6 parts of chlorinated paraffin, 6 parts of polyurethane, 2 parts of butyl acetate, 6 parts of calcined clay, 3 parts of talcum powder, 4 parts of ethylene glycol, 7 parts of phthalo blue, 3 parts of ethylene-vinyl acetate and 10 parts of dicyclopentadiene. The rubber sheath formula has the advantages of low cost, reasonable proportion, excellent performance, use stability and the like, improves the production benefits of factories and reduces the consumption of rubber, and the physical and mechanical properties of rubber sheaths are not reduced.

The invention discloses a strain TX-4 used for preventing diseases of aphelenchoides besseyi or vegetable root knot nematode and a preparation thereof, belonging to the technical field of preventing and treating diseases of crops and being specially used for biological prevention of the crops. The prevention result of field demonstration shows that the strain has the preventing effect of more than 90 percent to the aphelenchoides besseyi disease and has preventing effect of more than 70 percent to the vegetable root knot nematode disease. The strain TX-4 for preventing diseases of aphelenchoides besseyi or vegetable root knot nematode is bacillus with the Latin systematic name of Paenibacillus spp., the strain has been preserved in China Center for Type Culture Collection on March 19, 2009 and the preserving number is CCTCC No: M209038.