Emulsion-in-water insecticide and production process thereof

An insecticide and water emulsion technology, applied in the field of water emulsion insecticide and its production technology, can solve the problems of limited development, poor adhesion and penetration, easy to freeze, etc., and achieves simple production process, stable dosage form, The effect of low degradation rate

Active Publication Date: 2012-08-15
山东荣邦化工有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] (1) Short storage stability time: the normal storage time of pesticides is 2-3 years, while the normal storage time of water emulsion is about 1 year;
[0005] (2) Stratification is easy to occur: it will break the emulsion due to temperature, physical and chemical changes of the original drug and additives, ultraviolet rays, time, water quality, etc., that is, the separation of water and solvent to form stratification;
[0006] (3) Precipitation is prone to occur: due to the decomposition of auxiliary agents and the original drug, the original drug will be dropped out of the preparation, forming rice grains or crystals and sinking to the bottom, which will greatly reduce the efficacy and safety of the product. content of active ingredients;
[0007] (4) It is difficult to solve the problem of pesticide synergy: since water is the main solvent, the formation of water emulsion is a principle of dynamic stability. , is extremely unstable in this dosage form. Therefore, the surface swelling force of the normal dosage form of water-emulsion is similar to that of water. Poor adhesion and penetration are the biggest problems of water-emulsion, and it is difficult to improve the efficacy of the product.
[0008] (5) Emulsion in water is easy to freeze in winter, especially in northern my country where the temperature is lower than 15°C, which greatly limits the development of this formulation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Emamectin Benzoate Emulsion in Water

[0045] Consists of the following ingredients in weight percent:

[0046] Original drug emamectin benzoate 0.5%, methylnaphthalene 8%, cyclohexanone 2%, triphenylethylphenol polyoxyethyl ether 3%, sucrose 5%, ethylene glycol 5%, Acetic acid 0.5%, the balance water makes up.

[0047] The production technology of above-mentioned preparation comprises the following steps:

[0048] (1) Dissolving the original drug: first mix the original drug, methylnaphthalene, and cyclohexanone according to the above ratio, and stir for about 20 minutes until completely dissolved;

[0049] (2) Prepare the mother liquor: add triphenylethylphenol polyoxyethyl ether, sucrose, ethylene glycol, and acetic acid into the dissolved liquid in step (1) according to the above ratio, and mix and stir for 20 minutes to obtain the mother liquor;

[0050] (3) Finally, add the remaining water into the shear tank, and then add the mother liquor prepared in the abov...

Embodiment 2

[0053] Abamectin Water Emulsion

[0054] The following components are composed in weight percent:

[0055]The content of the original drug avermectin is 1.8%, the content of methylnaphthalene is 8%, the content of isophorone is 2%, the content of triphenylethylphenol polyoxyethyl ether is 6%, and the content of calcium dodecylbenzenesulfonate is 2%. , 10% sucrose content, 0.5% acetic acid content, 5% ethylene glycol content, supplemented with water.

[0056] The production technology of above-mentioned preparation comprises the following steps:

[0057] (1) Dissolving the original drug: mix the original drug, methylnaphthalene, and isophorone in proportion, and stir for about 30 minutes until completely dissolved;

[0058] (2) Preparation of mother liquor: Add triphenylethylphenol polyoxyethyl ether, calcium dodecylbenzenesulfonate, sucrose, acetic acid, and ethylene glycol into the original drug liquid dissolved in the above step (1) in proportion , mixed and stirred for a...

Embodiment 3

[0062] Beta-cyhalothrin emulsion in water

[0063] The following components are composed in weight percent:

[0064] The original drug beta-cyhalothrin 2.5%, methyl naphthalene 8%, isophorone 1%, triphenylethylphenol polyoxyethyl ether 2%, calcium dodecylbenzenesulfonate 1%, high gold Thiketone 1%, sucrose 5%, ethylene glycol 3%, acetic acid 0.5%, and the rest made up with water.

[0065] The production technology of above-mentioned preparation comprises the following steps:

[0066] (1) Dissolution of the original drug: Add the original drug, methylnaphthalene, and isophorone into the mixing tank in proportion, and stir for 30 minutes until the original drug is completely dissolved;

[0067] (2) Prepare mother liquor: Add triphenylethylphenol polyoxyethyl ether, calcium dodecylbenzenesulfonate, genthilon, sucrose, ethylene glycol, and acetic acid to the mixing tank in step (1) in proportion mixed with the dissolved original drug in the medium, and stirred for 30 minutes to...

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PUM

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Abstract

The invention discloses an emulsion-in-water insecticide and a production process thereof. The preparation comprises the following components in percentage by weight: 0.5-50% of active pharmaceutical ingredient, 8-15% of methylnaphthalene, 0-5% of isophorone, 0-5% of cyclohexanone, 2-8% of triphenylethyl phenol polyoxyethyl ether, 0-3% of calcium dodecylbenzene sulfonate, 0-2% of 1,2-benzisotniazol-3(2H)-one, 5-10% of sucrose, 0-10% of ethylene glycol, 0.5% of acetic acid and the balance of water. The preparation method comprises the following steps of: dissolving the active pharmaceutical ingredient, preparing mother liquor, and performing a shearing process. The emulsion-in-water insecticide disclosed by the invention has the advantages of wide range of application, stable formulation, obvious synergy and simple production process.

Description

technical field [0001] The invention relates to a water-emulsion insecticide, in particular to a water-emulsion insecticide and a production process thereof, belonging to the field of water-emulsion insecticides. Background technique [0002] The international code name of water emulsion dosage form is Ew, which was once called concentrated emulsion (Concentrate Emulsion). It is a preparation made by mixing liquid or mixed with a solvent to disperse the liquid pesticide original drug in water with small droplets of 0.5-1.5 microns. The appearance is milky white milk-like liquid. Generally speaking, the water solubility of the pesticide used to process the water emulsion is expected to be below 1000mg / L. Pesticides that are not sensitive to hydrolysis are easily processed into chemically stable aqueous emulsions due to the large amount of water in the formulation. Pesticides such as organophosphorus and carbamates are easily hydrolyzed, but through the selection of emulsifi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/04A01N25/30A01N43/90A01N53/08A01N53/06A01N37/38A01N57/16A01N47/24A01N43/58A01N57/14A01P7/04A01P7/02
Inventor 王龙华邓万平
Owner 山东荣邦化工有限公司
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