The invention relates to a composition containing methylamine-avermetins-benzote, and belongs to the technical field of pesticides. The composition is made by compounding the methylamine-avermetins-benzote, other active ingredients (at least one of pyriproxyfen and pymetrozine) and various common carriers and auxiliary agents, wherein, corresponding to one part of the methylamine-avermetins-benzote by weight, a feasible mixing range of other active ingredients is as follows: 0.5-19 parts of the pyriproxyfen by weight and 3-50 parts of the pymetrozine by weight. The composition can be used for control of a plurality of agricultural and horticultural pests of cotton, paddy rice, vegetables and the like (e.g., control of sweetpotato whitefly, common thrips, aphides, whitefly, jassid, paddy rice hopper, paddy leaf roller, asiatic paddy borer, yellow paddy borer, paddy weevil and diamond back moth), has significant synergistic action and broad insecticidal spectrum, and can effectively overcome or delay generation of resistance of pests against various active ingredients, and obtain significant control effect.