Emulsion in water containing abamectin and pyriproxyfen and application thereof

Abstract

The invention relates to the technical field of emulsion in water, and discloses an emulsion in water containing abamectin and pyriproxyfen and application thereof.The abamectin, the pyriproxyfen and a mixed solvent serve as raw materials and are evenly mixed, and an oil phase is obtained; an emulsifying agent, a defoaming agent, ethylene glycol and deionized water serve as raw materials and are evenly mixed to obtain a water phase, the water phase and an oil phase are evenly mixed to obtain the emulsion in water, the emulsion in water has good heat storage stability and cold storage stability, the death rate of diaphorina citri and tetranychus cinnabarinus reaches 80% or above when the emulsion in water is used for treating the diaphorina citri and the tetranychus cinnabarinus, and the emulsion in water has a good insecticidal effect. The prepared water emulsion containing abamectin and pyriproxyfen is a multifunctional environment-friendly product which is convenient to use, efficient, low in toxicity and low in cost, and has good market development potential.

Description

Technical Field

[0001] The present invention relates to the technical field of aqueous emulsion, and specifically relates to an aqueous emulsion containing abamectin and pyriproxyfen and its application. Background Art

[0002] Pesticide aqueous emulsion is an oil-in-water type mixed system with water as the continuous phase and active ingredients as the dispersed phase. Compared with traditional emulsifiable concentrate formulations, it has the following characteristics: water is used to replace a large amount of organic solvents, reducing the toxicity of pesticides, reducing environmental pollution, and being safer for humans and the environment; a large amount of organic solvents are saved, reducing production costs, and it occupies an important position among new pesticide formulations.

[0003] Abamectin, also known as avermectin, is an anti-parasitic active and agricultural-livestock dual-purpose antibiotic, belonging to the macrolide antibiotic insecticide and acaricide. Abamectin interacts with the chloride ion channel of the neurotransmitter γ-aminobutyric acid in pests, and realizes the blockage of the conduction between interneurons and motor neurons in the nervous system of target pests by strengthening the action of γ-aminobutyric acid, making it difficult for the nerve to transmit stimuli to the muscle, and the muscle cells cannot contract, causing the insect body to become paralyzed and die. Because it does not cause rapid dehydration of insects, its lethal effect is slow and its ovicidal activity is low.

[0004] Pyriproxyfen, also known as 4-phenoxyphenyl-(R,S)-2-(2-pyridyloxy)propyl ether, and its structural formula is: It belongs to the third generation of insecticides. Compared with the first and second generations of insecticides, it is safer for humans and the environment, and has the characteristics of high efficiency, low dosage, and long drug efficacy. Pyriproxyfen causes an imbalance in the hormone levels in insects by contacting the pupation period of insect larvae, inhibits embryogenesis, metamorphosis and the formation of adults, and effectively interrupts many important processes such as insect reproduction and development.

[0005] The frequent use of aqueous emulsions containing a single active ingredient not only has a narrow scope of action, but also easily causes the generation of weed resistance, which is not conducive to the sustainable development of the environment. Therefore, there is an urgent need for a new product to replace the aqueous emulsion containing a single active ingredient, increase the drug efficacy, delay diseases, and reduce economic losses. Summary of the Invention

[0006] The present invention includes an aqueous emulsion containing abamectin and pyriproxyfen and its application: by reasonably compounding abamectin and pyriproxyfen, the aqueous emulsion has the advantages of both, and the herbicidal composition of the present invention has a significant synergistic effect. The specific technical solutions are as follows:

[0007] An aqueous emulsion containing abamectin and pyriproxyfen, the aqueous emulsion comprises an oil phase and a water phase, and the mass ratio of the oil phase to the water phase is 14 - 18:82 - 86;

[0008] The oil phase comprises: abamectin, pyriproxyfen, mixed solvent;

[0009] The aqueous phase contains: an emulsifier, ethylene glycol, an antifoaming agent, and deionized water.

[0010] In one embodiment, preferably, the mass ratio of abamectin to pyriproxyfen is 1:0.5 - 1, and their dosage is 2 - 5% of the total mass of the aqueous emulsion.

[0011] In one embodiment, preferably, the mixed solvent is a mixed solution of xylene and isopropanol with a mass ratio of 1:1, and its dosage is 10 - 15% of the total mass of the aqueous emulsion.

[0012] In one embodiment, preferably, the emulsifier is a mixture of Span - 20 and Tween - 20 with a mass ratio of 1:1, and its dosage is 4 - 8% of the total mass of the aqueous emulsion.

[0013] In one embodiment, preferably, the antifoaming agent is a silicone antifoaming agent, and its dosage is 0.5 - 0.8% of the total mass of the aqueous emulsion; the dosage of ethylene glycol is 2 - 5% of the total mass of the aqueous emulsion, and the balance is deionized water.

[0014] In one embodiment, further preferably, the preparation method includes the following steps:

[0015] (1) Add abamectin, pyriproxyfen, and the mixed solvent of xylene and isopropanol to an oil - phase kettle, stir for 30 min to mix evenly, and obtain an oil phase;

[0016] (2) Add the emulsifier, antifoaming agent, ethylene glycol, and deionized water to an aqueous - phase kettle, stir for 30 min to mix evenly, and obtain an aqueous phase;

[0017] (3) Add the aqueous phase to the oil phase, shear at 5500 r / min for 30 min, and mix evenly to obtain an aqueous emulsion.

[0018] In one embodiment, further preferably, the aqueous emulsion is applied in the fields of controlling houseflies, mites, etc.

[0019] Compared with the prior art, the present invention has the following beneficial effects:

[0020] An aqueous emulsion containing abamectin and pyriproxyfen according to the present invention, by reasonably compounding and using abamectin and pyriproxyfen, enables the prepared aqueous emulsion to have the advantages of both, can inhibit the development of insects during the larval stage and the adult stage, achieve the purpose of killing insects. The two are compounded, showing a synergistic effect, avoiding the drug resistance generated by long-term single use, and enhancing the effect of killing insects. The present invention uses abamectin, pyriproxyfen, and a mixed solvent as raw materials, mixes them evenly to obtain an oil phase; uses an emulsifier, an antifoaming agent, ethylene glycol, and deionized water as raw materials, mixes them evenly to obtain an aqueous phase, and mixes the aqueous phase and the oil phase evenly to obtain an aqueous emulsion. This aqueous emulsion has good thermal storage stability and cold storage stability. By treating Diaphorina citri and Tetranychus cinnabarinus with the aqueous emulsion, their mortality rates both reach over 80%. The insect control effects of abamectin and pyriproxyfen alone are inferior to their compound use, and there is an obvious synergistic effect. The two cannot be eliminated or replaced. Detailed implementation mode

[0021] According to the following embodiments, the present invention can be better understood. However, those skilled in the art can easily understand that the content described in the embodiments is only used to illustrate the present invention and should not and will not limit the present invention described in detail in the claims.

[0022] Example 1:

[0023] This example is a preparation method of an aqueous emulsion containing abamectin and pyriproxyfen, including the following steps:

[0024] Step 1: Weigh 2% of abamectin and pyriproxyfen with a mass ratio of 1:0.5 according to mass percentage, and weigh 12% of a mixed solvent of xylene and isopropanol with a mass ratio of 1:1 according to mass percentage. Add the two to an oil phase kettle, stir for 30 minutes to mix evenly, and obtain an oil phase.

[0025] Step 2: Weigh 5% of Span-20 and Tween-20 emulsifiers with a mass ratio of 1:1 according to mass percentage, 0.8% of an organosilicon antifoaming agent according to mass percentage, and 2% of ethylene glycol according to mass percentage and add them to an aqueous phase kettle. Use deionized water to make up to 100%, stir for 30 minutes to mix evenly, and obtain an aqueous phase.

[0026] Step 3: Shear the aqueous phase and the oil phase with a mass ratio of 14:86 at 500 r / min for 30 minutes, mix evenly, and obtain an aqueous emulsion.

[0027] Example 2:

[0028] This example is a preparation method of an aqueous emulsion containing abamectin and pyriproxyfen, including the following steps:

[0029] Step 1: Weigh abamectin and pyriproxyfen at a mass ratio of 1:0.7 by mass percentage at 3%, and weigh the mixed solvent of xylene and isopropanol at a mass ratio of 1:1 by mass percentage at 15%. Add the two to the oil phase kettle and stir for 30 min to mix evenly to obtain the oil phase.

[0030] Step 2: Weigh Span-20 and Tween-20 emulsifiers at a mass ratio of 1:1 by mass percentage at 6%, weigh silicone defoamer at a mass percentage of 0.5%, and weigh ethylene glycol at a mass percentage of 4% and add them to the water phase kettle. Make up to 100% with deionized water and stir for 30 min to mix evenly to obtain the water phase.

[0031] Step 3: Shear the water phase and oil phase with a mass ratio of 18:82 at 500 r / min for 30 min and mix evenly to obtain the aqueous emulsion.

[0032] Example 3:

[0033] This example is a preparation method of an aqueous emulsion containing abamectin and pyriproxyfen, and includes the following steps:

[0034] Step 1: Weigh abamectin and pyriproxyfen at a mass ratio of 1:0.9 by mass percentage at 4%, and weigh the mixed solvent of xylene and isopropanol at a mass ratio of 1:1 by mass percentage at 10%. Add the two to the oil phase kettle and stir for 30 min to mix evenly to obtain the oil phase.

[0035] Step 2: Weigh Span-20 and Tween-20 emulsifiers at a mass ratio of 1:1 by mass percentage at 4%, weigh silicone defoamer at a mass percentage of 0.6%, and weigh ethylene glycol at a mass percentage of 4% and add them to the water phase kettle. Make up to 100% with deionized water and stir for 30 min to mix evenly to obtain the water phase.

[0036] Step 3: Shear the water phase and oil phase with a mass ratio of 14:86 at 500 r / min for 30 min and mix evenly to obtain the aqueous emulsion.

[0037] Example 4:

[0038] This example is a preparation method of an aqueous emulsion containing abamectin and pyriproxyfen, and includes the following steps:

[0039] Step 1: Weigh abamectin and pyriproxyfen at a mass ratio of 1:1 by mass percentage at 5%, and weigh the mixed solvent of xylene and isopropanol at a mass ratio of 1:1 by mass percentage at 12%. Add the two to the oil phase kettle and stir for 30 min to mix evenly to obtain the oil phase.

[0040] Step 2: Weigh 8% of Span-20 and Tween-20 emulsifiers with a mass ratio of 1:1, 0.5% of organosilicon defoamer, and 5% of ethylene glycol by mass percentage and add them to the aqueous phase kettle. Make up to 100% with deionized water and stir for 30 min to mix evenly to obtain the aqueous phase.

[0041] Step 3: Shear the aqueous phase and oil phase with a mass ratio of 17:83 at 500 r / min for 30 min and mix evenly to obtain the emulsion.

[0042] Comparative Example 1

[0043] Step 1: Weigh 2% of abamectin and 12% of a mixed solvent of xylene and isopropanol with a mass ratio of 1:1 by mass percentage. Add the two to the oil phase kettle and stir for 30 min to mix evenly to obtain the oil phase.

[0044] Step 2: Weigh 5% of Span-20 and Tween-20 emulsifiers with a mass ratio of 1:1, 0.8% of organosilicon defoamer, and 2% of ethylene glycol by mass percentage and add them to the aqueous phase kettle. Make up to 100% with deionized water and stir for 30 min to mix evenly to obtain the aqueous phase.

[0045] Step 3: Shear the aqueous phase and oil phase with a mass ratio of 14:86 at 500 r / min for 30 min and mix evenly to obtain the emulsion.

[0046] Comparative Example 2

[0047] Step 1: Weigh 2% of pyriproxyfen and 12% of a mixed solvent of xylene and isopropanol with a mass ratio of 1:1 by mass percentage. Add the two to the oil phase kettle and stir for 30 min to mix evenly to obtain the oil phase.

[0048] Step 2: Weigh 5% of Span-20 and Tween-20 emulsifiers with a mass ratio of 1:1, 0.8% of organosilicon defoamer, and 2% of ethylene glycol by mass percentage and add them to the aqueous phase kettle. Make up to 100% with deionized water and stir for 30 min to mix evenly to obtain the aqueous phase.

[0049] Step 3: Shear the aqueous phase and oil phase with a mass ratio of 14:86 at 500 r / min for 30 min and mix evenly to obtain the emulsion.

[0050] Refer to GB / T19136-2003. At room temperature, fill the emulsion in a clean ampoule bottle, place it in an ice-salt bath for refrigeration, quickly seal it with a high-temperature flame to avoid solvent volatilization, weigh it, place it in an incubator at 54±2°C for 14 days, take it out, cool it to room temperature, weigh it, measure the content of the active ingredient, and calculate the decomposition rate. Decomposition rate (%) = (content of active ingredient before heat storage of the sample - content of active ingredient after heat storage of the sample) / content of active ingredient before heat storage of the sample.

[0051] Refer to GB / T19137-2003. At room temperature, fill the emulsion in a clean ampoule bottle, quickly seal it with a high-temperature flame, store it in a low-temperature refrigerator at 0±2°C for 7 days, take it out, place it at room temperature, wait until it returns to room temperature, shake the sample, observe the appearance. If it is a homogeneous milky emulsion and no solid particles or oil substances precipitate, it is qualified.

[0052] Table 1:

[0053] Decomposition rate (%) Cold storage stability Example 1 3.45 Qualified Example 2 3.02 Qualified Example 3 2.80 Qualified Example 4 2.95 Qualified

[0054] As can be seen from the table, the decomposition rates of Examples 1-4 are all less than 5%, the heat storage performance is qualified, and it has good heat storage stability and cold storage stability.

[0055] Adopt the centrifugal tube medicine film method. Place the emulsion in a centrifugal tube to form a film. Select Diaphorina citri and Tetranychus cinnabarinus and raise them on leaf discs. Select 5-7-day-old female Diaphorina citri and Tetranychus cinnabarinus that are relatively large in size, full of vitality and uniform, and place 30 of them in each centrifugal tube. Place them in an incubator at a constant temperature of 26°C for 24 hours, and examine them under a microscope. Record as dead if one is completely immobile. Mortality rate (%) = number of observed dead / 30.

[0056] Table 2:

[0057]

[0058] As can be seen from the table, the emulsion prepared by the present invention has good bactericidal effects on Diaphorina citri and Tetranychus cinnabarinus. The highest insecticidal rates can reach 100% and 96% respectively. And abamectin and pyriproxyfen have obvious synergistic effects on Diaphorina citri and Tetranychus cinnabarinus. The mortality rate of a single emulsion is lower than the synergistic effect of the combination of the two. Therefore, the emulsion prepared by the present invention has good insecticidal effects.

[0059] In the description of this specification, the descriptions referring to terms such as "one embodiment", "example", "specific example", etc. mean that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in a suitable manner in any one or more embodiments or examples.

[0060] The above content is only an illustration and explanation of the present invention. Those skilled in the art of this technology can make various modifications or supplements to the described specific embodiments or use similar ways to substitute them. As long as they do not deviate from the invention or exceed the scope defined by the claims of this patent, they should fall within the protection scope of the present invention.

Claims

1. An aqueous emulsion containing abamectin and pyriproxyfen, characterized in that, The aqueous emulsion contains an oil phase and an aqueous phase, and the mass ratio of the oil phase to the aqueous phase is 14 - 18:82 - 86; The oil phase contains: abamectin, pyriproxyfen, and a mixed solvent; The aqueous phase contains: an emulsifier, ethylene glycol, an antifoaming agent, and deionized water.

2. The aqueous emulsion containing abamectin and pyriproxyfen according to claim 1, characterized in that, The mass ratio of abamectin to pyriproxyfen is 1:0.5 - 1, and their dosage is 2 - 5% of the total mass of the aqueous emulsion.

3. The aqueous emulsion containing abamectin and pyriproxyfen according to claim 1, characterized in that, The mixed solvent is a mixed solution of xylene and isopropanol with a mass ratio of 1:1, and its dosage is 10 - 15% of the total mass of the aqueous emulsion.

4. The aqueous emulsion containing abamectin and pyriproxyfen according to claim 1, characterized in that, The emulsifier is a mixture of Span - 20 and Tween - 20 with a mass ratio of 1:1, and its dosage is 4 - 8% of the total mass of the aqueous emulsion.

5. The aqueous emulsion containing abamectin and pyriproxyfen according to claim 1, characterized in that, The antifoaming agent is a silicone antifoaming agent, and its dosage is 0.5 - 0.8% of the total mass of the aqueous emulsion; the dosage of ethylene glycol is 2 - 5% of the total mass of the aqueous emulsion, and the balance is deionized water.

6. The aqueous emulsion containing abamectin and pyriproxyfen according to any one of claims 1-5, characterized in that, The preparation method includes the following steps: (1) Add abamectin, pyriproxyfen, and the mixed solvent of xylene and isopropanol to the oil - phase kettle, stir for 30 min to mix evenly to obtain the oil phase; (2) Add the emulsifier, antifoaming agent, ethylene glycol, and deionized water to the aqueous - phase kettle, stir for 30 min to mix evenly to obtain the aqueous phase; (3) Add the aqueous phase to the oil phase, shear at 5500 r / min for 30 min to mix evenly to obtain the aqueous emulsion.

7. The aqueous emulsion containing abamectin and pyriproxyfen according to claim 1, characterized in that, The aqueous emulsion is applied in the fields of controlling houseflies, mites, etc.

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